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Effects of Rubi Fructus Water Extract On Oxygen Free Radical Metabolizing Enzyme Activites  

Lee Kwang Gyu (College of Oriental Medicine, Woosuk University)
Cui Xun (Department of Oriental pharmacy, Woosuk University)
Lim Jong Pil (Department of Oriental pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 911-913 More about this Journal
Abstract
Rubi Fructus (fruit of Rubus coreanus Miq.), oriental medicine, has been used for remedy of the liver diseases and for tonic. In order to investigate the oxygen free radical, a harmful factor of aging, in liver of rats fed diets supplemented with the Rubi Fructus water extract(RX), Sprague-Dawley male rats have been fed a diet supplemented with 3% or 5% RX for a month. In rats fed 3% RX supplemented diet, hepatic cytochrome P-450 contents appeared to be increased, and catalase and superoxide dismutase activities were significantly increased compared with the control. There was no difference in glutathione peroxide and glutathione-S-transferase activities between the rats fed RX supplemented diets and the control diet. In conclusion, it is likely that rats fed a diet supplemented with RX may have the oxygen free radicals detoxication potential.
Keywords
Rubi Fructus(覆盆子); oxygen free radical; metabolizing enzyme;
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