• Journal of Oral Medicine and Pain
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• v.38 no.1
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• pp.87-95
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• 2013

Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a severe form of temporomandibular disorders (TMDs), presenting gradual breakdown of articular cartilage and subchondral bone by the functional load sustained to exceed the physiologic tolerance of the joint. In such a joint loaded, offensive bioactive materials such as matrix degrading proteins, cytokines, and free radicals increase in concentration to shift the tissue response in the joint to degeneration from regeneration or remodeling. Recently, it has been issued that obesity can play an offensive role in pathogenesis of OA in a metabolic way. Adipokines released by adipose cells are present at higher concentration in the arthritic joint and joints of obese individuals. However, because of conflicting data reported, further scientific study should be performed to elucidate the practical role of adipokines in pathogenesis of TMJ OA. As far as the clinical signs and symptoms of TMJ OA are not much different from those of other forms of TMD and any definitive treatment modality to control directly the bone resorptive activity is not available yet, the treatment of TMJ OA should be directed to reduce the physical load and enhance the physiologic tolerance of the joint by means of conservative treatment such as physical therapy, medication, and occlusal splint therapy for sufficient period and, if needed after that, supplementary surgical procedure such as intra-articular injection, arthrocenthesis, and arthroscopic surgery that have turned out to be effective to control OA signs and symtpoms. Enthusiastic reassurance and motivation for patients to control behaviors for themselves to reduce unnecessary functional load in daily life is very important for the joint to reach to more favorable orthopedic stability of the TMJ more quickly, guaranteeing more successful management TMJ OA.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.2
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• pp.105-117
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• 2020

Agaricus blazei Murill (Almond mushroom) has many beneficial effects, such as anti-cancer, immuneenhancement, and anti-obesity. Also, its skin benefits have been reported for antioxidant, anti-inflammatory, and whitening. In order to elucidate these effects, many studies have been conducted. In this study, we reconfirmed the skin efficacy of the extract of the mushrooms mushrooms. The Agaricus blazei extract showed inhibition of melanin synthesis, enhancement of collagen synthesis, and up-regulation of gene expression (hyaluronan syntahase-2, 3 and aquaporin-3) at 100 ㎍/mL. and identified the ingredients from the extract. We further investigated them to find an applicability as cosmetic ingredients. The ingredients were confirmed comparison of their spectroscopic data with literature values. They were identified as being ergosterol (1), 5-dihydroergosterol (2), cerevisterol (3), cerebroside B (4), cerebroside D (5), adenosine (6), and benzoic acid (7). Among these compounds, we evaluated skin efficacy for two cerebrosides and three ergosterol derivatives that have not been reported its efficacy. As a result, 5-dihydroergosterol (2) inhibited melanogenesis in B16F10 and promoted collagen biosynthesis in human dermal fibroblast. In addition, cerevisterol (3), cerebroside B (4), and cerebroside D (5) inhibited NO production in RAW 264.7 cell. In particular, cerebroside D (5) increased the expression of hyaluronan synthase-2 and aquaporin-3 genes in HaCaT. These results suggest that Agaricus blazei extract and isolated compounds can be used as cosmetic ingredients.

• Journal of the Korean Dietetic Association
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• v.9 no.4
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• pp.316-325
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• 2003

This study was carried out to compare the characteristics of the over weight elementary school students with those of desirable-weight children. Anthropometric parameters such as height, weight, BMI, body fat percentile, triceps skin fold thickness were measured. Dietary assessment and blood analysis were performed. The average ages of over weight children and desirable-weight children were 10.9$\pm$2.5 and 10.2$\pm$2.8 years, respectively. The means body fat percentile of over weight children and desirable-weight children were 27.5$\pm$3.7% and 20.2$\pm$3.8%. respectively. Plasma levels of TG, total cholesterol, LDL cholesterol, and HDL cholesterol of over weight children and desirable-weight children were 179.3$\pm$30.0, 104.9$\pm$26.6, 52.3$\pm$6.7 and 178.3$\pm$84.1 mg/dl, and those of desirable-weight children were 86.1$\pm$43.5, 183.7$\pm$16.5, 101.0$\pm$2.1 and 67.7$\pm$20.0 mg/dl, respectively. Plasma TG levels of over weight children were significantly higher than those of desirable weight children. On the other hand, plasma HDL-cholesterol levels of over weight children were significantly lower than those of desirable-weight children. Plasma levels of GOT and GPT were in normal range in both group however, GPT level of over weight children was higher than that of desirable weight children. Plasma levels of albumin, globulin, and BUN were all in normal range and no differences were found in both groups. Hematologic data did not show any difference between two groups except WBC, RBC and Hgb levels which were significantly higher in over weight group than those of desirable-weight children. Daily nutrients intake of over weight children and desirable-weight children were very similar and they were around the Korean RDA levels for each nutrients. However the intake of calcium of both groups were little over 50% of RDA. The consumption of dietary fiber was very low and the cholesterol intake was very high showing that the habitual meals of Korean school children were not well balanced.

