• Natural Product Sciences
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• v.26 no.3
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• pp.230-235
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• 2020

A pregnane steroid, 3α-hydroxy-pregn-7-ene-6,20-dione (1), was isolated from a Hydractinia-associated Cladosporium sphaerospermum SW67 by repetitive column chromatographic separation and high-performance liquid chromatography (HPLC) purification. The planar structure of 1 was elucidated from the analysis of the spectroscopic data (1D and 2D NMR spectra) and LC-MS data. The absolute configuration of 1 was determined by interpretation of ROESY spectrum of 1, together with the comparison of reported spectroscopic values in previous studies. To the best of our knowledge, this is the first report of the identification of the pregnane scaffold from C. sphaerospermum, a natural source. Compound 1 was evaluated for its effects on lipid metabolism and adipogenesis during adipocyte maturation and showed that compound 1 substantially inhibited lipid accumulation compared to the control. Consistently, the expression of the adipocyte marker gene (Adipsin) was reduced upon incubation with 1. Further, we evaluated the effects of 1 on lipid metabolism by measuring the transcription of lipolytic and lipogenic genes. The expression of the lipolytic gene ATGL was significantly elevated upon exposure to 1 during adipogenesis, whereas the expression of lipogenic genes FASN and SREBP1 was significantly reduced upon treatment with 1. Thus, our findings provide experimental evidence that the steroid derived from Hydractinia-associated C. sphaerospermum SW67 is a potential therapeutic agent for obesity.

• Korean Journal of Community Nutrition
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• v.5 no.1
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• pp.109-119
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• 2000

The purpose of this study was to measure serum lipids concentrations by gender and age, and to investigated the relation of serum lipids levels to cigarette smoking alcohol intake exercise and menopausal status in Korean adults. The subjects consisted of 463 healthy adult(29- men and 173 women) volunteers who were visiting the health Promotion Center in the Asan Medical Center from July 1, 1994 to July 22, 1994 Subjects were ambulatory free-living people and aged 20- 80 years, Anthropometric measurement was performed and serum triglyceride(TG), HDL-cholesterol and total cholesterol(TChol) concentrations were measure by automatic system(Hitachi 736-40). Data on life styles were obtained using structured questionnaires issued by a trained interviewer, All data were statistically analyzed by PC-SAS(Version 6.04) Serum concentrations of triglyceride and total cholesterol was higher(p<0.05) in men than in women, and serum HDL-cholesterol was lower(p<0.05) in men than in women. The prevalence of hyperlipidemia(TG>170 mg/dL and TChol>220 mg /dL) was 12.5% in men and 4.1% in women. The levels of serum triglyceride, total cholesterol and BMI increased with age in women. The distribution curves of serum triglyceride, total cholesterol and LDL-cholesterol of women were located in lower increased more rapidly with aging than in men, The distribution curves of BMI of women increased with aging after the thirties, The BMI of women was located in higher levels than of men in their sixties. The serum concentration of triglyceride and total cholesterol of male current-smokers and non- smokers were significantly(p<0.05) higher than those of ex-smokers. The concentrations triglyceride the male current0drinkers were higher(p<0.05) than those of male non-drinkers. In non-smokers and non- drinkers, serum TG concentration were lower (p<0.05) than those of current-smokers and current-drinkers. In exercisers, the serum triglyceride concentration was significantly(p<0.05) lower than in non- exercisers. In postmenopausal woman BMI and serum concentrations of TChol, TG and LDL-Chol were significantly by age and gender and smoking alcohol drinking, exercise and menopausal staus might be a better indicator to predict serum lipids in both genders.

• Women's Health Nursing
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• v.8 no.4
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• pp.570-582
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• 2002

The purpose of this study was to investigate the relationship between eating disorders, depression, and body dissatisfaction of middle aged women. Data was collected from June 1 to June 30, 1999 by means of a structured questionnaire. The subjects for this study were 99 middle aged women between the ages of 35 and 59, recruited from Seoul, Kyungido. The instruments were the BDI(Beck Depression Inventory) developed by Beck(1973), Eating Disorder Inventory(1997) developed by Garner & Garfinkel, Halm, Falk& Schwartz, Shin Mi Young. The instruments were the Body Dissatisfaction(1997) developed by Garner, Olstead & Polivy, Han osoo, yoo hee jung, shin Mi Young. The data was analyzed by the SPSS/PC program using frequency, percentage, mean, standard deviation, t-test, ANOVA and Pearson correlation coefficient. The results of this study are as follows 1. The mean body weight and height of the subjects were 57.49kg, 158.62cm. 2. Depending upon BMI, the obesity subjects were 18.2% and the rest(81.8%) were under weight or normal. More than 70% of the normal weight subjects(71 subjects) perceived their weight as overweight. 3. The total mean scores of anorexia nervosa were higher than bulimia nervosa. The total mean scores of eating disorders was 2.13. 4. The total mean scores of depression was 1.50. 5. The total mean scores of body dissatisfaction was 3.30. 6. There was a positive correlation between depression and eating disorders(r=.267, p<0.01)and, between body dissatisfaction and eating disorders(r=.273, p<0.01).There was not a significant correlation between depression and body dissatisfaction. According to the present study eating disorders in middle aged women developed because of the tendency to have negative perceptions of their bodies.

