• Title/Summary/Keyword: cutoff rate

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Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

  • Wang, Min;Wu, Wei-Dong;Chen, Gui-Ming;Chou, Sheng-Long;Dai, Xue-Ming;Xu, Jun-Ming;Peng, Zhi-Hai
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8625-8628
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    • 2016
  • Background: Central lymph node metastasis(CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of this study was to define the pathohistologic risk grading based on surgical outcomes. Materials and Methods: Statistical analysis was performed to figure out the optimal cut-off values of size in preoperative ultrasound images for defining the risk of CLNM in papillary thyroid microcarcinoma. Receiver operating characteristic curves (ROC) studies were carried out to determine the cutoff value(s) for the predictor(s). All the patients were divided into two groups according to the above size and the clinic-pathological and immunohistochemical parameters were compared to determine the significance of findings. Results: The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. Significant differences were observed on the multifocality, extrathyroidal extension and central lymph node metastasis between two groups which were divided according to the tumor size by the cutoff values. Patients in two groups showed different positive rate and intensity of Ki67. Conclusions: The size of PTMC in ultrasound images are helpful to predict the aggressiveness of the tumors, it could be an easy predictor for PTMC prognosis and assist us to choose treatment.

Evaluation of Air Flow Characteristics in accordance with Types of Waveguide-Below-Cutoff (WBC) Arrays and Their Shielding Effectiveness of Electromagnetic Pulse (EMP) (EMP 차폐를 위한 도파관 형상과 SE에 따른 유동 특성 평가)

  • Pang, Seung-Ki;Ahn, Hye-Rin;Yook, Jong-Gwan
    • Journal of the Korean Society for Geothermal and Hydrothermal Energy
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    • v.12 no.3
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    • pp.1-8
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    • 2016
  • In this study, we evaluated the flow characteristics of various types of waveguide-below-cutoff (WBC) arrays and their shielding effectiveness (SE) of electromagnetic pulses (EMP) based on computational fluid dynamics (CFD). Three types of waveguides were selected for analysis: (1) grid type, (2) honeycomb type, and (3) multi-layer types (2-ply, 4-ply, 6-ply, and 8-ply). To analyze the air flow characteristics, the flow velocities in the longitudinal center of the WBC and the differential pressures between the WBC array inlet and outlet were evaluated. Consequently, we derive the following conclusions: (1) despite an increase in the inlet velocity, the pressure drop of the 6-ply multi-layer type did not significantly increase as compared to that of other types of waveguides (waveguide thickness of 0.1 mm, SE of 100 dB); (2) the grid and honeycomb type had the fastest flow rate of 17.5 m/s, which is approximately 2.5 m/s faster than that at the inlet (waveguide thickness of 1 mm, module size of 30 mm); and (3) the average pressure drop of the grid type waveguide is the lowest in the overall model, whereas that of the 8-ply is the highest (waveguide thickness of 1 mm, module size of 30 mm, and SE of 80, 100 dB).

Geomorphological Processes and Changes of Waterfalls formed by Channel Avulsion (하도 변위에 의한 폭포의 형성과 변화)

  • Lee, Gwang-Ryul
    • Journal of the Korean Geographical Society
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    • v.48 no.5
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    • pp.615-628
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    • 2013
  • The waterfall can be formed by difference between the height of up and down part in new channel, is formed by channel avulsion that rapidly changing of river channel course. This study described types and processes of waterfalls by channel avulsion, and analyzed rates and factors of waterfall recession, on object to 7 waterfalls in South Korea. Bulyeong falls at Uljin-gun, Yongchu falls at Yeongdeok-gun, Jikyeon falls at Yanggu-gun and Gwangpum falls at Uljin-gun are formed by natural incised meander cutoff. Samhyeongje falls at Taebaek-si and Guryong falls are formed by river capture processes, and Palbong falls at Chungju-si is formed by artificial channel cutting for farm land secured. The locations of waterfalls gradually moved to upstream over time by head erosion. The recession rates were measured by 3~4m/ka on Bulyeong falls, Yongchu falls, Jikyeon falls and Samhyeongje falls, to estimate of formation age. Recession rates of these 4 waterfalls were analyzed that have clearly positive correlations with drainage area, precipitation, corrosion and weathering capability of bedrock, and initial height of waterfall.

