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Modulation of Amygdala Synaptic Transmission by Metabotropic Glutamate Receptors

  • Kim, Jung-Hyun;Park, Eun-Jin;Chang, Duk-Jin;Choi, Suk-Woo
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.6
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    • pp.303-306
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    • 2003
  • Metabotropic glutamate receptors (mGluRs), classified into three groups (group I, II, III), play a critical role in modulation of synaptic transmission at central and peripheral synapses. In the present study, extracellular field potential recording techniques were used to investigate effects of mGluR agonists on excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala. The non-selective mGluR agonist t-ACPD ($100{\mu}M$) produced reversible, short-term depression, but the group III mGluR agonist L-AP4 ($50{\mu}M$) did not have any significant effects on amygdala synaptic transmission, suggesting that group I and/or II mGluRs are involved in the modulation by t-ACPD. The group I mGluR agonist DHPG ($100{\mu}M$) produced reversible inhibition as did t-ACPD. Unexpectedly, the group II mGluR agonist LCCG-1 ($10{\mu}M$) induced long-term as well as short-term depression. Thus, our data suggest that activation of group I or II mGluRs produces short-term, reversible depression of excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala. Considering the long-term effect upon activation of group II mGluRs, lack of long-term effects upon activation of group I and II mGluRs may indicate a possible cross-talk among different groups of mGluRs.

The Relationship of Bone Mineral Densities and Period of Breast feeding in Premenopausal Women (폐경 전 여성의 모유수유기간과 골밀도와의 관련성 연구)

  • 이은남;이은옥;이광혜
    • Journal of Korean Academy of Nursing
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    • v.30 no.1
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    • pp.29-38
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    • 2000
  • To determine whether personal history of lactation in premenopausal women influence bone mineral density, a cross-sectional study was conducted. One hundred eighty-four premenopausal women were selected from women who had been checked for bone mineral density by dual energy x-ray absortiometry in lumbar spine, femoral neck, Ward's triangle, and trochanteric site at general hospitals in Seoul and Pusan. They completed a questionnaire including life style factors and reproductive history. In the data analysis, Pearson correlation coefficients were used to test any association between individual variables and bone mineral density and a statistical comparisons between long term lactation(>24 months) and short term lactation(<24 months) were made by one way analysis of covariance. The results were summarized as follows: 1) There was no significant difference in the bone mineral density of the lumbar vertebrae in premenopausal women between the long term lactation group(>24months) and the short term lactation group(<24months). 2) There was no significant difference in the bone mineral density of the femur neck, Ward's triangle, and trochanteric site in premenopausal women between the long term lactation group (>24months) and the short term lactation group (<24months). Considering these results, we suggest prospective studies that measure bone mineral density before and after, in addition to those during lactation. We also suggest the further study with premenopausal women less than 35 who have achieved peak adult bone mass.

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Factors Affecting Performance of the Infection Control of Carbapenem Resistant Enterobacteriaceae of Nursing Staffs in Long-term Care Hospitals (요양병원 간호인력의 카바페넴 내성 장내세균속균종 감염관리 수행 정도에 미치는 요인)

  • Kim, Gyuri;Lee, Jong-Eun
    • Journal of Home Health Care Nursing
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    • v.29 no.2
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    • pp.204-215
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    • 2022
  • Purpose: This study aimed to identify factors affecting the carbapenem-resistant enterobacteriaceae (CRE) infection control performance of nursing staff, who closely contact patients with CRE in long-term care hospitals. Methods: A cross-sectional study design was used. A total of 135 nursing staffs working in seven long-term care hospitals in the southern and northern areas of the K province in Korea were included. We measured the CRE infection control general characteristics, knowledge, perception, and performance. Results: The main factors affecting the CRE infection control performance were education, knowledge, and perception. The model explained the 60.8% total variance in CRE infection control. Conclusion: Appropriate infection control strategies should be prepared to provide high quality nursing care and prevent the spread of CRE infection in long-term care hospitals. Establishing an efficient infection control system in long-term care hospitals is necessary.

Cognitive Function and Activity of Daily Living of Older Adults Using Long-term Care Service (장기요양 이용 재가노인의 인지기능과 일상생활 능력)

  • Chang, Hyun-Sook;Lee, Hung Sa
    • Health Policy and Management
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    • v.22 no.4
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    • pp.522-537
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    • 2012
  • The purpose of this study was to analyze the level of the cognitive function and activities of daily living of the beneficiary older adults at home based on Korean Long-term Care Insurance System. A cross-sectional descriptive survey was conducted from November 2010 to May 2011, the final respondents were 1,026 beneficiary older adults taking home visit care covered in Korean long-term care insurance system. The questionnaire included general characteristics of subjects, cognitive function, ADL(Activity of daily living). The data was analyzed using the SPSS 20.0 version. There was significant difference in cognitive function and ADL between 1st Grade, 2nd Grade and 3rd Grade of long-term care classification. The correlated factors of cognitive function were ADL, long-term care grade, disability of arm and leg, limitation of joint, bed sore and tube feeding. The correlated factors of ADL were cognitive function, long-term care grade, disability of arm and leg, bed sore and tube feeding. This study suggests that cognitive functions have to be mainly considered in long-term care grade. It is necessary to make an effort to develop long-term care grade in Korean long-term care insurance system an cognitive function improvement program for the beneficiary older adults. Above all things government will be seriously contemplating of revise contents for long-term care grade to provide quality of care for the older adults.

