• Information Systems Review
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• v.21 no.1
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• pp.23-38
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• 2019

The social network service (SNS) is one of the important marketing channels, so many companies actively exploit SNSs by posting SNS messages with appropriate content and style for their customers. In this paper, we focused on the psychological distances embedded in the SNS messages and developed a method to measure the psychological distance in SNS message by mixing a traditional content analysis, natural language processing (NLP), and machine learning. Through a traditional content analysis by human coding, the psychological distance was extracted from the SNS message, and these coding results were used for input data for NLP and machine learning. With NLP, word embedding was executed and Bag of Word was created. The Support Vector Machine, one of machine learning techniques was performed to train and test the psychological distance in SNS message. As a result, sensitivity and precision of SVM prediction were significantly low because of the extreme skewness of dataset. We improved the performance of SVM by balancing the ratio of data by upsampling technique and using data coded with the same value in first content analysis. All performance index was more than 70%, which showed that psychological distance can be measured well.

• Information Systems Review
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• v.21 no.3
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• pp.131-149
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• 2019

As smart phones, tablets, and other digital devices become more pervasive, theoretical arguments around digital divide, which has previously focused on "access," is now expanding to effectively "utilize," actively "produce" and "share" information. Such discussion is significant because the impact on inter-personal and social networks depends on how digital divides are used, which can then recreate or exacerbate social inequality structures. This study examines the effect of individual's social relations and two types of social capital (i.e., bonding and bridging) on economic and socio-participatory usage of digital devices. An empirical analysis of dataset from 740 surveys reveals that the more horizontal the social relations of the individual, the more both bonding and bridging social capital increase. However, rather than the social relationship of the individual directly influencing the two types of digital device usage, it has an indirect effect on both economic and socio-participatory usage of digital devices. In particular, mediating effects of both bonding and bridging social capital exist in the case of economic usage of digital devices, whereas bonding social capital only has mediating effects on economic usage of digital devices. We discuss the role of social capital on digital devices usage and present the theoretical and practical implications.

• Korean Journal of Radiology
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• v.20 no.5
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• pp.749-758
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• 2019

Objective: To investigate whether a computer-aided diagnosis (CAD) system based on a deep learning framework (deep learning-based CAD) improves the diagnostic performance of radiologists in differentiating between malignant and benign masses on breast ultrasound (US). Materials and Methods: B-mode US images were prospectively obtained for 253 breast masses (173 benign, 80 malignant) in 226 consecutive patients. Breast mass US findings were retrospectively analyzed by deep learning-based CAD and four radiologists. In predicting malignancy, the CAD results were dichotomized (possibly benign vs. possibly malignant). The radiologists independently assessed Breast Imaging Reporting and Data System final assessments for two datasets (US images alone or with CAD). For each dataset, the radiologists' final assessments were classified as positive (category 4a or higher) and negative (category 3 or lower). The diagnostic performances of the radiologists for the two datasets (US alone vs. US with CAD) were compared Results: When the CAD results were added to the US images, the radiologists showed significant improvement in specificity (range of all radiologists for US alone vs. US with CAD: 72.8-92.5% vs. 82.1-93.1%; p < 0.001), accuracy (77.9-88.9% vs. 86.2-90.9%; p = 0.038), and positive predictive value (PPV) (60.2-83.3% vs. 70.4-85.2%; p = 0.001). However, there were no significant changes in sensitivity (81.3-88.8% vs. 86.3-95.0%; p = 0.120) and negative predictive value (91.4-93.5% vs. 92.9-97.3%; p = 0.259). Conclusion: Deep learning-based CAD could improve radiologists' diagnostic performance by increasing their specificity, accuracy, and PPV in differentiating between malignant and benign masses on breast US.

• Animal Bioscience
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• v.37 no.7
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• pp.1141-1155
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• 2024

