• 한국농림기상학회지
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• 제5권3호
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• pp.200-207
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• 2003

온도기반 생태모형을 경관규모에 적용하기 위해 널리 쓰이는 BioSIM을 우리나라 환경에 도입할 경우 예상되는 문제점을 파악하기 위해 먼저 일 최고기온 추정과정을 검토하였다. 과열지수 대신 사용되는 개방도의 신뢰성을 검증하기 위해 전라북도 순창군 동계면 전역을 대상으로 10${\times}$10m 면적 단위로 총 57만여 개 지점의 개방도를 계산하고, 같은 지점에 대해 추분, 하지, 동짓날의 과열지수를 계산하였다. 각 날짜별 과열지수의 변이를 개방도에 의해 설명하기 위한 2차 회귀식을 작성한 바 회귀식의 결정계수($R^2$)는 동지에 0.44, 하지에 0.50, 추분에 0.56으로 Regniere(1996)의 추정치 0.7-0.9에 비해 크게 낮았다. 따라서 개방도를 사용하여 추정된 복잡지형의 일 최고기온값은 신뢰도가 낮아 생태모형의 구동변수로 부적합하므로 반드시 과열지수를 직접 계산해서 사용해야 한다.

• Communications for Statistical Applications and Methods
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• 제30권1호
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• pp.1-19
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• 2023

Observational data with missing or incomplete data are common in biomedical research. Multiple imputation is an effective approach to handle missing data with the ability to decrease bias while increasing statistical power and efficiency. In recent years propensity score (PS) matching has been increasingly used in observational studies to estimate treatment effect as it can reduce confounding due to measured baseline covariates. In this paper, we describe in detail approaches to competing risk analysis in the setting of incomplete observational data when using PS matching. First, we used multiple imputation to impute several missing variables simultaneously, then conducted propensity-score matching to match statin-exposed patients with those unexposed. Afterwards, we assessed the effect of statin exposure on the risk of heart failure-related hospitalizations or emergency visits by estimating both relative and absolute effects. Collectively, we provided a general methodological framework to assess treatment effect in incomplete observational data. In addition, we presented a practical approach to produce overall cumulative incidence function (CIF) based on estimates from multiple imputed and PS-matched samples.

• Journal of Korean Neurosurgical Society
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• 제49권1호
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• pp.37-42
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• 2011

Objective: The author measured levels of fluoroscopic radiation exposure to the surgeon's body based on the different beam directions during kyphoplasty. Methods: This is an observational study. A series of 84 patients (96 vertebral bodies) were treated with kyphoplasty over one year. The patients were divided into four groups based on the horizontal and vertical directions of the X-Ray beams. We measured radiation exposure with the seven dosimetry badges which were worn by the surgeon in each group (total of 28 badges). Twenty-four procedures were measured in each group. Cumulative dose and dose rates were compared between groups. Results: Fluoroscopic radiation is received by the operator in real-time for approximately 50% (half) of the operation time. Thyroid protectors and lead aprons can block radiation almost completely. The largest dose was received in the chest irrespective of beam directions. The lowest level of radiation were received when X-ray tube was away from the surgeon and beneath the bed (dose rate of head, neck, chest, abdomen and knee: 0.2986, 0.2828, 0.9711, 0.8977, 0.8168 mSv, respectively). The radiation differences between each group were approximately 2.7-10 folds. Conclusion: When fluoroscopic guided-KP is performed, the X-Ray tube should be positioned on the opposite side of the operator and below the table, otherwise the received radiation to the surgeon's body would be 2.7-10 times higher than such condition.

• Safety and Health at Work
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• 제12권2호
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• pp.174-183
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• 2021

Background: Toluene diisocyanate (TDI) is a highly reactive chemical that causes sensitization and has also been associated with increased lung cancer. A risk assessment was conducted based on occupational epidemiologic estimates for several health outcomes. Methods: Exposure and outcome details were extracted from published studies and a NIOSH Health Hazard Evaluation for new onset asthma, pulmonary function measurements, symptom prevalence, and mortality from lung cancer and respiratory disease. Summary exposure-response estimates were calculated taking into account relative precision and possible survivor selection effects. Attributable incidence of sensitization was estimated as were annual proportional losses of pulmonary function. Excess lifetime risks and benchmark doses were calculated. Results: Respiratory outcomes exhibited strong survivor bias. Asthma/sensitization exposure response decreased with increasing facility-average TDI air concentration as did TDI-associated pulmonary impairment. In a mortality cohort where mean employment duration was less than 1 year, survivor bias pre-empted estimation of lung cancer and respiratory disease exposure response. Conclusion: Controlling for survivor bias and assuming a linear dose-response with facility-average TDI concentrations, excess lifetime risks exceeding one per thousand occurred at about 2 ppt TDI for sensitization and respiratory impairment. Under alternate assumptions regarding stationary and cumulative effects, one per thousand excess risks were estimated at TDI concentrations of 10 - 30 ppt. The unexplained reported excess mortality from lung cancer and other lung diseases, if attributable to TDI or associated emissions, could represent a lifetime risk comparable to that of sensitization.