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Significance of albumin to globulin ratio as a predictor of febrile urinary tract infection after ureteroscopic lithotripsy

  • Yi, Seung Yun;Park, Dong Jin;Min, Kyungchan;Chung, Jae-Wook;Ha, Yun-Sok;Kim, Bum Soo;Kim, Hyun Tae;Kim, Tae-Hwan;Yoo, Eun Sang
    • Journal of Yeungnam Medical Science
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    • v.38 no.3
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    • pp.225-230
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    • 2021
  • Background: We aimed to analyze the effectiveness of albumin to globulin ratio (AGR) in predicting postoperative febrile urinary tract infection (fUTI) after ureteroscopic lithotripsy (URS) and retrograde intrarenal surgery (RIRS). Methods: From January 2013 to May 2018, 332 patients underwent URS and RIRS. The rate of postoperative fUTI and risk factors for postoperative fUTI were analyzed using logistic regression. Patients were divided into postoperative fUTI and non-postoperative fUTI (non-fUTI) groups. AGR with other demographic and perioperative data were compared between the two groups to predict the development of fUTI after URS. Results: Of the 332 patients, postoperative fUTI occurred in 41 (12.3%). Preoperative pyuria, microscopic hematuria, diabetes mellitus, hypoalbuminemia, and hyperglobulinemia were more prevalent in the fUTI group. Patients in the fUTI group had larger stone size, lower preoperative AGR, longer operation time, and longer preoperative antibiotic coverage period. In a multivariable logistic analysis, preoperative pyuria, AGR, and stone size were independently correlated with postoperative fUTI (p<0.001, p=0.008, and p=0.041, respectively). Receiver operating curve analysis showed that the cutoff value of AGR that could predict a high risk of fUTI after URS was 1.437 (sensitivity, 77.3%; specificity, 76.9%), while the cutoff value of stone size was 8.5 mm (sensitivity, 55.3%; specificity, 44.7%). Conclusion: This study demonstrated that preoperative pyuria, AGR, and stone size can serve as prognostic factors for predicting fUTI after URS.

Semen parameters on the intracytoplasmic sperm injection day: Predictive values and cutoff thresholds of success

  • Moubasher, Alaa El din-Abdel Aal;Taha, Emad Abdelrehim;Elnashar, Ehab Mohamed;Maged, Ahmed Abdel Aal Abdel;Zahran, Asmaa Mohamed;Sayed, Heba Hassan;Gaber, Hisham Diab
    • Clinical and Experimental Reproductive Medicine
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    • v.48 no.1
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    • pp.61-68
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    • 2021
  • Objective: This study was conducted to investigate the relationship of semen parameters in samples used for intracytoplasmic sperm injection (ICSI) with fertilization and pregnancy rates in infertile couples. Methods: In this prospective study of Infertile couples with male factor infertility that had undergone ICSI, fractions of the same semen samples obtained for microinjection (to ensure the best predictability) were evaluated to determine the semen parameters and sperm DNA fragmentation index (DFI) on the day of oocyte recovery. Results: In total, 120 couples completed the study and were subdivided into fertilized (n=87) and non-fertilized couples (n=33). The fertilized couples were further classified into pregnant (n=48) and non-pregnant (n=39) couples. Compared to non-fertilized and non-pregnant couples, fertilized and pregnant couples showed statistically significantly higher sperm viability and percentage of normal sperm morphology, as well as significantly lower sperm DFI values. A receiver operating characteristic curve analysis of data from the 120 ICSI cycles showed that sperm viability, normal sperm morphology percentages, and sperm DFI were significant prognostic indicators of fertilization at cutoff values of 40%, 7%, and 46%, respectively. A sperm DFI of 46% showed sensitivity and specificity of 95% and 90%, respectively, for predicting fertilization, and no clinical pregnancies occurred in couples with a sperm DFI above 46%. Conclusion: Semen parameters from the ICSI day sample, especially sperm viability, normal morphology, and DFI, had an impact on fertilization and pregnancy outcomes in ICSI cycles.

