• Structural Engineering and Mechanics
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• v.41 no.4
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• pp.509-525
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• 2012

In recent years, CFRP material usage in strengthening applications gradually became widespread. Especially, the studies on the strengthening of shear deficient reinforced concrete beams with CFRP strips are chosen as a subject to numerous experimental studies and research on this subject are increased rapidly. The most important variable, that is affected on the failure mode of CFRP strips and that is needed for determining the shear capacity of the strengthened reinforced concrete beams, is the strain distribution between CFRP strips and concrete. Numerous experimental studies are encountered in the literature about the determination of strain distribution between CFRP strips and concrete. However, these studies mainly focused on the CFRP strips under axial tension. There are very limited numbers of experimental and analytic studies examining the strain distribution between concrete and CFRP strips, which are under combined stresses due to the effects of shear force and bending moment. For this reason, existing experimental study in the literature is used as model for ANSYS finite element software. Nonlinear finite element analysis of RC beams strengthened against shear with CFRP strips under reverse cyclic loading is performed. The strain distributions between CFRP strips and concrete that is obtained from finite element analysis are compared with the results of experimental measurements. It is seen that the experimental results are consisted with the results derived from the finite element analysis and important findings on the strain distribution profile are reached by obtaining strain values of many points using finite element method.

• Steel and Composite Structures
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• v.11 no.3
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• pp.207-223
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• 2011

The results of an experimental investigation are presented in this paper for retrofitting of shear damaged reinforced concrete beams by using U shaped CFRP strips. The experimental program is consisted of seven shear deficient T cross sectioned 1/2 scale simply supported beam specimens. One beam was used as reference specimen, and the remaining six specimens were tested in two stages. At the first stage, specimens were shear damaged severely, and then were retrofitted by using CFRP strips with or without fan type anchorages. Finally, retrofitted beams were tested up to failure. Three different CFRP strip spacing were used such as 125 mm, 150 mm, and 200 mm. The effect of anchorages on shear strength and behavior of the retrofitted specimens is investigated. CFRP strips without anchorages improved the shear strength, but no flexural failure mode was observed. Specimens showed brittle shear failure due to peeling of CFRP strip from RC beam surface. Shear damaged specimens retrofitted with anchoraged CFRP strips showed improved shear strength and ductile flexural failure. Maximum strains at anchoraged strips were approximately 68% larger than that of strips without anchorages.

• Earthquakes and Structures
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• v.23 no.1
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• pp.23-34
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• 2022

This paper presents experimental studies on reinforced concrete moment resisting frames that have engineered cementitious composite (ECC) in plastic hinge length (PHL) of beam/column members and beam-column joints. A two-story frame structure reduced by a 1:3 scale was further tested through a shake-table (seismic simulator) using multiple levels of simulated earthquake motions. One model conformed to all the ACI-318 requirements for IMRF, whereas the second model used lower-strength concrete in the beam/column members outside PHL. The acceleration time history of the 1994 Northridge earthquake was selected and scaled to multiple levels for shake-table testing. This study reports the observed damage mechanism, lateral strength-displacement capacity curve, and the computed response parameters for each model. The tests verified that nonlinearity remained confined to beam/column ends, i.e., member joint interface. Calculated response modification factors were 11.6 and 9.6 for the code-conforming and concrete strength deficient models. Results show that the RC-ECC frame's performance in design-based and maximum considered earthquakes; without exceeding maximum permissible drift under design-base earthquake motions and not triggering any unstable mode of damage/failure under maximum considered earthquakes. This research also indicates that the introduction of ECC in PHL of the beam/column members' detailing may be relaxed for the IMRF structures.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.10
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• pp.5237-5242
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• 2013

Recently, many bridges become not only functionally obsolete of bridge dick due to inadequate width but also structurally deficient of substructure due to erosion. In these case widening is almost always more economical than complete replacement, and therefore there is a need to make available the results of research and field experience pertaining to the widening of bridge substructure. But, an experimental study for the guarantee of unification between existing and new substructure with post-installed concrete set anchor is so insufficient that the development of post-installed concrete set anchor system for the unification should be settled promptly. The objective is to investigate the effects of anchor embedment depth and concrete strength on pullout characteristics of post-installed concrete set anchor embedded in plain concrete. The effects of embedment depth variable is depending on concrete strength as strong as concrete strength is pullout load is high. Regardless of concrete strength, embedment depth that less than 6 times appeared concrete failure mode but for embedment depth that over 8 times concrete strength has no affection on failure mode.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.4
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• pp.484-491
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• 2016

