• Phonetics and Speech Sciences
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• v.12 no.1
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• pp.43-50
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• 2020

This study investigated whether listeners' perceptual patterns varied according to base token selected for stimuli manipulation. Voice onset time (VOT) and fundamental frequency (F0) values were orthogonally manipulated, each in seven steps, using naturally produced words that contained a lenis (/kan/) and an aspirated (/k^han/) stop in Seoul Korean. Both native and non-native groups showed significantly higher numbers of aspirated responses for the stimuli constructed with /k^han/, evidencing the use of minor cues left in the stimuli after manipulation. For the native group the use of the VOT and F0 cues in the stop categorization did not differ depending on whether the base token included the lenis or aspirated stop, indicating that the results of previous studies remain tenable that investigated the relative importance of the acoustic cues in the native listener perception of the Korean stop contrasts by using one base token for manipulating perceptual stimuli. For the non-native group, the use patterns of the F0 cue differed as a function of base token selected. Some findings indicated that listeners used alternative cues to identify the stop contrast when major cues sound ambiguous. The use of the manipulated VOT and F0 cues by the non-native group was not native-like, suggesting that non-native listeners may have perceived the minor cues as stable in the context of the manipulated cue combinations.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.80-86
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• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• Speech Sciences
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• v.10 no.4
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• pp.241-254
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• 2003

The purpose of the present study was to investigate the sentence comprehension strategies used by Korean/English bilingual children when they listened to sentences of their first language, i.e., Korean. The framework of competition model was employed to analyze the influence of the second language, i.e., English, during comprehension of Korean sentences. The participants included 10 bilingual children (ages 7;4-13;0) and 20 Korean-speaking monolingual children(ages 5;7-6;10) with similar levels of development in Korean language as bilingual children. In an act-out procedure, the children were asked to determine the agent in sentences composed of two nouns and a verb with varying conditions of three cues (case-marker, animacy, and word-order). The results revealed that both groups of children used the case marker cues as the strongest cue among the three. The bilingual children relied on case-marker cues even more than the monolingual children. However, the bilingual children used animacy cues significantly less than the monolingual children. There were no significant differences between the groups in the use of word-order cues. The bilingual children appeared less effective in utilizing animacy cues in Korean sentence comprehension due to the backward transfer from English where the cue strength of animacy is very weak. The influence of the second language on the development of the first language in bilingual children was discussed.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.93-93
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• 2013

To make the rationale design of interface between cell and artificial surface, many studies have been controlled influencing cue which can typically be divided into two central categories: chemical cues based on modification surface chemical properties containing attractive/repulsive molecules, and physical cues that may include applied tension/stress, electrical polarization, magnetic field, and topography. Recently, researches have been focused on physical cue, especially topography. The surface topography may influence cellular responses for example, cell adhesion, cell morphology and gene expression. However, there were few systematic studies about these nanotopographical effects on neuronal developments in a feature size-dependent manner. Herein, we report a nanoscale-resolved study of nanotopographical effects on cellular adhesion and growth. In this study, we use substrates with packed glass beads by rubbing method for generating highly periodic nanotopographies with various sizes. We found that acceleration of neuritogenesis appeared only on the beads larger than 200 nm in diameter, and observed that filopodial thickness was comparable with this scale. This study is expected to be essential to elucidate the nanotopographical effect on cellular adhesion and growth.

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.368-375
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• 2021

The performance time of human operators has been recognized as a key aspect of human reliability in socio-complex systems, including nuclear industries. Because of the importance of the time factor, most existing human reliability assessment methods provide ways to quantify human error probabilities (HEPs) that are associated with the performance time. To quantify such kinds of HEPs, it is crucial to rationally predict the length of time required and time available and compare them. However, there have not been detailed guidelines that identify the critical cue presentation time or initial time of human performance, which is important to calculate the time information. In this paper, we introduce a time-related HEP calculation technique with a decision algorithm that determines the critical cue and its timing. The calculation process is presented with the application examples. It is expected that the proposed algorithm will reduce the variability in the time-related reliability assessment and strengthen the scientific evidence of the assessment process. The detailed description is provided in the technical report KAERI/TR-7607/2019.

• Asia-Pacific Journal of Business
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• v.13 no.1
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• pp.301-315
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• 2022

Purpose - The main objective of this study was to investigate tourists behavior by applying protection motivation theory and health belief model during COVID-19 pandemic. Specifically, the study examined how risk perception of COVID-19 affects tourists' protection motivation and travel avoidance intention. Design/methodology/approach - The empirical data was collected by self-administered questionnaires to obtain perception and behavior regarding COVID-19 pandemic situation. A total of 486 questionnaires were used for data analysis and SEM analysis was applied in order to examine seven hypotheses. Findings-The results showed that COVID-19 risk perception is a significant antecedent of threat appraisal, coping appraisal, and cue to action (H1, H2, H6). Moreover, protection motivation is affected by threat appraisal and coping appraisal (H3, H4) and influences on travel avoidance intention (H5). However, cue to action does not affect protection motivation (H7). Research implications or Originality - This study provides insightful implications for tourism industry practitioners who will prepare the post-corona field and the results enrich knowledge of the tourist behavior during pandemic situation.

