• 대한감각통합치료학회지
• /
• 제11권1호
• /
• pp.1-9
• /
• 2013

목적 : 본 연구는 구강활동을 병행한 감각통합치료가 발달장애 아동의 호흡과 구강협응능력에 미치는 효과를 알아보고자 하였다. 연구 방법 : 연구대상은 G시에 거주하는 만 6세 7개월의 남아로, 발달장애 진단을 받았다. 연구는 2012년 11월부터 2013년 2월까지 실시하였다. 실험은 개별실험연구 중 AB디자인을 사용하였다. 실험과정은 기초선(A) 3회기, 중재(B) 16회기이었다. 기초선 기간 동안에는 감각통합치료를 실시하였고, 중재기간동안에는 감각통합치료에 구강활동을 병행하여 실시하였다. 호흡기능은 폐활량 측정계로 측정하였으며, 구강협응능력은 "파타카(pataka)"를 10회 반복할 때 소요된 시간을 초단위로 측정하였다. 결과 : 아동의 호흡과 구강협응능력은 기초선과 비교하여 중재기간 동안 유의하게 증가하였다. 결론 : 구강활동을 병행한 감각통합치료가 아동의 호흡과 구강협응능력 향상에 긍정적이었다.

• 융합정보논문지
• /
• 제10권3호
• /
• pp.176-184
• /
• 2020

본 연구는 집단놀이치료가 발달장애아동의 문제행동 감소에 효과가 있는지 알아보고 위하여 연구를 실시하였다. 연구대상은 특수학교에 재학 중이며 장애인 단기보호센터를 이용하는 장애아동 5명이다. 연구기간은 2018.1. 2. - 2. 28. 까지 겨울방학을 활용하여 매주 2회 40분씩 총 12회기를 실시하였으며 측정도구는 문제행동 진단척도(K-CBCL)로 매 회기마다 행동변화를 질적으로 관찰하였다. 본 연구결과를 요약하면 다음과 같다. 첫째, 회기별 과정에서 장애아동들은 공격성, 위축, 우울, 불안 등이 유의미하게 감소하고 활동적이 모습이 증가하였다. 둘째, 집단놀이치료 개입 후 문제행동이 감소하고 외현화 문제보다 내재화 문제에서 더 많은 감소를 보였다. 본 연구의 결과는 집단놀이치료는 장애아동의 개별적인 특성에 따라 문제행동을 감소시키는데 의미가 있으므로 실천현장에 적용하고자 한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제32권1호
• /
• pp.35-40
• /
• 2021

Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating clinical efficacy in randomized control trials. Here, we investigate the clinical efficacy of ESDM intervention in young children with ASD in a community setting within Japan. Methods: All subjects were children with ASD who received ESDM intervention during the study period. Each ESDM session lasted 75 min and occurred once per week for at least 12 weeks. The outcome measures consisted of the Kyoto Scale of Psychological Development (K-test), Aberrant Behavior Checklist-Japanese version (ABC-J), and the Clinical Global Impression-Severity scale (CGI-S). Results: Twenty-seven subjects (29.4±6.4 months old) received ESDM intervention that lasted for 8.0±2.6 months on average. The score on Language and Social developmental quotient on the K-test increased significantly after the intervention. The total scores on the ABC-J and CGI-S significantly decreased after completion of the ESDM intervention. Conclusion: Our results suggest that ESDM intervention could reduce the severity of distinct clinical features of ASD, such as impairments in social interaction and communication assessed by the K-test, and maladaptive behavior rated by the ABC-J and CGI-S. We believe that the ESDM adapted to each institution might become one of the standard options for children with ASD in Japan.

