• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권5호
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• pp.332-336
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• 2012

Purpose: The third molar extraction is one of the mostly performed procedures in the department of oral and maxillofacial surgery. In most of dental clinic or hospital, the third molar extraction used to be frequently performed in an office-based surgery, and most patients did not have specific medical history with young ages. Medical history taking are dependent on the only way by asking to the patients about their individual conditions. Therefore, as the specialists of the oral and maxillofacial surgery in the field of dentistry, we suggest a new policy that the preoperative lab must be performed routinely before extraction of the third molar. Methods: This study is based on 1,096 patients who have been managed with third molar extractions, from March 2008 to September 2011 by a single surgeon. The preoperative lab, including complete blood count, coagulation panel, chemistry and serology, was performed before any surgical procedures. The results were informed to the patients regardless of their abnormalities, and any abnormalities related to the surgical procedures, such as platelet count and coagulation factors, were checked and corrected safely. Results: Through the preoperative blood test, systemic diseases that the patients had not recognized before, such as anemia, leukopenia, fatty liver and chronic renal disease, were identified. Patients with acute or chronic leukemia, Hepatitis B, and HIV positive, were also detected as a small number. Also, the possibilities of the cross-infection between dentists and patients or between patients and patients, and any other emergency situations can be prevented; as well as the public health condition can be improved, too. The patients were satisfied with low cost preventive blood test and high quality of medical services. Conclusion: Therefore, routine medical lab testing, including history taking are needed before an office-based minor surgery, such as third molar extractions, and these results were suggested as a new policy in the field of dentistry.

• 구강회복응용과학지
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• 제27권4호
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• pp.393-403
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• 2011

이 연구의 목적은 임상적으로 사용되는 RBM과 산부식 임플란트의 3년 생존율을 비교, 분석하기 위한 것이다. 총 152개의 RBM 임플란트를 식립하였고, 이 중 1개의 임플란트에서 실패가 발생하였는데, 원인은 식립체의 파절이었다. 또한 총 152개의 산부식 표면 임플란트를 식립하였는데, 이 중 7개의 임플란트에서 실패를 하였으며, 원인으로는 과열, 감염, 초기고정 불량 등이었다. RBM 임플란트의 생존율은 99.34%, 산부식 임플란트의 생존율은 95.39%로 두 가지 임플란트 모두 양호한 생존율을 보였으나, RBM 임플란트에서 다소 높은 생존율을 나타내었다.

• Journal of Periodontal and Implant Science
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• 제37권1호
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• pp.137-150
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• 2007

CADIA(Computer-assisted densitometric image analysis) method is used to analyze bone density changes around the implants. The usefullness and reproducibility of the method was assessed. We tried to find out if there is any possibility to quantitiate and qualitify peri-implant bone density change as time passes. And we concluded that this newly developed linear analysis is efficient for analyzing peri-implant bone density change non-Invasively. In this study, 2152 machined $Br{\aa}nemark$ fixtures installed from 1994 to 2002 in the department of Periodontics, Dental hospital of College of Dentistry, Yonsei University were included. Of these fixtures 22 radiographically analyzable failed fixtures were used as experimental group, and 22 successful implants placed in the same patient were used as control group. 1. 57 out of 1635 machined $Br{\aa}nemark$ standard and Mk II implants system failed, the survival rate was 96.5%. And 11 out of 517 machined $Br{\aa}nemark$ Mk III and Mk IV implants system failed, the survival rate was 97.9%. Total survival rate was 96.8%. 2. 22 failed implants were used for the analysis, 10 of which failed before prosthetic treatment due to infection and overheating. 12 failed due to overload after prosthetic treatment, 63.6% of which failed during the early phase of functional loading, i, e. before 1 year of loading. 3. Bone density change values around coronal region of the failed implants were $-6.54{\pm}6.35$, middle region were $-3.53{\pm}5.78$, apical region were $-0.75{\pm}10.33$, resulting in average of $-3.71{\pm}8.03$. 4. Bone density change values around coronal region of the successful implants were $4.25{\pm}4.66$, middle region were $6.33{\pm}5.02$, apical region were $9.89{\pm}4.67$, resulting in average of $6.27{\pm}5.29$. 5. There was a statistically significant difference between two groups (p<0.01). In conclusion, the linear analysis method using computer-assisted densitometric image analysis could be a useful method for the analysis of implants, and could be used for future implant researchs.