• Journal of the East Asian Society of Dietary Life
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• v.25 no.4
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• pp.616-630
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• 2015

To supply basic data for systemic nutrition education, perception of nutrition education and nutrition knowledge was investigated in elementary school students (4~6th grade) in Chungnam province. Forty-six percent of students had a normal level of interest in nutrition, and 43.8% of students had a normal level of nutrition knowledge. Male students (56.1%) and female students (43.7%) wanted nutrition education via lectures in class (p<0.001), with a significant difference based on gender. In addition, most students wanted 'cooking' as nutrition education content, with a significant difference based on gender (p<0.001). Approximately 59% of students (boys 53.7% and girls 64.6%) responded that the reason not to practice the contents of nutrition education is 'not interested' (male 44%, female 34.1%) (p<0.05). For necessity of nutrition education, 38.1% of subjects answered 'normal', and 42.8% of students responded that nutrition education is not helpful since there is no interest. On the contrary, necessity of nutrition education was recognized by 30.8% of male students and 30.8% of female students for prevention of obesity and health life with a balanced diet, respectively. Students (66%) wanted a nutrition teacher, and 33.2% of male students wanted nutrition education once a month, whereas 34.5% of female students wanted it once a week (p<0.01). And 54.8% of students responded that current frequency of nutrition education is adequate. The average score of nutrition knowledge for female students was higher than that of male students, and a higher grade received a higher score of nutrition knowledge. The level of nutrition knowledge was not relevant to the actual score of the individual. Based on this result, it is necessary to activate and expand nutrition education in elementary schools to emphasize the importance of nutrition education. Additionally, future nutrition education should be more available to practice in life as well as improvement of nutrition knowledge. Investigation into nutrition knowledge according to gender and grade is necessary for continuous and systemic nutrition education.

• Journal of dental hygiene science
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• v.16 no.2
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• pp.165-175
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• 2016

Health behavior is one component of life style and is defined as behaviors performed by a person to protect, promote, or maintain the their health. General health behavior habits include not smoking, weight management, moderate drinking, regular exercise. The aim of this study was to analyze the relationship between toothbrushing and general health behaviors in 1,013 adults using data from the 2008 Daejeon Health Promotion Survey. Results showed no significant difference by region in general health behavior and toothbrushing. Smoking, alcohol consumption and toothbrushing frequency were related to sex, age, monthly income, occupation, and the degree of obesity. The predictoers of toothbrushing more than a day by losistic regression were female sex (vs. male, OR 1.88, 95% CI 1.20~2.95), age ${\geq}65$ years (vs. twenties, OR 0.51, 95% CI 0.26~0.99), monthly income 2 miillions Korean Won (KRW) to 3 millions KRW (vs. <2 million won, OR 1.58, 95% CI 1.04~2.42), white collar (vs. self-employment, OR 2.74, 95% CI 1.62~4.64), and regular exercise (vs. never, OR 1.60, 95% CI 1.21~2.11). We recommend the independent administration of oral health promotion programs focusing on aged and vulnerable social group because general health behaviors except regular exercise were not related to toothbrushing frequency.

• Journal of Ginseng Research
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• v.44 no.4
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• pp.664-671
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• 2020

