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Characteristics of Percutaneous Absorption of Glycol ethers (Glycol ethers에 대한 피부 투과 특성)

  • Lee, Han-Seob;Choi, Sung-Boo;Kim, Nac-Joo;Keun, Jang-Hyoun;Hwang, Hyun-Suk;Baek, Jung-Hun;Choi, Jin-Ho;Lee, Ho-Joon
    • Journal of the Korean Applied Science and Technology
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    • v.30 no.1
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    • pp.116-126
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    • 2013
  • Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol commonly used in paints. These solvents typically have a higher boiling point, together with the favorable solvent properties of lower-molecular weight ethers and alcohols. The word "Glycol ethers" was registered as a United States trademark by Union Carbide Corp. Typically, glycol ethers are found in pharmaceuticals, sunscreens, cosmetics, inks, dyes and water based paints. On the other hand, glycol ethers are used in degreasers, cleaners, aerosol paints and adhesives. Most glycol ethers are relatively water soluble, biodegradable and only a few are considered toxic. Therefore, they are unlikely to pose an adverse risk to the environment. Recent study suggests that occupational exposure to glycol ethers is related to low motile sperm count in men, but the finding has been disputed by others. In this study, skin permeation of 3 types glycol ethers were studied in vitro using matrix such as solvent and detergent. The absorption of glycol ethers[methyl glycol ethers(MC), ethyl glycol ethers(EC) and butyl glycol ethers(BC)] has been measured in vitro through rat skin. Epidermal membranes were set up in Franz diffusion cells and their permeability to PBS measured to establish the integrity of the skin before the glycol ethers were applied to the epidermal surface. Absorption rates for each glycol ethers were determined and permeability assessment made to quantify any irreversible alterations in barrier function due to contact with the esters. Types of glycol ethers in vitro experimental results on MC> EC> BC quickly appeared in the following order: skin permeation was beneficial to the skin permeation small molecular weight, the difference in chemical structure, such as hydrophilic, because with the partition coefficient and solubility mechanisms and passive diffusion to increase the speed at which transmission is considered.

Effect of Different Seasons on the Performance of Grey Giant Rabbits under Sub-Temperate Himalayan Conditions

  • Bhatt, R.S.;Sharma, S.R.;Singh, Umesh;Kumar, Davendra;Bhasin, V.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.6
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    • pp.812-820
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    • 2002
  • An experiment was conducted on 190 progeny (winter -74; summer -59; rainy -57) of 12 Grey Giant rabbits (10 female +2 males), to assess the effect of different seasons in a year, on their reproductive, growth and productive performances along with feed efficiency, under sub-temperate Himalayan conditions. The daily meteorological attributes recorded during winter (October to March), summer (April to June) and rainy (July to September) seasons, and analysed were minimum and maximum temperature, relative humidity and rainfall. Various biological parameters recorded were doe weights at mating and kindling, litter size at birth, litter weight at birth, kit mortality, litter size at weaning, litter weight at weaning, weekly body weight up to 98 d and weaner mortality. Individual weight gains, dressing percentages, meat weights, liver weights, raw-pelt weights, processed pelt weights and processed pelt areas at slaughter on d 84 and 98, respectively were also recorded. The feed and fodder compositions and their nutritive values during different seasons were also analysed. Average ambient temperature during winter, summer and rainy seasons were $13.2{\pm}2.8$, $22.4{\pm}3.7$ and $24.8{\pm}2.3^{\circ}C$, respectively. The average relative humidity and total rainfall for winter, summer and rainy seasons were $68.9{\pm}1.5$% and $48{\pm}26.6$mm, $66.3{\pm}4.8$% and $125.6{\pm}56.8$ mm, and $77.3{\pm}1.3$% and $116.3{\pm}90.4$ mm, respectively. The weight of doe at mating and kindling, litter size at birth, litter weight at birth and litter size at weaning were comparatively higher whereas litter weight at weaning was significantly (p<0.05) higher during winter as compared to summer and rainy seasons. The kit mortality was significantly (p<0.05) higher during winter while the weaner mortality was significantly (p<0.05) higher during rainy season. At 84 d, the live weight per doe, slaughter weight, dressing percentage and liver weight were significantly (p<0.05) higher during winter than summer and rainy. Similarly, the gain in weight and meat weight at 84 and 98 d were significantly (p<0.05) higher during winter. The weight of raw pelt and processed pelt were recorded significantly (p<0.05) higher during winter while no difference in the area of processed pelts during different seasons could be observed. No difference in the biological performance could be observed between sexes in any of the seasons. Roughage analysis revealed comparatively higher crude protein percent and lower crude fibre percent during summer and rainy seasons than in winter. The roughage dry matter intake was comparatively higher during summer and rainy seasons vis-a-vis constant amount of concentrate supplied during all the three seasons. The digestibilities of dry matter was significantly (p<0.05) lower, whereas that of crude fiber, acid detergent fibre and cellulose were negative during winter. Interestingly, the feed:gain was exceedingly well during winter than in other seasons and it is concluded that it was the best season for production of rabbits under sub-temperate Himalayan conditions.

