• BMB Reports
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• 제45권4호
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• pp.221-226
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• 2012

Curcumin, a polyphenol responsible for the yellow color of the curry spice turmeric, possesses antiinflammatory, antiproliferative and antiangiogenic activities. However, anticoagulant activities of curcumin have not been studied. Here, the anticoagulant properties of curcumin and its derivative (bisdemethoxycurcumin, BDMC) were determined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT) as well as cell-based thrombin and activated factor X (FXa) generation activities. Data showed that curcumin and BDMC prolonged aPTT and PT significantly and inhibited thrombin and FXa activities. They inhibited the generation of thrombin or FXa. In accordance with these anticoagulant activities, curcumin and BDMC showed anticoagulant effect in vivo. Surprisingly, these anticoagulant effects of curcumin were better than those of BDMC indicating that methoxy group in curcumin positively regulated anticoagulant function of curcumin. Therefore, these results suggest that curcumin and BDMC possess antithrombotic activities and daily consumption of the curry spice turmeric might help maintain anticoagulant status.

• 생약학회지
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• 제17권1호
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• pp.91-99
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• 1986

The single treatment of mice with steam distillate, non-volatile ether extract and methanol extract from mace (Arils of Myristica fragrans) caused a significant prolongation of hexobarbital-induced narcosis and increase in strychnine toxicity as well as a significant decrease in hepatic microsomal drug metabolizing enzyme activities. On 7 consecutive daily administrations, however, the duration of hypnosis was markedly shortened and significant increases in the hepatic enzyme activities were shown. With systematic fractionation by $SiO_2$ column chromatography of non-volatile ether fraction monitoring by animal tests a new lignan (mp $70{\sim}72^{\circ}$, MW 328, $[{\alpha}]^{20}_D+5.28$) was isolated as an active principle and its structure was elucidated as (2R, 3S)-1-(3,4-methylendioxyphenyl)-2,3 dimethyl-4-(4-hydroxy-3-methoxyphenyl) butane.

• 환경위생공학
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• 제15권4호
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• pp.1-3
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• 2000

Indoor carbon monoxide (CO) concentration and personal CO exposures were measured Asan where CO poisoning from twenty coal usage briquette as a domestic fuel to cook and space heating. Twenty-five were houses selected from the Asan area for the survey conducted in February 1997. Newly developed passive CO samplers were placed in the kitchen and living room for the indoor concentration measurement and were worn by homemakers for personal exposure monitoring. The daily average of indoor CO concentration was 16ppm in the kitchen and 10ppm in the living room. The indoor concentration and personal exposures to CO were different in types of the space heating system. House ventilating methods and socioeconomic conditions were also important factors in determining the indoor and personal CO level in Asan.

• 한국대기환경학회지
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• 제15권3호
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• pp.267-280
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• 1999

To investigate the characteristics of high-ozone occurrences in the Greater Seoul Area(GSA), three high-ozone episodes were selected, for which the ozone warning for concentration above 120 ppb might be issued. The selection was on the basis of morning wind directions and speeds, and daily maximum ozone concentrations measured between 1990 and 1997. The episodes chosen to meet selection criteria were seven days in July 1992, nine days in July 1994, and three days in August 1994, as respectively characterized by southwesterly, easterly, and calm winds in the morning. However, more than 80% of high-ozone days in the GSA were associated with calm winds and the concomitant accumulation of local emission in the morning, rather than being due to transport of ozone or its precursors. This is believed to be the primary reason why ozone concentrations in the GSA varied in a completely different manner even between adjacent monitoring stations. Several premises for initiating research studies for resolving these local variations of ozone concentrations in the GSA are also discussed.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2013년도 춘계 종합학술대회 논문집
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• pp.169-170
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• 2013

본 논문에서는 패치형 생체신호 측정기와 스마트 디바이스를 활용하여 실시간으로 심박의 위험도를 확인할 수 있도록 하는 경고 및 위험 알림의 기준을 정의하고 이를 기반으로 하여 스마트 디바이스의 위험 심박 알림 모듈을 설계하였다. 제안하는 모듈을 이용하여 사용자는 언제 어디에서나 자신의 심장 건강에 대한 위험도를 확인하고 적절한 조치를 취함으로써 심질환으로 인해 발생 가능한 위험 상황을 예방할 수 있다.

