Archives of Pharmacal Research
- Volume 14 Issue 1
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- Pages.30-34
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (I) -Synthesis of 3',5'-cyclic phosphates of 2'-substituted secouridines and secoribavirins-
- Hong, Kyong-Aie (College of Pharmacy, Seoul National University) ;
- Yang, Jae-Wook (College of Pharmacy, Seoul National University) ;
- Chun, Soo-Joon (College of Pharmacy, Seoul National University) ;
- Ha, Eun-Young (College of Pharmacy, Seoul National University) ;
- Kim, Joong-Hyup (Korea Institute of Science and Technology) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University) ;
- Chung, Won-Keun (College of Pharmacy, Seoul National University)
- Published : 1991.03.01
Abstract
The synthetic study of 3',5-cyclic phosphates of 2'-substituted 2',3'-secouridines and 2',3'-secoribavirins toward development of new antiviral agents is described. These cyclic phosphates were synthesized from their respective 4-nitrophenyl 3',5'-cyclic phosphate triesters. These triesters were prepared from the corresponding 2'-azido and 2'-bromo 2',3'-seconucleosides.