• 말소리와 음성과학
• /
• 제12권1호
• /
• pp.43-50
• /
• 2020

This study investigated whether listeners' perceptual patterns varied according to base token selected for stimuli manipulation. Voice onset time (VOT) and fundamental frequency (F0) values were orthogonally manipulated, each in seven steps, using naturally produced words that contained a lenis (/kan/) and an aspirated (/k^han/) stop in Seoul Korean. Both native and non-native groups showed significantly higher numbers of aspirated responses for the stimuli constructed with /k^han/, evidencing the use of minor cues left in the stimuli after manipulation. For the native group the use of the VOT and F0 cues in the stop categorization did not differ depending on whether the base token included the lenis or aspirated stop, indicating that the results of previous studies remain tenable that investigated the relative importance of the acoustic cues in the native listener perception of the Korean stop contrasts by using one base token for manipulating perceptual stimuli. For the non-native group, the use patterns of the F0 cue differed as a function of base token selected. Some findings indicated that listeners used alternative cues to identify the stop contrast when major cues sound ambiguous. The use of the manipulated VOT and F0 cues by the non-native group was not native-like, suggesting that non-native listeners may have perceived the minor cues as stable in the context of the manipulated cue combinations.

• Archives of Pharmacal Research
• /
• 제17권2호
• /
• pp.80-86
• /
• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• 음성과학
• /
• 제10권4호
• /
• pp.241-254
• /
• 2003

The purpose of the present study was to investigate the sentence comprehension strategies used by Korean/English bilingual children when they listened to sentences of their first language, i.e., Korean. The framework of competition model was employed to analyze the influence of the second language, i.e., English, during comprehension of Korean sentences. The participants included 10 bilingual children (ages 7;4-13;0) and 20 Korean-speaking monolingual children(ages 5;7-6;10) with similar levels of development in Korean language as bilingual children. In an act-out procedure, the children were asked to determine the agent in sentences composed of two nouns and a verb with varying conditions of three cues (case-marker, animacy, and word-order). The results revealed that both groups of children used the case marker cues as the strongest cue among the three. The bilingual children relied on case-marker cues even more than the monolingual children. However, the bilingual children used animacy cues significantly less than the monolingual children. There were no significant differences between the groups in the use of word-order cues. The bilingual children appeared less effective in utilizing animacy cues in Korean sentence comprehension due to the backward transfer from English where the cue strength of animacy is very weak. The influence of the second language on the development of the first language in bilingual children was discussed.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
• /
• pp.93-93
• /
• 2013

To make the rationale design of interface between cell and artificial surface, many studies have been controlled influencing cue which can typically be divided into two central categories: chemical cues based on modification surface chemical properties containing attractive/repulsive molecules, and physical cues that may include applied tension/stress, electrical polarization, magnetic field, and topography. Recently, researches have been focused on physical cue, especially topography. The surface topography may influence cellular responses for example, cell adhesion, cell morphology and gene expression. However, there were few systematic studies about these nanotopographical effects on neuronal developments in a feature size-dependent manner. Herein, we report a nanoscale-resolved study of nanotopographical effects on cellular adhesion and growth. In this study, we use substrates with packed glass beads by rubbing method for generating highly periodic nanotopographies with various sizes. We found that acceleration of neuritogenesis appeared only on the beads larger than 200 nm in diameter, and observed that filopodial thickness was comparable with this scale. This study is expected to be essential to elucidate the nanotopographical effect on cellular adhesion and growth.

• Nuclear Engineering and Technology
• /
• 제53권2호
• /
• pp.368-375
• /
• 2021

The performance time of human operators has been recognized as a key aspect of human reliability in socio-complex systems, including nuclear industries. Because of the importance of the time factor, most existing human reliability assessment methods provide ways to quantify human error probabilities (HEPs) that are associated with the performance time. To quantify such kinds of HEPs, it is crucial to rationally predict the length of time required and time available and compare them. However, there have not been detailed guidelines that identify the critical cue presentation time or initial time of human performance, which is important to calculate the time information. In this paper, we introduce a time-related HEP calculation technique with a decision algorithm that determines the critical cue and its timing. The calculation process is presented with the application examples. It is expected that the proposed algorithm will reduce the variability in the time-related reliability assessment and strengthen the scientific evidence of the assessment process. The detailed description is provided in the technical report KAERI/TR-7607/2019.

• 아태비즈니스연구
• /
• 제13권1호
• /
• pp.301-315
• /
• 2022

Purpose - The main objective of this study was to investigate tourists behavior by applying protection motivation theory and health belief model during COVID-19 pandemic. Specifically, the study examined how risk perception of COVID-19 affects tourists' protection motivation and travel avoidance intention. Design/methodology/approach - The empirical data was collected by self-administered questionnaires to obtain perception and behavior regarding COVID-19 pandemic situation. A total of 486 questionnaires were used for data analysis and SEM analysis was applied in order to examine seven hypotheses. Findings-The results showed that COVID-19 risk perception is a significant antecedent of threat appraisal, coping appraisal, and cue to action (H1, H2, H6). Moreover, protection motivation is affected by threat appraisal and coping appraisal (H3, H4) and influences on travel avoidance intention (H5). However, cue to action does not affect protection motivation (H7). Research implications or Originality - This study provides insightful implications for tourism industry practitioners who will prepare the post-corona field and the results enrich knowledge of the tourist behavior during pandemic situation.

