• 대한본초학회지
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• 제34권1호
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• pp.43-50
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• 2019

Objectives : The purpose of this study was to proofread 'one ryang' in the Decoction of ${\ll}$Treatise on Cold Damage Diseases${\gg}$. Methods : I found out the ratio of maximum dose and minimum dose in this book. On the basis of the ratio, I corrected 'one ryang' in diverse decoctions. Results : In any decoction, maximum dose of medicinal medica in one decoction could not exceed four times minimum dose. Specifically, in the case that maximum dose in one decoction is sixteen ryang, it could not exceed eight times minimum dose in the same decoction. Any medicinal medica used in two decoctions or more, its maximum dose could not exceed four times minimum dose in other decoctions. On the basis of these results, it should be changed into three ryangs that are one ryang dose of 'Haematitum' of Seonbokdaeja Tang, 'Ginger' of Bujageongang Tang, Baektong Tang, Baektonggajeodamjep Tang and Senggangsasim Tang. Furthermore it should be changed into two ryangs that are one ryang dose of 'Coptidis Rhizoma' of Sohamhyung Tang, 'Ginger' of Dowha Tang, 'Ginseng Radix' of Whubaksenggangbanhagamchoinsam Tang, 'Polyporus, Poria Sclerotium, Alismatis Rhizoma, Talcum and Asini Corii Colla' of Jeoryeong Tang, 'Cimicifugae Rhizoma, Atractylodis Rhizoma Alba and Anemarrhenae Rhizoma' of Mahuangshengma Tang and 'Cassiae Cortex Interior' of Gyejigamchoryonggolmoryeo Tang. Conclusions : These results suggest that one ryang of thirteen medicinal medica such as Haematitum or Ginger of eleven decoctions such as Seonbokdaeja Tang or Bujageongang Tang should be changed into two or three ryangs.

• 대한암한의학회지
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• 제17권2호
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• pp.17-22
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• 2012

Background : Sulfasalazine for treating ulcerative colitis has a clinical limitation due to its adverse effects. This case is about a patient with ulcerative colitis who could not tolerate sulfasalazine and was improved by Do-che decoction-based Korean medicine. Method and Results : Purulent and bloody diarrhea more than 20 times a day, mild fever, chilling and tenesmus were main symptoms of this patient who was diagnosed as ulcerative colitis 10 years ago. Do-che decoction-based Korean medicine which was recommended for purulent and bloody diarrhea in Dong-Ui-Bo-Gam, the classic literature of Traditional Korean Medicine was given to the patient for more than 1 month. After treatment, the frequency of purulent and bloody diarrhea, tenesmus and fever was decreased remarkably, and C-reactive protein, erythrocyte sedimentation rate, white blood cell count and maximum temperature also dropped to the normal range. Conclusion : Do-che decoction-based Korean medicine has a potential effect and may be a alternative therapeutic option in patients with ulcerative colitis who cannot tolerate sulfasalazine due to its adverse effects.

• 한국환경과학회지
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• 제16권2호
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• pp.241-245
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• 2007

We studied concentration of heavy metals in Sagunjatang. In this experiment was analyzed the concentration of heavy metals of boiled Sagunjatang, decoction and its ingredient herbal medicines. The concentration of heavy metals(As, Pb, and Cd) were analysed using ICP-AES, and Hg was analysed by mercury analyzer. The average concentration of heavy metals in Sagunjatang were as follows : In all ingredient herbal medicines (Glycyrrhizae Radix, Atractylodes Macrocephala, Poria Cocos and Jinseng) of Sagunjatang, As(arsenite) contents in ail samples was in the range of 0.369-0.723ppm, Cd(cadmium) was in the range of 0.000-0.085ppm, Pb(lead) was in the range of 0.059-0.871ppm and Hg(mercury) was in the range of 0.001-0.004ppm. In boiled Sagunjatang, the concentration of heavy metals(As, Pb, Cd and Hg) was in the range of 0.000-0.016ppm, respectively. In the decoction of herbal medicines after boiled, the concentration of heavy metals was in the range of 0.004-0.387ppm. These results suggest that Sagunjatang which we take is less harmful than herbal medicine itself, and there are more significant for using the decoction of herbal medicines.

