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Individual Bioequivalence Tests under 3 X 2 Design (3 X 2 교차설계법에서 개인 생물학적 동등성 검정)

  • Jung, Gyu-Jin;Lim, Nam-Kyoo;Park, Sang-Gue
    • The Korean Journal of Applied Statistics
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    • v.23 no.1
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    • pp.139-150
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    • 2010
  • In recent years, more generic drug products became available. The current regulation for assessing the bioequivalence of two drug formulations is based on the concept of average bioequivalence. This approach has been indicated to be insufficient for assessing switchability between two drug formulations and US FDA has adopted individual bioequivalence as one of the bioequivalence criterion since 2001. The US FDA recommends that individual bioequivalence be assessed based on $2\;{\times}\;4$ crossover design, while a $2\;{\times}\;3$ crossover design may be used as an alternative design to reduce the length and cost of the study. In this paper, a statistical procedure for assessment of individual bioequivalence under $3\;{\times}\;2$ crossover designs is proposed and some statistical points are discussed with $2\;{\times}\;3$ crossover design and $2\;{\times}\;3$ extra-reference design through simulation studies.

Experimental Results of New Ion Source for Performance Test

  • Kim, Tae-Seong;Jeong, Seung-Ho;Jang, Du-Hui;Lee, Gwang-Won;In, Sang-Yeol
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.269-269
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    • 2012
  • A new ion source has been designed, fabricated, and installed at the NBTS (Neutral Beam Test Stand) at the KAERI (Korea Atomic Energy Research Institute) site. The goalis to provide a 100 keV, 2MW deuterium neutral beam injection as an auxiliary heating of KSTAR (Korea Super Tokamak Advanced Research). To cope with power demand, an ion current of 50 A is required considering the beam power loss and neutralization efficiency. The new ion source consists of a magnetic cusp bucket plasma generator and a set of tetrode accelerators with circular copper apertures. The plasma generator for the new ion source has the same design concept as the modified JAEA multi-cusp plasma generator for the KSTAR prototype ion source. The dimensions of the plasma generator are a cross section of $59{\times}25cm^2$ with a 32.5 cm depth. The anode has azimuthal arrays of Nd-Fe permanent magnets (3.4 kG at surface) in the bucket and an electron dump, which makes 9 cusp lines including the electron dump. The discharge properties were investigated preliminarily to enhance the efficiency of the beam extraction. The discharge of the new ion source was mainly controlled by a constant power mode of operation. The discharge of the plasma generator was initiated by the support of primary electrons emitted from the cathode, consisting of 12 tungsten filaments with a hair-pin type (diameter = 2.0 mm). The arc discharge of the new ion source was achieved easily up to an arc power of 80 kW (80 V/1000 A) with hydrogen gas. The 80 kW capacity seems sufficient for the arc power supply to attain the goal of arc efficiency (beam extracted current/discharge input power = 0.8 A/kW). The accelerator of the new ion source consists of four grids: plasma grid (G1), gradient grid (G2), suppressor grid (G3), and ground grid (G4). Each grid has 280 EA circular apertures. The performance tests of the new ion source accelerator were also finished including accelerator conditioning. A hydrogen ion beam was successfully extracted up to 100 keV /60 A. The optimum perveance is defined where the beam divergence is at a minimum was also investigated experimentally. The optimum hydrogen beam perveance is over $2.3{\mu}P$ at 60 keV, and the beam divergence angle is below $1.0^{\circ}$. Thus, the new ion source is expected to be capable of extracting more than a 5 MW deuterium ion beam power at 100 keV. This ion source can deliver ~2 MW of neutral beam power to KSTAR tokamak plasma for the 2012 campaign.