• Journal of Radiation Protection and Research
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• 제40권1호
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• pp.25-35
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• 2015

We analyzed the differential effects of histopathology, apoptosis and expression of radiation response genes after chronic low dose rate (LDR) and acute high dose rate (HDR) radiation exposure in spleen, lung and liver of rats. Female 6-week-old Sprague-Dawley rats were used. For chronic low-dose whole body irradiation, rats were maintained for 14 days in a $^{60}Co$ gamma ray irradiated room and received a cumulative dose of 2 Gy or 5 Gy. Rats in the acute whole body exposure group were exposed to an equal dose of radiation delivered as a single pulse ($^{137}Cs$-gamma). At 24 hours after exposure, spleen, lung and liver tissues were extracted for histopathologic examination, western blotting and RT-PCR analysis. 1. The spleen showed the most dramatic differential response to acute and chronic exposure, with the induction of substantial tissue damage by HDR but not by LDR radiation. Effects of LDR radiation on the lung were only apparent at the higher dose (5 Gy), but not at lower dose (2 Gy). In the liver, HDR and LDR exposure induced a similar damage response at both doses. RT-PCR analysis identified cyclin G1 as a LDR-responsive gene in the spleen of rats exposed to 2 Gy and 5 Gy gamma radiation and in the lung of animals irradiated with 5 Gy. 2. The effects of LDR radiation differed among lung, liver, and spleen tissues. The spleen showed the greatest differential effect between HDR and LDR. The response to LDR radiation may involve expression of cyclin G1.

• 전기전자학회논문지
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• 제23권4호
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• pp.1457-1460
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• 2019

본 논문에서는 위치추적과 방사선 측정이 가능한 일체형 방사선 피폭 방호 소방관 인명구조 경보기의 혼합형 센서부 개발을 제안한다. 방사선피폭선량을 측정하기 위하여 크기와 무게를 최소화 할 수 있는 반도체형 방사선 측정 센서인 PIN-Diode 방사선 측정 센서모듈을 사용한다. PIN-Diode 방식의 방사선 측정 센서 특성을 높이기 위하여 누설전류를 제거하기 위한 설계를 수행한다. IMU 센서모듈을 사용하여 3축에 대한 데이터와 가속도에 대한 수치를 합산하여 사고추정과 동시에 현재 소방관의 위치를 추정한다. 제안된 일체형 방사선 피폭 방호 소방관 인명구조 경보기를 위한 혼합형 센서부의 효율을 판단하기 위하여 공인시험기관에서 실험하였다. 누적선량 측정범위는 세계 최고 수준인 10μSv~10mSv 범위에서 측정이 되었다. 정확도는 ±6.3%~±9.0%(137Cs) 측정 불확도가 측정되어 국제 표준인 ±15% 이하에서 정상동작 됨이 확인되었다. 또한 위치정확성은 ±10% 이내로 측정되어 높은 수준의 결과가 도출되어 그 효용성이 입증되었다. 따라서 보다 많은 소방관에게 성능이 우수한 일체형 방사선 피폭 방호 소방관 인명구조 경보기 보급이 될 수 있으리라 기대된다.

