• 대한한방내과학회지
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• 제15권2호
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• pp.70-108
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• 1994

The kinds and remedies of intoxication were investigated throughout total 22 books of oriental medicine. The results are as follows 1. The kinds of intoxication were 91, most of which were plant intoxications and animal intoxications. 2. The kinds of detoxication medicines was 203, the most popularly prescribed of which were Radix Glycyrrhizae Semen Glycine. 3. The prescribed medicines were most nonpoisonous ones, but some of them were poisonous. 4. The medicines with Han seong(寒性) were most popularly prescribed. The ones with On seong(溫性), Pung seong(平性), Youl seong(熱性), Yang seong(凉性) follows 5. The most popularly prescribed medicine was sweet taste(甘味). The nest ones were pungent taste(辛味), bitter taste(苦味), sour taste(酸味), salty taste(鹹味). 6. The most popularly prescribed medicine was Chung Youl(淸熱) medicines.

• Archives of Pharmacal Research
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• 제10권3호
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• pp.149-152
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• 1987

The present work was undertaken to investigate the effect of diallyl disulfide on ethacrynic acid toxicity. Ethacrynic acid-induced morality and formation of lipid peroxide were inhibited by diallyl disulfide. Furthermore, decreasing effect of glutathione S-transferase and glutathione level in the liver by ethacrynic acid were reduced by diallyl disulfide. These results suggested that the inducing effect of diallyl disulfide on the ethacrynic acid metabolizing enzyme, glutathione S-transferase, is believed to be a possible detoxication mechanism for the ethacrynic acid toxicity in mice.

• Archives of Pharmacal Research
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• 제8권4호
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• pp.197-203
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• 1985

It was attempted to observe the effect of garlic on the hepatic glutathione s-transferase and glutathione peroxidase activity in this study. Glutathione s-transferase (EC 2.5.1.18) are thought to play a physiological role in initiating the detoxication of potential alkylating agents, inclnding pharmacologically active compounds. Glutathione peroxidase (EC 1. 11. 1. 9) might play an important role in the protection of cellular structures against oxidative challenge. The activities of glutathione s-transferase and glutathione peroxidase in rat liver were increased by the treatment of garlic juice. Allicin fraction, heat-treated allicin fraction and garlic butanol fraction markedly inhibited glutathione s-transferase activity in vitro, whereas glutathione peroxidase activity was significantly increased in heat-treated allicin fraction and garlic butanol fraction.

• 생명과학회지
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• 제9권3호
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• pp.300-307
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• 1999

The enzyme activities and antioxidative of tocopherol and ascorbate were investigated at the levels of liver, kidney homogenates and sera of SD-rats intoxicated with tetrachlorocarbon$CCl_4$. GOT and GPT activities of sera in the $CCl_4$ group were 3, 6 times increased compared to normal group. But they tended to decrease significantly in tocopherol and ascorbate administered group. As for BUN and total cholesterol they were the same. HDL-cholesterol in the $CCl_4$group was 42% decreased compared to normal group. HDL-cholesterol was about 26% increased in the tocopherol group and tocopherol ascorbate group compared to $CCl_4$ group. MDA and SOD activities in the liver and the kidney tissue homogenates were significantly increased in $CCl_4$ group compared to normal group. But they were decreased significantly in the tocopherol group and tocopherol-ascorbate group compared to $CCl_4$ group. In view of this study tocopherol and ascorbated were ascorbate were effective on the detoxication of liver and kidney injury.

• Preventive Nutrition and Food Science
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• 제3권1호
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• pp.67-70
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• 1998

To investigate an effect of Gam-Roa tea on the free radical or alcohol detoxicating enzyme activities, the rats got a drink at the Gam-Roa tea instead of water for 3 months, and then the animals were sacrificed and obtained the following findings. The animals receiving Gam-Roa tea showed a decreasing tendency of hepatic xanthine oxithine oxidase activity and significantly incresed content of cytochrome P-450 compared with the control. Furthermore, hepatic superoxide dismutase and glutathione S-transferase activities were also more increased in rats received Gam-Roa tea than in the control group, those receiving water. On the other hand, alcohol or aldehyde dehydrogenase activities were more increased in rats receiving Gam-Roa tea than the control. In conclusion, it is likely that the liver of rats receiving Gam-Roa tea may have the oxygen free radical or alcohol detoxication potential.

• Toxicological Research
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• 제12권1호
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• pp.41-46
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• 1996

This study was performed to investigate the antitoxic component in methanol fraction of Lonicerae fios. The results were as follows: 1. When a 500 ppm of water soluble fraction of Lonicerae flos was administered, it showed the highest antitoxic effect. 2. Generally, detoxication effects by methanol fraction of Lonicerae fios increased. When the ethyl acetate soluble fraction of Lonicerae rios was administered, it exhibited the highest antitoxic effect against the toxicity of cadmium in Liver. 3. The combined administration of cadmium and methanol fraction of Lonicerae rios significantly increased metallothionein in liver compared to administration of cadmium only. This phenomenon was more remarkable when the ethyl acetate soluble fraction of Lonicerae fios was administered with cadmium chloride.