Improving Power Conversion Efficiency and Long-term Stability Using a Multifunctional Network Polymer Membrane Electrolyte; A Novel Quasi-solid State Dye-sensitized Solar Cell

  • Gang, Gyeong-Ho;Gwon, Yeong-Su;Song, In-Yeong;Park, Seong-Hae;Park, Tae-Ho
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.484.2-484.2
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    • 2014
  • There are many efforts to improving the power conversion efficiencies (PCEs) of dye-sensitized solar cells (DSCs). Although DSCs have a low production cost, their low PCE and low thermal stability have limited commercial applications. This study describes the preparation of a novel multifunctional polymer gel electrolyte in which a cross-linking polymerization reaction is used to encapsulate $TiO_2$ nanoparticles toward improving the power conversion efficiency and long-term stability of a quasi-solid state DSC. A series of liquid junction dye-sensitized solar cells (DSCs) was fabricated based on polymer membrane encapsulated dye-sensitized $TiO_2$ nanoparticles, prepared using a surface-induced cross-linking polymerization reaction, to investigate the dependence of the solar cell performance on the encapsulating membrane layer thickness. The ion conductivity decreased as the membrane thickness increased; however, the long term-stability of the devices improved with increasing membrane thickness. Nanoparticles encapsulated in a thick membrane (ca. 37 nm), obtained using a 90 min polymerization time, exhibited excellent pore filling among $TiO_2$ particles. This nanoparticle layer was used to fabricate a thin-layered, quasi-solid state DSC. The thick membrane prevented short-circuit paths from forming between the counter and the $TiO_2$ electrode, thereby reducing the minimum necessary electrode separation distance. The quasi-solid state DSC yielded a high power conversion efficiency (7.6/8.1%) and excellent stability during heating at $65^{\circ}C$ over 30 days. These performance characteristics were superior to those obtained from a conventional DSC (7.5/3.5%) prepared using a $TiO_2$ active layer with the same thickness. The reduced electrode separation distance shortened the charge transport pathways, which compensated for the reduced ion conductivity in the polymer gel electrolyte. Excellent pore filling on the $TiO_2$ particles minimized the exposure of the dye to the liquid and reduced dye detachment.

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Modification of RFSP to Accommodate a True Two-Group Treatment

  • Bae, Chang-Joon;Kim, Bong-Ghi;Suk, Soo-Dong;D. Jenkins;B. Rouben
    • Proceedings of the Korean Nuclear Society Conference
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    • 1996.05a
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    • pp.185-190
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    • 1996
  • RFSP is a computer program to do fuel management calculations for CANDU reactors. Its main function is to calculate neutron flux and power distributions using two-energy-group, three dimensional neutron diffusion theory. However, up to now the treatment has not been true two-group but actually "one-and-half groups". In other words, the previous (1.5-group) version of RFSP lumps the fast fission term into the thermal fission term. This is based on the POWDERPUFS-V Westcott convention. Also, there is no up-scattering term or bundle power over cell flux (H1 factor) for the fast group. While POWDERPUFS-V provides only 1.5 group properties, true two-group cross sections for the design and analysis of CAUDU reactors can be obtained from WIMS-AECL. To treat the full two-group properties, the previous RFSP version was modified by adding the fast fission, up-scatter terms, and H1 factor. This two-group version of RFSP is a convenient tool to accept lattice properties from any advanced lattice code (e.g. WIMS-AECL DRAGON, HELIOS...) and to apply to advanced fuel cycles. In this study, the modification to implement the true two-group treatment was performed only in the subroutines of the *SIMULATE module of RFSP. This module is the appropriate one to modify first, since it is used for the tracking of reactor operating histories. The modified two-group RFSP was evaluated with true two-group cross sections from WIMS-AECL. Some tests were performed to verify the modified two-group RFSP and to evaluate the effects of fast fission and up-scatter for three core conditions and four cases corresponding to each condition. The comparisons show that the two-group results are quite reasonable and serve as a verification of the modifications made to RFSP. To assess the long-term impact of the full 2-group treatment, it is necessary to simulate a long period (several months) of reactor history. It will also be necessary to implement the full two-group treatment of reactivity devices and assess the reactivity-device worths.ce worths.