• Journal of Animal Science and Technology
• /
• 제65권4호
• /
• pp.767-778
• /
• 2023

The aim of the research is to identify that porcine oocytes can function as recipients for interspecies cloning and have the ability to develop to blastocysts. Furthermore each mitochondrial DNA (mtDNA) in interspecises cloned embryos was analyzed. For the study, mouse-porcine and porcine-porcine cloned embryos were produced with mouse fetal fibroblasts (MFF) and porcine fetal fibroblasts (PFF), respectively, introduced as donor cells into enucleated porcine oocytes. The developmental rate and cell numbers of blastocysts between intraspecies porcine-porcine and interspecies mouse-porcine cloned embryos were compared and real-time polymerase chain reaction (PCR) was performed for the estimate of mouse and porcine mtDNA copy number in mouse-porcine cloned embryos at different stages.There was no significant difference in the developmental rate or total blastocyst number between mouse-porcine cloned embryos and porcine-porcine cloned embryos (11.1 ± 0.9%, 25 ± 3.5 vs. 10.1 ± 1.2%, 24 ± 6.3). In mouse-porcine reconstructed embryos, the copy numbers of mouse somatic cell-derived mtDNA decreased between the 1-cell and blastocyst stages, whereas the copy number of porcine oocyte-derived mtDNA significantly increased during this period, as assessed by real-time PCR analysis. In our real-time PCR analysis, we improved the standard curve construction-based method to analyze the level of mtDNA between mouse donor cells and porcine oocytes using the copy number of mouse beta-actin DNA as a standard. Our findings suggest that mouse-porcine cloned embryos have the ability to develop to blastocysts in vitro and exhibit mitochondrial heteroplasmy from the 1-cell to blastocyst stages and the mouse-derived mitochondria can be gradually replaced with those of the porcine oocyte in the early developmental stages of mouse-porcine cloned embryos.

• 스마트미디어저널
• /
• 제13권5호
• /
• pp.19-25
• /
• 2024

발달장애인의 사회 진입을 막는 가장 큰 행동 유형은 공격 행동이다. 공격 행동은 발달장애인 자신의 안전뿐만 아니라 타인의 신체적 안전에도 위협이 될 수 있다. 본 연구에서는 저전력 프로세서를 활용한 웨어러블 시스템을 제안한다. 제안된 시스템은 IMU(Inertial Measurement Unit, 관성 측정 장치)가 적용되어, 사용자의 행동을 분석할 수 있으며, 개발된 시스템에 부착된 LED 배열을 통해 일정 시간 이상 공격 행동이 감지되지 않을 시, 흥미로운 LED 패턴을 표현하여 발달장애인에게 보상을 통한 행동 중재를 제공한다. 전원이 제한된 환경에서 장시간 착용해야 하는 시스템을 구현하기 위해 데이터의 전처리 과정부터 AI 모델 적용까지 전 단계에 걸쳐서 성능-에너지 소모 간 최적화 방법을 제시한다.

• Biomolecules & Therapeutics
• /
• 제6권1호
• /
• pp.82-88
• /
• 1998

LBO0014, a new recombinant human erythropoietin, was at dose levels of 0, 120, 600, and 3,000 IU/kg/day administered intravenously to pregnant Sprague-Dawley rats during the organogenetic period. All dams were subjected to caesarean section on day 20 of pregnancy, Effects of test substance on dams and embryonic development of Fl fetuses were examined. No treatment-related changes in clinical signs, body weight, and food consumption were observed at all doses tested. At necropsy spleen enlargement was found at 3,000 lU/kg. There was an ulcrease in the spleen weight at 600 and 3,0007/kg. Developmental toxicity was evident as increased resorptions at 3,000 lU/kg. At 600 and 3,000 RJ/kg, retarded ossification of fetuses occurred at an incidence of 31.3% and 64.7%, respectively. In addition, there was a delay in ossification of sternebrae and sacrocaudal vertebrae at 600 and 3,000 lU/kg. A decrease in the number of metacarpi and metatarsi was also seen at 3,000 nJ/kg. The results show that the no observed adverse effect dose level (NOAEL) for material toxicity was over 3,000 IU/kg/day and the NOAEL for developmental toxicity was 120 IU/kg/day.