An Empirical Study on the Effects of Category Tactics on Sales Performance in Category Management - A Comparative Study by Store Type and Market Position - (카테고리 매출성과에 영향을 미치는 카테고리 관리 전술들에 대한 실증연구 - 점포유형과 시장포지션에 따른 비교분석 -)

  • Chun, Dal-Young
    • Journal of Distribution Research
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    • v.12 no.3
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    • pp.23-48
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    • 2007
  • Category management has been implemented to enhance competitiveness in the food distribution industry since 2000 in Korea. This study helps to understand why suppliers achieve better or worse performance than competitors in a category. The major objective of this article is to explore which category tactics are effective to have influence on category performance when suppliers as a category captain implement category management with variety enhancer categories like shampoo, toothpaste, and detergent. The Nielsen data were analyzed using regression and Chow test. The empirical results that were varied upon the store type and market position found out which specific actions on product assortments, pricing, shelving, and product replenishment can increase category sales. Specifically, in the case of market leader in large supermarket, the significant indicators of category sales with respect to category tactics are the out-of-stock rate, the variance across brand shares, the forward inventory, and the days supply of a product. However, in the case of follower in large supermarket, the significant indicators of category sales are the variance across brand shares, the forward inventory, and the days supply of a product. On the other hand, in the case of small supermarket, the significant factors on category sales for both market leader and follower are the retail distribution rate, the variance across brand shares, the forward inventory, and the days supply of a product category. In sum, regardless of the store type and market position, dominant brands in a category, the forward inventory, and short days supply of a product improved performance in all categories. Critical difference is that the out-of-stock rate acted as a key ingredient for the market leader between large and small supermarket and the retail distribution rate for the follower between large and small supermarket. This article presents some theoretical and managerial implications of the empirical results and finalizes the paper by addressing limitations and future research directions.

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Clinical analysis of acute drug intoxication and foreign body ingestion in Wonju: comparison between the 1990s and the 2000s (1990년대와 2000년대의 원주시 소아에서 발생한 급성약물중독과 이물질섭취 환아의 비교분석)

  • Eum, Joo Pil;Suh, Jin Suk;Kim, Hwang Min
    • Clinical and Experimental Pediatrics
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    • v.50 no.2
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    • pp.138-142
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    • 2007
  • Purpose : The purpose of this study is to find out the changing pattern of drug or foreign body ingestion between 1990s and 2000s in Wonju Christian Hospital, which is located in one of the most rapidly urbanizing cities in Korea. Methods : We retrospectively reviewed the medical records of patients with acute drug intoxication and foreign body ingestion from January 1991 to December 1994 and from January 2001 to December 2004. We performed clinical analysis and compared the results of the 1990s and 2000s. Results : There were 43 cases of acute drug intoxication in the 1990s, and 35 cases in the 2000s. Foreign body ingestion was 47 cases in the 1990s and 22 cases in the 2000s. The ingested foreign bodies were chiefly coins (46.8 percent), Weiqi chips (14.9 percent), plastic toys (6.4 percent) and others (31.9 percent) in the 1990s. In the 2000s, others (58.2 percent) were the most commonly ingested foreign body with mercury batteries (23.8 percent), nails (9 percent), pins (9 percent) following. The most common cause of drug intoxication was medical drugs (37.2 percent) others (23.2 percent), agricultural agents (13.9 percent), carbon monoxide (11.6 percent), rodenticide (9.3 percent), insecticide (9.3 percent) in the 1990s. In the 2000s the most common causes were others (34.3 percent), medical drug (31.4 percent), agriculture agents (20 percent), detergent (11.4 percent), insecticide (2.9 percent) and carbon monoxide (2.9 percent). The highest incidence age group was the 1-3 year old group, both in acute drug intoxication and foreign body ingestion. There were no changes in the incidence age group between the 1990s and the 2000s. Conclusion : There were some significant changes in the cause of acute drug intoxication and foreign body ingestion between the 1990s and 2000s. New education programs for preventing acute drug intoxication and foreign body ingestion are important and necessary.

