• 대한한의학회지
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• 제28권4호
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• pp.104-113
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• 2007

Background : Amygdalin is abundant in Armeniacae semen, and it is recently reported to treat cancers and relieve pain. But modus operandi of amygdalin at the level of neuron has not been reported, yet. Objective : This study aimed to find out the effect of amygdalin on glycine- and glutamate-induced ion currents in periaqueductal gray (PAG) neurons. And it was investigated that amygdalin participates in the regulation of the descending pain control system in the level of PAG neurons. Method : We investigated that the changes of glycine- and glutamate-induced ion currents in PAG neurons through application of lipopolysaccharides (LPS) and application of amygdalin with LPS by using the nystatin-perforated patch clamp method. Result : Application of LPS on PAG neurons resulted in increased glycine-induced ion current, and in decreased glutamate-induced ion current. In contrast, application of amygdalin with LPS resulted in decreased glycine-induced ion current increased by LPS, and increased glutamate-induced ion current decreased by LPS. Conclusion : Amygdalin from Armeniacae semen controls glycine- and glutamate-induced ion current by LPS in PAG neurons, and it is suggested that amygdalin participates in the regulation of the descending pain control system in the level of PAG neurons.

• 전기저널
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• 통권306호
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• pp.42-51
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• 2002

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 2006년도 제15차 추계학술대회
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• pp.118-120
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• 2006

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2003년도 추계 국제심포지움 및 학술발표회
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• pp.26-32
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• 2003

• 생약학회지
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• 제12권2호
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• pp.111-118
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• 1981

• Journal of Microbiology
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• 제41권3호
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• pp.175-182
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• 2003

Production of ribosomally synthesized antimicrobial peptides usually referred to as bacteriocins is an inducible trait in several gram positive bacteria, particularly in those belonging to the group of lactic acid bacteria. In many of these organisms, production of bacteriocins is inducible and induction requires secretion and extracellular accumulation of peptides that act as chemical messengers and trigger bacteriocin production. These inducer peptides are often referred to as autoinducers and are believed to permit a quorum sensing-based regulation of bacteriocin production. Notably, the peptides acting as autoinducers are dedicated peptides with or without antimicrobial activity or the bacteriocins themselves. The autoinducer-dependent induction of bacteriocin production requires histidine protein kinases and response regulator proteins of two-component signal transduction systems. The current working model for the regulation of class II bacteriocin production in lactic acid bacteria and the most relevant direct and indirect pieces of evidence supporting the model are discussed in this minireview.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2006년도 춘계공동학술대회 논문집
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• pp.1235-1239
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• 2006

Fractal manufacturing system (FrMS) distinguishes itself from other manufacturing systems by the fact that there is a fractal repeated at every scale. A fractal is a volatile organization which consists of goal-oriented agents referred to as AIR-units (autonomous and intelligent resource units). AIR-units unrestrictedly reconfigure fractals in accordance with their own goals. Their goals can be dynamically changed along with the environmental status. Since goals of AIR-units are represented as fuzzy models, an AIR-unit itself is a fuzzy logic controller. This paper presents a goal regulation mechanism in the FrMS. In particular, a reinforcement learning method is adopted as a regulating mechanism of the fuzzy goal model, which uses only weak reinforcement signal. Goal regulation is achieved by building a feedforward neural network to estimate compatibility level of current goals, which can then adaptively improve compatibility by using the gradient descent method. Goal-oriented features of AIR-units are also presented.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.593-600
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• 2009

In Korea, the government has developed SEUMTER, an administration system for building related public service, to facilitate and promote the electronic submission and permission activities. SEUMTER is progressing legality system based on 2D drawing for building administration permission service. However, there are a lot of problems related to legality system owing to complexity of Korea regulation relation and structure, inefficiency of legality system based on 2D drawing, duplication examination of document (soliciting forms for civil affairs) and drawing. Therefore, the purpose of this study is to develop legality system for building administration permission service based on BIM in Korea. To achieve this purpose, the authors have investigated permission procedure and regulation structure that is used in current building administration permission and suggested permission procedure and regulation structure for legality system based on BIM. In addition, the authors have investigated element technologies (for examples, method of structured regulation, BIM model checker, Viewer, etc) for legality system based on BIM. Finally, the authors have suggested strategy and hereafter direction for application of legality system based on BIM.

• 전력전자학회:학술대회논문집
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• 전력전자학회 1999년도 전력전자학술대회 논문집
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• pp.626-630
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• 1999

A new integrated single-stage zero current switched(ZCS) quasi-resonant converter (QRC) for the power factor correction(PFC) converter is introduced in this paper. The power factor correction can be achieved by the discontinuous conduction mode(DCM) operation of an input current. The proposed converter has the characteristics of the good power factor, low line current harmonics, and tight output regulation. Furthermore, the ringing effect due to the output capacitance of the main switch can be eliminated by use of active clamp circuit.

• Journal of Power Electronics
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• 제16권3호
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• pp.1209-1217
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• 2016

This paper presents a novel charge pump scheme that combines the advantages of Fibonacci and Dickson charge pumps to obtain 30 V voltage for display driver integrated circuit application. This design only requires four external capacitors, which is suitable for a small-package application, such as smart card displays. High-amplitude (<6.6 V) clocks are produced to enhance the gate drive of a Dickson charge pump and improve the system's current drivability by using a voltage-doubler charge pump with a pulse skip regulator. This regulation engages many middle-voltage devices, and approximately 30% of chip size is saved. Further optimization of flying capacitors tends to decrease the total chip size by 2.1%. A precise and simple model for a one-stage Fibonacci charge pump with current load is also proposed for further efficiency optimization. In a practical design, its voltage error is within 0.12% for 1 mA of current load, and it maintains a 2.83% error even for 10 mA of current load. This charge pump is fabricated through a 0.11 μm 1.5 V/6 V/32 V process, and two regulators, namely, a pulse skip one and a linear one, are operated to maintain the output of the charge pump at 30 V. The performances of the two regulators in terms of ripple, efficiency, line regulation, and load regulation are investigated.