• Biomolecules & Therapeutics
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• v.6 no.2
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• pp.219-224
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• 1998

The bioequivalence of two clarithromvcin products was evaluated with 16 normal male volunteers (age 23-28 yr, body weight 57.5-75.517g) following single oral dose. Test product was ReYon Clarithromycin tablets (ReYon Pharm. Corp., Korea) and reference product was Klarici $d_{R}$ tablets (Abbott Korea). Both products contain 250 mg of clarithromucin. One tablet of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). The determination of clarithromycin was accomplished using a modified agar well diffusion bioassay. As a result of the assay validation, the quantification of clarithromycin in human serum by this technique was possible down to 0.03$\mu$g/ml using 100$\mu$l of serum. The coefficient of variation (C.V.) was less than 10%. Average drug concentrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products P>0.05); the area under the curve to last sampling time (24 hr) (AU $Co_{24hr}$ (8.10$\pm$ 1.26 vs 8.22$\pm$ 1.627g . hr/ml), AUC from time zero to infinite (AU $Co_{\infty}$) (8.61 $\pm$ 1.28 vs 8.84$\pm$ 1.71 $\mu$g . hr/ml), maximum plasma concentration ( $C_{msx}$) (0.87$\pm$0.22 vs 0.88$\pm$0.19 $\mu$g/ml) and time to maximum plasma concentration ( $T_{max}$) (2.69 $\pm$0.48 vs 2.56$\pm$ 0.51 hr). The differences of mean AU $Co_{24h}$, $C_{msx}$ and $T_{msx}$ between the two products (1.44, 1.39, and 4.65%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $Co_{24hr}$, and $C_{max}$ were more than 0.8 and less than 0.2, respectivly. Although the power for $T_{max}$ was under 0.8, $T_{max}$. of the two products was not significantly different each other (p>0.05). These results suggest that the bioavailability of ReYon Clarithromycin tablets is not significantly different from that of Klarici $d_{R}$ tablets. Therefore, two products are bioequivalent based on the current results. results.sults.sults.s.s.s.s.s.s.s.

• 한국해양학회지
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• v.29 no.2
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• pp.164-170
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• 1994

The well preserved ostracodes of the Chunbuk Formation in Pohang Basin were analyzed isotopically to understand paleoceanographic conditions of the southeastern park of Korean peninsula which Songhacdong, and Mulcheonri areas range from - 2.2 to - 0.7% (PDB), - 0.7 to 0.0% , and -20.0 to - 0.8%, and their corresponding paleotemperatures range from ca 20 to 27$^{\circ}C$ (average = 24$^{\circ}C$), 17 to 20$^{\circ}C$ (average = 18$^{\circ}C$), and 20 to 26$^{\circ}C$ (average=23$^{\circ}C$),respectively. Assuming the $\delta$/SUP 18/O composition of the Middle Miocene seawater was about - 0.34% (SMOW), the paleotemperatures of the Middle Miocene shallow seawater in the Pohang Basin was almost equal to or slightly higher than the present summer temperature (ca 16 to 20$^{\circ}C$) near Pohang area. Carbon isotopic value of Cyhere omotenipponica is - 0.8% (PDB), reflecting marine carbonate carbon composition. Carbon isotopic compositions of other ostracodes such as Aurial okumurai, Trachyleberis niitsmai, Urocythereis sp., Urocythereis cf. gorokuensis, and Acanthocythereis mutsuensis range from - 5.2 to - 3.4% (PDB), which might have secreted their shells out of equilibrium with ambient seawater. This disequilibrium was most likely to have resulted from metabolic (=vital) effect, rather than temperature of productivity.

• Journal of Climate Change Research
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• v.9 no.1
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• pp.13-29
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• 2018