• Journal of East-West Nursing Research
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• v.18 no.1
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• pp.25-30
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• 2012

Purpose: The purpose of this study was to verify the influence of health point system on the lifestyle among the patients with chronic diseases listed in iCDMS, a project of the Incheon Metropolitan Center for Chronic Disease Control and Prevention. Methods: The data were collected 1,000 persons among the patients listed in iCDMS from March 16, 2009 to December 21, 2010 by telephone survey. The data were analyzed by descriptive statistics, ${\chi}^2$-test, odds ratio and logistic regression with the SPSS 18.0 program. Results: The higher the percentage of the accumulation of the points of necessary medical examinations they have, the better the lifestyle the participants practice moderation in drinking, exercise, and diet (p<.05). Also the higher the percentage e accumulative points of education and visit, the stronger the intention to improve the lifestyle such as for example, receiving the guidance of no smoking, giving up drinking, or being conscious of nutrition and obesity (p<.05). Conclusion: This study suggests that the motivation through an incentive system can increase self-care make an effect on the care of patients with chronic diseases.

• Journal of the Korean Dietetic Association
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• v.21 no.2
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• pp.154-172
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• 2015

The prevalence of obesity is continuing to increase. Self-perceived body image among women has drawn a lot of attention in Korea due to unhealthy weight control trials. This study was conducted to determine the relationship between self-perceived body image and dietary intakes among Korean women. For the analysis, 1,747 subjects were selected after eliminating those who were likely to have recently altered their diet based on the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) data. The subjects were divided into three groups: underweight, normal, and obese groups according to their perception of body image. Daily nutrient intakes, NAR (Nutrient Adequacy Ratio), and food intake frequency were assessed according to age group and body image perception. Only energy intake showed differences among the three body image perception groups across all age groups, but not statistical differences. Analysis of NAR and the order of most frequently consumed food items confirmed these findings. The ratio of underweight women that perceived their body size as normal or overweight was higher with younger age. Incorrect body image perception and unhealthy weight control behaviors can cause nutritional problems. This study confirmed that nutritional knowledge is important for healthy weight control trials. Nutritional education for healthy dieting should be emphasized among Korean women.

• Genomics & Informatics
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• v.10 no.4
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• pp.256-262
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• 2012

Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping technologies has allowed us to perform genome-wide association studies (GWASs). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWASs. Multifactor dimensionality reduction (MDR) is one of the powerful and efficient methods for detecting high-order gene-gene ($G{\times}G$) interactions. However, the biological interpretation of $G{\times}G$ interactions identified by MDR analysis is not easy. In order to aid the interpretation of MDR results, we propose a network graph analysis to elucidate the meaning of identified $G{\times}G$ interactions. The proposed network graph analysis consists of three steps. The first step is for performing $G{\times}G$ interaction analysis using MDR analysis. The second step is to draw the network graph using the MDR result. The third step is to provide biological evidence of the identified $G{\times}G$ interaction using external biological databases. The proposed method was applied to Korean Association Resource (KARE) data, containing 8838 individuals with 327,632 single-nucleotide polymorphisms, in order to perform $G{\times}G$ interaction analysis of body mass index (BMI). Our network graph analysis successfully showed that many identified $G{\times}G$ interactions have known biological evidence related to BMI. We expect that our network graph analysis will be helpful to interpret the biological meaning of $G{\times}G$ interactions.

• The Korean Journal of Community Living Science
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• v.27 no.1
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• pp.147-159
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• 2016

The purpose of this study was to evaluate the dietary quality of Korean females according to BMI, using the Korea National Health and Examination Survey data (KNHANES V-1). The study incorporated an individual-based, one-on-one interview with a cohort of 3,552 Korean females, including underweight, obese, and normal subjects, based on BMI calculation from 8,958 samples throughout the country. In this study, BMI between 18.5 and 25 was considered as normal, < 18.5 as underweight, and ${\geq}25$ as obese. We classified the subjects into three groups: the underweight group (n = 206), normal group (n = 2,353) and obese group (n = 993). The result of analysis of nutrient intake was a percentage of Korean RNI. Overall, calcium intake tended to be lower for groups with lower BMI. The result of dietary quality are as follows: For NAR analysis, all groups showed a less than 1.0 for all nutrient levels. In particular, with respect to calcium, all groups showed to have a lower NAR score than that of other nutrients; this was also the case for the Vitamin A. The average NAR score was 0.76 in the underweight group, 0.83 in the normal group, and 0.78 in the obese group. The results suggest the necessity of obesity-related nutritional education programs in Korea, particularly for Korean women.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.3
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• pp.271-282
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• 2005