Effect of Seeding Date and Varieties of Italian Ryegrass on Forage Yield and Quality of Early Spring-seeded at Paddy Field in Southern Region (남부지역 논에서 봄파종시 이탈리안 라이그라스 품종 및 파종시기가 수량과 사료가치에 미치는 영향)

  • Kim, Ki Soo;Lee, Suk Kyung;Choi, Young Sun;Park, Do Hwan;Ji, Hee Jung;Jung, Jong Seong;Choi, Ki Choon;Kim, Won Ho
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.35 no.1
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    • pp.50-56
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    • 2015
  • Italian ryegrass is generally cultivated by a winter forage in a paddy field, the harvest season overlaps with rice transplantion in some cases. In addition, farmers can miss the optimal seedtime for Italian ryegrass because of the rainy season. Therefore, this research was conducted between October 2012 and June 2013 in Kwangjin, Korea to examine the effect of spring-seeding on the yields and quality of Italian ryegrass for the determination of an alternative if the optimal seedtime is missed. This trial consists of four different seeding dates (15 February, 25 February, 5 March, and 15 March) and three varieties (Kowinmaster, Kowinearly, and Green farm). The Italian ryegrass varieties "Kowinmaster," "Kowinearly," and "Green farm" were sown on February 15. The heading date of each variety showed from May 12 to May 9 and interval time of five days but the Treatment of March 15 planting date showed three days interval. The Kowinmaster variety, planted on February 15, was 93.0 cm taller on March 15 with a height of 105.7 cm. The Kowinearly and Green farm varieties planted on February 15 were of a similar height on February 25 and received a poor lodging score when planted quickly. The dry matter (DM) yield of the Kowinearly planted on February 15 was high but that of Green farm was low at 6,609 kg/ha and a difference was not shown between the varieties. The DM yield was different for those varieties planted on February 15 and March 15 (P<0.05). The crude protein content (CPC) of those varieties planted on February 15 showed an average of 8.8%, while those that were planted on March 15 showed an average that was about 2.3% higher at 11.1%; furthermore, the latter also showed lower acid detergent fiber (ADF) and total digestible nutrient (TDN) contents, by 2.1% and 1.5%, respectively. The relative feed value was about 5.9% higher, depending on the seeding date, as well as being slower and showing less difference between the varieties. According to this study, Italian ryegrass planted in a paddy field of the southern region of Korea on February 25 will produce a high-quantity yield with nutritive value.

Biological Hazard Analysis of Paprikas, Strawberries and Tomatoes in the Markets (유통중인 파프리카, 딸기 및 토마토의 생물학적 위해요소 분포 조사)

  • Yu, Yong-Man;Youn, Young-Nam;Hua, Quan Juan;Cha, Guang-Ho;Lee, Young-Ha
    • Journal of Food Hygiene and Safety
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    • v.24 no.2
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    • pp.174-181
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    • 2009
  • The consumption of "ready-to-eat" agricultural products is recently increasing and the safety of these agricultural products is forefront of public concerns. The 120 samples of paprikas, strawberries and tomatoes, which are the representative exported agricultural products, were purchased at the department stores and discount stores in Daejeon. And we determined the microbiological and parasitological contamination level of these agricultural products using culture media, multiplex PCR, commercial bacterial detection kit and microscopy, and also evaluated the decontamination method. Mean counts of total aerobic bacteria from these agricultural products ranged from $1.3{\times}10^4$ CFU/g to $1.8{\times}10^5$ CFU/g, and mean counts of coliforms ranged from $1.4{\times}10^3$ CFU/g to $9.6{\times}10^3$ CFU/g. There was no significant difference in the level of bacterial contamination between the agricultural products from department stores and the ones from discount stores. Strawberry showed the highest contamination level for the bacteria and we also found the unidentified parasite eggs. Enterobacter cloacae was the most frequently isolated bacteria strain, but no food poisoning pathogenic bacteria except Staphylococcus aureus was isolated from the products by multiplex PCR. Compared to unwashed products, tab water-washed ones showed 80% decrease of the counts of total aerobic bacteria on the agricultural products, and the rates decreased more by incorporating detergent or ultrasonic wave treatment. We concluded that the biological contamination levels among paprikas, strawberries and tomatoes were the highest in strawberries, but there were not significant difference according to distribution systems.