Objective: RNA epigenetic modifications play an important role in regulating immune response of mammals. Bovine mastitis induced by Staphylococcus aureus (S. aureus) is a threat to the health of dairy cattle. There are numerous RNA modifications, and how these modification-associated enzymes systematically coordinate their immunomodulatory effects during bovine mastitis is not well reported. Therefore, the role of common RNA modification-related genes (RMRGs) in bovine S. aureus mastitis was investigated in this study. Methods: In total, 80 RMRGs were selected for this study. Four public RNA-seq data sets about bovine S. aureus mastitis were collected and one additional RNA-seq data set was generated by this study. Firstly, quantitative trait locus (QTL) database, transcriptome-wide association studies (TWAS) database and differential expression analyses were employed to characterize the potential functions of selected enzyme genes in bovine S. aureus mastitis. Correlation analysis and weighted gene co-expression network analysis (WGCNA) were used to further investigate the relationships of RMRGs from different types at the mRNA expression level. Interference experiments targeting the m⁶ A demethylase FTO and utilizing public MeRIP-seq dataset from bovine Mac-T cells were used to investigate the potential interaction mechanisms among various RNA modifications. Results: Bovine QTL and TWAS database in cattle revealed associations between RMRGs and immune-related complex traits. S. aureus challenged and control groups were effectively distinguished by principal component analysis based on the expression of selected RMRGs. WGCNA and correlation analysis identified modules grouping different RMRGs, with highly correlated mRNA expression. The m⁶ A modification gene FTO showed significant effects on the expression of m⁶ A and other RMRGs (such as NSUN2, CPSF2, and METTLE), indicating complex co-expression relationships among different RNA modifications in the regulation of bovine S. aureus mastitis. Conclusion: RNA epigenetic modification genes play important immunoregulatory roles in bovine S. aureus mastitis, and there are extensive interactions of mRNA expression among different RMRGs. It is necessary to investigate the interactions between RNA modification genes regulating complex traits in the future.

• Journal of the Korean GEO-environmental Society
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• v.25 no.1
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• pp.5-11
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• 2024

Ground subsidence mainly occurs in urban areas with high population density, so it is necessary to clearly identify the cause of occurrence and prepare in advance. The main cause of ground subsidence is reported to be the creation of cavities in the ground due to damage to underground pipes, but the property information and influencing factors of underground pipes to predict and prepare for ground subsidence are not properly established. Therefore, in this study, factors showing a significant correlation with the occurrence of ground subsidence were selected among the underground facility property information and a regression equation was proposed through logistic regression analysis. For this purpose, data on underground structures and ground subsidence history information in the target area were collected, and the target area was divided into girds of 100m x 100m in size using QGIS. The underground facility attribute information and ground subsidence history information contained within the gird were extracted. Then, preprocessing was performed to construct a dataset and correlation analysis was performed. As a result, factors excluding the year of sewer pipes and communication pipes and the average depth of communication pipes, heat pipes, and gas pipes were found to have a significant correlation with ground subsidence. In addition, a regression equation for whether ground subsidence occurred in the target area is proposed through logistic regression analysis.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.493-498
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• 2024

With the rapid advancement of generative artificial intelligence technology, there is growing interest in how to utilize it in practical applications. Additionally, the importance of prompt engineering to generate results that meet user demands is being newly highlighted. Exploring the new possibilities of generative AI can hold significant value. This study aims to utilize ChatGPT 4.0, a leading generative AI, to propose an effective method for evaluating user experience through the analysis of online customer review data. The user experience evaluation method was based on the six-layer elements of user experience: 'functionality', 'reliability', 'usability', 'convenience', 'emotion', and 'significance'. For this study, a literature review was conducted to enhance the understanding of prompt engineering and to grasp the clear concept of the user experience hierarchy. Based on this, prompts were crafted, and experiments for the user experience evaluation method were carried out using the analysis of collected online customer review data. In this study, we reveal that when provided with accurate definitions and descriptions of the classification processes for user experience factors, ChatGPT demonstrated excellent performance in evaluating user experience. However, it was also found that due to time constraints, there were limitations in analyzing large volumes of data. By introducing and proposing a method to utilize ChatGPT 4.0 for user experience evaluation, we expect to contribute to the advancement of the UX field.

• Molecules and Cells
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• v.47 no.3
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• pp.100033.1-100033.13
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• 2024

Considering the recent increase in the number of colorectal cancer (CRC) cases in South Korea, we aimed to clarify the molecular characteristics of CRC unique to the Korean population. To gain insights into the complexities of CRC and promote the exchange of critical data, RNA-sequencing analysis was performed to reveal the molecular mechanisms that drive the development and progression of CRC; this analysis is critical for developing effective treatment strategies. We performed RNA-sequencing analysis of CRC and adjacent normal tissue samples from 214 Korean participants (comprising a total of 381 including 169 normal and 212 tumor samples) to investigate differential gene expression between the groups. We identified 19,575 genes expressed in CRC and normal tissues, with 3,830 differentially expressed genes (DEGs) between the groups. Functional annotation analysis revealed that the upregulated DEGs were significantly enriched in pathways related to the cell cycle, DNA replication, and IL-17, whereas the downregulated DEGs were enriched in metabolic pathways. We also analyzed the relationship between clinical information and subtypes using the Consensus Molecular Subtype (CMS) classification. Furthermore, we compared groups clustered within our dataset to CMS groups and performed additional analysis of the methylation data between DEGs and CMS groups to provide comprehensive biological insights from various perspectives. Our study provides valuable insights into the molecular mechanisms underlying CRC in Korean patients and serves as a platform for identifying potential target genes for this disease. The raw data and processed results have been deposited in a public repository for further analysis and exploration.