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Development of the Structure for Enhancing Capillary Force of the Thin Flat Heat Pipe Based on Extrusion Fabrication (압출형 박판 히트파이프의 모세관력 향상을 위한 구조 개발)

  • Moon, Seok Hwan;Park, Yoon Woo
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.40 no.11
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    • pp.755-759
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    • 2016
  • The use of heat pipes in the electronic telecommunication field is increasing. Among the various types of heat pipes, the thin flat heat pipe has relatively high applicability compared with the circular heat pipe in the electronic packaging application. The thin flat heat pipe based on extrusion fabrication has a simple capillary wick structure consisting of rectangular cross sectional grooves on the inner wall of the pipe. Although the groove serves as a simple capillary wick, and many such grooves are provided on the inner wall, it is difficult for the grooves to realize a sufficiently high capillary force. In the present study, a thin flat heat pipe with a wire bundle was developed to overcome the drawback of poor capillary force in the thin flat heat pipe with grooves, and was evaluated by conducting tests. In the performance test, the thin flat heat pipe with the wire bundle showed a lower thermal resistance of approximately 3.4 times, and a higher heat transfer rate of approximately 3.8 times with respect to the thin flat heat pipe with grooves as the capillary wick respectively. The possibility of using the wire bundle as a capillary wick in the heat pipe was validated in the present study; further study for commercializing this concept will be taken up in the future.

A Study on Construction Manner of City Wall Parks in China Beijing (북경의 성곽역사공원 조성방식 연구)

  • Li, Ao-Fei;Kang, Tai-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.33 no.4
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    • pp.129-139
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    • 2015
  • Parks in order to find the inspiration and implication from their construction. The research is focused on a few cross-sectional city wall parks, which are Huangchenggen city wall park, Ming city wall park and Yuandadu city wall park. to come to the conclusion, it defines the generic concept of city wall park, clarifies the transitional process of the city of Beijing, organize the current situation and basis of the construction of the Beijing city wall parks. besides, by analyzing the Beijing city wall parks' specific construction manners including the basis of their planning, the support by government, planning functionality, landscape theme arrangement and gardening arrangement, the research puts forwards their construction characters and drawbacks. through comprehensive analysis on the aspects above, a series of inspirations are obtained for the construction of city wall parks. these include: specialized and legally valid regulation systems need to be setup before planning; government and citizens' proactive support is necessary for the protection of ancient city wall ruins and the construction of the city wall parks; when planning, existing situation should be utilized to the maximum extent, efficiency of space usage should be improved through smooth connection between different spacial locations.

Does Cultural Intelligence enhance Export SME's Capability for Utilizing Foreign Market Informations? (문화 인텔리전스는 수출중소기업의 해외시장정보 활용능력을 키우는가?)

  • Hong, Songhon
    • International Commerce and Information Review
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    • v.19 no.1
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    • pp.127-152
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    • 2017
  • One of the biggest challenges in export activities of SME is the increasingly cultural diversity that requires especially export managers to adapt their doing business in many different kinds of cross-cultural situations effectively. A relative newly developed concept 'Cultural Intelligence' has been evaluated as a key element for the success in international business activities. This study aims to investigate empirically the role of Cultural Intelligence(CQ), one component of cultural competence, on export marketing adaptation. The statistical method used to test the hypotheses was Structural Equation Modeling using PLS. The results of this study are follows. The moderating role of Cultural Intelligence between information seeking and information using abilities is more stronger in marketing rather than relationship adaptation. Cultural Intelligence moderates between them. Critical factors affecting Cultural Intelligence are also discussed; foreign language fluency, business travels in abroad, characteristics of the business travels, multi-lingual ability, pre-education related cultural subjects, and visit experience in foreign countries. Especially, export managers' foreign language ability leads to much stronger influence on cultural intelligence. The result of the empirical study provides important implications for export SME and export supporting organizations. Export firms and supporting organizations must expand programs widely in multi cultural training and education to help managers gain a better understanding in a various export environment.

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Migration, Gender and Scale: New Trends and Issues in the Feminist Migration Studies (이주, 젠더, 스케일: 페미니스트 이주 연구의 새로운 지형과 쟁점)