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Analysis of the Mean Energy in $SiH_4-Ar$ Mixture Gases ($SiH_4-Ar$ 혼합기체의 평균 에너지에 관한 연구)

  • Kim, Sang-Nam
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.55 no.2
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    • pp.57-61
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    • 2006
  • This paper calculates and gives the analysis of mean energy in pure $SiH_4,\;Ar-SiH_4$ mixture gases ($SiH_4-0.5[%],\;5[%]$) over the range of $E/N =0.01{\sim}300[Td]$, p = 0.1, 1, 5.0 [Torr] by Monte Carlo the Backward prolongation method of the Boltzmann equation using computer simulation without using expensive equipment. The results have been obtained by using the electron collision cross sections by TOF, PT, SST sampling, compared with the experimental data determined by the other author. It also proved the reliability of the electron collision cross sections and shows the practical values of computer simulation. The calculations of electron swarm parameters require the knowledge of several collision cross-sections of electron beam. Thus, published momentum transfer, ionization, vibration, attachment, electronic excitation, and dissociation cross-sections of electrons for $SiH_4$ and Ar, were used. The differences of the transport coefficients of electrons in $SiH_4$, mixtures of $SiH_4$ and Ar, have been explained by the deduced energy distribution functions for electrons and the complete collision cross-sections for electrons. A two-term approximation of the Boltzmann equation analysis and Monte Carlo simulation have been used to study electron transport coefficients.

A Longitudinal Study on Adolescent's Multicultural Acceptability and School Adjustment using Autoregressive cross-lagged model

  • Kim, Hyun-Joo;Park, Hwie-Seo
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.7
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    • pp.153-160
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    • 2019
  • This study aims to analyze the mutual influences between adolescents' multicultural acceptability and school adjustment. Research problems for research are as follows. First, is multicultural acceptability and school adjustment stable over time? Second, what is the longitudinal impact of school adjustment on multicultural acceptability over time? Third, what is the longitudinal impact of multicultural acceptability on school adjustment over time? The results of analyzing the research problems by applying the autoregressive cross-lagged model are as follows. First, the autoregressive model of school adjustment has a significant effect on the future time point and is stable over time. Second, the autoregressive model of multicultural acceptability have a significant effect on the future time point and is stable over time. Third, cross-lagged effect from school adjustment to multicultural acceptability has a statistically significant effect on the multicultural acceptability at a later time, and is stable over time. Fourth, cross-lagged effect from multicultural acceptability to school adjustment was not statistically significant at the time of multicultural acceptability, and there was no change with time. This study is meaningful to provide the theoretical and practical implications by verifying the influence of the three - year term data over time.

Analysis of Factors Affecting Regional Total Fertility Rate: Using a Model Considering Cross-sectional Dependence (지역 합계출산율에 영향을 미치는 요인 분석: 횡단면 의존성을 고려한 모형을 이용하여)

  • So-Youn Kim;Su-Yeol Ryu
    • Asia-Pacific Journal of Business
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    • v.15 no.1
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    • pp.335-352
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    • 2024
  • Purpose - Low fertility rate is a serious problem, and this study analyzes factors affecting total fertility rate using panel data from 16 metropolitan cities and provinces in Korea from 2000 to 2022. Design/methodology/approach - Estimating the SAR model considering the weak cross-sectional dependence that exists in variables related to the regional total fertility rate, and using the DKSE estimation method considering the strong cross-sectional dependence. Findings - Estimation results considering weak and strong cross-sectional dependence were similar, confirming the robustness of the results. Female labor force participation rate has a positive effect on total fertility rate, and employment rate has no effect. However, the interaction term is a negative (-) sign. Crude marriage rate has a positive effect on total fertility rate, and apartment price has a slightly positive effect. Environmental factor has no effect, and policy factor has a negative effect. Research implications or Originality - In order for an increase in the female labor force participation rate to lead to an increase in the total fertility rate, qualitative improvements in female employment must be made. Financial investment policies for childbirth must increase their effectiveness. The problem of low fertility rate requires not only population policy but also social, economic, cultural, environmental, and policy conditions to be considered.

Diffusion Coefficients for Electrons in SF6-Ar Gas Mixtures by MCS-BEq (MCSBEq에 의한 SF6-Ar혼합기체의 확산계수)

  • Kim, Sang-Nam
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.64 no.3
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    • pp.125-129
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    • 2015
  • Energy distribution function for electrons in SF6-Ar mixtures gas used by MCS-BEq algorithm has been analysed over the E/N range 30~300[Td] by a two term Boltzmann equation and a Monte Carlo Simulation using a set of electron cross sections determined by other authors experimentally the electron swarm parameters for 0.2[%] and 0.5[%] $SF_6-Ar$ mixtures were measured by time-of-flight(TOF) method, The results show that the deduced longitudinal diffusion coefficients and transverse diffusion coefficients agree reasonably well with theoretical for a rang of E/N values. The results obtained from Boltzmann equation method and Monte Carlo simulation have been compared with present and previously obtained data and respective set of electron collision cross sections of the molecules.