• Structural Engineering and Mechanics
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• 제41권3호
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• pp.379-393
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• 2012

Of the various methods of splicing reinforcing bar in reinforced concrete structure, mortar-filled sleeve reinforcement splice offers diverse benefits, not only in terms of structural performance but also for the construction process. Consequently, after the mortar-filled sleeve splices have been developed in recent years, research and development on these splices has been actively carried out, in order to evaluate its macro structural performance, such as its strength and stiffness, with the aim of enabling this system to be applied to construction in the field as early as possible. However, to make a proper evaluation on the overall structural performance of the mortar-filled sleeve reinforcing bar splice, it is of critical importance to understand the lateral confining action of the sleeve, which is known to affect the bond strength between the embedded bar and mortar in the sleeve. Accordingly, in this study, an experiment of monotonic loading and cyclic loading was conducted with a full-sized mortar-filled sleeve splice attaching strain gauges on the sleeve surface with experimental variables such as development length of bar, etc. Based on the test results, the effect of the lateral confining action of the sleeve was analyzed and considered in terms of the bond strength between the bar and mortar in this splice.

• 콘크리트학회논문집
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• 제14권2호
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• pp.239-248
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• 2002

철근 콘크리트 면부재의 주기거동을 나타내기 위하여 소성모델과 손상모델의 통합구성모델을 개발하였다. 인장-압축을 받는 콘크리트의 응력은 개념적으로 콘크리트의 스트럿 작용에 의한 압축응력과 인장균열에 의한 인장응력의 합으로 정의하였다. 인장균열의 비등방손상에 의하여 영향을 받는 압축파괴의 등방손상을 나타내기 위하여 다중파괴기준을 갖는 소성모델을 사용하였으며, 다중균열 방향에서 인장응력-변형률 관계를 나타내기 위하여 다중고정균열손상모델과 인장균열의 소성유동모델의 개념을 사용하였다. 이러한 통합모델은 주기 인장-압축 상태의 철근 콘크리트의 거동측성, 즉 다중 인장균열 방향, 점진적으로 회전하는 균열 손상, 콘크리트의 압축파괴를 나타낼 수 있다. 제안된 구성모델은 유한요소해석에 적용되었으며, 주기하중을 받는 철근 콘크리트 전단패널 및 전단벽에 대한 기존의 실험결과들과의 비교를 통해 검증되었다.

• 대한약리학회지
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• 제19권1호
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• pp.93-99
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• 1983

Hydrocortisone 5 mg/kg which exerts minimal effect on the renal function and furosemide 1 mg/kg which induces moderate amount of diuresis were injected intraperitoneally to study their effects on the renal cyclic nucleotides content in rats. 1) The renal tissue levels of cAMP were significantly increased by administration of hydrocortisone, but there was no significant change in the furosemide group compared with that of saline treated control group. Moderate elevation in renal cAMP level was noted by the combined administration of hydrocortisone and furosemide, but this elevation was less than that of hvdrocortisone treated group. 2) The renal cGMP level did not show nay remarkable change after the administration of hydrocortisone, however, there were a significant increase by the administration of furosemide alone or combination of both drugs. The level of renal cGMP was higher and maintained longer in the combined treated group than furosemide treated group. The result of this experiment indicates that the potentiating effect of hydrocortisone on the diuretic action of furosemide nay be related to the renal levels of cGMP rather than that of cAMP.

• 대한의생명과학회지
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• 제27권4호
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• pp.270-276
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• 2021