• Korean Journal of Radiology
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• v.21 no.12
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• pp.1345-1354
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• 2020

Objective: To evaluate radiomics analysis in studies on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a radiomics quality score (RQS) system to establish a roadmap for further improvement in clinical use. Materials and Methods: PubMed MEDLINE and EMBASE were searched using the terms 'cognitive impairment' or 'Alzheimer' or 'dementia' and 'radiomic' or 'texture' or 'radiogenomic' for articles published until March 2020. From 258 articles, 26 relevant original research articles were selected. Two neuroradiologists assessed the quality of the methodology according to the RQS. Adherence rates for the following six key domains were evaluated: image protocol and reproducibility, feature reduction and validation, biologic/clinical utility, performance index, high level of evidence, and open science. Results: The hippocampus was the most frequently analyzed (46.2%) anatomical structure. Of the 26 studies, 16 (61.5%) used an open source database (14 from Alzheimer's Disease Neuroimaging Initiative and 2 from Open Access Series of Imaging Studies). The mean RQS was 3.6 out of 36 (9.9%), and the basic adherence rate was 27.6%. Only one study (3.8%) performed external validation. The adherence rate was relatively high for reporting the imaging protocol (96.2%), multiple segmentation (76.9%), discrimination statistics (69.2%), and open science and data (65.4%) but low for conducting test-retest analysis (7.7%) and biologic correlation (3.8%). None of the studies stated potential clinical utility, conducted a phantom study, performed cut-off analysis or calibration statistics, was a prospective study, or conducted cost-effectiveness analysis, resulting in a low level of evidence. Conclusion: The quality of radiomics reporting in MCI and AD studies is suboptimal. Validation is necessary using external dataset, and improvements need to be made to feature reproducibility, feature selection, clinical utility, model performance index, and pursuits of a higher level of evidence.

• The Journal of the Acoustical Society of Korea
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• v.43 no.1
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• pp.78-88
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• 2024

Ship-radiated noise received by passive sonar that can measure underwater noise can be identified and classified ship using Detection of Envelope Modulation on Noise (DEMON) analysis. However, in a low Signal-to-Noise Ratio (SNR) environment, it is difficult to analyze and identify the target frequency line containing ship information in the DEMONgram. In this paper, we conducted a study to extract target frequency lines using semantic segmentation among deep learning techniques for more accurate target identification in a low SNR environment. The semantic segmentation models U-Net, UNet++, and DeepLabv3+ were trained and evaluated using simulated DEMONgram data generated by changing SNR and fundamental frequency, and the DEMONgram prediction performance of DeepShip, a dataset of ship-radiated noise recordings on the strait of Georgia in Canada, was compared using the trained models. As a result of evaluating the trained model with the simulated DEMONgram, it was confirmed that U-Net had the highest performance and that it was possible to extract the target frequency line of the DEMONgram made by DeepShip to some extent.

• BMB Reports
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• v.57 no.3
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• pp.161-166
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• 2024

Aberrant DNA methylation plays a critical role in the development and progression of colorectal cancer (CRC), which has high incidence and mortality rates in Korea. Various CRC-associated methylation markers for cancer diagnosis and prognosis have been developed; however, they have not been validated for Korean patients owing to the lack of comprehensive clinical and methylome data. Here, we obtained reliable methylation profiles for 228 tumor, 103 adjacent normal, and two unmatched normal colon tissues from Korean patients with CRC using an Illumina Infinium EPIC array; the data were corrected for biological and experiment biases. A comparative methylome analysis confirmed the previous findings that hypermethylated positions in the tumor were highly enriched in CpG island and promoter, 5' untranslated, and first exon regions. However, hypomethylated positions were enriched in the open-sea regions considerably distant from CpG islands. After applying a CpG island methylator phenotype (CIMP) to the methylome data of tumor samples to stratify the CRC patients, we consolidated the previously established clinicopathological findings that the tumors with high CIMP signatures were significantly enriched in the right colon. The results showed a higher prevalence of microsatellite instability status and MLH1 methylation in tumors with high CMP signatures than in those with low or non-CIMP signatures. Therefore, our methylome analysis and dataset provide insights into applying CRC-associated methylation markers for Korean patients regarding cancer diagnosis and prognosis.