• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.145-154
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• 2016

Objectives: The aim of this paper is to investigate the activities of Malaysian local herbs (Clinacanthus nutans Lindau, Strobilanthes crispus, Murdannia bracteata, Elephantopus scaber Linn., Pereskia bleo, Pereskia grandifolia Haw., Vernonia amygdalina, and Swietenia macrophylla King) for anti-hypertensive and vasorelaxant activity. An infrared (IR) macro-fingerprinting technique consisting of conventional fourier transform IR (FTIR), second-derivative IR (SD-IR), and two-dimensional correlation IR (2D-correlation IR) analyses were used to determine the main constituents and the fingerprints of the Malaysian local herbs. Methods: The herbs were collected, ground into powder form, and then macerated by using three different solvents: distilled water, 50% ethanol, and 95% ethanol, respectively. The potentials of the extracts produced from these herbs for use as vasorelaxants were determined. Additionally, the fingerprints of these herbs were analyzed by using FTIR spectra, SD-IR spectra, and 2D-correlation IR spectra in order to identify their main constituents and to provide useful information for future pharmacodynamics studies. Results: Swietenia macrophylla King has the highest potential in terms of vasorelaxant activity, followed by Vernonia amygdalina, Pereskia bleo, Strobilanthes crispus, Elephantopus scaber Linn., Pereskia grandifolia Haw., Clinacanthus nutans Lindau, and Murdannia bracteata. The tri-step IR macro-fingerprint of the herbs revealed that most of them contained proteins. Pereskia bleo and Pereskia grandifolia Haw. were found to contain calcium oxalate while Swietenia macrophylla King was found to contain large amounts of flavonoids. Conclusion: The flavonoid content of the herbs affects their vasorelaxant activity, and the tri-step IR macro-fingerprint method can be used as an analytical tool to determine the activity of a herbal medicine in terms of its vasorelaxant effect.

• Journal of Biosystems Engineering
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• v.35 no.4
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• pp.224-230
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• 2010

The purpose of this study was to develop position control system of an electric actuator for automatic shuttle shifting of a tractor. The electric actuator was installed at the link of the forward-reverse gearshift of the tractor transmission, and controlled in the ranges of forward, neutral, and reverse positions. The position control system of the electric actuator was developed based on PID (Proportional Integral Derivative) controller and transfer function of the electric actuator. The coefficients of the PID controller were determined by Ziegler-Nichols (Z-N) method and optimized using simulation program. The prototype AMT (Automated Manual Transmission) test unit of the tractor was installed and used to evaluate the performance of the position control. The evaluation system for the control performance consisted of forward-reverse actuator, motor driver, and controller. The tests were conducted as the controlled positions of the actuator were changed from neutral position to forward, neutral, and reverse positions in sequence. The sequential tests were repeated 20 times. The operations of changing the gearshift were considered as the step response of the control system. Maximum overshoot, settling time, and steady-state error were analyzed. The results showed that performance of the position control system was reasonable and qualified. The maximum overshoots, the steady-state errors, and the settling times of the position control system were 10~20%, 1~5%, and 0.92~1.49 sec, respectively. The modifications of the electric actuator will be required to enhance the performance of position control during field operation.

• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.1969-1982
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• 2015

The virtual inertia control (VIC) of wind turbine with directly-driven permanent-magnet synchronous generator (D-PMSG) can act similarly to the conventional synchronous generator in inertia response and frequency control, thereby supporting the system frequency stability. However, because the wind speed is inconstant and changeable to a certain extent and the D-PMSG is a complex nonlinear system, there are great difficulties in the virtual inertia optimal control of the D-PMSG. Based on the design principle of the active disturbance rejection control (ADRC), this paper presents a new VIC strategy for the D-PMSG from the perspective of power disturbance suppression in the system. The strategy helps fulfill the power grid disturbance estimation and compensation by means of the extended state observer (ESO) so as to improve the disturbance-resisting performance of the system. Compared with conventional proportional-derivative virtual inertia control (PDVIC), this method, which is of better adaptability and robustness, can not only improve the property of the D-PMSG responding to the system frequency but also reduce the influence of wind speed disturbance. The simulation and experiment results have verified the effectiveness and feasibility of the VIC based on the ADRC.

