• Journal of Pharmaceutical Investigation
• /
• v.38 no.3
• /
• pp.191-197
• /
• 2008

The purpose of the present study was to examine the pharmacokinetics and lymphatic delivery of the oligopeptide, a model peptide of X antigen epitope peptides, after the intramuscular administration of the peptide-bearing liposomes in rats. $^{14}C$-labelled peptide was used as a tracer to analyze the peptide levels in plasma, bile, urine, tissue homogenates, and lymph nodes (superior cervical nodes, brachial nodes and superior mesenteric nodes). Model peptide rapidly disappeared from the plasma by 30 min (${\alpha}$ phase) after i.v. administration, which was followed by the late disappearance. The apparent plasma half-lives ($t_{1/2({\alpha}),app}$) of the peptide at the ${\alpha}$ phase when administered at a dose of 0.2-1.0 mg/kg were about 5 min. The maximum plasma concentration ($C_{max}$) was $1.52\;{\mu}g/mL$, after the i.m. administration of the peptide at a dose of 1.0 mg/kg. The bioavailability, which was calculated from the time zero to last quantitative time, of the i.m. administered peptide was over 60%. Of the various tissues tested, the peptide was mainly distributed in the kidney after the i.m. administration. The peptide levels in the kidney 3 hr after the i.m. administration were higher than those of maximum plasma concentration ($C_{max}$). The cumulative amounts of the peptide found in the urine 72 hr after the administration of 1.0 mg/kg were 2-folder higher than those in the bile, suggesting that the peptide is mostly excreted in the urine. Moreover, the concentrations of the peptide in the lymph nodes were as high as that of the plasma and the tissues. In conclusion, the peptide concentration in the lymph nodes was maintained by 24 hr after the i.m. administration of the peptide-bearing liposomes.

• Journal of Pharmaceutical Investigation
• /
• v.23 no.2
• /
• pp.71-80
• /
• 1993

The purpose of this study was to compare the intrinsic absorptivity of piperacillin in the jejunum and the nasal cavity, to investigate the effect of bile salts, fatty acids and their mixed micelles on the intestinal and nasal absorption of piperacilIin, to examine the reversibiIity of bile salt-fatty acid mixed micelles absorption promoting action and to design an effective intranasal drug delivery system for antibiotics. And absorption promoters used were bile salts [sodium cholate (NaC), sodium glycocholate (NaGC)], unsaturated fatty acids [oleic acid (OA), linoleic acid (LA)] and their mixed micelles (NaC-LA). The present study employed the in situ nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of piperacillin were $0.40{\pm}0.04{\times}10^{-5}cm/sec(mean{\pm}S.E)$ in the jejunum and $1.32{\pm}0.08{\times}10^{-5}\;cm/sec$ in the nasal cavity, which indicated that intrinsic absorptivity of piperacillin was greater in the nasal cavity than in the jejunum. When absorption promoters were used in the rat nasal cavity, the decreasing order of apparent piperacillin permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was NaC-LA $(4.62{\pm}0.16)$> NaC $(4.36{\pm}0.32)$>LA$(2.24{\pm}0.26)$ NaGC $(2.17{\pm}0.21)$>OA $(1.53{\pm}0.16)$. The increase in permeability of piperacillin was 3.5-fold in the rat nasal cavity and 1.5-fold in the rat jejunum for formulations containing NaC-LA mixed micelles as compared to those without absorption enhancer. The effect of NaC-LA mixed micellar solutions was synergistic and was greater than that with single adjuvant. The reversibility of nasal mucosal permeability was observed within approximately 2 hr after removal of NaCLA mixed micelles from the nasal cavity. These results suggest that NaC-LA mixed micelles can be used as nasal mucosal absorption promoters of poorly absorbed drugs.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.20 no.4
• /
• pp.7-16
• /
• 2020

The mobile electronic notification service delivers notifications through mobile phone text or app-based message push to solve various problems of the paper-based mail service. And it is a service that an electronic document relay company proves to prove delivery. In order for public and administrative agencies to provide mobile electronic notification service, the user's identification information of the mobile phone number or the subscribed app is required. To overcome these limitations, ICT-regulated sandbox system was used to allow collective conversion of users' resident registration numbers into connecting information (CI). Therefore, in this paper, we propose a technical method for safe management of user CI in mobile electronic notice service, identity verification of electronic notice readers, and prevention of forgery and forgery of electronic notices. Through the proposed method, it is confirmed that the service can be activated by minimizing the adverse function of the mobile electronic notification service by securing the user's convenience and technical safety for the CI.

• Journal of Internet Computing and Services
• /
• v.20 no.5
• /
• pp.113-119
• /
• 2019

The key features of 5G mobile communications recently commercialized can be represented by High Data Rate, Connection Density and Low Latency, of which the features most distinct from the existing 4G will be low Latency, which will be the foundation for various new service offerings. AR and self-driving technologies are being considered as services that utilize these features, and 5G Network Latency is also being discussed in related standards. However, it is true that the discussion of E2E Latency from a service perspective is much lacking. The final goal to achieve low Latency at 5G is to achieve 1ms of air interface based on RTD, which can be done through Ultra-reliable Low Latency Communications (URLLC) through Rel-16 in early 20 years, and further network parity through Mobile Edge Computing (MEC) is also being studied. In addition to 5G network-related factors, the overall 5G E2E Latency also includes link/equipment Latency on the path between the 5G network and the IDC server for service delivery, and the Processing Latency for service processing within the mobile app and server. Meanwhile, it is also necessary to study detailed service requirements by separating Latency for initial setup of service and Latency for continuous service. In this paper, the following three factors were reviewed for initial setup of service. First, the experiment and analysis presented the impact on Latency on the Latency in the case of 1 Data Lake Setup, 2 CRDX On/Off for efficient power, and finally 3H/O on Latency. Through this, we expect Low Latency to contribute to the service requirements and planning associated with Latency in the initial setup of the required services.

