• Journal of the Korean Society of Safety
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• v.16 no.2
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• pp.57-62
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• 2001

In order to analyze the mechanism of semiconductor device damages by ESD, this paper adopts a new charged-device model(CDM), field-induced charged nudel(FCDM), simulator that is suitable for rapid routine testing of semiconductor devices and provides a fast and inexpensive test that faithfully represents ESD hazards in plants. The high voltage applied to the device under test is raised by the fie]d of non-contacting electrodes in the FCDM simulator. which avoids premature device stressing and permits a faster test cycle. Discharge current md time are measured and calculated The FCDM simulator places the device at a huh voltage without transferring charge to it, by using a non-contacting electrode. The only charge transfer in the FCMD simulator happens during the discharge. This paper examine the field charging mechanism, measure device thresholds, and analyze failure modes. The FCDM simulator provides a Int and inexpensive test that faithfully represents factory ESD hazards. The damaged devices obtained in the simulator are analyzed and evaluated by SEM Also the results in this paper can be used for to prevent semiconductor devices from ESD hazards.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.25 no.4
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• pp.287-292
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• 2012

In this study, Multi-Channel Magnetic Flux Leakage(MFL) sensor - based inspection system was applied to monitor the condition of cables. This inspection system measures magnetic flux to detect the local faults(LF) of steel cable. To verify the feasibility of the proposed damage detection technique, an 8-channel MFL sensor head prototype was designed and fabricated. A steel cable bunch specimen with several types of damage was fabricated and scanned by the MFL sensor head to measure the magnetic flux density of the specimen. To interpret the condition of the steel cable, magnetic flux signals were used to determine the locations of the flaws and the level of damage. Measured signals from the damaged specimen were compared with thresholds set for objective decision making. In addition, the magnetic flux density values measured from every channel were summed to focus on the detection of axial location. And, sum of flux density were displayed with threshold. Finally, the results were compared with information on actual inflicted damages to confirm the accuracy and effectiveness of the proposed cable monitoring method.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.4
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• pp.417-423
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• 2015

In this study, Magnetic Flux Leakage(MFL)-based inspection system was applied to detect the local fault of wire rope. To verify the feasibility of the proposed damage detection technique, an 4-channel MFL sensor head prototype was designed and fabricated. A wire rope with several types of cross-sectional damages were fabricated and scanned by the MFL sensor head to measure the magnetic flux density of the wire rope specimen. To interpret the condition of the wire rope, magnetic flux signals were used to determine the locations of the flaws. To improve the resolution of signal, the instantaneous variation value of magnetic flux was utilized. Measured signals from the damaged specimen were compared with thresholds set for objective decision making. Finally, the results were compared with information on actual inflicted damages to confirm the accuracy and effectiveness of the proposed cable monitoring method.

• Toxicological Research
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• v.34 no.4
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• pp.281-290
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• 2018

Exposure to chemical agents is an inevitable consequence of modern society; some of these agents are hazardous to human health. The effects of chemical carcinogens are of great concern in many countries, and international organizations, such as the World Health Organization, have established guidelines for the regulation of these chemicals. Carcinogens are currently categorized into two classes, genotoxic and non-genotoxic carcinogens, which are subject to different regulatory policies. Genotoxic carcinogens are chemicals that exert carcinogenicity via the induction of mutations. Owing to their DNA interaction properties, there is thought to be no safe exposure threshold or dose. Genotoxic carcinogens are regulated under the assumption that they pose a cancer risk for humans, even at very low doses. In contrast, non-genotoxic carcinogens, which induce cancer through mechanisms other than mutations, such as hormonal effects, cytotoxicity, cell proliferation, or epigenetic changes, are thought to have a safe exposure threshold or dose; thus, their use in society is permitted unless the exposure or intake level would exceed the threshold. Genotoxicity assays are an important method to distinguish the two classes of carcinogens. However, some carcinogens have negative results in in vitro bacterial mutation assays, but yield positive results in the in vivo transgenic rodent gene mutation assay. Non-DNA damage, such as spindle poison or topoisomerase inhibition, often leads to positive results in cytogenetic genotoxicity assays such as the chromosome aberration assay or the micronucleus assay. Therefore, mechanistic considerations of tumor induction, based on the results of the genotoxicity assays, are necessary to distinguish genotoxic and non-genotoxic carcinogens. In this review, the concept of threshold of toxicological concern is introduced and the potential risk from multiple exposures to low doses of genotoxic carcinogens is also discussed.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.11a
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• pp.132-132
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• 2003

