• Journal of Pharmaceutical Investigation
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• 제19권1호
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• pp.47-61
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• 1989

• Journal of Pharmaceutical Investigation
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• 제18권4호
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• pp.217-227
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• 1988

• Applied Biological Chemistry
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• 제49권4호
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• pp.309-314
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• 2006

울산지역에서 생산된 단감의 품종 및 부위의 생리활성을 체계적으로 조사하고자, 주요성분과 70% 에탄올 추출물의 전자공여능 등을 분석한 결과는 다음과 같다. 일반성분 함량은 수분 $77.68{\sim}84.65%$, 조회분 $0.3{\sim}0.6%$, 조지방 $0.29{\sim}0.39%$, 조단백질 $0.52{\sim}0.61%$로 나타났다. 확인된 유기산 및 유리당은 각각 malic acid, citric acid, succinic acid, fumaric acid 및 glucose, fructose, sucrose 이었다. 지방산은 linolenic acid, vaccenic acid, palmitic acid가 주된 지방산이었고, 무기질의 함량은 K이 $84.9{\sim}103.7mg%$로 가장 높아 전체 무기질의 약 60% 이상을 차지하였다. 비타민 C, 총페놀성화합물 및 총플라보노이드 함량은 각각 139.91, 169.36 및 60.79mg%로 부유과피에서 가장 높았다. 전자공여능 및 xanthine oxidase 저해활성은 부유과피가 각각 $30.6{\sim}91.2$ 및 $26.3{\sim}91.9%$로 가장 높았고, 아질산염소거능은 과피가 $51.0{\sim}76.4%$로 과육에 비해 높았으며, 품종별 차이는 없었다.

• 생약학회지
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• 제39권4호
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• pp.316-323
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• 2008

In this study, we have investigated the HPLC analysis methods and quantitative analysis of standard compounds for quality standardization of a medicinal crude drug GCSB-5, a herbal formulation consisting of 6 medicinal plants (Acanthopanacis Cortex, Achyranthis Radix, Ledebouriellae Radix, Cibotii Rhizoma, Glycine Semen, Eucommiae Cortex) which are used in traditional medicine to treat various bone disorders. HPLC analysis methods of acanthoside D(Acanthopanacis Cortex), 20-hydroxyecdysone(Achyranthis Radix) which were known standard compounds among 6 medicinal plants were developed on crude material and product. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline. Content of acanthoside D and 20-hydroxyecdysone on raw material of GCSB-5 were decided at 0.577-0.578 mg/g and 0.311-0.312 mg/g. And we confirmed that content of acanthoside D and 20-hydroxyecdysone on GCSB-5 preparation were 0.302-0.303 mg/capsule and 0.113-0.115 mg/capsule.

• 생약학회지
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• 제26권1호
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• pp.31-39
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• 1995

In order to investigate the chemical and pharmacological characterization of crude drug processing, the triterpenoidal constituents of Glycyrrhizae Radix(GR) were examined. Processed GR has been often used to reinforce and change the efficacy of GR. Glycyrrhizin(GL) is one of the main constituents of GR. Following procedure described in the oriental medicinal reference, GR and GL were heated at $140^{\circ}C{\sim}240^{\circ}C$ in GC oven. And then, the content of GL in the processed GR and GL was analyzed by HPLC. GL was transformed to $18-{\beta}-glycyrrhetic\;acid\;mono-{\beta}-D-glucuronide(GM)$ and glycyrrhetic acid(GA) by processing at $170^{\circ}C$. Determination of the content of GL increasing the heating temperature showed that GL was decomposed by heat above $150^{\circ}C$. It was also found that the content of GL in GR processed by heat above $170^{\circ}C$ remakeably decreased.