Biochemical Characterization of Phospholipase C$\delta$from liver of Mud loach (Misgurnus mizolepis) (미꾸라지 간으로부터 포스포리파아제 C델타 단백질의 생화학적 특성)

  • Seo, Jung-Soo;Lim, Sang-Uk;Kim, Na-Young;Lee, Sang-Hwan;Oh, Hyun-Suk;Lee, Hyung-Ho;Chung, Joon-Ki
    • Journal of fish pathology
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    • v.18 no.1
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    • pp.67-80
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    • 2005
  • Phosphoinositide-specific phospholipase $C\delta$ $PLC\delta$) plays an important role in many cellular responses and is involved in the production of second messenger. The present study was conducted to obtain the biochemical characteristics of the expressed recombinant $PLC\delta$ in E. coli cloned from Misgurnus mizolepis and partially purified $PLC\delta$ enzymes from liver tissues of M. mizolepis (wild ML-$PLC\delta$). The ML $PLC\delta$ gene was cloned and expressed under the previous report (Kim et al., 2004), and purified the recombinant protein by successive chromatography using $Ni^{2+}$-NTA affinity column and gel iltration FPLC column. The wild ML-$PLC\delta$ protein was solublized with 2 M KCI and purified by successive chromatography on open heparin-Sephagel and analytical TSKgel heparin-5PW. Both the recombinant and wild ML-$PLC\delta$ form of protein showed a concentration-dependent PLC activity to phosphatidylinositol 4,5-bis-phosphate (PIP$_2$) or phosphatidylinositol (PI). Its activity was absolutely $Ca^{2+}$- dependant, which was similar to mammalian $PLC\delta$ isozymes. Maximal PI-hydrolytic activations of recombinant and wild ML- TEX>$PLC\delta$ was at pH 7.0 and pH 7.5, respectively. In addition, the enzymatic activities of recombinant and wild ML-$PLC\delta$ were increased in concentration-dependent manner by detergent, such as sodium deoxycholate SDC), phosphatidylethanolamine (PE) and phosphatidylcholine (PC). The activities decreased in contrast by a polyamine, such as spermine. Western blotting showed that several types of $PLC\delta$ isozymes exist in various organs. Taken together our results, it suggested that the biochemical characteristics of ML-$PLC\delta$ are similar with those of mammalian $PLC\delta1$ and ${\delta}3$ isozymes.

Studies on Dry Matter Yield s, Chmical Composition And Net Energy Accumlation in Three Leading Temperate Grass Species III. Seasonal changes of chemical components under dfferent cutting managements (주요북방형 목초의 건물수량 , 화학성분 및 Net Energy 축적에 관한 연구 III. 예취관리에 화학성분의 계절적 변화)

  • 김정갑;양종성;한흥전
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.6 no.3
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    • pp.157-163
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    • 1986
  • Synthesis and accumulation pattern of Weender components in orchardgrass (Dactylis glomerata L.) cv. Potomac and Baraula, perennial ryegrass (Lolium perenne L.) cv. Reveille and Semperweide and meadow fescue (Festuca pratensis Huds.) cv. Cosmos 11 and N.F.G. were studied under different growth environments and cutting managements. The field experiments were conducted as a split plot design with three cutting regimes of 6-7 cuts at grazing stage, 4-5 cuts at silage and 3 cuts at hay stage from 1975 to 1979 in Korea and West Germany. The results obtained are summarized as follows: 1. Air temperature, rainfalls and solar radiation were found to be an important meteorological factors influenced to synthesis and accumulation of Weender components. Under high temperature and strong solar radiation during summer season in Korea, accumulation of crude fiber and cell-wall constituents (NDF) in the plants, as average of all grass species and cutting regimes, were increased to about 30.1% and 48.7% from 27,9% and 42.9% in spring, respectively, while total nonstructural carbohydrates (TNC) were decreased to 1.52% in summer from 4.01% in spring. In West Germany, the concentration of Weeder components showed little seasonal variation. 2. Crude fiber and neutral detergent fiber (NDF) were shown higher concentration in orchardgrass than those of perennial ryegrass and meadow fescue, but N-free extractions and TNC as well as net energy value were less accumulated in orchardgrass. Orchardgrass contained lower net energy contents with 534 StE. 431 StE and 575 StE/kg for Suweon, Cheju and Freising, respectively, as compared with 624 StE (Suweon), 491 StE (Cheju) and 657 StE/kg (Freising) in meadow fescue.