This study presented evaluation procedure for selecting appropriate GCMs and downscaling method by focusing on the climate extreme indices suitable for climate change adaptation. The procedure includes six stages of processes as follows: 1) exclusion of unsuitable GCM through raw GCM analysis before bias correction; 2) calculation of the climate extreme indices and selection of downscaling method by evaluating reproducibility for the past and distortion rate for the future period; 3) selection of downscaling method based on evaluation of reproducibility of spatial correlation among weather stations; and 4) MME calculation using weight factors and evaluation of uncertainty range depending on number of GCMs. The presented procedure was applied to 60 weather stations where there are observed data for the past 30 year period on Korea Peninsula. First, 22 GCMs were selected through the evaluation of the spatio-temporal reproducibility of 29 GCMs. Between Simple Quantile Mapping (SQM) and Spatial Disaggregation Quantile Delta Mapping (SDQDM) methods, SQM was selected based on the reproducibility of 27 climate extreme indices for the past and reproducibility evaluation of spatial correlation in precipitation and temperature. Total precipitation (prcptot) and annual 1-day maximum precipitation (rx1day), which is respectively related to water supply and floods, were selected and MME-based future projections were estimated for near-future (2010-2039), the mid-future (2040-2069), and the far-future (2070-2099) based on the weight factors by GCM. The prcptot and rx1day increased as time goes farther from the near-future to the far-future and RCP 8.5 showed a higher rate of increase in both indices compared to RCP 4.5 scenario. It was also found that use of 20 GCM out of 22 explains 80% of the overall variation in all combinations of RCP scenarios and future periods. The result of this study is an example of an application in Korea Peninsula and APCC Integrated Modeling Solution (AIMS) can be utilized in various areas and fields if users want to apply the proposed procedure directly to a target area.

• Korean Journal of Materials Research
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• v.29 no.4
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• pp.205-210
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• 2019

$Pb(Zr,Ti)O_3$ (PZT) is used for the various piezoelectric devices owing to its high piezoelectric properties. However, lead (Pb), which is contained in PZT, causes various environment contaminations. $(K,Na)NbO_3$ (NKN) is the most well-known candidate for a lead-free composition to replace PZT. A single crystal has excellent piezoelectric-properties and its properties can be changed by changing the orientation direction. It is hard to fabricate a NKN single crystal due to the sodium and potassium. Thus, $(Na,K)NbO_3-Ba(Cu,Nb)O_3$ (NKN-BCuN) is chosen to fabricate the single crystal with relative ease. NKN-BCuN pellets consist of two parts, yellow single crystals and gray poly-crystals that contain copper. The area that has a large amount of copper particles may melt at low temperature but not the other areas. The liquid phase may be responsible for the abnormal grain growth in NKN-BCuN ceramics. The dielectric constant and tan ${\delta}$ are measured to be 684 and 0.036 at 1 kHz in NKN-BCuN, respectively. The coercive field and remnant polarization are 14 kV/cm and $20{\mu}C/cm^2$.

• Economic and Environmental Geology
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• v.54 no.6
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• pp.699-707
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• 2021

Hwajinpo Lagoon, located on the eastern coast of Korea, is a unique environment where freshwater and saltwater are mixed. Systematic management of the lagoon is required because it is a biodiversity-rich and area of high conservation value. The existing environment of the lagoon was evaluated by identifying the distribution of the groundwater level and groundwater flow characteristics. In addition, hydrogeochemical fluctuations were analyzed to determine the effect of seawater intrusion into the aquifer. The results demonstrate that the freshwater-saltwater interface is distributed throughout the aquifer and rises when water of the lagoon evaporates due to prolonged periods of low rainfall and high temperature, thereby increasing the possibility of seawater inflow through groundwater. As for the ionic delta properties (difference between the measured and theoretical concentration of mixed waters), it was estimated that the cation-exchange and precipitation reactions occurred in the aquifer due to seawater intrusion. The ratio of seawater mixed at each point was calculated, using oxygen isotopes and chloride as tracers, resulting in an average of 0.3 and a maximum of 0.87. The overall seawater mixing ratio appears to be distributed according to the distance from the coast. However, some of the results were deviated from the theoretical expectations and reflected the characteristics of the nearby aquifers. Further research on seasonal changes and simulation of seawater intrusion mechanisms is required for specific analysis.

• Journal of architectural history
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• v.32 no.3
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• pp.7-20
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• 2023