  • Jung, Hyun-Joo
    • Journal of the Korean Geographical Society
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    • v.43 no.6
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    • pp.894-913
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    • 2008
  • This study examines scale issues in the contemporary feminist migration literature. Scale appears as important, yet poorly understood concept in this field of study. The increasing attention to the feminization of migration requires not only gendered, but also scalar-sensitive approaches. Feminists criticize the conventional approach to the migration as a gender-blind approach that privileges national scale around which migration processes are organized. Claiming multiscalar and interscalar analyses, they propose investigations ranging from macro to micro processes which include globalized gendered division of labor, transnational family networks, and reproduction which takes place in and through the bodies and homes of migrant women. The migrant women, the major actors in recent transnational migration, cross various borders: the national boundaries and the public and private divides, in particular. This crossover can unsettle patriarchal gender relations which have been established based on the physical and symbolic division of nation-states and public/private spheres. Blurring these divisions accompanies social construction of various scales. The transnational family networks of migrant women, for example, show the construction of a transnational scale by migrant women as well as globalization from below. This paper points out misunderstandings of scale in the feminist migration literature and attempts to fill the gaps by introducing the meanings and implications of scales developed mostly by feminist geographers. In so doing, it promotes the interdisciplinary communication.

Evaluation of Partial Safety Factors for Tetrapod Armor Blocks Depending on the Shape Parameter of Extreme Wave Height Distributions (극치파고분포의 형상 모수에 따른 Tetrapod 피복블록의 부분안전계수 산정)

  • Kim, Seung-Woo;Suh, Kyung-Duck;Lee, Dong-Young;Jun, Ki-Cheon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.1B
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    • pp.59-69
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    • 2012
  • Probabilistic design is required to effectively consider the coastal environment of great uncertainty. However, designers who are familiar with the deterministic design method prefer a method which is similar to the existing method but is based on the probabilistic concept. Therefore, the partial safety factor method has been adopted as a new design method over the world. In Korea, Tetrapod is widely used for armoring rubble mound breakwaters. Even though the partial safety factor method developed in the United States and Europe covers Tetrapods, the limited wave and structure conditions in its development make the engineers hesitate about its use in practical breakwater design. In this study, partial safety factors for Tetrapod armor blocks have been developed by analyzing 116 breakwater cross-sections and wave conditions in 16 trade harbors and 15 coastal harbors with the FORM and optimal code calibration approach. Especially, partial safety factors have been proposed depending on the shape parameter of the Weibull extreme wave height distribution. For other types of extreme distributions, it is possible to apply the proposed partial safety factors using the relationship between skewness coefficient and shape parameter. Finally, the proposed partial safety factors have been applied to existing structures to show that they better satisfy the target reliability of the structures than previous partial safety factors.

Behavior Analysis of RMPM Applied Steel Frame Structures (반력모멘트를 이용한 라멘형 철골구조물의 거동분석)

  • Ahn, Jin Hee;Kim, Jun Hwan;Kim, Tae Yeon;Kim, Sang Hyo;Lee, Sang Woo
    • Journal of Korean Society of Steel Construction
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    • v.19 no.6
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    • pp.611-620
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    • 2007
  • The beam-column connection is the critical design section of general steel frame structures owing to the behavioral characteristics of the structural system. As most members of a frame structure are composed of rolled section beams, the cross-section of the beam members is governed by the negative bending moment near beam-column connections. Such a design concept leaves a redundant load-carrying capacity at the positive bending regions of the beam members leading to design inefficiency. Therefore, it is of utmost importance to redistribute the beam end moments and reduce the stresses at the beam-column connections for a more efficient design of steel frame structures. In this study, reaction-moment prestressing method (RMPM) was proposed for the innovative design and construction of steel frame structures. The RMPM is a prestressing method utilizing the elastic bending deformation of a beam member induced by temporary prestressing for the distribution of a relatively large bending moment to other sections for the efficient use of the beam section. By the application of the RMPM, the negative bending moment at the beam-column connections can be significantly reduced, ultimately leading to possible use of smaller beam sections. Through a series of model tests and numerical analyses of steel frame structures, the moment distributing effect and feasibility of the RMPM was verified.