Second-order nonlinear optical(NLO) materials have been extensively studied for applications in photonic devices, such as frequency doubling and electro-optical(EO) modulation, because of their large optical nonlinearity, excellent processibility, low dielectric constant, and high laser damage thresholds. The poling behaviour of NLO chromophore in organic/inorganic matrixes showed the randomization of poled NLO chromophore in the absence of poling Held. The liquid crystal molecules in a droplet showed a long-range orientational order along a director. Therefore, liquid crystal effects on poling behaviour of NLO chromophore dispersed in organically modified inorganic sol-gel materials were investigated. Using sol-gel process for the development of NLO material has received increasing attention, Organically modifked inorganic NLO sol-Eel materials are obtained via incorporation of the organic NLO active chromophore into an alkoxysilane based inorganic network. One of the most important thing in this works was that tetraethoxysilane(TEOS) and methyltrimathoxysilane(HTMS) were used as precursor followed by hydrolysis and condensation without using any acidic catalyst during the process. The NLO chromophores in the liquid crystal nanodomains were well mixed with I/O hybrid matrix, deposited on transparent ITO-coated glasses. The poling behaviour of liquid crystal effects of NLO chromophore dispersed in I/O hybrid matrix were investigated by UV-vis spectroscopy. Size distribution and morphology of the NLO chromophores doped in the liquid crystal nanodomains dispersed in I/O hybrid matrix were investigated by SEM.

• The Korean Journal of Pain
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• v.26 no.4
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• pp.356-360
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• 2013

Background: Nerve injury sometimes leads to chronic neuropathic pain associated with neuroinflammation in the nervous system. In the case of chronic neuropathic pain, the inflammatory and algesic mediators become predominant and result in pain hypersensitivity following nervous system damage. It is well known that urinary trypsin inhibitor (ulinastatin, UTI) has an anti-inflammatory activity. Recently, the neuroprotective action of UTI on the nervous system after ischemic injury has been reported. Thus, we evaluated the neuroprotective effect of ulinastatin in a rat model of neuropathic pain. Methods: Neuropathic pain was induced with L5 spinal nerve ligation (SNL) in male Sprague-Dawley rats weighing 100-120 g. The rats were divided into 3 groups, with n = 8 in each group. The rats in the control group (group 1) were administered normal saline and those in group 2 were administered UTI (50,000 U/kg) intravenously through the tail vein for 3 days from the day of SNL. Rats in group 3 were administered UTI (50,000 U/kg) intravenously from the $5^{th}$ day after SNL. The paw withdrawal threshold was measured using the von Frey test for 3 days starting from the $5^{th}$ day after SNL. Results: The paw withdrawal thresholds were significantly increased in the rats of group 2 compared to the other groups (P < 0.05). Conclusions: Ulinastatin, which was administered for 3 days after SNL, increased the paw withdrawal threshold and it could have a neuroprotective effect in the rat model of neuropathic pain.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.262-267
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• 2008

Recently, landslides frequently occur on natural slope and/or man-made cut slope during periods of intense rainfall. With a rapidly increasing population on or near steep terrain, landslides have become one of the most significant natural hazards. Thus, it is necessary to protect people from landslides and to minimize the damage of houses, roads and other facilities. To accomplish this goal, many landslide monitoring systems have been developed throughout the world. In this paper, a simple landslide detection system that enables people to escape the endangered area is introduced. The system is focused on the debris flows which happen frequently during periods of intense rainfall. The system is based on the wireless sensor network (WSN) that is composed of wireless sensor nodes, gateway, and remote server system. Wireless sensor nodes and gateway are deployed by commercially available Microstrain G-Link products. Five wireless sensor nodes and one gateway are installed at the test slope for detecting ground movement. The acceleration and inclination data of test slope can be obtained, which provides a potential to detect landslide. In addition, thresholds to determine whether the test slope is stable or not are suggested by a series of numerical simulations, using geotechnical analysis software package. It is obtained that the alarm should be issued if the x-direction displacement of sensor node is greater than 20mili-meters and the inclination of sensor node is greater than 3 degrees. It is expected that the landslide detection method using wireless senor network can provide early warning where landslides are prone to occur.