• 한국환경보건학회지
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• 제45권3호
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• pp.273-284
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• 2019

Objective: This study was performed to estimate the number of those who used humidifier disinfectants (HDs) and experienced health effects from exposure to HDs in Korea between 1994 and 2011. Methods: A nationwide interview survey was conducted for the representative sample to identify the proportion of those who used HDs among the general population (n=3,001). Another online survey was conducted for those exposed to HDs to find the proportion of those who experienced health effects among those who were exposed to HDs (n=3,993). Statistics for population size by region and year (1994-2011) were used to estimate the cumulative number of those exposed to HDs and those who experienced health effects. In terms of the proportion of those exposed to HDs, those less than 30 years of age were excluded due to an issue related to information bias. Various approaches for estimation included the capture-recapture method for estimation of those who experienced health effects. Results: The cumulative proportion of those exposed to HDs was 6.7% among the general population, and the proportion of those who experienced health effects among those who were exposed to HDs was 13.9%. Based on these factors, it was estimated that 3.5 to 4.0 million people were exposed to HDs and 350 to 400 thousand experienced health effects at least requiring visiting a hospital. Conclusion: It is suggested that a nationwide representative sample may be essential for population size estimation of those exposed to environmental risk factors and of those who experienced health effects.

• 한국전자파학회논문지
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• 제24권12호
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• pp.1158-1166
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• 2013

본 논문은 Mobi-Kids 연구의 노출량 평가를 위해 휴대전화 대표 모델에 대해 연구 프로토콜에 따른 SAR 계산방법을 분석하고, 역학조사 대상자가 사용한 휴대전화의 무선주파수 누적 노출량을 평가하는 방법을 제안한다. 휴대전화 대표 모델의 출력을 동일하게 가정하고, 서로 다른 연령의 4개 머리 모델에서의 SAR 분포를 계산하여 데이터베이스를 구축한다. 역학조사 대상자가 사용한 특정 휴대전화 모델의 머리 SAR은 SAR 적합성 시험결과를 활용하여 보정 인자를 적용함으로써 구한다. 그리고 휴대전화 특성과 함께 사용 시간, 좌 우측 비율 같은 대상자의 휴대전화 사용 패턴에 대한 인자를 고려하여 누적 에너지를 산출하게 된다.

• 한국지역지리학회지
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• 제20권4호
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• pp.444-453
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• 2014

환경위험의 피해가 환경불평등과 사회불평등의 상호작용으로 인해 환경약자가 더 많이 피해를 받게 되는 환경 피해 불평등이 심화될 것으로 전망되고 있다. 본 연구는 서울시를 대상으로 미국 캘리포니아 환경보호청에서 개발한 환경보건 스크리닝 툴을 적용하여 통합적인 지역 규모의 누적영향을 평가하였다. 환경보건 취약지역을 스크리닝하기 위하여 환경노출과 건강영향의 환경부담, 민감집단과 사회경제적 요인의 인구특성에 따라 10개 지표를 선정하였다. 환경보건 스크리닝 툴을 통하여 2009~2011년 서울시 누적영향평가를 실시한 결과, 서울의 강서와 강남지역에서 위험요인이 높게 나타났며 강서지역은 환경부담과 인구특성 모두에서 위험요인이 높았고, 강남지역은 환경부담요인이 높은 것으로 나타났다. 연구결과는 민감 취약계층 등 환경약자를 고려한, 공정하고 효율적인 환경정책을 추진하기 위한 과학적인 근거를 제공할 수 있다.

• 한국환경보건학회지
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• 제45권1호
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• pp.71-81
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• 2019

Objectives: The lung injuries by exposure to the humidifier disinfectants (HDs) were reported in 2011, Korea. For the HD victims, environmental exposure level and clinical diagnosis were conducted to determine the levels of damage by HDs. Methods: The exposure assessment to the HDs from 1st to 4th questionnaire surveys were carried out for 5,245 victims. And the affecting factors of exposure levels were analyzed by characterizing exposure and demographic information. By using of exposure concentration and cumulative time, exposure levels were classified and compared by percentage of clinical diagnosis classes. The high exposure and low clinical diagnosis rating groups, and low exposure and high clinical diagnosis rating groups were analyzed to overcome the limitation of past exposure assessment such as recall bias. Results: Among the all applicants damaged by the humidifier disinfectants, survivors were 4,028 and the dead were 1,217. And male and female were 2,675, and 2,547, respectively. In case of occurrence age of lung disease, under 10 years was majority age group (1,536) and followed by thirties (917). Pregnant women and fetuses were 339 and 439, respectively. And the damages by exposure to the HDs were concentrated on these susceptible populations in groups with low exposure and high clinical diagnosis rating. On the other hand, the groups classified by high exposure and low clinical diagnosis rating were shown different characterization. Conclusions: The questionnaire survey on past exposure may be uncertain due to recall bias. However, the relationship between classified exposure levels and clinical diagnosis ratings might be shown positive correlation if the exposure assessment errors were analyzed and controlled.