• Toxicological Research
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• v.6 no.1
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• pp.109-119
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• 1990

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced lysis of erythrocytes. Ro-09-0198-induced hemolysis was temperature-dependent and the sensitivity of hemolysis differed greatly among animal species. Preincubation of the peptide with phosphatidylethanolamine reduced the hemolytic activity, whereas other phospholipids present in erythrocytes in nature had no effect. A study of the structural requirements on phosphatidylethanolamine necessary for interaction with the peptide indicates that Ro09-0198 recognizes strictly a particular chemical structure of phosphatidylethanolamine: dialkylphosphoethanolamine as well as 1-acylglycerophosphoethanolamine showed the same inhibitory effct on hemolysis induced by Ro09-0198 as diacylphosphatidyl-ethanolamine, whereas phosphoethanolamine gave no inhibitory effect. Neither phosphatidyl-N-monomethylethanolamine nor alkylphosphopropanolamine had an inhibitory effect. Proton resonances of the peptide were observed in dimethyl sulfoxide solution in the presence of 1-dodecanoyl-sn-glycerophosphoethanolamine. This peptide caused permeability increase and aggregation of liposomes containing phosphatidylethanolamine. A glycerol backbone and a primary amino group of phosphatidylethanolamine are necessary for interaction with Ro09-0198 to cause membrane damage. Ro09-0198 induced a selective permeability change on liposomes. Glucose and umbelliferyl phosphate were effluxed significantly, but sucrose was only slightly permeable and inulin could not be released. Platelet aggregation and serotonin release simultaneously induced by Ro09-0198. Addition of peptide to rat platelet, loaded with the fluorescent $Ca^{++}$ chelator quin-2, caused immediate rise in cytosolic free $Ca^{++}$ to liposomal membrane containing phosphatidylethanolamine was observed dose dependently.

• Journal of the Society of Naval Architects of Korea
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• v.32 no.1
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• pp.103-117
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• 1995

A design-oriented method for analysis of the structural damage due to ship collisions is developed by using the idealized structural unit method(ISUM). The method takes into account yielding, crushing, rupture, the coupling effects between local and global failure of the structure, the influence of strain-rate sensitivity and the gap/contact conditions. The method is verified by a comparison of experimetal and numerical results obtained from test models of double-skin plated structures in collision/grounding situations with the present solutions. As an illustrative example, the method has been used for analyses of a side collision of a double-hull tanker. Several factors affecting ship collision response. namely the collision speed and the scantlings/arrangements of strength members, are discussed.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.118-124
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• 2015

Purpose: The symptoms and signs of urinary tract infection (UTI) in early infancy are non-specific. Prompt diagnosis of UTI is important, as untreated UTI results in renal damage. Especially, febrile UTI in young infants coexist with other serious bacterial infections. The purpose this study was to propose modified Rochester criteria to differentiate viral infection from urinary tract infection. Methods: We carried out a retrospective investigation of 168 infants less than three months old with a tympanic temperature $>38^{\circ}C$ who were admitted to Chung-Ang University Hospital between 2011 and 2014. We compared the symptoms, physical examination results, and laboratory data between viral infection and UTI groups. A modified Rochester criterion was composed of statistically significant factors. Results: A total of 76 and 92 infants with UTI and a viral infection, respectively, were included. Statistically significant differences in gender, previous admission history, neutrophil ratio, and urine WBC count were found between the two study groups. Using a cut off value of 3 points, the sensitivity and specificity of the modified Rochester criteria were 71.28% and 78.57%, respectively. Conclusion: The modified Rochester criteria may give an outline for identifying young infants with UTI.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.2
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• pp.66-74
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• 2017

Since risers have to be operated without being replaced during the design life time after installation, fatigue evaluation as well as strength analysis should be performed. The fatigue life of the riser is known to be dominantly influenced by wave loading and vortex induced vibration (VIV) phenomena. The fatigue life evaluation method and the behavior characteristics of the riser by the wave have been done a lot. Even though the VIV is an important source of fatigue damage for SCR, the evaluation method and behavior characteristics by VIV have not been studied relatively. Most of the S / W for calculating VIV fatigue are a semi-empirical model based on various theoretical models and experiments. For better understanding of VIV response, it is necessary to investigate the effect of parameters which affects the analysis result. This paper summarizes the results of parametric study performed to enhance the understanding of relationship between each parameter and fatigue analysis result.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.8
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• pp.651-656
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• 2012

A study on capacitive characteristics of stylus pen for touch panel are progressed in this paper. Also the main factors for capacitive sensitivity are studied. Namely, highly sensitive stylus pen which can be applied to capacitive touch panel are studied based on the analysis of materials and process conditions regardless of pattern shapes. Stylus pen was made of PDMS(Poly-Di-Methyl-Siloxane) and conductive metal powders which does not damage the touch panel surface. We tried to get the advantages of both the properties of soft PDMS and conductive metal powders. We found that potential difference of capacitance change with conductivity of the composite materials(PDMS + metal powders) it implies that during touch process, large voltage difference can be caused by the high conductive materials of stylus pen. Stylus pen made by PDMS with mixed with Ag powders which has large conductivity shows more capacitance change of 1 pF than PDMS with other materials of Ni or C powders.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.65 no.4
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• pp.280-284
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• 2016

Stability and reliability of a power system in many respects depend on the condition of power transformers. Essential devices as power transformers are in a transmission and distribution system. Being one of the most expensive and important elements, a power transformer is a highly essential element, whose failures and damage may cause the outage of a power system. To detect the power transformer faults, dissolved gas analysis (DGA) is a widely-used method because of its high sensitivity to small amount of electrical faults. Among the various diagnosis methods, Rogers diagonsis method has been widely used in transformer in service. But this method cannot offer accurate diagnosis for all the faults. This paper proposes a fault diagnosis method of oil-filled power transformers using PNN(Probability Neural Network) based Rogers diagnosis method. The test result show better performance than conventional Rogers diagnosis method.

