• Title/Summary/Keyword: cyclic phosphate of seconucleoside

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A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (I) -Synthesis of 3',5'-cyclic phosphates of 2'-substituted secouridines and secoribavirins-

  • Hong, Kyong-Aie;Yang, Jae-Wook;Chun, Soo-Joon;Ha, Eun-Young;Kim, Joong-Hyup;Chun, Moon-Woo;Chung, Won-Keun
    • Archives of Pharmacal Research
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    • v.14 no.1
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    • pp.30-34
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    • 1991

  • The synthetic study of 3',5-cyclic phosphates of 2'-substituted 2',3'-secouridines and 2',3'-secoribavirins toward development of new antiviral agents is described. These cyclic phosphates were synthesized from their respective 4-nitrophenyl 3',5'-cyclic phosphate triesters. These triesters were prepared from the corresponding 2'-azido and 2'-bromo 2',3'-seconucleosides.

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