• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.259-266
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• 2020

Cardiovascular diseases are the primary reason of mortality, among which myocardial infarction (MI) is the most dominant and prevalent. This study was considered to examine D-Limonene protective action against isoproterenol (ISO) induced MI. Wister male rats were dispersed into four groups. Normal and D-Limonene control group in which rats administered saline or D-Limonene. ISO control animals were administered saline for 21 days then challenged with ISO (85 mg/kg, subcutaneously) on 20th and 21st day for MI induction. D-Limonene pretreated group in which animals were pretreated with D-Limonene 50 mg/kg orally for 21 days then administered ISO on 20th and 21st day. MI prompted variations were assessed by myocardial infarction area determination, blood pressure (BP) alterations, cardiac injury biomarkers and inflammatory mediators measurements. For more depth investigation, both the apoptotic status was evaluated via measuring mRNA expression of Bcl-2 and Bax as well as mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signal transduction were investigated via Western blotting. MI group revealed significant infarcted area, blood pressure alterations, myocardial injury enzymes intensification together with inflammatory cytokines amplification. MI was associated with activation of MAPK-ERK signal pathway and apoptotic status within the myocardium. On the other hand, pretreated with D-Limonene demonstrated deterred infracted area, reduced myocardial enzymes, improved BP indices, lessened inflammatory levels. Furthermore, D-Limonene pretreatment caused a decline in MAPK proteins pathway and Bax relative mRNA expression, while intensifying Bcl-2 mRNA expression promoting that D-Limonene may constrain MI induced myocardial apoptosis. D-Limonene mitigated MI injury through MAPK/NF-κB pathway inhibition and anti-apoptotic effect.

• Journal of the Korean Society of Safety
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• v.32 no.3
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• pp.41-47
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• 2017

Recent studies have shown that there are various systems which can be used to monitor hazardous area in a debris flow location, but lack of methodological research on the exact location where each instrument should be installed has hindered the success of this systems. The objective of this study is to suggest the measurement system for monitoring debris-flow and propose the effective method to determine location of measurement system. Previously studied, from 1991 to 2015, were referred and the applied ratio of every instrument was investigated. The measurement information was divided into 8 categories including rainfall, debris-flow velocity, displacement, fluid pore pressure, ground vibration, image processing, impact force and peak flow depth. The result of this study revealed that the most applied instruments to be rain gauge and geophone for measuring average rainfall and ground vibration respectively. The Analytic Hierarchical Process (AHP) method was selected to determine installation location of instrument and the weighting factors were estimated through fine content, soil thickness, porosity, shear strength, elastic modulus, hydraulic conductivity and saturation. The soil thickness shows highest weights and the fine content relatively demonstrates lowest weights. The score of each position can be calculated through the weighting factors and the lowest score position can be judged as the weak point. The weak point denotes the easily affecting area and thus, the point is suitable for installing the measurement system. This study suggests a better method for safely managing the debris-flow through a precise location for installing measurement system.

• Analytical Science and Technology
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• v.7 no.3
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• pp.301-313
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• 1994

X-Ray Photoelectron Spectroscopy(XPS) and Rutherford Backscattering Spectroscopy(RBS) are used for the analysis of additives, examination of chemical structure and determination of identity with qualitative and quantitative analysis of surface elements, binding energy level and depth profiling in the surface. We analyzed surface of polyethylene, acrylonitrile butadien rubber, polypropylene, glass, fiber and paper treated with $XeF_2$ or C-F plasma by XPS and RBS. It was found that fluoro element was penetrated to sample surface and the distribution of surface elements are different than untreated samples.

• Microbiology and Biotechnology Letters
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• v.46 no.2
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• pp.162-170
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• 2018

Non-typhoidal Salmonella is one of the main pathogens causing food-borne illness in humans, with up to 20% of cases resulting from consumption of pork products. Over the gastroenteritis signs, multidrug resistant Salmonella has arisen. In this study, pan-susceptible phenotypic strains of Salmonella enterica serotype Weltevreden recovered from pig production chain in Chiang Mai, Thailand during 2012-2014 were chosen for analysis. The aim of this study was to use whole genome sequencing (WGS) data with an emphasis on antimicrobial resistance gene investigation to assess their pathogenic potential and genetic diversity determination based on whole genome Multilocus Sequence Typing (wgMLST) to expand epidemiological knowledge and to provide additional guidance for disease control. Analyis using ResFinder 3.0 for WGS database tracing found that one of pan-susceptible phenotypic strain carried five classes of resistance genes: aminoglycoside, beta-lactam, phenicol, sulfonamide, and tetracycline associated genes. Twenty four and 36 loci differences were detected by core genome Multilocus Sequence Typing (cgMLST) and pan genome Multilocus Sequence Typing (pgMLST), respectively, in two matching strains (44/13 vs A543057 and A543056 vs 204/13) initially assigned by conventional MLST and Pulsed-field Gel Electrophoresis (PFGE). One hundread percent discriminant ability can be achieved using the wgMLST technique. WGS is currently the ultimate molecular technique for various in-depth studies. As the findings stated above, a new of "gold standard typing method era" for routine works in genome study is being set.