The present study investigated the effect of Sinetrol-XPur (polyphenolic Citrus spp. and Paullinia cupana Kunth dry extract) and defined the action mode for cyclic adenosine monophosphate (cAMP)-dependent uncoupling protein (UCP)-2 activation. Leptin-deficient obese mice were treated with two different doses, 100 mg/kg body weight (BW) and 300 mg/kg BW of each AIN93G supplement, for 7 weeks. Treatment of obese mice with both low and high doses of Sinetrol-XPur significantly reduced body weight gain compared to control obese mice. White adipose tissue weight of mice was reduced by 30.96% in high dose-supplemented groups. Serum total cholesterol and triglyceride were reduced by a high dose of Sinetrol-XPur by 20.02% and 30.96%, respectively. Serum level of high density lipoprotein (HDL) was significantly increased by treatment with both doses, as the ratio of HDL to low density lipoprotein increased by 138.78% and 171.49%, respectively. Regarding expression of biochemical factors related to lipid metabolism, fatty acid synthase significantly decreased and UCP-2 increased upon treatment with a high dose of Sinetrol-XPur, but there was no significant difference in lipoprotein lipase and hormone-sensitive lipase. To define cellular mechanism, intracellular cAMP levels in 3T3-L1 adipocytes significantly increased in a dose-dependent manner over the range of $50{\sim}250{\mu}m/mL$. The phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine clearly blocked cAMP, suggesting that Sinetrol-XPur promotes lipolysis of adipocytes through inhibition of cAMP-dependent PDE, resulting in induction of cAMP response element binding protein and UCP-2. These results suggest that Sinetrol-XPur supplementation is a viable option for reducing body weight and fat by improving serum lipid profiles and genetic expression of lipid metabolic factors, especially activation of cAMP-dependent UCP-2.

• Economic and Environmental Geology
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• v.28 no.6
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• pp.613-621
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• 1995

It is understood that many big tungsten deposits such as the Sangdong in Korea, Fugigatami in Japan, Yukon in Canada, Pine Creek in U.S.A and Vostok in Russia were formed at late Cretaceous ages. However, most of tungsten mineralization in China where half the total world tungsten ores is reserved took place in late Jurassic to early Cretaceous ages. While the close association of molybdenum with tungsten mineralization is observed in the deposits related with Cretaceous magma, tungsten deposits in China related with late Jurassic to early Cretaceous show a close association of tin as well as molybdenum mineralization. It is characteristic that tungsten mineralization in China was followed by tin mineralization. The mode of occurrence of tungsten ore deposits in China is various and may represent the origin of tungsten in general, since the larger half of total amount of tungsten ores in the world are reserved in China. In case of Korea, more than 90% of total production of tungsten was occupied by the Sangdong tungsten deposit, which produced molybdenite as a byproduct Even if tin is detected in ppm unit content, no cassiterite is found in the Sangdong tungsten orebody. A similar type of two tungsten deposits is comparatively studied in order to confirm the published data; one is the Moping tungsten deposit in China and the other is the Dehwa tungsten deposit in Korea. Mineral assemblages occurring in quartz veins of both deposits are more or less same except that zinnwaldite and cassiterite occur only in the former deposit Ages of zinnwaldite and muscovite closely with molybdenite in the former deposit are 181.1 Ma and 167.8 Ma respectively, while muscovites associated with molybdenite in the latter deposit show ages of 80.9 Ma and 80.2 Ma. These results may represent deficient supply of tin from the source granitoid from which tungsten was derived in Korean peninsula during Cretaceous period, while tin supplied during tungsten mineralization tended to increase and the active tin mineralization followed the Jurassic tungsten mineralization in China.