• International Journal of Advanced Culture Technology
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• v.11 no.4
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• pp.346-351
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• 2023

With the rapid development of Artificial Intelligence (AI) technology, there is an increasing variety of methods for creating 3D models. These include innovations such as text-only generation, 2D images to 3D models, and combining images with cue words. Each of these methods has unique advantages, opening up new possibilities in the field of 3D modeling. The purpose of this study is to explore and summarize these methods in-depth, providing researchers and practitioners with a comprehensive perspective to understand the potential value of these methods in practical applications. Through a comprehensive analysis of pure text generation, 2D images to 3D models, and images with cue words, we will reveal the advantages and disadvantages of the various methods, as well as their applicability in different scenarios. Ultimately, this study aims to provide a useful reference for the future direction of AI modeling and to promote the innovation and progress of 3D model generation technology.

• Phonetics and Speech Sciences
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• v.16 no.1
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• pp.17-24
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• 2024

The Korean three-way stop contrast (lenis, aspirated, fortis) is currently undergoing a sound change, such that the primary cue distinguishing lenis and aspirated stops is shifting from voice onset time (VOT) to F0. Despite recent discussions of this shift, research on voice quality, traditionally considered an additional cue signaling the contrast, remains sparse. This study investigated the extent to which the associated voice quality [as reflected in the acoustic measurements of H1^*-H2^*, H1^*- A1^*, and cepstral peak prominence (CPP)] contributes to the three-way stop contrast, and how the realization is conditioned by prominence- vs. boundary-induced prosodic strengthening amid the ongoing sound change. Results for 12 native Korean speakers indicate that there was a substantial distinction in voice quality among the three stop categories with the breathiness of the vowel being the greatest after the lenis, intermediate after the aspirated, and least after the fortis stops, indicating the role of voice quality in the maintenance of the three-way stop contrast. Furthermore, prosodic strengthening has different effects on the contrast and contributes to the enhancement of the phonological contrast contingent on whether it is induced by prominence or boundary.

• Journal of Life Science
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• v.33 no.11
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• pp.868-875
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• 2023

Kinesin-1 is a motor protein identified as the first member of the kinesin superfamily (KIF), which plays a role in intracellular cargo transport by acting as microtubule-dependent motor proteins within cells. Kinesin-1 consists of two heavy chains (KHCs, also known as KIF5s) and two light chains (KLCs). The 93 amino acids in the carboxyl (C)-terminal tail region of KIF5A are not homologous to the C-terminal tail region of KIF5B or the C-terminal tail region of KIF5C. In this study, we used a yeast two-hybrid screen to identify the binding proteins that interacted with the C-terminal region of KIF5A. We found an association between KIF5A and CUE domain containing 2 (CUEDC2), which is proposed to function as an adaptor protein involved in ubiquitination pathways and protein trafficking. CUEDC2 bound to the C-terminal region of KIF5A and did not interact with KIF5B (the motor of kinesin-1), KIF3A (the motor of kinesin-2), or kinesin light chain 1 (KLC1). KIF5A specifically bound to the C-terminal region of CUEDC2. Furthermore, KIF5A did not interact with another isoform: CUEDC1. In addition, glutathione S-transferase (GST) pull-downs showed that KIF5A directly bound GST-CUEDC2 but did not interact with GST-CUEDC1 and GST alone. When myc-KIF5A and EGFP-CUEDC2 were co-expressed in HEK-293T cells, CUEDC2 co-immunoprecipitated with kinesin-1, and myc-KIF5A and FLAG-CUEDC2 colocalized in the cells. These results suggest that in intracellular cargo transport by kinesin-1, CUEDC2 serves as an adaptor protein connecting kinesin-1 and cargo by binding to KIF5A.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.2 no.1
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• pp.35-43
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• 2009

In this paper, we introduce a reading training program offering visual-auditory cue with noise cancellation function (RT program) developed by us. The RT program provides some training sentences with visual-auditory cues. Motor speech disorder patients can use the visual and/or auditory cues for reading training. To provide convenient estimation of training result, we developed a noise cancellation algorithm. The function of the algorithm is to remove noise and auditory-cues which are recorded with reading speech at the same time while patient read the sentences in PC monitor. In addition, we developed a function for finding out the first starting time of reading sound after a patient sees a sentence and begins to read the sentence. The recorded speeches are acquired from six people(three male, three female) in four noisy environments (interior noise, white noise, car interior noise, babble noise). We evaluated the timing error for starting time between original recorded speech and processed speech in condition of executing noise cancellation function and not executing. The timing error was improved as much as $4.847{\pm}2.4235[ms]$ as the effect of noise cancellation. It is expected that the developed RT program helps motor speech disorder patient in reading training and symptom evaluation.