• International Journal of Industrial Entomology and Biomaterials
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• v.6 no.2
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• pp.125-132
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• 2003

Uzi fly (Exorista bombycis Louis) is one of the major larval endo-parasitoid of silkworm (Bombyx mori). It causes extensive damage to sericulture industry. The application of synthetic organic pesticides has tremendous impact on minimizing pest population but their overuse and frequent misuse and high sensitivity towards the silkworms, has forced the entomologists to search for alternatives to chemical control, which is safe to silkworm, environment and farm workers. Biological control continues to offer exciting possibilities for the control of fly pest population. It is environmentally safe alternative to chemical control and offering a long-term protection. Several potential hymenopteran parasitoids have been screened. Among successful natural enemies, Nesolynx thymus, Trichomalopsis apanteloctena, Trichopria sp., Brachymeria lasus, Pediobius sp., Spalangia sp., Spilomicrus karnatakensis and Dhirhinus sp. are important. It is essential to predict accurately the efficacy of these natural enemies in a new habitat prior to its introduction. The important desirable attributes of these potential parasitoids viz., host searching capacity, specificity, power of increase and fitness and adaptability of the parasitoid in new environment has been recorded. Results of the host parasitoid interaction indicate that the aging of the host function as a factor that influence the host finding efficiency of the parasitoid. It is highly scored with 15-20 hrs old pupa of the host. However, aging of the parasitoid does not significantly affect it. The sex ratio is female biased which is advantageous from biological control point of view, Biological suppression methods involving conservation and utilization of natural enemies have been discussed in detail.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.6
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• pp.247-258
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• 2000

It is thought that impact damages and hygrothermals can affect to CFRP (Carbon-fiber reinforced plastic) composite laminated due to the sensitivity on the composite laminated Therefore, this paper focuses on the fracture mechanisms experimentally based on a scanning acoustic microscope (SAM) when subjected to impact damages, i.e., foreign object damages(FOD), and also the influence of impact damages and hygrothermals on residual fatigue bending strength of CFRP laminates. Composite laminates used in the experiment are CF/EPOXY orthotropy laminated plates, which constist of two-interfaces [04/904]s. A steel ball launched by an air gun collides against CFRP laminates to generate impact damages. Bending fatigue tests are periodically interrupted for a nondestructive evaluation (NDE) measurement of the progrossive damages to built the fracture mechanism by impact damages, and three-point fatigue bending tests are carried out to investigate the influence of hygrothermals on the effect on the residual bending fatigue strength of CFRP laminates.

• International Journal of Automotive Technology
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• v.8 no.3
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• pp.309-317
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• 2007

In this study, we conducted a vibration fatigue analysis of the lower control arm in a vehicle suspension system. The vehicle was driven during the tests so that the dynamic effects could be taken into account. The dynamic load of the frequency domain was superimposed on the frequency response analysis. We performed a virtual proving ground test using multi-body dynamics, along with a finite element analysis and fatigue life predictions. Shape optimization was also considered using the design of the experimental approach, and a response surface analysis was performed to improve the durability performance of the lower control arm. We identified the elements that had the most influence on the optimal shape of the finite element model and analyzed the sensitivity of those elements. Then the optimal points that minimized the amount of damage to the areas of interest were determined through a response surface analysis. The results suggested that the fatigue life of the model increased as its mass was not increased excessively, and demonstrated that these design procedures yielded an appropriate optimized lower control arm model.

• Journal of Microbiology and Biotechnology
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• v.16 no.7
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• pp.1125-1131
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• 2006

A kan'::luxCDABE fusion strain that was both highly bioluminescent and responsive to benzoic acid was constructed by transforming E. coli strain W3110 with the plasmid pUCDK, which was constructed by digesting and removing the 7-kb KpnI fragment from the promoterless luxCDABE plasmid pUCD615. Experiments using buffered media showed that this induction was dependent on the pH of the media, which influences the degree of benzoic acid protonation, and the expression levels seen are likely due to acidification of the cytoplasm by uncoupling of benzoic acid. Consequently, the sensitivity of this strain for benzoic acid was increased by nearly 20-fold when the pH was shifted from 8.0 to 6.5. Benzoic acid derivatives and several phenolics also resulted in significantly increased bioluminescent signals. Although these compounds are known to damage membranes and induce the heat-shock response within E. coli, bacterial strains harboring mutations in the fadR and rpoH genes, which are responsible for fatty acid biosynthesis during membrane stress and induction of the heat-shock response, respectively, showed that these mutations had no effect on the responses observed.