XML-based Single Sign-On Scheme for Internet Protocol TV(IPTV)Services (IPTV 서비스 제공을 위한 XML 기반의 단일인증 구조)

  • Lee, Seung-Hun;Shin, Dong-Il;Shin, Dong-Kyoo
    • Journal of Broadcast Engineering
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    • v.14 no.4
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    • pp.463-474
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    • 2009
  • By employing the subscriber concept in broadcasting services, IPTV (Internet Protocol Television) operators provide various grades of services to subscribers based on the billing level of the subscribers. With the income from subscribers for a basis, IPTV operators plan to provide high quality services. Since Web browser-based IPTV provides T-commerce and E-commerce services as well as television services, users may frequently visit other service domains to buy goods or content. To provide the user with charged or private services, these service domains request authentication of user. The existing authentication system is not appropriate for the IPTV service environment because the environment unavoidably forces the user to cross from one authentication-based service domain to another. Single sign-on provides a user with transparent authentication services by enabling an authenticated user to move between authentication-based service domains without any re-authentication. Like this distributed environment, since the IPTV service environment also provides a variety of authentication-based services, transparent authentication service needs to be provided to subscribers who want to access charged or private services. In this paper, we propose a new user authentication scheme for the IPTV environment. This scheme integrates the Security Assertion Markup Language (SAML), which is a standard for XML-based single sign on. We validate this scheme using a simple use case scenario.

The Effects of Management Consulting Quality and Consultant Capability on Entrepreneurial Firms' Performance (창업기업의 경영성과에 있어서 컨설팅품질과 컨설턴트역량의 영향에 대한 연구: 흡수능력과 자원역량의 매개효과를 중심으로)

  • Yoon, Ki-Chang
    • Journal of Distribution Science
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    • v.14 no.5
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    • pp.81-89
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    • 2016
  • Purpose - Prior researches have empirically focused on the effect of management consulting quality and consultant capability on entrepreneurial firms' performance. This study, however, focused on investigating the moderating role of absorptive capacity and resource capability between management consulting and entrepreneurial firms' performance. So, this study investigated the relationship among consulting quality, consultant capability, absorptive capacity, resource capability, and entrepreneurial firms' performance from the resource based view (RBV). Especially, this study focused on the mediating role of absorptive and resource capability in relational structure of entrepreneurial firms' dimensions. Research design, data, and methodology - In this study, research hypotheses and model are established by the prior researches from the fields of strategic management and entrepreneurial behavior. Concretely, H1~H4 are the relationship between consulting (consulting quality, consultant capability) and innovation (absorptive capacity, resource capability); H5 is the relationship between absorptive capacity and resource capability; and H6~H7 are the relationship between innovation (absorptive capacity, resource capability) and management performance. The data was collected 207 copies from entrepreneurial firms in South Korea. These firms were established in January 2014 and maintained by November 2015 in high-tech industry. The questionnaire was consisted of five dimensions; consulting quality, consultant capability, absorptive capacity, resource capability, and management performance. Each dimension measured multi items on a 5-point Likert scale. The hypotheses and research model are analyzed using structural equation modeling (SEM) with AMOS 22. Results - The results of this study are as follows. 1) Consulting quality significantly influenced on the absorptive capacity of entrepreneurial firms. 2) But, consultant capability did not influence on the absorptive capacity of entrepreneurial firms. 3) Consulting quality and consultant capability significantly influenced on the resource capability of entrepreneurial firms. 4) Absorptive capacity significantly influenced on the resource capability of entrepreneurial firms; 5) Absorptive capacity did not significantly influence on the management performance of entrepreneurial firms. 6) Resource capability, however, significantly influenced on the management performance of entrepreneurial firms. By these results, absorptive capacity of entrepreneurial firms had a mediating role partly among consulting quality, consultant capability, and management capability. The resource capability of entrepreneurial firms had a mediating role among consulting quality, consultant capability, and management capability, perfectly. Conclusions - According to this study, the high level of consulting quality and consultant capability may enforce the resource capability of entrepreneurial firms. It means, practically, that external knowledge is a driver for innovation, and then the innovation effects on the management performance of entrepreneurial firms. So, at the initial stage, the management consulting programs are very important to entrepreneurial firms and should be conceived as an essential element. This study may contribute to the advancement of academic in field of new start business, small business, or venture business based on resources, especially the role of absorptive capacity and resource capability between consulting programs and management performance. However, this study has some limitations. They are the measurement of consulting quality's items, cross-sectional research, and the limitation of concept and industry.