Physiological agents trigger a signaling process called "inside-out signaling" and activated platelets promote adhesion, granule release, and conformational changes of glycoprotein IIb/IIIa (αIIb/β₃). Activated αIIb/β₃ interacts with fibrinogen and initiates a second signaling step called "external signaling". These two signaling pathways can cause hemostasis or thrombosis, and thrombosis is a possible medical problem in arterial and venous vessels, and platelet-mediated thrombosis is a major cause of cardiovascular disease (CVD). Therefore, modulating platelet activity is important for platelet-mediated thrombosis and cardiovascular disease. Esculetin is a coumarin-based physiologically active 6,7-dihydroxy derivative known to have pharmacological activity against obesity, diabetes, renal failure and CVD. Although some studies have confirmed the effects of esculetin in human platelet activation and experimental mouse models, it is not clear how esculetin has antiplatelet and antithrombotic effects. We confirmed the effect and mechanism of action of escultein on human platelets induced by collagen. As a result, esculetin decreased Ca²⁺ recruitment through upregulation of inositol 1, 4, 5-triphosphate receptor. In addition, esculetin upregulates cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-dependent pathways and inhibits fibrinogen binding and thrombus contraction. Our results demonstrate the antiplatelet effect and antithrombotic effect of esculetin in human platelets. Therefore, we suggest that esculetin could be a potential phytochemical for the prevention of thrombus-mediated CVD.

• 대한수학회보
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• 제38권2호
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• pp.347-355
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• 2001

Let ($X, \omega$) be a closed symplectic 4-manifold. Let a finite cyclic group G act semifreely, holomorphically on X as isometries with fixed point set $\Sigma$(may be empty) which is a 2-dimension submanifold. Then there is a smooth structure on the quotient X'=X/G such that the projection $\pi$:X$\rightarrow$X' is a Lipschitz map. Let L$\rightarrow$X be the Spin$^c$ -structure on X pulled back from a Spin$^c$-structure L'$\rightarrow$X' and b_2^$+(X')>1. If the Seiberg-Witten invariant SW(L')$\neq$0 of L' is non-zero and $L=E\bigotimesK^-1\bigotimesE$ then there is a G-invariant pseudo-holomorphic curve u:$C\rightarrowX$,/TEX> such that the image u(C) represents the fundamental class of the Poincare dual $c_1$(E). This is an equivariant version of the Taubes' Theorem.

• Earthquakes and Structures
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• 제6권3호
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• pp.317-334
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• 2014

The work is concerned with an investigation of the advantages stemming from the use of lightweight aggregate concrete in earthquake-resistant reinforced concrete construction. As the aseismic clauses of current codes make no reference to lightweight aggregate concrete beams made of lightweight aggregate concrete but designed in accordance with the code specifications for normal weight aggregate concrete, together with beams made from the latter material, are tested under load mimicking seismic action. The results obtained show that beam behaviour is essentially independent of the design method adopted, with the use of lightweight aggregate concrete being found to slightly improve the post-peak structural behaviour. When considering the significant reduction in deadweight resulting from the use of lightweight aggregate concrete, the results demonstrate that the use of this material will lead to significant savings without compromising the structural performance requirements of current codes.

• Journal of Applied Biological Chemistry
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• 제61권3호
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• pp.257-265
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• 2018

The Panax ginseng Mayer is used in conventional medicine in Asia owing to its preventing effects on thrombosis, hypertension, atherosclerosis, vasorelaxation and myocardial infarction. Because platelets are crucial mediators of cardiovascular diseases, many studies have investigated its functions. The previous study showed the antiplatelet effects of crude ginseng fraction and two of its components, ginsenoside Rg3 (20S and 20R). In addition, ginsenoside Rg3-enriched fraction shows an inhibitory effect on collagen-activated rat platelets. However, the mechanism underlying this effect remains unclear. Thus, I investigated the inhibitory action of ginsenoside Rg3 (20S, G-Rg3) on the regulation of signaling molecules involved in ${\alpha}IIb/{\beta}_3$ activation. I found that G-Rg3, in a cyclic AMP dependent manner, inhibited thrombin-induced activation of human platelets and affinity of fibrinogen and fibronectin with ${\alpha}IIb/{\beta}_3$. Thus, in the present study, G-Rg3 showed an inhibitory effect on glycoprotein IIb/IIIa (${\alpha}IIb/{\beta}_3$) activation, suggesting its potential use for preventing platelet-mediated thrombotic disease.

