• Proceedings of the PSK Conference
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• 2003.04a
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• pp.179.2-179.2
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• 2003

The cytotoxic activity of 13(E)-Labd-13-ene-8$\alpha$, 15-diol(1), isolated from the ethanol extract of Brachyglottis monroi was evaluated against tumor cell lines such as P388, SNU-C4 MDA-MB231, B 16 melanoma and A549 in vitro. By mean of spectral analysis particularly by the aid of various two dimensional NMR experiments, 1H-NMR and 13C-NMR signals of (1) was completely assigned, and thus the structure of (1) was established unambiguously. (omitted)

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.6
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• pp.537-545
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• 2016

This research examined the oral environmental factors to identify the risk factors for oral bacteria detection. This study comprised of 60 office workers aged between 20 and 65 years, and was performed from January 15 to February 28, 2015. The study variables measured were the stimulated and unstimulated salivary flow rates, salivary buffering, saliva pH, dry mouth at the dorsum of the tongue and the sublingual region, halitosis, and the degree of tongue-coating as oral environmental factors. To identify the presence of oral bacteria, pathogens were detected by extracting the gDNA of the resting salivary flow rate. The risk of S.mutans detection was 15 times higher with smokers, 1.3~1.6 times higher when the resting or stimulated salivary flow rate was reduced by 1 mm. The risk of P.intermedia detection was 13 times higher in smokers, 4.3 times higher as the severity of oral dryness was lowered, and 4 times higher for adults with a tongue coating than those without. In addition, the risk of detecting TM7 was 5.5 times higher as sublingual dryness was decreased by 1mm. The oral bacterial count will be reduced considerably by smoking cessation education and habits that facilitate a salivary flow rate. Furthermore, adults with good and well-managed dental hygiene are anticipated to have less oral bacteria and fewer dental diseases.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.5
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• pp.1221-1228
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• 2012

This study was carried out in order to offer basic data for preventing halitosis by understanding about the factors related to self-awareness of halitosis and about the relationship with stress and compulsion targeting students for the Department of Dental Hygiene. As a result of research, the whole subjects were indicated to be 1.76 points for the mean in stress, 1.62 points for the mean in compulsion, and 1.84 points for the mean in self-awareness of halitosis. The group of feeling the tongue to be white and the inside of the mouth to be sticky in own symptom inside the mouth was indicated to be 2.02 points(p=0.000) for stress and 2.00 points(p=0.000) for self-awareness of halitosis. The group of often feeling a sense of oral dryness was indicated to be 2.23 points(p=0.000) for stress, 1.95 points(p=0.000) for compulsion, and 1.89 points(p=0.046) for self-awareness of halitosis. The self-awareness of halitosis stood at r=0.133 with compulsion, thereby having indicated slight positive correlation. Stress and compulsion showed high positive correlation with r=0.425. Accordingly, there is a need of infusing recognition through steady education as a dental hygienist who will have interest in emotional factor along with grasping diverse causes for halitosis, and who will be in charge of a future patients' halitosis.

• Journal of the Korea Convergence Society
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• v.6 no.6
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• pp.9-15
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• 2015

The study aims to examine the knowledge and awareness of care workers on oral health knowledge at the geriatric care facilities in order to improve and develop oral health services. For the research method, the study carried out a questionnaire survey to 163 care workers working at the geriatric care facilities (10) in D Metropolitan City from May 1~31, 2015 and then the collected data were statistically analyzed. As a result, the oral health knowledge of care workers was 20.09 points out of total 26 points (77.2%). The highest knowledge was 'proper toothbrushing method' with 93.0% and the lowest one was 'knowledge on the use of oral supplementary goods' with 58.1%. Those with experience of oral health education had higher demand on oral health education (P<0.001), and those with higher experience of oral health education had significantly higher oral health knowledge (P<0.001), demand (P<0.01) and awareness (P<0.05). As for factors influencing care workers' oral health awareness, if they had higher oral health knowledge points (P<0.01), oral health education demand (P<0.01), they had higher oral health awareness level. Accordingly, it is required to provide efficient, sustainable and practical oral health education of care workers considering oral characteristics of the long-term hospitalized patients at the care hospital. And, the role of dental hygienist as the person in charge of oral health education is necessary. Therefore, institutional support from the government is required to assign professional personnel.