• 대한한의학회지
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• 제24권1호
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• pp.133-140
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• 2003

Objectives : Kochiae Fructus (dried fruits of Kochia scoparia L. Schrad,) is used in the treatment of skin diseases as internal or external medicine in Oriental Medicine, but there has not been experimental study of Kochiae Fructus as an external medicine. The purpose of this study was to investigate if it has certain effects on the skin or not. Methods : By a skin prick test method, we evaluated the effects of wet dressing with Kochiae Fructus decoction in different concentrations on histamine-induced itch, erythema and wheal responses, and compared them with the effects of calamine lotion and distilled water in 8 healthy volunteers aged 26-32. Results : The mean intensity and duration of itch were most decreased after wet dressing with a Kochiae Fructus decoction of 100mg/150ml. The time required for erythema to reach the maximal size was around 5 minutes in all groups, and the size of erythema was smallest on the skin taking wet dressing with the Kochiae Fructus decoction of highest concentration. The size of wheal was also smallest after wet dressing with the highest concentration Kochiae Fructus decoction. The effects of wet dressing with Kochiae Fructus decoction on skin were dependent on their concentrations. Conclusions : Kochiae Fructus suppressed the histamine-induced skin responses, which supports the ancient herbal literatures which describe that Kochiae Fructus has a certain effectiveness on some skin diseases.

• 대한한방부인과학회지
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• 제23권1호
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• pp.97-107
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• 2010

Purpose: This study was designed to verify the effect of Herbal Decoction for Sitz Bath on postpartum mother's perineal healing. Methods: Women who had given birth vaginally and had an episiotomy were included in study. The primary outcome for study was severity of pain, discomfort, rated on a 10-cm visual analog scale from 0("no pain") to 10("worst pain ever"). As a secondary outcome, we also evaluated side effect and "feeling". Results: In clinical trial, perineal pain, perineal discomfort, after-pain were significantly low at postpartum 3th days, respectively. And mothers were satisfied with "Herbal Decoction for Sitz Bath". Conclusion: According to these results, we finally concluded that "herbal decoction for sitz bath" for perineal care could be effective in healing the perineum.

• 대한한의학회지
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• 제24권2호
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• pp.59-65
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• 2003

This study was conducted to analyze metal concentration changes following processing steps for crude, remnant after boiling, and decoction of Korea herbal drugs. We measured meta.! concentration from 20 random patients who visited Oriental medical clinics for treatment of several diseases through normal action. The results obtained were as below: First, in the study to acknowledge quality control between Korean Lab and Harvard Lab in the US, 20 equal herbal samples resulted in the same values, so we confirmed the precision of measurement results from both labs. Second, hazardous metal mean concentration in crude, remnant after boiling, and decoction of herbal drugs were $32.5{\mu\textrm{g}}/22.1{\mu\textrm{g}}/8.8{\mu\textrm{g}}$ for As, $0.0{\mu\textrm{g}}/0.0{\mu\textrm{g}}/0.0{\mu\textrm{g}}$ for Cd, $1.0{\mu\textrm{g}}/0.0{\mu\textrm{g}}/0.0{\mu\textrm{g}}$ for Hg and $5416.3{\mu\textrm{g}}/3639.6{\mu\textrm{g}}/1002.6{\mu\textrm{g}}$ for Pb, respectively. These metal concentrations decreased 72.9-100.0% compared to crude status. The same trend was also visible in the other essential elements. From reviewing these results, we could carefully conclude that decoction had the least amount of metal concentration and is the optimal way to intake herbal drugs.