• International Journal of Advanced Culture Technology
• /
• 제11권4호
• /
• pp.346-351
• /
• 2023

With the rapid development of Artificial Intelligence (AI) technology, there is an increasing variety of methods for creating 3D models. These include innovations such as text-only generation, 2D images to 3D models, and combining images with cue words. Each of these methods has unique advantages, opening up new possibilities in the field of 3D modeling. The purpose of this study is to explore and summarize these methods in-depth, providing researchers and practitioners with a comprehensive perspective to understand the potential value of these methods in practical applications. Through a comprehensive analysis of pure text generation, 2D images to 3D models, and images with cue words, we will reveal the advantages and disadvantages of the various methods, as well as their applicability in different scenarios. Ultimately, this study aims to provide a useful reference for the future direction of AI modeling and to promote the innovation and progress of 3D model generation technology.

• 말소리와 음성과학
• /
• 제16권1호
• /
• pp.17-24
• /
• 2024

The Korean three-way stop contrast (lenis, aspirated, fortis) is currently undergoing a sound change, such that the primary cue distinguishing lenis and aspirated stops is shifting from voice onset time (VOT) to F0. Despite recent discussions of this shift, research on voice quality, traditionally considered an additional cue signaling the contrast, remains sparse. This study investigated the extent to which the associated voice quality [as reflected in the acoustic measurements of H1^*-H2^*, H1^*- A1^*, and cepstral peak prominence (CPP)] contributes to the three-way stop contrast, and how the realization is conditioned by prominence- vs. boundary-induced prosodic strengthening amid the ongoing sound change. Results for 12 native Korean speakers indicate that there was a substantial distinction in voice quality among the three stop categories with the breathiness of the vowel being the greatest after the lenis, intermediate after the aspirated, and least after the fortis stops, indicating the role of voice quality in the maintenance of the three-way stop contrast. Furthermore, prosodic strengthening has different effects on the contrast and contributes to the enhancement of the phonological contrast contingent on whether it is induced by prominence or boundary.

• 생명과학회지
• /
• 제33권11호
• /
• pp.868-875
• /
• 2023

Kinesin-1은 kinesin superfamily (KIF) 단백질 중에서 처음으로 확인된 모터 단백질로 세포내 미세소관 의존하여 세포내 cargo를 수송한다. Kinesin-1은 두 개의 중쇄(KHC, 또는 KIF5)와 두 개의 경쇄(KLC)로 구성된다. KIF5A의 C-말단의 93개 아미노산은 KIF5B와 KIF5C의C-말단 꼬리 영역과는 상동성이 없다. 본 연구에서 우리는 KIF5A의 C-말단 영역과 특이적으로 결합하는 단백질을 분리하기 위해 효모 2-하이브리드 스크리닝을 하였다. 본 연구에서 우리는 KIF5A와 결합하는 단백질로 유비퀴틴화 경로 및 단백질 수송에 관여하는 어댑터 단백질로 기능하는 CUE 도메인을 가진 CUEDC2를 확인하였다. CUEDC2는 KIF5A의 C-말단 영역과 결합하지만, KIF5B, KIF3A 및KLC1과는 결합하지 않았다. KIF5A는 CUEDC2의 C-말단 영역과 특이적으로 결합하였지만, CUEDC2의 다른 isoform인 CUEDC1과는 결합하지 않았다. 또한, KIF5A와 CUEDC2의 결합은 글루타티온 S-트랜스퍼라제(GST) 풀다운으로 단백질간 결합을 확인하였다. HEK-293T 세포에서 myc-KIF5A와 FLAG-CUEDC2을 공동 발현되었을 때, CUEDC2는 kinesin-1과 공동 면역 침전되었고, myc-KIF5A와 EGFP-CUEDC2는 세포내의 같은 위치에서 발현하였다. 이러한 결과들은 kinesin-1에 의한 세포내 화물 수송에서 CUEDC2는 KIF5A에 결합하여 kinesin-1과 화물을 연결하는 어댑터 단백질 역할을 시사한다.

• 재활복지공학회논문지
• /
• 제2권1호
• /
• pp.35-43
• /
• 2009

본 논문에서는 개발된 잡음제거 기능을 갖춘 시-청각 단서 제공 읽기 훈련 프로그램(이하 프로그램)을 소개한다. 프로그램은 시-청각 단서들을 지닌 훈련용 문장들을 제공한다. 말운동장애인들은 읽기훈련을 위해서 시각단서와 청각단서들을 각각 또는 동시에 사용 가능하다. 훈련 결과의 평가 편의성 제공을 위해서 잡음제거 알고리즘을 개발하였다. 알고리즘은 피험자가 컴퓨터화면에 제공된 문장을 읽을 때 읽는 말소리와 함께 녹음된 잡음과 청각단서 소리를 제거한다. 또한 피험자가 읽기 연습을 시작할 때 최초의 말소리 개시시간을 검출하는 기능을 구현하였다. 말소리의 녹음은 4가지 잡음환경(실내 잡음, 백색 잡음, 자동차 내부잡음, 배블 잡음)에서 성인 6명(남성 3 명, 여성 3명)으로부터 하였다. 잡음제거 전과 후에 대한 조건에서 녹음된 말소리의 실제 시작 시간과 프로그램상에서 찾은 시간과의 오차를 실험하였다. 잡음제거 전과 후에서의 시간오차가 $4.847{\pm}2.4235[ms]$ 향상되었다. 개발된 프로그램은 말운동장애인의 훈련 및 증상 평가에 도움이 될 수 있으리라 사료된다.