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Effect of Sowing and Harvesting Dates on Forage Productions and Feed Values of Rye and Triticale in Youngnam Mountain Area (영남산간지역에서 호밀과 트리티케일의 파종 및 수확시기가 생산성과 사료가치에 미치는 영향)

  • Lee, Hyuk-Jun;Han, Ouk-Kyu;Joo, Young-Ho;Lee, Seong-Shin;Paradhipta, Dimas Hand Vidya;Ku, Ja-Hwan;Min, Hyeong-Gyu;Oh, Jung-Sik;Kim, Sam-Churl
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.40 no.1
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    • pp.57-65
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    • 2020
  • This study was conducted to investigate the effect of sowing and harvesting dates on agronomic characteristics and feed values of rye and triticale at Sanchoeng, South Korea. The experimental design consisted of the different sowing and harvesting dates as follows; rye (Secale cereale L., cv. Gogu) of sowing (October 15, 25, and November 5) in 2015 and harvesting (April 20, May 1 and May 11) in 2016, and triticale (X Triticosecale, cv. Joseong) of sowing (October 15, 25, and November 5) in 2015 and harvesting (May 18, 28, and June 7) in 2016. In rye, fresh and dry matter (DM) yields increased (p<0.05) with the delayed-harvesting date. Crude protein (CP) content and relative feed value (RFV) decreased (p<0.05) with the delayed-harvesting date, but neutral detergent fiber (NDF) content increased (p<0.05). In triticale, fresh and dry matter (DM) yields increased (p<0.05) with the delayed-harvesting date. The CP content decreased (p<0.05) with the delayed-harvesting date, but NDF content and RFV increased (p<0.05). This study concluded that rye sown in the middle of October then harvested in early May, and the triticale sown at the end of October then harvested at the end May are recommended to increase dry matter yield and feed value.

The Survey of Total Mixed Ration Plant in Korea (국내 TMR 배합소에 대한 실태조사)

  • Ki, Kwang-Seok;Lee, Wang-Shik;Lee, Hyun-June;Kim, Sang-Bum;Baek, Kwang-Soo;Lim, Keun-Bal;Cho, Won-Mo;Kim, Hyeon-Shup;Jeong, Ha-Yeon;Jeo, Joon-Mo
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.28 no.2
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    • pp.99-106
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    • 2008
  • This experiment was carried out to show a reform measures by grouping for problems by the survey of TMR plants. Twenty total mixed ration (TMR) plants (10 cooperation and 10 private plants) were surveyed, of which 13 plants, 65% of total TMR plants, committed TMR formulae to a outside nutrition specialist (TMR formulator). With respect to consulting fee for TMR formulae, $500{\sim}900$ thousands Won was paid monthly. On the basis of dry matter 1kg, the prices of TMR products were $325.6{\sim}347.0$Won, whereas those of wet TMR products $365.7{\sim}375.0$Won, which was appeared to be factors to increase management cost. And also, because the TMR plants did not provide TDN (total digestible nutrient) value on their products, nutritional balance feeding for cows could not be managed in farms. It was calculated, based on ADF (acid detergent fiber) value, that TDN value in dry type TMR was 63.0% and 73.2% fur private and cooperation TMR plants, respectively and that the corresponding figure in wet type TMR was 64.9% and 67.2%. According to TMR plant employee's opinion, a prier items to enlarge TMR utilization were TMR education, TMR advertisement, and improvement of ability to make TMR formula. Therefore, for the purpose of further development of TMR, special education of persons related to TMR should be supported.