• Journal of Acupuncture Research
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• v.24 no.6
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• pp.69-73
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• 2007

목적 : X-ray를 통해 안면마비에 다용되는 예풍과 안면통에 다용되는 하관에서의 안전한 자침 깊이에 대하여 고찰하여 보고자 하였다. 방법 : 건강한 지원자들에게 원치 않을 경우 언제든지 시험을 중지할 권리가 있다는 것을 공지한 후, 시험에 동의한 남녀 각각 2명의 피험자들을 대상으로 대학병원 침구과 전문의가 예풍과 하관을 직자(直刺)($40mm{\times}0.35mm$ 일회용 침)하였다. 피험자의 이상 반응 유무를 살피며 안면신경 혹은 삼차신경이 지나가는 경로로 알려진 깊이까지 진침(進鎬)하였다. 유침(留鍼) 상태에서 Skull X-ray의 AP view와 Lateral view를 촬영하였다. 결과 : 피험자들은 침병이 피부에 도달 하는 동안(40mm 직자) 자침 혈위에서 중창감(重脹感)을 자각하였으며, 추후 어떠한 이상 반응도 보이지 않았다. 결론 : 안면마비와 안면통의 효율적인 치료를 위하여 안면신경과 삼차신경에 근접할 수 있는 혈위인 예풍과 하관에서의 40mm 직자는 신경염이나 뇌 손상과 같은 이상 반응을 유발하지 않았다.

• Journal of Oral Medicine and Pain
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• v.40 no.4
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• pp.146-154
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• 2015

Purpose: The purpose of present study was to develop a method for assessing the chronological age of Korean adults based on the relationship between age and size of pulp cavity using dental radiographs of mandibular first molars. Methods: A total of 325 dental radiographs of Korean adults with known age and gender were selected for the study (199 males and 126 females) which were taken in the period between January 2009 and June 2014 at the Pusan National University Dental Hospital. The measurements were carried out on both orthopantomographs (OPGs) and intraoral periapical radiographs of mandibular first molar and the following ratios were calculated: pulp chamber floor height ratio (F/L), pulp chamber ceiling height ratio (R/L), and pulp chamber depth ratio (D/L). Results: The ratios of measurements on intraoral periapical images of mandible first molar generally produce more reliable data than the measurements on OPGs. The pulp chamber floor height ratio and pulp chamber thickness ratio showed significant correlation with age, whereas the pulp chamber ceiling height ratios showed weak correlation with age. It was found that the best correlations between the ratios and age were found for pulp chamber thickness ratios (r=-0.731 to -0.751). The multiple regression models were derived using 3 ratios that were significantly correlated with age. The determination coefficients ($R^2$) of the models ranged from 0.556 to 0.596. Conclusions: Our results indicate that the pulp chamber thickness and pulp chamber floor height in mandibular first molar are an age-dependent variable in adults which can be used to estimate age with reasonable accuracy. The higher image quality of dental radiographs will probably narrow the age estimation error and improve dental age estimation.

• Journal of Digital Contents Society
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• v.4 no.1
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• pp.11-21
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• 2003

In computer vision, the goal of stereopsis is to determine the surface structure of real world form two or more perspective views of scene. It is similar to human visual system. We can avoid obstacles, recognize objects, and manipulate machine using three-dimensional information. Until recently, only gray-level images have been used as input to computation for depth determination, but the availability of color can further enhance the performance of computational stereopsis. There are many models to provide efficient color system. The simplest model, RGB model treats color as if it were composed of separate entities. Each color channel is processed individually by the same stereopsis module as used in the gray-level model. His Model decouples intensity component from color information. So it can deal with color properties without defect intensity information. Opponent color model is based on human visual system. In this model, the red-green-blue colors are combined into three opponent channels before further processing.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.7-13
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• 2008

To obtain a shear-wave velocity profile in geotechnical practice, various seismic investigation methods which have their own strength and weakness are being frequently used. Generally, geotechnical site have lateral variation of the properties, so it is needed to determine 2-dimensional shear wave velocity imaging of the site. In this study, harmonic wavelet analysis of wave (HWAW) method is applied to determination of 2-D $V_s$ imaging. HWAW method which is based on time-frequency analysis using harmonic wavelet transform have been developed to determine phase and group velocities of waves. HWAW method uses the signal portion of the maximum local signal/noise ratio to evaluate the phase velocity to minimize the effects of noise. HWAW method determine detailed local $V_s$ profile because one experimental setup which consists of one pair of receivers with spacing of 1~3m is used to determine the dispersion curve of the whole depth. So, 2-D Vs imaging with relatively high resolution can be determined through a series of HWAW test. In order to estimate the applicability of HWAW method, field tests were performed in 4 sites. Through field applications and comparison with other test results, the good accuracy and applicability of the proposed method were verified.

• Journal of the Korean Geotechnical Society
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• v.16 no.1
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• pp.19-30
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• 2000

The major design parameters of the anchored sheet-pile wall include the determination of required penetration depth, the force acting on the anchor, and the maximum bending moment in the piling. Blum solved the fixed earth supported wall using the equivalent beam method, assuming that the wall can be separated into upper and lower parts of the point of contraflexure. Design charts help designer by simplifying the design procedure. But they have some difficulties under some Geotechnical and geometrical conditions. For example, the conventional design charts can compute design parameters only when the ground water table exists above the dredge line. In this paper, the design charts which can be used for the ground water table existing under the dredge line are presented. And simplified formulae are developed by regression analysis. It is found that simplified formulae are not only very useful for the practice of design but also they can evaluate the result of numerical methods or design charts.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.1
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• pp.15-20
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• 2009

The results of crack evaluation by conventional UT(Ultrasonic Test)is highly depend on the inspector's experience or knowledge of ultrasound. Phased array UT system and its application methods for small crack length evaluation will be a good alternative method which overcome present UT weakness. This study was aimed at checking the accuracy of crack length evaluation method by electronic scanning and discuss about characteristics of electronic scanning for crack length evaluation. Especially ultrasonic phased array with electronic scan technique was used in carrying out both sizing and detect ability of crack as its length changes. The response of ultrasonic phased array was analyzed to obtain the special method of determining crack length without moving the transducer and detect-ability of crack minimal length and depth from the material. A method of crack length determining by electronic scanning for the small crack is very real method which has it's accuracy and verify the effectiveness of method compared to a conventional crack length determination.