• Analytical Science and Technology
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• v.9 no.2
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• pp.198-202
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• 1996

A rapid and simple method for the determination of histamine by reverse-phase high performance liquid chromatography with fluorescence detection was established. 9-Fluorenylmethyl chloroformate(FMOC) was used as fluorescent derivative reagent. The optimum conditions for the derivatization such as pH, reaction time and the concentration of FMOC were investigated. Linearity of calibration curve was obtained between $0.1{\mu}g/ml$ and $0.5{\mu}g/ml$(r=0.992) and the limit of detection was $0.01{\mu}g/ml$.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.2
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• pp.197-205
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• 2017

We investigate the slat noise generation mechanism by using large-eddy simulation (LES) and simple source modeling based on linearized Euler equations. An incompressible LES of an MD 30P30N three-element airfoil in the high-lift configuration is conducted at $Re_c=1.7{\times}10^6$. Using the total derivative of the hydrodynamic pressure (DP/Dt) acquired from the incompressible LES, representative noise sources in the slat cove region are characterized in terms of simple sources such as frequency-specific monopoles and dipoles. Acoustic radiation around the 30P30N multi-element airfoil is effectively computed using the Brinkman penalization method incorporated with the linearized Euler equation. The directivity pattern of $p^{\prime}_{rms}$ at $r=20c_{slat}$ in the multiple sources is closely compared to that obtained by the application of the LES/Ffowcs-Williams and Hawking's methods to the entire flow field. The power spectrum of p' at ${\theta}=290^{\circ}$ is in good agreement with the data reported in BANC-III, especially the broadband part of the spectrum with a decaying slope ${\propto}f^{-3}$.

• Ocean Systems Engineering
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• v.6 no.3
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• pp.265-287
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• 2016

The change of the global performance of a turret-moored FPSO (Floating Production Storage Offloading) with DP (Dynamic Positioning) control is simulated, analyzed, and compared for two different internal turret location cases; bow and midship. Both collinear and non-collinear 100-yr GOM (Gulf of Mexico) storm environments and three cases (mooring-only, with DP position control, with DP position+heading control) are considered. The horizontal trajectory, 6DOF (degree of freedom) motions, fairlead mooring and riser tension, and fuel consumptions are compared. The PID (Proportional-Integral-Derivative) controller based on LQR (linear quadratic regulator) theory and the thrust-allocation algorithm which is based on the penalty optimization theory are implemented in the fully-coupled time-domain hull-mooring-riser-DP simulation program. Both in collinear and non-collinear 100-yr WWC (wind-wave-current) environments, the advantage of mid-ship turret is demonstrated by the significant reduction in heave at the turret location due to the minimal coupling with pitch mode, which is beneficial to mooring and riser design. However, in the non-collinear WWC environment, the mid-turret case exhibits unfavorable weathervaning characteristics, which can be reduced by employing DP position and heading controls as demonstrated in the present case studies. The present study also reveals the plausible cause of the failure of mid-turret Gryphon Alpha FPSO in milder environment than its survival condition.

• Journal of Astronomy and Space Sciences
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• v.25 no.3
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• pp.249-254
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• 2008