• 대한소아치과학회지
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• 제35권3호
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• pp.532-538
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• 2008

Lesch-Nyhan 증후군은 드물게 나타나는 X 염색체 열성 유전 질환으로 purine의 대사 장애를 보이는 질환이다. Purine의 대사 장애는 대사에 관여하는 효소인 hypoxanthine guanine phosphoribosyl transferase의 결손 또는 활성 감소로 인하여 나타나며, 요산의 과다 생산에 의한 요산과다혈증, 요산과다뇨증 등의 신장계 증상과 정신지체, 무도증 등의 신경학적 장애를 보이고, 구강이나 손가락에 대한 자해를 나타낸다. 이 중 자해 행위는 입술과 혀, 손가락을 깨무는 경우가 흔하고, 심하면 혀와 손가락이 완전히 절단될 수도 있다. 이 경우 자해로 인한 통증뿐 아니라, 연조직 결손으로 인한 심미적인 문제와 상처 부위로의 2차 감염이 발생할 수 있다. 이러한 Lesch-Nyhan 증후군 환자에서 자해를 막기 위해 여러 방법이 사용되고 있는데, 이 중 치과적으로 접근하는 방법으로는 마우스 가드나 lip bumper 등의 장치를 이용하는 방법과 해당 치아들을 모두 발거하는 방법, 악교정 수술을 통해 개방 교합을 형성해 주는 방법 등이 있다. 본 증례는 13세 9개월의 Lesch-Nyhan 증후군 환아로서 자해에 의해 혀에 심각한 외상을 가한 경우로 마우스 가드를 이용한 보존적인 방법을 사용하였으나 계속적으로 혀에 외상을 가해 하악 전치 뿐 아니라 구치까지 발거하여 치료하였다.

• 농촌의학ㆍ지역보건
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• 제4권1호
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• pp.20-30
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• 1979

To investigate the status of morbidity and medicare utilization during last 8 months from 1 st Oct. 1977 to 31th May, 1978 in the area under Sam-Wha Medicare Insurance Union, a study was carried out through analyzing the medicare records of patients who are enrolled. For the study, 3 doctors and one nurse were mobilized and the results are as follows: 1) The total number of the Medicare insurance Union members in the study area were 5,735 composed of 3,000 males(52.3%) and 2,735 females(47.7%). 2) The total number of patients were 1,405 composed of 783 males (55. 0%) and 622 females(45. 0%) and the incidence rate per 1,000 population was 245.0 of total(261.0 in males and 227.4 in females). 3) Five major diseases with 52, 7% of total patients were acute upper respiratory infection(20.7%), peptic ulcer(12.2%), bronchitis(5.5%), injuries(5.2%) and dental problems(5.1%). 4) The order of the incidence rate of age group per 1,000 population was the year group on 0-4(342.6), 25-44(312.7), 45-64(307.0), 65 and over(240.3), 15-24(178.8) and 5-14(164.8). 5) Of the 1,405 total patients, the out-patients were 1,661(96.9%) and the in-patients were 44(3.1%) and the ratio wae 30.9 : 1.0. 6) Among the out-patients 96.7% of them were cared in primary medicare facilities, 1.0,% in secondary care, and 2.3% in tertiary care. And among the in-patients 50. 5% of them were cared in primary medicare facilities, 4. 5% in secondary care, 45. 5% in tertiary care. 7) Duration of medicare was concentrated within a week in 84. 3% of total patients.

• 대한임상검사과학회지
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• 제52권3호
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• pp.221-228
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• 2020

Ochrobactrum anthropi는 oxidase를 생산하는 비발효산소성 그람음성 막대균으로 외관이 비슷하고 oxidase가 양성인 비발효 세균과 혼합배양 시 구분이 힘들고 생화학적 동정 장비로는 정확한 동정에 한계가 있다. 따라서 본 연구에서는 생화학적 검사 방법으로 동정이 힘든 세균동정의 Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Platform (MALDI-TOF) 법의 유용성을 제시하고자 하였다. MicroScan을 이용해 검사했던 O. anthropi 5례를 분석한 결과, 최종보고까지 6.2일이 소요되었으며 E. coli의 3.0일에 비해 3.5일이 더 소요되었다. 5번 환자 고름 검체는 Achromobater xylosoxidans와 혼합감염으로 여러 번의 계대 배양과 재검사로 인해 11.3일이 소요되었는데, MALDI-TOF법으로 검사한 경우 한 번에 동정되었다. 4명의 환자는 기저질환이 있는 60세 이상이었고 기회감염과 원내감염의 가능성을 배제할 수 없었으며, 그 중 92일 만에 채취된 검체는 imipenem과 meropenem에 내성이었다. 따라서 O. anthropi처럼 동정이 까다로운 세균은 신속하고 적절한 환자 치료를 위해 MALDI-TOF법을 이용한 검사가 매우 유용할 것으로 사료된다.