• Journal of Korean society of Dental Hygiene
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• v.23 no.4
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• pp.219-226
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• 2023

Objectives: This study aimed to investigate the effects of rhubarb extract on osteoclast differentiation in bone marrow-derived macrophages (BMMs). Osteoclasts are vital for bone resorption and remodeling. Osteoclast dysregulation can contribute to various bone-related disorders that directly affect oral health. Rhubarb, a medicinal plant with anti-inflammatory properties, has been shown to modulate bone metabolism. Methods: BMMs were isolated from the femurs and tibias of 5-week-old C57BL/6 mice and cultured in the presence of mouse macrophage colony-stimulating factor (M-CSF) for 3 days. Subsequently, BMMs were treated with M-CSF and receptor activator of nuclear factor-κB ligand (RANKL) to induce osteoclast differentiation. Results: Rhubarb extract effectively suppressed osteoclast differentiation in BMMs. Furthermore, rhubarb extract inhibited the mRNA expression of tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CTSK), which are essential for osteoclastogenesis. Moreover, it inhibited the RANKL-induced expression of nuclear factor of activated T cell c1 (NFATc1), a crucial transcription factor in osteoclast differentiation. Conclusions: These results suggest that rhubarb extract promotes oral health by inhibiting osteoclastogenesis in BMMs. Thus, rhubarb extract shows promise as a therapeutic agent for bone-related disorders that directly affect oral health, particularly those associated with abnormal osteoclast activity. Further research and exploration of the underlying mechanisms are warranted to fully understand their potential clinical applications.

• Journal of Periodontal and Implant Science
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• v.33 no.2
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• pp.289-299
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• 2003

The autogenous free gingival graft is the most predictable procedure currently used to increase the width of　the attached gingiva in periodontics. But the major disadvantage of the procedure is to create the multiple surgical wounds at both a donor site and a recipient site. The other problem is the limited amount of available　graft material in oral cavity. Therefore, recent researches have been focused to develop the biomaterial to substitute the autogenous gingival tissue. The purpose of this study was to evaluate the histologic healing after　grafting of bilayer artificial dermis, compared to the free gingival graft. Four non-smoking subjects (mean age, 32.5 years) in systemically healthy state and good oral hygiene were selected according to their particular needs for correction of mucogingival problems as suggested by Nabers(1966). The recipient sites were prepared through the procedure for the free gingival graft and were grouped according to the graft materials: Experimental group(n=5) - bilayer artifcia1 dermis ($Terudermis^{(R)}$; Terumo Co. Japan) and Control group(n=6) - free gingival graft with autogenous palatal mucosa. Biopsies were harvested at 1,2,3 and 6 weeks postsurgery to evaluate histologically. At the third week in the experimental group and at the second week of in the control group, the grafts has been clinically stabilized on the recipient bed and the graft border has been blended into the surrounding tissue. In the experimental group after 1 week of grafting, the epithelial migration from the adjacent tissue to graft material was seen and after 3 weeks of grafting, the : nflmmation decreased, collagen layer of the artificial dermis was lost and the basement membrane of epithelium was formed. After 6 weeks of grafting, both groups demonstrated orthokeratinized epithelium and increased thickness of epithelial tissue and the rete peg formation, similar to the adjacent tissue, Histologic evaluation revealed a biologic acceptance and incorporation of the collagen layers of the graft tissue to the host tissue, without foreign body reaction. In conclusion, a bilayer artificial dermis is essentially similar to autogeneous free gingival graft in the correction of mucogingival problems, and has the advantages of decreased patient morbidity (no donor site) and availability of abundant amounts of graft material when needed.