We report the distance modulus of nearby dwarf irregular galaxy NGC 6822 estimated from the so-called Tip of Red-giant Branch (TRGB) method. To detect the apparent magnitudes of the TRGB we use the color-magnitude diagrams (CMDs) and luminosity functions (LFs) in the near-infrared JHK bands. Foreground stars, main-sequence stars, and supergiant stars have been classified on the (g - K, g) plane and removed on the near-infrared CMDs, from which only RGB and AGB stars are remained on the CMDs and LFs. By applying the Savitzky-Golay filter to the obtained LFs and detecting the peak in the second derivative of the observed LFs, we determined the apparent magnitudes of the TRGB. Theoretical absolute magnitudes of the TRGB are estimated from Yonsei-Yale isochrones with the age of 12Gyr and the metallicity range of -2.0 <[Fe/H]< -0.5. The derived values of distance modulus to NGC 6822 are (m - M) = $23.35{\pm}0.26$, $23.20{\pm}0.42$, and $23.27{\pm}0.50$ for J, H, and K bands, respectively. Distance modulus in bolometric magnitude is also derived as (m - M) = $23.41{\pm}0.17$. We compare the derived values of the TRGB distance modulus to NGC 6822 in the near-infrared bands with the previous results in other bands.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.49 no.7
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• pp.339-345
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• 2000

This paper deals with the displacement estimation of magnetically suspended simple 1 DOF(degree of freedom) system without the displacement sensor. Inherently electro-magnet for control has two natural feedback loops. One is the transfer function which represents the dependance of the amount of the magnetic flux on the gap displace-ments. The other is the transfer function expressing the properties that the back electromotive force is derived from the time derivative of the magnetic flux. Through these two feedback loops, information about the gap length can be represented by the magnetic flux and the coil current. This means that the gap length can be detected from these two states variables of the electromagnet without a displacements sensor(self-sensing). The displacement can be estimated with the magnetic flux subtracted by the coil current. In this paper we use a balance beam in order to deal with the displacement sensorless estimation of the magnetic bearing system. For the stable estimation of the gap displacements by using the method of self-sensing simple PD controller is used. We first show the mathematical model of the balance beam, and then we show the effectiveness of the current and flux feedback for making stable estimation of the gap displacements for the balance beam. Simulation results show the effectiveness of the current and flux feedback for good estimation of the displacement without using displacement sensor.

• KSBB Journal
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• v.32 no.2
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• pp.108-116
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• 2017

Omeprazole, a benzimidazole derivative, suppresses gastric acid secretion by inhibiting $H^+/K^+$ ATPase in gastric parietals cells, and by reducing $H^+$ concentration. To improve stability of esomeprazole magnesium dihydrate (ESMD), enteric-coated preperation was composed of core tablet, subcoating and enteric coating layer. We were evaluated in vitro dissolution characteristics between test and reference ESMD preparation and stability. We could prepare enteric-coated formulation of ESMD by controlling disintegrating agent and coating ratio which could rapidly dissolved in neutral or alkali medium. The formulation D5 with crospovidone of 1.25% and coating ratio of 16.25% had a similar dissolution behavior compare to reference preparation. Difference factor ($f_1$) and similarity factor ($f_2$) were 0~15 and 50~100 and there was no significant difference in bioequivalence between formulations. The content and dissolution rate of formulation D5 were $96.54{\pm}0.21$ and $78.56{\pm}0.87%$ without change of color in accelerated condition ($40^{\circ}C$, RH 75%, high density polyethylene (HDPE) container) for 6 months. This study concluded that our enteric coated preparation of ESMD could be an useful method to improve stability of unstable drug without direct contact with coating material.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11C
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• pp.1071-1076
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• 2006

In this paper, we develop face and hand tracking for sign language recognition system. The system is divided into two stages; the initial and tracking stages. In initial stage, we use the skin feature to localize face and hands of signer. The ellipse model on CbCr space is constructed and used to detect skin color. After the skin regions have been segmented, face and hand blobs are defined by using size and facial feature with the assumption that the movement of face is less than that of hands in this signing scenario. In tracking stage, the motion estimation is applied only hand blobs, in which first and second derivative are used to compute the position of prediction of hands. We observed that there are errors in the value of tracking position between two consecutive frames in which velocity has changed abruptly. To improve the tracking performance, our proposed algorithm compensates the error of tracking position by using adaptive search area to re-compute the hand blobs. The experimental results indicate that our proposed method is able to decrease the prediction error up to 96.87% with negligible increase in computational complexity of up to 4%.