• 대한한의학회지
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• 제32권5호
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• pp.41-49
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• 2011

Objectives: To optimize the preservation method of herbal decoction, we investigated the content of principle components of Pyungwi-san, liquiritin, glycyrrhizin, and hesperidin according to preservation temperature and period. We also investigated the changing patterns of pH and microbial population in Pyungwi-san decoction as a model case. Methods: With samples preserved at different temperatures, the content of liquiritin, glycyrrhizin, and hesperidin was determined using HPLC and microbial population was determined as viable counting method up to 8 times every month. Identification of isolated bacteria was performed by 16S rDNA analysis. Results: The content of liquiritin and glycyrrhizin did not change according to the preservation temperature and period, but that of hesperidin was severely decreased at room temperature. The isolate from the decoction was identified as Bacillus licheniformis by 16S rDNA sequence analysis. Microbial population appeared after 3 months' preservation and reached maximum value at 4 months; at all tested temperatures, the pH showed the lowest value (4.4-4.5) simultaneously. Conclusion: From the results, it seems to be that the microbial growth affects the pH of preserved decoction but not the change of liquiritin and glycyrrhizin content.

• 대한본초학회지
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• 제25권1호
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• pp.9-12
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• 2010

Objectives : To evaluate the extraction efficiency of water decoction with or without non-woven fabric underlying comparison of the HPLC (high-performance liquid chromatography) profiles of the hesperidin which is the standard of Citri Pericarpium. Methods : Pyungwisan, which is comprised of Atractylodis Rhizoma, Magnoliae Cortex, Citri Pericarpium, Glycyrrhizae Radix, Zingiberis Rhizoma, and Ziziphy Fructus, was extracted in boiling water with non-woven fabric or without non-woven fabric. Then hesperidin content was analyzed by HPLC. Results : The contents of hesperidin in the water extract of Pyungwisan which was decocted without non-woven fabric showed $219.57{\pm}2.51\;mg/g$ and $138.90{\pm}6.32\;mg/g$ in with non-woven fabric decoction. Conclusions : These results suggest that herbal decoction without non-woven fabric might increase extraction efficiency.

• 대한한의학회지
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• 제19권1호
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• pp.410-418
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• 1998

From the ancient times, herbs, animals and minerals were used as natural medicine to cure human disease in diverse ways. One of the representative forms in oral intake is decoction. But medicinal decoction degenerates as time passes just as all foods do by the environmental factors, such as micro-organism, enzyme, light and the air. Nowadays, as medicinal decoctions are kept in bottles and retort pouch for longtime, some standard data for preservation is necessary. In order to measure the standard statistics for safe preservation, Youngsunjetongeum used to treat rheumatism, and gout 'were used. According to this experiment which measured pH, specific gravity, analgesic effect and anti-inflammatory effect, the results were as follows: 1. No remarkable change was found in pH and in the specific gravity of decoction. 2. As for the analgesic effect induced by acetic acid in mice, no remarkable decrease in its medicinal efficacy was found, until the 9th day, but it showed in its medicinal efficacy from the 11th day. 3. As for the resultant anti-inflammatory effect caused by vascular permeability, induced by carrageenin and acetic acid, no remarkable decrease in its medicinal efficacy was found until the 9th day, but showed decrease in its medicinal efficacy from 11th day. In conclusion, keeping the natural medicinal decoction more than 9 days should be avoided.

• 대한상한금궤의학회지
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• 제7권1호
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• pp.45-52
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• 2015

Objective : This case report aims to demonstrate the effect of Oryeong-san on Insomnia. Methods : A 26 year old woman suffered from insomnia with mental and physical exhaustion, reduced stamina, lack of concentration in daytime. According to Diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung and treated by Oryeong-san decoction. The result of administration was evaluated by Insomnia Severity Index. Results : After administration of Oryeong-san decoction for 1 month, Insomnia Severity Index was decreased from 24(clinical insomnia, severe) to 1(no clinically significant insomnia). Conclusions : The patient completely recovered from insomnia and daytime symptoms as treated by Oryeong-san decoction according to Diagnostic system based on Shanghanlun provisions.