• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.190-192
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• 2006

The clinical characteristics of photodamaged skin, such as coarse and fine wrinkle are not accurately evaluable with previous methods. Public awareness for wrinkle treatment and prevention which rely on proper assessment and evaluation of the underlying skin changes has been increased as the population ages. In this paper, we suggest an in-vivo method and instrument that allow us to acquire a wrinkle-enhanced image to improve the accuracy of quantitative and qualitative analysis for skin wrinkle. The method used involved white LED illumination and photography through polarizing filters. Finally, the polarized light photography yields an accurate and evaluable parameter of photodamaged skin, especially fine and coarse wrinkle.

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.265-270
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• 2007

Polarization imaging systems have been widely used to selectively characterize skin lesions. Nevertheless, current systems are used in single-mode due to the limitations of a fixed polarization mode and a single-working distance of light source, in which uniform light distribution is achieved on target area. To address such limitations, we developed a variable polarization imaging system based on multi-working distance of light source for various clinical diagnoses. In this study, we characterize the imaging system and present experiment results demonstrating its clinical usefulness. The imaging system consists of a CCD color camera, linear polarization filters, and a single-layered LED ring light source which provides uniform light distribution at multi-working distances. The first polarizer was placed on the light source and the second polarizer placed on objective lens provides continuous linear polarization angle from $0^{\circ}\;to\;90^{\circ}$. The clinical efficacy of the imaging system was investigated by acquiring and analyzing clinical images of skin wrinkle and dental plaque. With the experiments, we verified the potential usefulness of the imaging system for other clinical applications.

• Applied Microscopy
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• v.40 no.4
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• pp.245-251
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• 2010

In this study, we applied 15% glycolic acid peeling agent and 30% glycolic acid peeling agent to the dorsal skin of mice and analyzed the oil content, moisture content, and pH value of the skin before and after test using cutometer. Ultrastructure for changes in the epidermis of mice were observed under a dermoscope and a scanning electron microscope before and after test. When using 15% glycolic acid peeling agent, the changes of moisture content was measured 74.67 AU for the normal control group and 70.21 AU for the experimental group, the oil content was 13.49 mg/$cm^2$ for the normal control group before test and 8.25 mg/$cm^2$ after test, and the pH value was 6.70 and 5.36 before and after test, respectively. When using 30% glycolic acid peeling agent, the moisture content was measured 74.46 AU for the normal control group before test and 53.50 AU for the experimental group after test, the oil content was 13.82mg/$cm^2$ and 5.70 mg/$cm^2$ before and after test, and the pH value was 6.45 and 4.58 before and after test, respectively. As such, it was found that the changes of moisture and oil content on the skin rely on the concentration of peeling agent and the degree of exfoliation of keratin. The surface of stratum corneum of mice with application of 15% glycolic acid peeling agent was relatively smooth and the exposed cellular surface of keratinocyte had some wrinkles. The surface of stratum corneum of mice with application of 30% glycolic acid peeling agent was smooth. No wrinkles were observed under high-resolution scanning electron microscope.