• 한국공간구조학회논문집
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• 제23권4호
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• pp.89-96
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• 2023

The seismic retrofits of existing structures have been focused on the control of structural responses which can be achieved by providing displacement capacity through inelastic ductile action at supplemental devices. Due to their hysteretic characteristics, it is expected to sustain damage through repeated inelastic behaviors including residual deformation which might increase repair costs. To solve such drawbacks of existing yielding devices, this study proposes a self-centering disc spring brace that sustains large axial deformation without structural damage while providing stable energy dissipation capacity. The hysteretic behaviors of suggested brace are first investigated based on the quasi-static cyclic test procedure. Experimental results present the effective self-centering behavior and an analytical model is then suggested in order to reasonably capture the flag-shaped hysteretic behavior of the disc spring brace.

• Animal cells and systems
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• 제3권2호
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• pp.103-113
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• 1999

Many in-depth reviews related to regulations of prolactin secretion are available. We will, therefore, focus on controversial aspects using personal opinion in this review. The neuroendocrine control of prolactin secretion from the anterior pituitary gland involves multiple factors including prolactin-release inhibiting factor (PIF) and prolactin releasing factor (PRF). The PIF exerts a tonic inhibitory control in the physiological conditions. The PIF should be able to effectively inhibit prolactin release or a lifetime, but the inhibitory action of dopamine cannot be sustained for a long period of time. Perifusion of a high concentration of dopamine (l ,000 nM) could not sustain inhibitory action on prolactin release but when a small amount of ascorbic acid (0.1 mM) is added in a low concentration of dopamine (3 nM) solution, prolactin release was inhibited for a long period. Ascorbate is essential for dopamine action to inhibit prolactin release. We have, therefore, concluded that the PIF is dopamine plus ascorbate. The major transduction system for dopamine to inhibit prolactin release is the adenylyl cyclase system. Dopamine decreases cyclic AMP concentration by inhibiting adenylyl cyclase, and cyclic AMP stimulates prolactin release. However, the inhibitory mechanism of dopamine on prolactin release is much more complex than simple inhibition of CAMP production. The dopamine not only inhibits cyclic AMP synthesis but also inhibits prolactin release by acting on a link(s) after the CAMP event in a chain reaction for inhibiting prolactin release. Low concentrations of dopamine stimulate prolactin release. Lactotropes are made of several different subtypes of cells and several different dopamine receptors are found in pituitary. The inhibitory and stimulatory actions induced by dopamine can be generated by different subtype of receptors. The GH$_4$ZR$_7$ cells express only the short isoform (D$_{2s}$) of the dopamine receptor, as a result of transfecting the D$_{2s}$ receptors into GH$_4$C$_1$ cells which do not express any dopamine receptors. When dopamine stimulates or inhibits prolactin release in GH$_4$ZR$_7$ cells, it is clear that the dopamine should act on dopamine D$_{2s}$ receptors since there is no other dopamine receptor in the GH$_4$ZR$_7$. Dopamine is able to stimulate prolactin release in a relatively low concentration while it inhibits in a high concentration in GH$_4$ZR$_7$. These observations indicate that the dopamine D$_2$ receptor can activate stimulatory and/or inhibitory transduction system depending upon dopamine concentrations.

• 한국식품영양과학회지
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• 제32권4호
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• pp.645-653
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• 2003

Taste receptor cells respond to gustatory stimuli using a complex arrangement of receptor molecules, signaling cascades and ion channels. When stimulated, these cells produce action potentials that result in the release of neurotransmitter onto an afferent nerve fiber that in turn relays the identity and intensity of the gustatory stimuli to tie brain. A variety of mechanisms are used in transducing the four primary tastes. Direct interaction of the stimuli with ion channels appears to be of particular importance in transducing stimuli reported as salty or sour, whereas tile second messenger systems cyclic AMP and inositol trisphosphate are important in transducing bitter and sweet stimuli. In addition to the four basic tastes, specific mechanisms exist for the amino acid glutamate, which is sometimes termed the fifth primary taste. The emerging picture is that not only do individual taste qualities use more than one mechanism, but multiple pathways are available for individual tastants as well.