• 종양간호연구
• /
• 제11권1호
• /
• pp.26-32
• /
• 2011

Purpose: The purpose of this study was to analyze the trend of cognitive developmental interventions on patients with breast cancer who underwent chemotherapy. Methods: The researcher searched databases and selected 17 literatures using chemotherapy, breast cancer, cognitive function and intervention as searching key words. Searched databases included Ovid, Pubmed, Proquest and Medline and data collection period was from January 2000 to May 2010. Results: Interventions for patients with breast cancer have been continuously developed and frequent research topics included breast cancer, chemotherapy, quality of life, and cognitive function. In terms of study design, four research articles were pre-experimental study designs, one was case study, and the rest of studies were non-equivalent pretest-posttest control group design. Effects of intervention were examined in only 5 studies among 17. The interventions were not found to have direct effects in cognitive improvement. Conclusion: It is needed to figure out the mechanism of cognitive deterioration of the patients with breast cancer who underwent chemotherapy. And nursing interventions needs to be developed in order to hold up the cognitive downhill and help their cognitive rehabilitation.

• Toxicological Research
• /
• 제17권2호
• /
• pp.97-106
• /
• 2001

Korean ginseng products have been fumigated with ethylene oxide (EO) for sterilization and prolongation of storage periods. However, there had been controversies indicating that the consumption of food treated with EO might cause harmful effects in human. Since, in Korea the use of EO gas for food treatment was banned in 1991. Since then, irradiation technique has been developed as an alternative. This study was carried out to investigate the effects of irradiated ginseng on fertility, and reproductive and developmental toxicity. Either EO gas fumigated or gamma-irradiated ginseng was administered to male rats by oral gavage for 63 days during the premating period. Female rats were administered from 14 days before mating to day 20 of gestation or to day 21 of lactation. The exposure amount of irradiation used was 5, 10 and 30 kGy, respectively. There were no treatment related changes of darns in clinical signs, and parturition. No treatment related changes in food consumption, body/organ weights, male/female reproductive and fertility performances were observed. F1 fetuses showed no external abnormality. Reflex/sensory junctions, physical/behavioral development, and reproductive performance of F1 rats were not adversary affected. The results of this study show that gamma-irradiated ginseng, up to 30 kGy, has no adverse effects on the fertility, reproduction and development in Wistar rats.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2000년도 추계 학술대회지
• /
• pp.12-27
• /
• 2000

During the recent decades, he problem of climate variability and change has been in the forefront of scientific problems. The objective of this study was to assess the impact of climate variability on crop growth and yield. The growth duration was the main impact of climate variability on crop yield. Phyllochronterval was shortened in the global worming situations. A simple model to describe developmental traits was provided from heading data of directly seeded rice cultivars and temperature data. Daily mean development rate could be explained by the average temperature during the growth stage. Simple regression equation between daily mean development rate(x) and the average temperature(y) during the growth period as y = ax + b. It can be simply modified as x = 1/a $\ast$ (y-b). The parameters of the model could depict the thermo sensitivity of the cultivars. On the base of this model, the three doubled CO2 GCM scenarios were assessed. The average of these would suggest a decline in rice production of about 11% if we maintained the current cultivars. Future cultivar's developmental traits could be suggested by the two model parameters.

• Clinical and Experimental Pediatrics
• /
• 제45권4호
• /
• pp.535-539
• /
• 2002

저자들은 생후 3일째 시작된 경련과 특징적인 피부 병변을 주소로 입원한 환아에서 피부 생검과 뇌 자기 공명 촬영으로 중추 신경계 발달 이상을 동반한 색소 실조증 1례를 경험하였고 중추 신경계 발달 이상은 치명적인 예후 인자로 사료되며 이를 문헌 고찰과 함께 보고하는 바이다.