• Diabetes and Metabolism Journal
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• v.42 no.6
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• pp.519-528
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• 2018

Background: Clinical manifestations of diabetic peripheral neuropathy (DPN) vary along the course of nerve damage. Nerve conduction studies (NCS) have been suggested as a way to confirm diagnoses of DPN, but the results have limited utility for evaluating clinical phenotypes. The current perception threshold (CPT) is a complementary method for diagnosing DPN and assessing DPN symptoms. We compared NCS variables according to clinical phenotypes determined by CPT measurements. Methods: We retrospectively enrolled patients with type 2 diabetes mellitus who underwent both NCS and CPT tests using a neurometer. CPT grades were used to determine the clinical phenotypes of DPN: normoesthesia (0 to 1.66), hyperesthesia (1.67 to 6.62), and hypoesthesia/anesthesia (6.63 to 12.0). The Michigan Neuropathy Screening Instrument (MNSI) was used to determine a subjective symptom score. DPN was diagnosed based on both patient symptoms (MNSI score ${\geq}3$) and abnormal NCS results. Results: A total of 202 patients (117 men and 85 women) were included in the final analysis. The average age was 62.6 years, and 71 patients (35.1%) were diagnosed with DPN. The CPT variables correlated with MNSI scores and NCS variables in patients with diabetes. Linear regression analyses indicated that hypoesthesia was associated with significantly lower summed velocities and sural amplitudes and velocities, and higher summed latencies, than normoesthesia. Sural amplitude was significantly lower in patients with hyperesthesia than in patients with normoesthesia. Conclusion: NCS variables differed among patients with diabetes according to clinical phenotypes based on CPT and decreased sural nerve velocities was associated with hyperesthesia.

• Earthquakes and Structures
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• v.10 no.1
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• pp.141-161
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• 2016

In seismic fragility and risk analysis, the definition of structural limit state (LS) capacities is of crucial importance. Traditionally, LS capacities are defined according to design code provisions or using deterministic pushover analysis without considering the inherent randomness of structural parameters. To assess the effects of structural randomness on LS capacities, ten structural parameters that include material strengths and gravity loads are considered as random variables, and a probabilistic pushover method based on a correlation-controlled Latin hypercube sampling technique is used to estimate the uncertainties in LS capacities for four typical reinforced concrete frame buildings. A series of ten LSs are identified from the pushover curves based on the design-code-given thresholds and the available damage-controlled criteria. The obtained LS capacities are further represented by a lognormal model with the median $m_C$ and the dispersion ${\beta}_C$. The results show that structural uncertainties have limited influence on $m_C$ for the LSs other than that near collapse. The commonly used assumption of ${\beta}_C$ between 0.25 and 0.30 overestimates the uncertainties in LS capacities for each individual building, but they are suitable for a building group with moderate damages. A low uncertainty as ${\beta}_C=0.1{\sim}0.15$ is adequate for the LSs associated with slight damages of structures, while a large uncertainty as ${\beta}_C=0.40{\sim}0.45$ is suggested for the LSs near collapse.

• Clinical and Experimental Reproductive Medicine
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• v.47 no.4
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• pp.277-283
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• 2020

Objective: The sperm DNA fragmentation index (DFI) guides the clinician's choice of an appropriate assisted reproductive technology (ART) procedure. The DFI can be determined using commercially available methodologies, including sperm chromatin dispersion (SCD) kits and sperm chromatin structure assay (SCSA). Currently, when DFI is evaluated using SCD kits, the result is analyzed in reference to the SCSA-derived threshold for the choice of an ART procedure. In this study, we compared DFI values obtained using SCSA with those obtained using SCD and determined whether the difference affects the choice of ART procedure. Methods: We compared SCSA to two SCD kits, CANfrag (n=36) and Halosperm (n=31), to assess the DFI values obtained, the correlations between tests, the technical repeatability, and the impact of DFI on the choice of ART. Results: We obtained higher median DFI values using SCD kits than when using SCSA, and this difference was significant for the CANfrag kit (p<0.001). The SCD kits had significantly higher coefficients of variation than SCSA (p<0.001). In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) would be chosen for a significantly higher proportion of patients if a decision were made based on DFI derived from SCD rather than DFI determined using SCSA (p=0.003). Conclusion: Our results indicate that SCD kit-specific thresholds should be established in order to avoid the unnecessary use of IVF/ICSI based on sperm DNA damage for the management of infertility. Appropriate measures should be taken to mitigate the increased variability inherent to the methods used in these tests.