Effect of therapeutic radioiodine activity on ablation response in differentiated thyroid cancer patients with cut-off serum thyroglobulin levels after 2 weeks of thyroid hormone withdrawal: a retrospective study

  • Ji Young Lee;Hee-Sung Song;Young Hwan Kim
    • Journal of Medicine and Life Science
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    • v.19 no.3
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    • pp.95-102
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    • 2022
  • This retrospective study aimed to investigate whether there was a difference in the success rate of removal of residual thyroid tissue in patients with the same cutoff serum thyroglobulin (Tg) value-measured 2 weeks after thyroid hormone withdrawal (THW)-for different radioactive iodine (RAI) activities. We identified 132 patients with papillary thyroid cancer who were treated with total thyroidectomy and RAI therapy to evaluate the efficacy of three radioactivities of I-131: 1,110, 3,700, and 5,550 MBq. Serum Tg testing was performed 1 week before RAI treatment and 2 weeks after THW (pre-Tg); the cutoff pre-Tg level was below 10 ng/mL. Stimulated Tg levels were measured on the day of I-131 administration (off-Tg). After 6 months of treatment, we compared the groups for complete ablation, defined as no uptake on a diagnostic I-131 scan, stimulated Tg level of <1.0 ng/mL, and Tg antibody level of <100 ng/mL. Ninety-five patients (72.0%) achieved complete ablation, with 57.1% (8/14), 78.2% (68/87), and 61.3% (19/31) in the 1,110 MBq, 3,700 MBq, and 5,550 MBq groups, respectively. There was no significant difference in the complete ablation rates between the three groups. In the multivariate analysis, the off-Tg level was a significant predictor of complete ablation. RAI therapy with low radioactivity (1,110 MBq) seemed sufficient for ablation in patients with papillary thyroid cancer with a pre-Tg level below 10 ng/mL. The off-Tg level is a promising and useful predictor of complete ablation after initial RAI therapy.

A Tapping the usefulness of Whole Blood Interferon-${\gamma}$ Assay for Diagnosing Tuberculosis Infection in Children (소아 결핵 감염 진단에 있어서 결핵 특이항원 자극 Interferon-${\gamma}$ 분비능 측정의 진단적 유용성)

  • Soon, Eu-Gene;Lim, Baek-Keun;Kim, Hwang-Min;NamGoong, Mee-Kyung;Cha, Byung-Ho;Uh, Young;Chun, Jin-Kyong
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.5
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    • pp.280-285
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    • 2010
  • Background: $QuantiFERON^{(R)}$-TB Gold In Tube (QFT-G IT) has been used for diagnosing latent tuberculosis infection and active tuberculosis (TB) since 2007. However, there has not been enough data on QFT-G IT for universal use in children. In this study, we evaluated the clinical usefulness of the QFT-G IT in pediatric practice. Methods: We retrospectively reviewed the clinical records of 70 patients younger than 18 years of age who had taken QFT-G IT and had a tuberculin skin test (TST) between July 2007 and July 2009 at Wonju Christian Hospital. The subjects were divided into two groups, asymptomatic TB exposure group and disease group. Four patients who were taking immunosuppressants during the study period were excluded. Results: A total of 66 immunocompetent children were included in this study. Among 27 asymptomatic children who had contact histories of TB, 6 (22.2%) were found to be positive by QFT-G IT. Eleven (40.7%) and 5 (18.5%) children were found to be positive by TST with cutoff values of ${\geq}5mm$ and ${\geq}10mm$, respectively. Agreement was fair to good between QFT-G IT and TST (${\kappa}=0.59$: cutoff value ${\geq}5mm$, ${\kappa}=0.7$: cutoff value ${\geq}10mm$). In disease group, 14 patients (35.9%) were diagnosed with active tuberculosis, 8/14 (57.1%) were positive on TST and 9/14 (64.3%) on QFT-G IT. The positive rate of acid-fast bacilli smear, TB-polymerase chain reaction, and culture for tuberculosis was 11% (1/9), 27.3% (3/11) and 33.3% (3/9), respectively. Conclusion: Our data support that the QFT-G IT can be used as an additional diagnostic tool for latent and active tuberculosis infection in children.