• Biomolecules & Therapeutics
• /
• v.21 no.2
• /
• pp.161-169
• /
• 2013

The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol$^{(R)}$, sodium cholate, sodium caprate, hydroxypropyl ${\beta}$-cyclodextrin) were investigated for their ability to enhance the permeation of ZMR across Caco-2 cell monolayers. The flux and $P_{app}$ of ZMR in the presence of sodium caprate (SC) was significantly higher than other PEs in comparison to control, and was selected for further investigation. All concentrations of SC (10-200 mM) demonstrated enhanced flux of ZMR in comparison to control. The highest flux (13 folds higher than control) was achieved for the formulation with highest SC concentration (200 mM). The relative BA of ZMR formulation containing SC (PO-SC) in plasma at a dose of 10 mg/kg following oral administration in rats was 317.65% in comparison to control formulation (PO-C). Besides, the $AUC_{0-24\;h}$ of ZMR in the lungs following oral administration of PO-SC was $125.22{\pm}27.25$ ng hr $ml^{-1}$ with a $C_{max}$ of $156.00{\pm}24.00$ ng/ml reached at $0.50{\pm}0.00$ h. But, there was no ZMR detected in the lungs following administration of control formulation (PO-C). The findings of this study indicated that the oral formulation PO-SC containing ZMR and SC was able to enhance the BA of ZMR in plasma to an appropriate amount that would make ZMR available in lungs at a concentration higher (>10 ng/ml) than the $IC_{50}$ concentration of influenza virus (0.64-7.9 ng/ml) to exert its therapeutic effect.

• The Journal of the Korea Contents Association
• /
• v.18 no.1
• /
• pp.587-595
• /
• 2018

This research aims to analyze the importance-performance among multiplex cinema selection attributes. Therefore, we collected data for visitors who visited the multiplex cinema and want to watch movies. Of the various multiplex cinema selection attributes, four factors were deduced that includes: major services, human services, physical environment, auxiliary services using exploratory factor analysis. In the quadrant I, the area of 'Concentrate Here' was 'diversity of screening time', 'diversity of movie genre', 'convenience of mobile app use', 'size and convenience of parking facility'. In the quadrant II, 'Keep up the Good Work' area was 'convenience of website booking', 'discounts through card partnerships', 'employee friendliness', 'accurate employee information delivery', 'comfortable seating', 'screen size', 'cinematic sound quality', and 'convenience of traffic' etc. The quadrant III, 'Low Priority' appeared to be 'membership system', 'tidiness of staff attire', 'resting space for waiting time', 'accessibility to the neighboring area', 'diversity of the snack corner', and 'overall cleanliness' etc. The quadrant IV, 'Possible Overkill' was 'appropriateness of the auditorium temperature' and 'service proficiency'.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.22 no.10
• /
• pp.1361-1370
• /
• 2018

With the advent of OTT, the new concept of content delivery service is growing interest in the market, the development of appropriate equipment and application program is needed. In order to provide OTT service, a system to receive UHD broadcast to collect free content is needed. In this study, we designed an OTT service providing system that operates on 4K UHD video adapter hardware capable of IPTV service. First, we analyzed the situation to provide video free contents service and implemented a system to collect free contents. To validate the research and to make practical use of it, we have developed a mobile program for free content service and distributed it through the Google App Store. It is also installed in an OTT box with the ability to provide free content on the open market and is in service in several countries including Brazil.

• Journal of Advanced Navigation Technology
• /
• v.23 no.2
• /
• pp.158-165
• /
• 2019

The existing web page was downloaded and provided to the user every time the user requested the page. Therefore, if the same page is repeatedly requested by the user, only the download for the same resource is repeated. This is a factor that causes unnecessary consumption of data. We focus on reducing data consumption caused by unnecessary requests between users and servers, and improving content delivery speed. Therefore, in this paper, we propose a caching system and an algorithm that can reduce the data consumption while maintaining the latest cache by comparing the hash value using the hash function that can detect the change of the file requested by the user.

• Journal of Digital Convergence
• /
• v.17 no.4
• /
• pp.249-254
• /
• 2019

As an alternative to the growing problem of weather anomalies, users are using mobile weather apps to predict the weather. Even though it provides clear information, the user makes mistakes in forecasting the weather. For this reason, The purpose of this study is to find elements that can be prepared for the volatile weather through mobile application. Jakob Nielsen's "heuristic" evaluation found weaknesses in the application. Then I proceeded to analyze it from a behavioral economics standpoint. As a result, the two applications had various functions and accurate information. However, user accessibility was low and focused on 'information delivery'.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.22 no.4
• /
• pp.165-170
• /
• 2022

By reducing time spent outside, a shopping system was developed for middle-aged and elderly people who mainly use neighborhood marts and neighborhood mart managers. The main functions of this app are direct shopping and online shopping, and it was developed using QR code using Zxing library on Android and Kakao Map using Kakao API. In addition, it provides information such as payment statistics and bulletin board posts that members need through recycler view and graphs in an easy-to-read manner. Through this system, members can efficiently manage by reducing fatigue when using the mart through direct purchase using QR code and delivery through map, and reducing manpower wastage as a mart manager. Also, as a mart manager, more consumers will be able to sell more items.