• Korean Journal of Veterinary Research
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• v.39 no.2
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• pp.247-256
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• 1999

A disease of young Holstein calves characterized by recurrent pneumonia, ulcerative and granulomatous stomatitis, enteritis with bacterial overgrowth, periodontitis, delayed wound healing, persistent neutrophilia and death at an early age had been originally described in 1983 and again in 1987. Most of these calves had stunted growth and a persistent, progressive neutrophilia (often exceeding 100,000/ml). By investigation of pedigrees, all of the affected calves have now been traced to a common sire and confirmed by polymerase chain reaction (PCR) diagnostic DNA testing to be homozygous carriers of a defective allele for bovine CD18. Neutrophils from these calves have several functional deficits and, most importantly, fail to adhere in a ${\beta}_2$-integrin dependent manner. The ${\beta}_2$-integrins represent a family of glycoproteins which participate in various leukocyte adhesion reactions during host defense. The presence or absence of ${\beta}_2$-integrin molecules can be demonstrated on the surface of neutrophils, monocytes and lymphocytes from normal or affected calves using specific monoclonal antibodies and flow cytometry, or by colloidal gold immunolabeling and scanning electron microscopy in backscatter mode. Deficiency of the ${\beta}_2$-integrins on all leukocyte types in Holstein calves is analogous to leukocyte adhesion deficiency (LAD) seen in humans. Neutrophils in bovine (BLAD) and human LAD patients are unable to adhere to the endothelial lining of the cardiovascular system thus interrupting egression of neutrophils into infected tissues. Other leukocytes, while still deficient in expression of the ${\beta}_2$-integrins, are still able to efficiently egress from the blood stream due to interactions of other adhesion molecules that are not as highly expressed on neutrophils. Both BLAD cattle and LAD children (who do not receive bone marrow transplants) often die at an early age as a result of the failure of neutrophils to extravasate into infected tissues. In 1991, Shuster, et $al^{27}$, identified two point mutations within the alleles encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency. One mutation causes an aspartic acid to glycine substitution at amino acid 128 (D128G) in an extracellular region of this adhesion glycoprotein that is highly conserved (> 95% identity) between humans, cattle and mice. The other mutation is silent. Numerous calves with clinical symptoms of leukocyte adhesion deficiency have since been tested and all have been found homozygous for the D128G allele. In addition, calves homozygous far the D128G allele have been identified during widespread DNA testing in the United States. All cattle with the mutant allele are related to one bull, who through artificial insemination (A.I.), sired many calves in the 1950's and 1960's. The carrier frequency of the D128G CD18 allele among U.S. Holstein cattle had reached approximately 15% among active A.I. bulls and 8% among cows. By 1993, the organization of the dairy industry and the diagnostic test developed to genotype cattle, enabled virtually complete eradication of bovine leukocyte adhesion deficiency among current and future A.I. bulls.

• Journal of Korea Water Resources Association
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• v.31 no.4
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• pp.385-396
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• 1998

The south-western part of Korea is situated in an unbalance of water supply and demand relating to the Keum, Mankyung, Dongjin and Youngsan River and their estuary reservoirs. For example, the Keum River estuary reservoir is discharging the larger amount of yearly runoff into the sea due to the small storage capacity, while Saemankeum estuary reservoir which is under construction, has the smaller runoff comparing with its strorage capacity. And the downstream area of the Youngsan River, such as Youngkwang, Youngam are deficient in water due to larger demand and smaller supply. In order to solve the above unbalanced water supply and demand and also to improve the water use effciency, the Hierarchical Operation Model for Multi-reservoir System(HOMMS) has been developed and applied to analyze the multi-reservoir operation assuming that the above reservoirs were linked each other. The result of this study shows that $2,148{\times}106\;\textrm{m}^3$ of annual additional water requirement for agricultural and rural water demands are required in this region at 2011 of target year, and these demands can be resolved by diverting and reusing $1,913{\times}106\;\textrm{m}^3$ of the released water from the estuary reservoirs into the sea.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.3 no.1
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• pp.86-93
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• 2003