• 환경위생공학
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• 제9권2호
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• pp.32-40
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• 1994

The concentration of ozone in 5 major cities in Korea( Seoul, Pusan, Taegu, Kwangjoo, Incheon ) has been shown increasing trend after 1984, while decreasing trend in Hsan. According to the data from 12 monitoring stations in 9 cities of metropolitan area from January 1994 to August 1994, ozone concentration exceeded short term standard 99 times and 87%(861imes) of those was occurred during July and Augusta while the maximum ozone concentration was appeared mainly between 14: 00 and 17: 00 daily. As the result of epidemiological survey, main substances which irritate eyes were identified to be PAN and formaldehyde rather than ozone while ozone was identified to be reachable to deep part of respiratory system main target organ of ozone.

• Toxicological Research
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• 제1권1호
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• pp.17-30
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• 1985

Mycotoxins are a group of toxicants giving a risk potential to human health in connection with the daily food intake. Food commodities once contaminated with mycotoxins can not be detoxified by any economic means and prevention was suggested as the only measure. In order to minimize the economic loss and health hazard posed by mycotoxins and toxicoses, systematic and toxicological studies on the subject should be undertaken. Most reports in Korea were concentrated on the mycological studies of relatively easy techniques and the confirmation or quantitation of mycotoxins was rarely done. Research topics to be undertaken in future may be exemplifid below: (1) Establishing assay methods for individual or multi-residue of mycotoxins (2) Monitoring of mycotoxins for suspicious food or feed samples in Korea (3) Epidemiological survey of mycotoxicoses (4) Etiological survey of disease outbreaks associated with mycotoxins (5) Accumulation of testing method and data on the toxicity of mycotoxins (6) Legal regulation to control mycotoxins and development of their detoxification / elimination methods

• 세라미스트
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• 제21권2호
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• pp.38-48
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• 2018

This paper reports a comprehensive review of the state-of-the-art in research on the enhancement of sensing properties for the detection of gases in exhaled breath. Daily health monitoring and early diagnosis of specific diseases via the analysis of exhaled breath is possible. Because biomarkers in exhaled breath are emitted in a very small amount, it is necessary to develop highly sensitive gas sensors. In recent years, a number of researches have been carried out using various strategies for the enhancement of sensing properties such as doping, catalyst, hollow sphere, heterojunction, size effect. We introduced each strategy and summarized recent progress on sensing properties for detection of biomarkers in exhaled breath.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• 제24권1호
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• pp.19-27
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• 1996

The ozone layer monitoring program of the Global Environment Laboratory at Yonsei University in Seoul, established as one of the Global Ozone Observing System($GO_3OS$) of the World Meteorological Organization(WMO), has been carried out daily by measuring total ozone and its vertical distribution using a Dobson Ozone Spectrophotometer(Beck #124) since 1984. In this paper, we review the organization and the historical background of ozone measurements in Korea, describe data acquisition and analysis systems, and briefly summarize the results from our ozone observations.

• 한국환경과학회지
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• 제12권10호
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• pp.1033-1041
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• 2003

Hourly data of PM10 concentration collected from nine automatic air quality monitoring stations in Busan from 1999 to 2002 were analyzed to evaluate the spatio-temporal variation and meteorological characteristics of PM10 episodes in Busan metropolitan area. Mean concentrations ranged from 47$\mu\textrm{g}$/㎥ to 77$\mu\textrm{g}$/㎥. For most stations, mean seasonal hourly concentrations are lowest in summer and highest in spring. PM10 episode above daily mean standard(150$\mu\textrm{g}$/㎥) exhibited a maximum frequency at Gamjeondong and a minimum at Dongsamdong, and a maximum in March and a minimum in July and August. The diurnal variation of PM10 episode days is strongly influenced by traffic loads and meteorological conditions.