• 한국응용곤충학회지
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• 제30권1호
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• pp.10-17
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• 1991

벼멸구의 살충제 저항성 기구를 구명하고자 fenobucarb와 carbofuran으로 벼멸구를 18세대 이상 누대 선발하여 얻어진 저항성 벼멸구를 대상으로 저항성 기루를 조사하였으며, 얻어진 결과 중 살충제의 체벽 투과량, 대사 및 대사산무렝 대하여 보고하고자 한다. Fenobucarb및 carbofuran은 처리 1시간 이내에 처리된 양의 50%이상이 벼멸구 체벽을 투과하였고, 계통별 체벽 투과량 차이는 크지 않았으나, 저항성 계통에서 적었으며, 배설된 양도 처리 3시간 이후 저항성 계통에서 증가하여 5시간 후에는 감수성 계통에 비해 각각 1.9배, 1.6배가 많았다. 벼멸구 체내에서는 두 살충제 모두 감수성 계통에 비하여 저항성 계통에서 2시간 정도 빠르게 분해되었다. 벼멸구 homogenate를 이용하여 대사산물을 조사한 결과 fenbucarb의 주 대사산물은 OSBP(o-sec-butyl phenol)이고, crbofuran의 주 대사산물은 3-ketocarbofuran phenol이었으며, 대사산물량은 저항성 계통에서 2배 정도 증가하였다. 주 대사산물인 OSBP 및 3-ketocarbofuran phenol의 감수성 벼멸구에 대한 반수치사약량은 100$\mu\textrm{g}$/g 이상으로 독성이 없었다. 살충제의 빠른 분해대사는 벼멸구의 주요한 저항성 기구중 하나인 것으로 나타났다.

• 동의생리병리학회지
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• 제16권5호
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• pp.911-913
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• 2002

Rubi Fructus (fruit of Rubus coreanus Miq.), oriental medicine, has been used for remedy of the liver diseases and for tonic. In order to investigate the oxygen free radical, a harmful factor of aging, in liver of rats fed diets supplemented with the Rubi Fructus water extract(RX), Sprague-Dawley male rats have been fed a diet supplemented with 3% or 5% RX for a month. In rats fed 3% RX supplemented diet, hepatic cytochrome P-450 contents appeared to be increased, and catalase and superoxide dismutase activities were significantly increased compared with the control. There was no difference in glutathione peroxide and glutathione-S-transferase activities between the rats fed RX supplemented diets and the control diet. In conclusion, it is likely that rats fed a diet supplemented with RX may have the oxygen free radicals detoxication potential.

• 한방안이비인후피부과학회지
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• 제13권2호
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• pp.1-19
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• 2000

1. The furuncle is nail shaped, whitch tip is sharp and root is deep, very dangerous. It's progress is so rapid and it corresponds to the acute suppurative infection of western medicine. 2. The cause and pathology of the furuncle were divided into three parts, inappropriate care (improper diet and excessive sex), surgical trauma (epidernic infection by domestic animal as like cattle, hoarses, pigs, sheep etc), external evil. 3. The early syndrome of the furuncle is swollen pain, various change of color, fidgetiness, restlessness, aversion to cold, headache, nausea and vomitting etc. Though apply acupuncture, there is no pain and bleeding. There may be streak of blood, curdy of muscles and widen swolling. If it is progressed, its sphere becomes diffuse. This is called as the serious case of furuncle(정독주황). 4. The maim treatment of the furuncle is clear away heat and toxic materials. The method was moxibustion, sticking-plaster, purge blood, oral taking the medicine of detoxication and fire extinguishing etc. 5. The main prescriptionst are omisodokyum(五味消毒飮), hwangyeonheadoktang(黃連解毒湯), ohyangyeongyotang(五香連翹湯), hyeongbangpaedoksan(荊防敗毒散) and so on. The main external prescriptionst are okrhosan(玉露散), cheonchugo(千 膏), guildao(九一丹), palyidan(八二丹), taeyulgo(太乙膏), hongyugo(紅油膏) and so on.

• Biomolecules & Therapeutics
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• 제1권2호
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• pp.160-165
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• 1993

The effects of Glycyrrhizae Radix (GR) on the metabolism of acetaminophen (AA) were examined in male Sprague-Dawley rats. The methanol extract of GR (500 mg/kg) was administered orally to rats for 6 days. AA and its metabolites excreted in bile, urine and blood within 120 min after dosing of AA (150 mg/kg, i.v.) were assayed by HPLC. Treatment of rats with the methanol extract of GR significantly increased the cumulative biliary excretion of AA-glucuronide (156% of the control) and decreased that of AA-sulfate (63% of the control). The cumulative urinary excretion of AA-glucuronide was also significantly increased to 132% of the control. GR treatment significantly increased total (biliary plus urinary) excretion of AA-glucuronide (172% of the control) without influencing thioether and sulfate conjugates of AA. The results clearly show that GR enhances UDP-glucuronosyl transferase-mediated detoxication of AA, but may not influence sulfotrans-ferase-mediated and cytochrome P-450-mediated metabolites formation.