• Journal of dental hygiene science
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• v.11 no.4
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• pp.319-324
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• 2011

This study aimed to investigate the current situation of toothbrushing guidance with child care teachers in day care facilities caring and managing infants and young children and to grasp problems neglected in using toothpaste and guiding toothbrushing to provide basic data for measures to cope with them. This study included 165 child care teachers or teachers of the kindergartens who agreed with its purpose. By excluding 10 questionnaires with omitted or conflicting answers, 156 ones were finally analyzed in this study. The correlation between education about oral health and toothbrushing guidance, the subjects with and without the experience of the education did not show any significant difference in time to encourage toothbrushing, behaviors of toothbrushing guidance, guidance on prevention of toothpaste intake and perception of an appropriate amount of toothpaste (p>0.05) while perception of the importance of oral health was significantly related with the education on oral health (p<0.05). Therefore, education system for specialists in oral health to offer a specific and systemic education and oral health education programs for child care teacher, are considered to be necessary.

• Journal of Digital Convergence
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• v.11 no.12
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• pp.615-620
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• 2013

This research is a data analysis result of a future gout treatment was carried out in order to take advantage of basic data by Planned Population Federation of Korea in 2012, classified by gender. Using SPSS 18.0 analysis, frequency analysis, chi-squared analysis and logistic regression analysis were conducted. As a result, there were exceptional number of male subjects that required hyperuricemia thorough complete examination, and in case of hypouricemia, it is notable to find much more female subjects (p<0.001). Subjects that required thorough complete examination per age group and hypouricemia were significantly higher in those above the age of 70 years(p<0.001). Conclusions that required hyperuricemia thorough complete examination were a bit higher in the city areas and hypouricemia was a bit higher in the county areas, hyperuricemia was a bit higher in ratio in inland areas and hypouricemia was a bit higher in ratio in the coastal areas. I believe that continuous observation of gout prevalence rate based on this research by year, age group, and gender, would be extremely useful in making decisions regarding the changing trend of gout prevalence rate. In addition, hyperuricemia increased in postmenopausal women, as well as research on the causes of hypouricemia study.

• Journal of the Korean Society of Radiology
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• v.15 no.2
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• pp.153-158
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• 2021

X-ray image analysis is a very important field to improve the early diagnosis rate and prediction accuracy of periodontal disease. Research on the development and application of artificial intelligence-based algorithms to improve the quality of such dental X-ray images is being widely conducted worldwide. Thus, the aim of this study was to design a super-resolution algorithm for predicting periodontal disease and to evaluate its applicability in dental X-ray images. The super-resolution algorithm was constructed based on the convolution layer and ReLU, and an image obtained by up-sampling a low-resolution image by 2 times was used as an input data. Also, 1,500 dental X-ray data used for deep learning training were used. Quantitative evaluation of images used root mean square error and structural similarity, which are factors that can measure similarity through comparison of two images. In addition, the recently developed no-reference based natural image quality evaluator and blind/referenceless image spatial quality evaluator were additionally analyzed. According to the results, we confirmed that the average similarity and no-reference-based evaluation values were improved by 1.86 and 2.14 times, respectively, compared to the existing bicubic-based upsampling method when the proposed method was used. In conclusion, the super-resolution algorithm for predicting periodontal disease proved useful in dental X-ray images, and it is expected to be highly applicable in various fields in the future.

• Journal of Convergence for Information Technology
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• v.8 no.5
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• pp.37-43
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• 2018

The study was implemented the convergence research on oral health beliefs G area S university convergence course. The final analysis of 168 students agreed to research purpose and method was conducted from March 26 to June 11, 2018. The benefits was highest at 3.99 points, and the severity was lowest at 2.01 about oral health belief. The t-test and ANOVA outcome about oral health improvement behavior and oral health belief were dental clinic visit was benefits and importance, scaling experience was sensitivity, benefits and importance, use of auxiliary oral care products was importance to be statistically significant. The imported oral health beliefs for oral health improve and a variety of programs for oral health education need to be developed within university to learn knowledge of oral health behavior and attitude changed for correct oral health beliefs.