• BMB Reports
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• 제49권10호
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• pp.554-559
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• 2016

Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigen-presenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes ᴅ-alanyl-ᴅ-alanine dipeptidase, which catalyzes the hydrolysis of ᴅ-alanyl-ᴅ-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

• 한국응용과학기술학회지
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• 제35권2호
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• pp.532-539
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• 2018

본 연구는 건강신념모형을 적용하여 임상에서 근무하는 간호사의 손씻기 수행도를 분석하기 위한 서술적 조사연구이다. 본 연구의 대상은 G 광역시에 위치한 일개 병원에 근무하는 임상 간호사 162명이다. 자료수집은 2017년 9월 1일부터 2017년 10월 31일까지였다. 수집된 자료는 SPSS (SPSS Version 20.0, IBM, US)를 이용하여 빈도분석, 백분율, 일원분산분석, t-검정, pearson 상관계수분석 및 다중회귀분석으로 통계처리 하였다. 일반적 특성에 따른 손씻기에 대한 수행도는 모든 영역에서 평균은 3.1점으로 높았으나 통계적으로 유의한 차이는 보이지 않았다. 일반적 특성에 따른 손씻기에 대한 건강신념은 연령에서는 지각된 유익성 영역에서 유의한 차이를 보였으며(p<0.05), 근무연수에서는 지각된 유익성, 지각된 장애성 영역에서 유의한 차이를 보였다(p<0.05). 다섯 개의 하위영역간의 상관관계를 분석한 결과는 지각된 유익성과 지각된 장애성은 부의 상관관계를 나타냈으며, 수행을 위한 동기는 정의 상관관계를 보였다. 본 연구의 결과를 통해 손씻기에 대한 건강신념을 고려한 지속적인 병원에서의 감염관리교육과 올바른 손씻기 교육을 진행한다면 손씻기 수행도가 높아질 것으로 판단된다.

• Archives of Plastic Surgery
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• 제38권2호
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• pp.155-160
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• 2011

Purpose: Fibrillar collagens like type I collagen, are the major constituent of the extracellular matrix and structural protein of bone. Also, it can be a scaffold for osteoblast migration. The purpose of this study is to estimate the effects of absorbable atelo-collagen sponge (Teruplug$^{(R)}$, Terumo biomaterials Co., Tokyo, Japan) insertion in tooth extraction sites on periodontal healing of the second molar, healing of the fractured mandibular bone and new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Methods: In our study of six cases of mandibular angle fractures, all of them underwent the extraction of the third molar tooth & absorbable atelo-collagen sponge insertion in tooth extraction site. Three of them had a intraoral infection & oral opening to fracture site, two of the six had dental caries, and only one had reduction problem due to third molar position. Six consecutive patients with noncomminuted fractures of the mandibular angle were treated by open reduction and internal fixation using one noncompression miniplates and screws placed through a transoral incision. Results: All of the patients have showed good postoperative functions and have not experienced complications requiring second surgical intervention. There was well healing of the mandibular bone and the most new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Conclusion: The results of this study suggest that absorbable atelo-collagen sponge is relatively favorable bone void filler with prevention of tissue collapse, food packing, and enhance periodontal healing. Thus, the use of atelo-collagen sponge and one noncompression miniplate seems to be relatively easy, safe, and effective for the treatment of fractures of the mandibular angle and third molar extraction.

• 미생물학회지
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• 제48권3호
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• pp.212-215
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• 2012

Ursolic acid (UA)와 oleanolic acid (OA)들의 메티실린 저항성 Staphylococcus aureus (MRSA)에 대한 항균 활성에는 상반된 의견들이 있다. 본 연구는 한국인으로부터 분리된 19개의 MRSA에 대한 UA와 OA의 항균 활성을 최소성장억제농도 및 최소살균농도를 측정하여 조사하였다. 연구 결과, 메티실린 감수성 균주인 S. aureus KCTC $1621^T$가 MRSA 균주들보다 UA와 OA에 대한 저항성이 컸다. UA와 OA 각각의 MRSA 19 균주에 대한 최소살균농도는 4-32 ${\mu}g/ml$와 16->256 ${\mu}g/ml$로 넓은 범위를 보였다. UA와 OA에 대한 균주에 따른 항균 작용의 차이는 UA와 OA의 항균 기전이 밝혀져 있지 않기 때문에 이해하기 힘들다. 이러한 결과들은 MRSA에 대한 UA와 OA의 항균 효과는 균주들 간의 UA와 OA에 대한 저항 능력에 의한 것임을 시사한다.