• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.2
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• pp.148-153
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• 2006

Effects of ${\alpha}$-chymotrypsin modification on degree of hydrolysis (DH), solubility, emulsifying capacity and thermal aggregation of laboratory-purified soy protein isolate (SPI) using a lipoxygenase-defected soybean (Jinpum-kong) and commercial soy protein isolate (Supro 500E) were compared. SPIs were hydrolyzed by ${\alpha}$-chymotrypsin at pH 7.8 and $37^{\circ}C$ for 30 min. DHs of Supro 500E and Jinpum-kong SPI were increased by ${\alpha}$-chymotrypsin modification, and DH of Supro 500E was higher than that of Jinpum-kong SPI. DH of ${\alpha}$-chymotrypsin treated Jinpum-kong SPI was similar with untreated Supro 500E and DH of treated Supro 500E was the highest. Solubility, emulsifying capacity and thermal aggregation of SPIs were increased by ${\alpha}$-chymotrypsin modification, and these changes were highly related to changes in DH. Functional properties of Supro 500E were higher than Jinpum-kong SPI in both of untreated and ${\alpha}$-chymotrypsin treated SPIs.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.4
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• pp.172-179
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• 2001

A component based method out of load modeling is to aggregate component load model according to the composition rate of each component load at load bus based on the circuit theory. But the most of component loads respond complex nonlinear characteristics respect to voltage and frequency variation due to the control techniques and semiconductor elements applied to component load. It needs to verify this approach through actual experiment of the aggregation of component load even if it can be down. To identify this aggregation method well known, this paper is proposed the classifying method of component load characteristics for component loads to group by quantitative analysis. The component load characteristics were divided into several types by KSOM (kohonen self organizing map), which can classify multi-dimension vector, component load pattern, into two-dimension vector. Some ambiguous cases happened from KSOM were classified by the proposed closing degree.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.1254-1263
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• 1993

Representing knowledge uncertainty , aggregating evidence confidences , and propagation uncertainties are three key elements that effect the ability of a rule-based expert system to represent domains with uncertainty . Fuzzy set theory provide a good mathematical tool for representing the vagueness associated with a variable when , as the condition of a rule , it only partially corresponds to the input data. However, the aggregation of ANDed and Ored confidences is not as simple as the intersection and union operators defined for fuzzy set membership. There is, in fact, a certain degree of compensation that occurs when an expert aggregates confidences associated with compound evidence . Further, expert often consider individual evidences to be varying importance , or weight , in their support for a conclusion. This paper presents a flexible approach for evaluating evidence and conclusion confidences. Evidences may be represented as fuzzy or nonfuzzy variables with as associat d degree of certainty . different weight can also be associated degree of certainty. Different weights can also be assigned to the individual condition in determining the confidence of compound evidence . Conclusion confidence is calculated using a modified approach combining the evidence confidence and a rule strength. The techniques developed offer a flexible framework for representing knowledge and propagating uncertainties. This framework has the potention to reflect human aggregation of uncertain information more accurately than simple minimum and maximum operator do.

• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.115-121
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• 2006

The aim of this study was to develop new protein/peptide depot system instead of poly(DL-lactic acid-coglycolic acid) (PLGA) microspheres. Pullulan was chemically modified by the addition of acetic anhydride (pullulan acetate; PA) and then investigated as new depot system for protein/peptide delivery. PA microspheres (PAM) with lysozyme as a model protein were prepared by w/o/w double emulsion method. The microspheres had a mean size of 10-50 mm with a spherical shape. The size distributions reduced with increasing the degree of acetylation. The loading efficiency of lysozyme was also increased. Lysozyme aggregation behavior in the microsphere was monitored to estimate the change of protein stability during preparation step. The ratios of protein aggregation in PAMs are lower than that of PLGA microsphere, in particular, PA 5 showed lowest as about 16%. The result indicated that the increase of acetylation suppressed the aggregation of protein. The release profiles of lysozyme from PAMs were significantly different. High acetylation effectively improved lysozyme release kinetics by reducing initial burst release and extending continuous release over a period of time. To check the effect of preservation for structural stability of lysozyme, the activity of lysozyme released from PA 5 was also observed. The activity of lysozyme was maintained almost 100% for 25 day. Therefore, PAM may become to a useful carrier for delivery of protein/peptide drugs, if it will be supported by biocompatibility and biodegradability results.

• Journal of Korean Society of Forest Science
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• v.110 no.1
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• pp.106-115
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• 2021

The aim of the study was to analyze the spatial characteristics of the main producing areas of nontimber forest products. We analyzed the spatial aggregations of the main producing area and their changes using the Moran's I index. We found that 45% of nontimber forest products were significanty spatially clustered. Additionally, in five major products, we observed that the main producing area has expanded and the degree of aggregation has also strengthened over the last ten years. The results of this study can be effectively used for forest policies, such as determining the location and size of the distribution centers of specific forest products.