The compositions of ethnic groups in Macau vary with time. Prior to the opening of the port, the majority of the residents in Macau were Chinese people, including those living on land and at sea. After the port was opened, with the increase of Portugal businessmen and missionaries, the population was divided into Chinese people and foreigners (so-called 'Yiren' or 夷人 in Chinese). Chinese people living on land were mainly of Hakka, Fujian, and Cantonese descent. Those living at sea were referred to as 'Tanka People' (named 'Danmin' or 蜑民in Chinese). They lived on floating boats for their entire lives and were similar to the 'drifters' in Japan. Since modern times, many refugees from mainland China and Southeast Asia flooded into Macau due to warfare. The development of industrialization required a larger number of laborers, and some 'coolies' entered Macau in legal or illegal ways, making it a multi-ethnic city. However, the Tanka people were not considered a minority ethnic group under the national ethnic policy of 56 ethnic groups since they did not have an exclusive language and shared dialects in different regions. As the ports inhabited by Tanka people gradually restored foreign trade, the boats and stilt houses used by Tanka people were dismantled to expand the infrastructure area of the ports. Many Tanka people began to live on land and marry people on land, leading to the disappearance of the Tanka group in Macau. The fishing boats and stilt houses used by Tanka people have also disappeared, with only a few remaining in areas such as Pearl River Delta and Hong Kong. This paper examines the natural and social environment of Tanka people in Macau from the Ming and Qing dynasties to the Republic of China, as well as the adaptive changes they adopted for the aforementioned environment in terms of living space and architectural type, on the basis of summarizing the historical activities of Tanka people. Finally, this study provides a layout plan and interior structure of the most commonly used boat for Tanka people from the Ming and Qing dynasties to the Republic of China, with the use of CAD and other technical software, along with reference to written historical documentation, and provides a case study for further research on the architectural history of Macau's inner harbor cities, from anthropological and folklore perspectives.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3B
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• pp.311-319
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• 2006

A bed level change model(SED-FLUX) is introduced based on the realistic sediment transport process including bed load and suspended load behaviours at the bottom boundary layer. The model SED-FLUX includes wave module, hydrodynamic module and sediment transport and diffusion module that calculate suspended sediment concentration, net sediment erosion flux($Q_s$) and bed load flux. Bed load transport rate is evaluated by the van Rijn's TRANSPOR program which has been verified in wave-current fields. The net sediment erosion flux($Q_s$) at the bottom is evaluated as a source/sink term in the numerical sediment diffusion model where the suspended sediment concentration becomes a verification parameter of the $Q_s$. Bed level change module calculates a bed level change amount(${\Delta}h_{i,j}$) and updates a bed level. For the model verification the limit depth of the bed load transport is compared with the field experiment data and some formula on the threshold depth for the bed load movement by waves and currents. This model is applied to the beach profile changes by waves, then the model shows a clear erosion and accumulation profile according to the incident wave characteristics. Finally the beach evolution by waves and wave-induced currents behind the offshore breakwater is calculated, where the model shows a tombolo formation in the landward area of the breakwater.

• Korean Journal of Radiology
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• v.23 no.4
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• pp.446-454
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• 2022

Objective: To evaluate whether hyperoxia-induced ΔR₁ (hyperO₂ΔR₁) can accurately identify histological infarction in an acute cerebral stroke model. Materials and Methods: In 18 rats, MRI parameters, including hyperO₂ΔR₁, apparent diffusion coefficient (ADC), cerebral blood flow and volume, and ¹⁸F-fluorodeoxyglucose uptake on PET were measured 2.5, 4.5, and 6.5 hours after a 60-minutes occlusion of the right middle cerebral artery. Histological examination of the brain was performed immediately following the imaging studies. MRI and PET images were co-registered with digitized histological images. The ipsilateral hemisphere was divided into histological infarct (histological cell death), non-infarct ischemic (no cell death but ADC decrease), and nonischemic (no cell death or ADC decrease) areas for comparisons of imaging parameters. The levels of hyperO₂ΔR₁ and ADC were measured voxel-wise from the infarct core to the non-ischemic region. The correlation between areas of hyperO₂ΔR₁-derived infarction and histological cell death was evaluated. Results: HyperO₂ΔR₁ increased only in the infarct area (p ≤ 0.046) compared to the other areas. ADC decreased stepwise from non-ischemic to infarct areas (p = 0.002 at all time points). The other parameters did not show consistent differences among the three areas across the three time points. HyperO₂ΔR₁ sharply declined from the core to the border of the infarct areas, whereas there was no change within the non-infarct areas. A hyperO₂ΔR₁ value of 0.04 s^-1 was considered the criterion to identify histological infarction. ADC increased gradually from the infarct core to the periphery, without a pronounced difference at the border between the infarct and non-infarct areas. Areas of hyperO₂ΔR₁ higher than 0.04 s^-1 on MRI were strongly positively correlated with histological cell death (r = 0.862; p < 0.001). Conclusion: HyperO₂ΔR₁ may be used as an accurate and early (2.5 hours after onset) indicator of histological infarction in acute stroke.