• 혜화의학회지
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• 제4권2호
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• pp.333-333
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• 1996

Chinese medicine is a precious treasure inherited from ancient ancestors. It is accredited for the prosperous growth of the Chinese nations. However, the descriptions of the herbs in the ancient herbal are not in detail and the great numbers of herbs used which grows in wide geographic areas together with various local folk names, new substitutes and new folk medicines had increased, many Chinese herbs are composed of herbs that are labeled with identical names but actually are of different origins and different grades. Similar situation had occurred in China, japan and Korea In Taiwan, misused Chinese crude drugs are also very common in the past. This phenomenon had caused a lot of confusion and had great influence the clinical efficacy of the treatment. In the past, Professor Hong Yen Hsu, Na Chi, Woei Song Kan and Kung Yin Yen had studied the origins of Chinese crude drugs in Taiwan based on the morphological identification and found that the origins of Ma-Tou-Ling, Pu-Kung-Yin, Tu-Chung, Wang-Pu-Liu-Hsing, Pan-lan-Ken, Niu-Chi, Fang-Chi, Huang-Chi, PienHsiu and Sha Wan-Tzi are different from that of the species used in mainland China. In order to assure the quality and clinical efficacy of the crude drugs, besides the traditional morphological methods, we bad recently combined modem chemical and pharma-cological methods to assess drug quality. Drugs that have been evaluated without effects should be abandoned. The species of those commonly misued crude drugs used in compound formula preparations are also identified Based on the pharmacological results, a suitable species is recommended so as to improve the clinical efficacy of those preparations. In this paper, we like to report our recent studies on Niu Chi(Achyranthis Bidentatae Radix, Cyathulae Radix and Strobilanthis Radix). Fang-Chi(Arstolochiae Fangchi Radix, Stephaniae Tetrandrae Radix and Cocculus Radix) and Huang-Chi(Astragali Radix and Hedysari Radix) using comparative pharmacognosy methods.

• 생약학회지
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• 제33권3호통권130호
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• pp.157-168
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• 2002

Aconites distribute widely in northern hemispere of the earth reaching to arctic zone from warm and temperate one. Chinese crude drug 'Cho O'(草烏) has been used as a remedy for apoplexy, dyspepsia, neuralgia, chronic rheumatis etc. Though the botanical origin of the crude drug has been considered to be Aconitum species of Ranunculaceae, there has been no confirmation on it. To clarify the botanical origin of Cho O, the morphological and anatomical characteristics of the roots of Aconitum species growing in Korea, i.e. A. chiisanense, A. ciliare, A. jaluense, A. napiforme, A. proliferum, A. pseudoproliferum and A. triphyllum were studied. As the result, Cho O was proved to be the roots of Aconitum triphyllum, A. jaluense, A. chiisanense and A. napiforme.

• 생약학회지
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• 제31권2호
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• pp.256-258
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• 2000

'Jeol Chung Yum' is a Chinese patent medicine, which is used for a disease of women peculiarity by extravasated blood, a kind of stagnation state of blood and of menstrual irregularity in Korea; This medicine consists of 10 kinds of powdery mixtures, and microscopic method can advantageously be used for identification as it requires only a small amount of specimens. In this paper, the effectiveness of this methods will be exemplified by the identification of the ingredients in 'Jeol Chung Yum' which contains 10 powdered crude drug ingredients.

• 생약학회지
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• 제36권2호통권141호
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• pp.141-144
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• 2005

Chinese crude drug 'Dang Gui' has been used mainly as a tonifying the blood, promoting blood circulation, relieving pain and moistening the bowels. To clarify the botanical origin of 'Dang Gui' from Korea, the anatomical characteristics of Angelica gigas, Angelica sinensis and Angelica acutiloba were studied. As a result, it was clarified that 'Dang Gui' from Korea was the root of Angelica gigas.

• 생약학회지
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• 제31권3호
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• pp.288-294
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• 2000

The Korean crude drug 'Suk Wi' has been used as the folk remedy for diuretic and gonorrhea. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of Suk Wi, studied on the morphological and anatomical characteristics of Pyrrosia species growing wild in Korea i.e., P. linearifolia, P. lingua, P. petiolosa, P. tricuspis and Suk Wi from Korea on Korean market. As a result, it was made clear that Suk Wi from Korea was derived from Pyrrosia lingua and P. petiolosa.