• Biomedical Science Letters
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• v.18 no.3
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• pp.237-243
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• 2012

This study was undertaken to know the effect of fat diet (for eight weeks) on changes of inflammatory markers [tumor necrosis factor (TNF-${\alpha}$) and prostaglandin $E_2$ ($PGE_2$)] and blood coagulation system [platelet aggregation function (PAF), prothrombin time (PT), activated partial thromboplastin time (aPTT)] in rats. Serum TNF-${\alpha}$, $PGE_2$, biochemical markers, PAF, PT, aPTT, and body weight were measured and compared between the control (normal diet-rats) and the fat group (fat diet-rats). The weights in the fat group were higher than those of the control group. TNF-${\alpha}$, $PGE_2$, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine levels were greater in the fat group compared with the control group. The degree of platelet aggregation was lower, whereas PT and aPTT levels were longer in the fat group than in the control group. These findings have shown that fat diet may cause inflammatory response, diabetes, liver and renal dysfunction, and disturbances of fibrinolysis and coagulation system.

• Macromolecular Research
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• v.11 no.1
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• pp.53-61
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• 2003

A molecular-thermodynamic model is developed for the salt-induced protein precipitation. The protein molecules interact through four intermolecular potentials. An equation of state is derived based on the statistical mechanical perturbation theory with the modified Chiew's equation for the fluid phase, Young's equation for the solid phase as the reference system and a perturbation based on the protein-protein effective two body potential. The equation of state provides an expression for the chemical potential of the protein. In a single protein system, the phase separation is represented by fluid-fluid equilibria. The precipitation behaviors are simulated with the partition coefficient at various salt concentrations and degree of pre-aggregation effect for the protein particles. In a binary protein system, we regard the system as a fluid-solid phase equilibrium. At equilibrium, we compute the reduced osmotic pressure-composition diagram in the diverse protein size difference and salt concentrations.

• Environmental and Resource Economics Review
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• v.9 no.3
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• pp.461-487
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• 2000

Kang et al. (1999) computed a composite environmental index in Korea by practicing the survey for environmental experts. They used the weighted sum form among feasible aggregation forms. In this study, we carry out the survey for both experts and non-experts to see the degree of differences of the weights for nine types of environmental problems between two groups. In addition, we apply different aggregation forms such as linear sum, weighted sum, root-sum-power, root-mean-square forms and compare these four outcomes. We found no significant discrepancy in the trends of composite indices. In case we rely on the weights provided by the experts, the composite index, on average, has been increased annually by about 7.2% over the 1986~1997 period, which informs us that overall environmental quality in 1997 has been worse than in 1986 by about 1.8 times.

• Bulletin of Food Technology
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• v.17 no.3
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• pp.69-74
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• 2004

A soy protein hydrolysate was found to inhibit rat platelet aggregation induced by ADP, an aggregating agent. To find out its principal antiplatelet peptide(s), the soy protein hydrolysate was separated successively by gel filtration chromatography, revere-phase HPLC, and cation exchange HPLC. During the course of separation, we observed that most fractions had antiplatelet effects, which suggests that most peptides have some degree of antiplatelet effect. Following the inhibitory fractions, we purified and identified two new peptides, SSGE and DEE, by LC-electrospray ionization MS and peptide equencing. Both peptides were highly hydrophilic. The concentrations to obtain 50% inhibition ($IC_50$) of the aggregation intensity were approximately $\458muM$ and $\485muM$, respectively, for SSGE and DEE.

• Journal of Korean Society of Transportation
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• v.13 no.3
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• pp.87-98
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• 1995

본 연구는 교통망 집성화(Aggregation)를 수행하기 위한 간단한 개념을 제시하고, 그 개념을 교통망 설계 문제(Network Design Problem)의 개략적이나 상당히 타당성 있는 해답을 얻기 위해 적용함으로써 교통망 집성화 정도(degree)의 효율성 및 유용성을 검증함에 그 목적이 있다. 교통망 집성화 및 O-D 교통량 측정 절창가 먼저 제시된 후, 교통망 설계 문제에 적용되었다. 본래의 교통망과 집성화된 교통망상에서의 교통망 설계 문제의 실행 결과가 언급되고, 또한 정확도 및 계산시간 측면에서의 비교가 고찰되었다. 교통망 설계 문제에 대한 개략적이나 비교적 정확한 해답을 고도로 집성화된 교통망으로부터 추정할 수 있음이 본 논문의 결과로서 검증되었다.