Hemoglobin, Hematocrit and Serum Ferritin as Markers of Iron Status (빈혈판정 지표로서의 헤모글로빈, 헤마토크릿 및 혈청 페리틴)

  • 정해랑;문현경;송범호;김미경
    • Journal of Nutrition and Health
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    • v.24 no.5
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    • pp.450-457
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    • 1991
  • The iron status of 57 female college students was evaluated by measurements of hemoglobinCHb). hematocritCHct) and serum ferritin(Ferritin). Mean values for Hb, Hct and Ferritin were $13.9\pm$ 0.96g/dl, $41.4\pm$ 2.85% and $20.7\pm$ l5.5ng/mL respectively. Ferritin as well as Hb. Hct were not statistically different from normal distribution. although ferritin were skewed to the right. The prevalence of anemia defined by Hb < 12g/dI. Hct ~36 % and Ferritin <12ng/ml were found to be 5.3, 10.3 and 36.8%, respectively. By using Hb as a screening tool at a cutoff point of 12g/dI. 2.8% of healthy subjects will be incorrectly classified as anemic and 90.5 % of anemic as healthy. Sensitivity and specificity were calculated at various cutoff points of Hb and Hct. The estimates of sensitivity and specificity allow Hb 14.0g/dl as cutoff point for good predictor of anemia.

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The Capability Comparison of Positioning Performances using GPS and GPS/GLONASS (GPS와 GPS/GLONASS의 측위수행 능력 비교)

  • Park, Woon-Yong;Lee, In-Su;Kim, Jin-Soo
    • Journal of Korean Society for Geospatial Information Science
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    • v.9 no.1 s.17
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    • pp.59-66
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    • 2001
  • Satellite visibility, Accuracy, and Availability were increased by the combined GPS/GLONASS. But, there are some problems such as differences in the time frame, differences in the coordinate datum, and the problem of solving carrier phase ambiguities in the combined carrier frequency solutions due to different GLONASS frequency. Therefore, the accuracy of single point positioning using the combined GPS/GLONASS will be assessed, and intend to study the characteristics of the combined GPS/GLONASS with considered the rate of data acquisition according to the visibility of satellite and elevation cutoff at the combined GPS/GLONASS.

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Improvement of Speech Recognition Performance in Running Car by Considering Wind Noise (바람잡음을 고려한 자동차에서의 음성인식 성능 향상)

  • Lee, Ki-Hoon;Lee, Chul-Hee;Kim, Chong-Kyo
    • Proceedings of the KSPS conference
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    • 2004.05a
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    • pp.231-234
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    • 2004
  • This paper describes an efficient method for improving the noise-robustness in speech recognition in a running car by considering wind noise. In driving car, mainly three kind of noises engine noise, tire noise and wind noise, are severely affect recognition performance. Especially wind noise is an important factor in driving car with window opened. We analyzed wind noise in various driving conditions that are 60, 80, 100 km/h with window fully opened, window half opened. We clarified that the recognition rate is significantly degenerated when the wind noise components in the frequency range above 200 Hz are large. We developed a preprocessing method to improve the noise robustness despite of wind noise. We adaptively changed the cutoff frequency of the front-end high-pass filter from 100 through 200 Hz according to the level of the wind noise components. By this method, the recognition rate is considerably improved for all kind of driving conditions

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