Background : The SCL began screening of newborns and high risk group blood spots with tandem mass spectrometry (MS/MS) in April 2001. Our goal was to determine approximate prevalence of metabolic disorders, optimization of decision criteria for estimation of preventive effect with early diagnosis. This report describes the ongoing effort to identify more than 30 metabolic disorders by MS/MS in South Korea. Methods : Blood spot was collected from day 2 to 30 (mostly from day 2 to 10) after birth for newborn. Blood spot of high risk group was from the pediatric patients in NICU, developmental delay, mental retardation, strong family history of metabolic disorders. One punch (3.2 mm ID) of dried blood spots was extracted with $150{\mu}L$ of methanol containing isotopically labelled amino acids (AA) and acylcarnitines (AC) internal standards. Butanolic HCl was added and incubated at $65^{\circ}C$ for 15 min. The butylated extract was introduced into the inlet of MS/MS. Neutral loss of m/z 102 and parent ion mode of m/z 85 were set for the analyses of AA and AC, respectively. Diagnosis was confirmed by repeating acylcarnitine profile, urine organic acid and plasma amino acid analysis, direct enzyme assay, or molecular testing. Results : Approximately 31,000 neonates and children were screened and the estimated prevalence (newborn/high risk group), sensitivity, specificity and recall rate amounted to 1:2384/1:2066, 96.55%, 99.98%, and 0.73%, respectively. Confirmed 28 (0.09%) multiple metabolic disorders (newborn/high risk) were as follows; 13 amino acid disorders [classical PKU (3/4), BH4 deficient-hyperphenylalaninemia (0/1), Citrullinemia (1/0), Homocystinuria (0/2), Hypermethioninemia (0/1), Tyrosinemia (1/0)], 8 organic acidurias [Propionic aciduria (2/1), Methylmalonic aciduria (0/1), Isovaleric aciduria (1/1), 3-methylcrotonylglycineuria (1/0), Glutaric aciduria type1 (1/0)], 7 fatty acid oxidation disorders [LCHAD def. (2/2), Mitochondrial TFP def. (0/1), VLCAD def. (1/0), LC3KT def. (0/1). Conclnsion : The relatively normal development of 10 patients with metabolic disorders among newborns (except for the expired) demonstrates the usefulness of newborn screening by MS/MS for early diagnosis and medical intervention. However, close coordination between the MS/MS screening laboratory and the metabolic clinic/biochmical geneticists is needed to determine proper decision of screening parameters, confirmation diagnosis, follow-up scheme and additional tests.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.1610-1610
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• 2001

Microbiological examination of silage is of little value in gauging the outcome of silage, and so chemical analysis is more reliable and meaningful indicator of quality. On the other hand chemical assessments of the principal fermentation products provide an unequivocal basis on which to judge quality. Livestock require energy, protein, minerals and vitamins from their food. While fresh forages provide these essential items, conserved forages on the other hand may be deficient in one or more of them. The aim of the conservation process is to preserve as many of the original nutrients as possible, particularly energy and protein components (Woolford, 1984). Silage fermentation is important to preservation of forage with respect of feeding value and animal performance. Chemical and bacteriological changes in the silo during the fermentation process can affect adversely nutrient yield and quality (Moe and Carr, 1984). Many of the important chemical components of silage must be assayed in fresh or by extraction of the fresh material, since drying either by heat or lyophilisation, volatilises components such as acids or nitrogenous components, or effects conversion to other compounds (Abrams et al., 1987). Maize silage dorms the basis of winter rations for the vast majority of dairy and beef cattle production in Uruguay. Since nutrient intake, particularly energy, from forages is influenced by both voluntary dry matter intake and digestibility; there is a need for a rapid technique for predicting these parameters in farm advisory systems. Near Infrared Reflectance Spectroscopy (NIRS) is increasingly used as a rapid, accurate method of evaluating chemical constituents in cereals and dried forages. For many years NIRS was applied to assess chemical composition in dry materials (Norris et al., 1976, Flinn et al., 1992; Murray, 1993, De Boever et al., 1996, De la Roza et al., 1998). The objectives of this study were (1) to determine the potential of NIRS to assess the chemical composition of dried maize samples and (2) to attempt calibrations on undried samples either for farm advisory systems or for animal nutrition research purposes in Uruguay. NIRS were used to assess the chemical composition of whole - plant maize silage samples (Zea mays, L). A representative population of samples (n = 350) covering a wide distribution in chemical characteristics were used. Samples were scanned at 2 nm intervals over the wavelength range 400-2500 nm in a NIRS 6500 (NIRSystems, Silver Spring, MD, USA) in reflectance mode. Cross validation was used to avoid overfitting of the equations. The optimum calibrations were selected on the basis of minimizing the standard error of cross validation (SECV). The calibration statistics were R$^2$ 0. 86 (SECV: 11.4), 0.90 (SECV: 5.7), 0.90 (SECV: 16.9) for dry matter (DM), crude protein (CP), acid detergent fiber (ADF) in g kg$\^$-1/ on dry matter, respectively for maize silage samples. This work demonstrates the potential of NIRS to analyse whole - maize silage in a wide range of chemical characteristics for both advisory farm and nutritive evaluation.