This study analyzed the physical indices, food habits and nutrient intakes of patients with hypertension, to provide better research data for the prevention and the cure for disease as well as basic data for nutrition education. The subjects were 44 patients who visited the general hospital, located in Daegu, to receive hypertension treatment The lifestyle, food habit, nutrient intakes, anthropometric measurements, body fat and blood pressure were measured as main indices. By the BMI, $72.8\%$ of the patients were over weight or obesity $(>23\;kg/m^2)$. In the male group, the WHR tended to increase according to the BMI (p<0.05). In the female group, the body fat tended to increase according to the BMI (p<0.05). The group with more monthly income showed lower systolic blood pressure than the group with smaller monthly income (p<0.05). The scores about food habits concerning balanced diet and preference for salt were low, which implied that food habits of subjects were not desirable. The intakes of riboflavin and calcium didn't meet the RDA requirements. Especially, the lack of calcium was more ap~nt in the female patients than the male ones. Despite this, they had more than enough protein, vitamin C, and iron. The physical indices according to blood pressure revealed that the group of higher blood pressure showed greater WHR (p<0.001). The male group with higher systolic blood pressure showed greater BMI than one with lower systolic blood pressure (p<0.05). As for nutrient intakes according to blood pressure, the group with higher blood pressure had more sodium and iron than one with lower blood pressure (p<0.05). The patients with hypertension tended to be more overweight or obese, preferred salty foods, and were in an unbalanced state of nutrient intakes. Thus more systematic and ongoing measures should be pursued to take care of patients with hypertension.

• Safety and Health at Work
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• v.8 no.2
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• pp.117-129
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• 2017

Chronic disease rates have become more prevalent in the modern American workforce, which has negative implications for workplace productivity and healthcare costs. Offering workplace health interventions is recognized as an effective strategy to reduce chronic disease progression, absenteeism, and healthcare costs as well as improve population health. This review documents intervention and evaluation strategies used for health promotion programs delivered in workplaces. Using predetermined search terms in five online databases, we identified 1,131 published items from 1995 to 2014. Of these items, 27 peer-reviewed articles met the inclusion criteria; reporting data from completed United States-based workplace interventions that recruited at-risk employees based on their disease or disease-related risk factors. A content rubric was developed and used to catalogue these 27 published field studies. Selected workplace interventions targeted obesity (n = 13), cardiovascular diseases (n = 8), and diabetes (n = 6). Intervention strategies included instructional education/counseling (n = 20), workplace environmental change (n = 6), physical activity (n = 10), use of technology (n = 10), and incentives (n = 13). Self-reported data (n = 21), anthropometric measurements (n = 17), and laboratory tests (n = 14) were used most often in studies with outcome evaluation. This is the first literature review to focus on interventions for employees with elevated risk for chronic diseases. The review has the potential to inform future workplace health interventions by presenting strategies related to implementation and evaluation strategies in workplace settings. These strategies can help determine optimal worksite health programs based on the unique characteristics of work settings and the health risk factors of their employee populations.

• Korean Journal of Clinical Pharmacy
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• v.27 no.2
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• pp.83-91
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• 2017

Background: Piperacillin/tazobactam (TZP) is an antibiotic against a broad spectrum of gram-positive, gram-negative, and aerobic and anaerobic strains of bacteria. Due to changes in its pharmacokinetic and pharmacodynamic parameters by TZP-treated patients' renal functions and obesity, it is important to administrate and monitor TZP based on their renal functions and Body Mass Index (BMI) levels. The purpose of this study was to determine the appropriateness of administration doses of TZP based on renal functions of obese cancer patients in a tertiary hospital. Methods: This study was retrospectively conducted with obese cancer patients with $BMI{\geq}30kg/m^2$ in a tertiary hospital, Korea from September 2004 to August 2014. Data were collected through Electronic Medical Record (EMR) which contained laboratory data and TZP dosing of each patient. Results: Among 7,058 patients during the study period, 102 prescriptions were selected based on inclusion and exclusion criteria and classified by their renal functions. Although TZP should be used based on patients' renal functions to adjust its dose, its initial dose and dosing interval were consistently used without considering patients' renal functions on a regular basis. Especially, in the comparison with FDA dosing standard of TZP, approximately twice patients with $20mL/min{\leq}CrCl{\leq}40mL/min$ received domestically 4.5 g instead of 2.25 g as the TZP starting dose. Conclusion: The appropriate doses of TZP were administered to almost all of obese cancer patients; however, the recommended TZP dose was different between Korea and other countries by twice the amount. Further related studies are necessary to clearly determine the results, to optimize TZP treatment for obese patients with cancer in clinical practice, and to design and develop new TZP formulations for them in pharmaceutical industry.