Background: Ginsenoside compound-Mc1 (Mc1) is a member of the deglycosylated ginsenosides obtained from ginseng extract. Although several ginsenosides have a cardioprotective effect, this has not been demonstrated in ginsenoside Mc1. Methods: We treated H9c2 cells with hydrogen peroxide (H₂O₂) and ginsenoside Mc1 to evaluate the antioxidant effects of Mc1. The levels of antioxidant molecules, catalase, and superoxide dismutase 2 (SOD2) were measured, and cell viability was determined using the Bcl2-associated X protein (Bax):B-cell lymphoma-extra large ratio, a cytotoxicity assay, and flow cytometry. We generated mice with high-fat diet (HFD)-induced obesity using ginsenoside Mc1 and assessed their heart tissues to evaluate the antioxidant effect and the fibrosis-reducing capability of ginsenoside Mc1. Results: Ginsenoside Mc1 significantly increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the H9c2 cells. The expression levels of catalase and SOD2 increased significantly after treatment with ginsenoside Mc1, resulting in a decrease in the production of H₂O₂-mediated reactive oxygen species. Treatment with ginsenoside Mc1 also significantly reduced the H₂O₂-mediated elevation of the Bax:Bcl2 ratio and the number of DNA-damaged cells, which was significantly attenuated by treatment with an AMPK inhibitor. Consistent with the in vitro data, ginsenoside Mc1 upregulated the levels of catalase and SOD2 and decreased the Bax:B-cell lymphoma-extra large ratio and caspase-3 activity in the heart tissues of HFD-induced obese mice, resulting in reduced collagen deposition. Conclusion: Ginsenoside Mc1 decreases oxidative stress and increases cell viability in H9c2 cells and the heart tissue isolated from HFD-fed mice via an AMPK-dependent mechanism, suggesting its potential as a novel therapeutic agent for oxidative stress-related cardiac diseases.

• Journal of dental hygiene science
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• v.15 no.1
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• pp.83-89
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• 2015

To investigate the necessity of periodontal treatments, and the association of the health lifestyle with periodontal treatments, the data of 11,488 adults targeted in the 5th (2010, 2012) National Health and Nutrition Examination Survey were used in this study. Chi-squared test was conducted to compare the subjects' general features with the health lifestyle of the patients who needed periodontal treatments. Logistic regression analyses were conducted to confirm the variables that could affect the necessity of periodontal treatments. As a result of verifying the necessity of periodontal treatments according to the general features and health lifestyle, the necessity decreased with the higher income level and education level, and in the cases of nonsmokers, frequent toothbrushing, and using oral hygiene products. When the subjects who did not had oral examinations, their necessity for periodontal treatments significantly increased (p<0.01). The variables that affected the necessity of periodontal treatments included residence, gender, education level, obesity, and oral examinations (p<0.01). Therefore, health lifestyle was thought an important variable that had affected the oral health status. Professional dental hygienists must provide people with action programs of health lifestyle to promote the national oral health status.

• Journal of Life Science
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• v.19 no.11
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• pp.1644-1650
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• 2009

The purpose of this study was to investigate the effects of 12-week walking exercise on body composition, physical fitness, cardiovascular function, blood lipids, GH, IGF-1and leptin in obese and normal middle school girls. Participants included 12 pairs of middle school girls who were matched for sex, age and stratified by BMI (Obese Group: BMI$\geq$25.0; Normal Group: BMI<23.0). The variables of all factors were measured in all the subjects before and after the 12-week walking exercise program. The test data were analyzed by paired t-test, and t-test using the SPSS 14.0 statistics package and the alpha level of p<0.05 was set for all tests of significance. Body composition showed a significant difference in both groups, but the variables of physical fitness, cardiovascular function, blood lipids, growth hormone, and leptin did not show a significant difference in the two groups. We conclude that regular and continuous walking exercise improved body composition, physical fitness, cardiovascular function, blood lipids, and insulin factors in both groups. Consequently, these findings suggest that walking exercise will be effective for preventing obesity and improving health-related factors in the middle school girls.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.4
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• pp.333-339
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• 2014

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.2
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• pp.287-294
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• 2003

The purpose of this study was to develop a web-based internet program for nutritional assessment and diet management of patient having hyperlipidemia. Hyperlipidermia were classified by hypercholesterolemia and hypertriglyceridemia. The program consisted of four parts according to their functions and contents. The first part explained the metabolism of lipids and defined the hyperchotesterolemia and hypertriglyceridemia. The second part is to assess the general health status such as body weight, obesity index, basal metabolic rate and total energy requirement by the input of age, sex, height, weight and degree of activity. This part also provides the Patient with menus lists and 1 day menu suitable to his weight, activity and the status of hyperlipidemia and offers the information for food selection, snacks, convenience foods, dine-out, behavioral modification, cooking methods, food exchange lists, and information on energy and nutrients of foods and drinks, and top 20 foods classified by nutrients. The third part is designed to investigate diet history of patient, that is, to find out his inappropriate dietary habit and give him some suggestions for appropriate dietary behavior. This part also offers on-line counseling and frequently asked Questions. The fourth part is evaluating their energy and nutrients intake by comparing with recommended dietary allowance for Koreans or standardized data for patient with hyperlipidemia. In this part, it is also analyzing energy and nutrients of food consumed by food group and meals, and evaluating the status of nutrient intake. These results are finally displayed as tabular forms and graphical forms on the computer screen.