• Korean Journal of Agricultural and Forest Meteorology
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• v.18 no.4
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• pp.327-336
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• 2016

The Bagan, the central part of Myanmar, is dry zone where the mean annual precipitation is less than 600 mm for the last ten years. Forest in this region has been degraded due to biotic and abiotic disturbances. While there have been various efforts to rehabilitate the degraded area, the information on growth and physiological characteristics of planting species and the impacts of planting trees in the region still lacks. Therefore, this study was conducted to determine the growth and physiological water use efficiency characteristics of five species (Azadirachta indica A. Juss., Acacia catechu Willd., Eucalyptus camaldulensis Dehn., Acacia leucophloea (Roxb.) Willd. and Albizia lebbek (L.) Willd.) which are utilized as rehabilitation species in the dry zone and to identify the impacts of tree planting on microclimate change in dry zone. The growth and the foliar carbon isotope composition of seedlings and the above mentioned five species planted in 2005 were measured. And from February 2015 to January 2016, microclimatic factors air temperature and relative humidity at 60 cm and 2 m above soil, soil temperature, soil water contents and precipitation were measured at every 30-minute interval from the two weather stations installed in the plantation located in Ngalinpoke Mt. Range. One was established in the center of A. indica plantation, and the other was in the barren land fully exposed to the sunlight. Among the five species, A. indica and A. lebbek which showed higher water use efficiency could be recommended as rehabilitation species in dry zone. Planting trees in the dry area was shown to affect the change of microclimate with shading effects, declining temperature of the land surface and aridity of the air, and to contribute to conserving more water in soil by preventing direct evaporation and containing more water with fine roots of trees.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.3
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• pp.192-200
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• 2008

To evaluate the hemodynamic changes and the predictive factors of the clinical outcome in pediatric patients with moyamoya disease, we analyzed pre/post basal/acetazolamide stress brain perfusion SPECT with automated volume of interest (VOIs) method. Methods: Total fifty six (M:F = 33:24, age $6.7{\pm}3.2$ years) pediatric patients with moyamoya disease, who underwent basal/acetazolamide stress brain perfusion SPECT within 6 before and after revascularization surgery (encephalo-duro-arterio-synangiosis (EDAS) with frontal encephalo-galeo-synangiosis (EGS) and EDAS only followed on contralateral hemisphere), and followed-up more than 6 months after post-operative SPECT, were included. A mean follow-up period after post-operative SPECT was $33{\pm}21$ months. Each patient's SPECT image was spatially normalized to Korean template with the SPM2. For the regional count normalization, the count of pons was used as a reference region. The basal/acetazolamide-stressed cerebral blood flow (CBF), the cerebral vascular reserve index (CVRI), and the extent of area with significantly decreased basal/acetazolamide- stressed rCBF than age-matched normal control were evaluated on both medial frontal, frontal, parietal, occipital lobes, and whole brain in each patient's images. The post-operative clinical outcome was assigned as good, poor according to the presence of transient ischemic attacks and/or fixed neurological deficits by pediatric neurosurgeon. Results: In a paired t-test, basal/acetazolamide-stressed rCBF and the CVRI were significantly improved after revascularization (p<0.05). The significant difference in the pre-operative basal/acetazolamide-stressed rCBF and the CVRI between the hemispheres where EDAS with frontal EGS was performed and their contralateral counterparts where EDAS only was done disappeared after operation (p<0.05). In an independent student t-test, the pre-operative basal rCBF in the medial frontal gyrus, the post-operative CVRI in the frontal lobe and the parietal lobe of the hemispheres with EDAS and frontal EGS, the post-operative CVRI, and ${\Delta}CVRI$ showed a significant difference between patients with a good and poor clinical outcome (p<0.05). In a multivariate logistic regression analysis, the ${\Delta}CVRI$ and the post-operative CVRI of medial frontal gyrus on the hemispheres where EDAS with frontal EGS was performed were the significant predictive factors for the clinical outcome (p =0.002, p =0.015), Conclusion: With probabilistic map, we could objectively evaluate pre/post-operative hemodynamic changes of pediatric patients with moyamoya disease. Specifically the post-operative CVRI and the post-operative CVRI of medial frontal gyrus where EDAS with frontal EGS was done were the significant predictive factors for further clinical outcomes.