• Biomolecules & Therapeutics
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• v.10 no.2
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• pp.124-128
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• 2002

Hantaan (HTN) and Puumala (PUU) viruses are major etiological agents of hemorrhagic fever with renal syndrome (HFRS), an important public health problem in Korea after the Korean War. The objective of present study was to determine allergenic potency of an inactivated combination vaccine against HTN and PUU viruses inflection. As a series of allergenicity assessment, a homologous active systemic anaphylaxis (ASA) and homologous/heterologous passive cutaneous anaphylaxis (PCA) tests using the mice and guinea pigs were carried out. In the ASA test, no anaphylactic symptoms were observed in the guinea pigs sensitized with the vaccine alone as well as the vaccine emulsified with an adjuvant. By homologous PCA test, the vatscine did not induced the potential IgE antibody production in the sera obtained from the sensitized guinea pigs. In addition, IgE against the vaccine was not significantly enhanced from the mice inoculated with the vaccine, which was judged by the heterologous PCA test in rats. On the other hand, the inoculation of ovalbumin appeared to allergenic reactions both in the ASA and PCA tests. The results suggest that a combination vaccine against HW and PUU viruses have no allergenic potential in mice or guinea pigs.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.10.1-10.14
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• 2020

Immune checkpoint inhibitors (ICIs) have shown remarkable benefit in the treatment of patients with non-small-cell lung cancer (NSCLC) and have emerged as an effective treatment option even in the first-line setting. ICIs can block inhibitory pathways that restrain the immune response against cancer, restoring and sustaining antitumor immunity. Currently, there are 4 PD-1/PD-L1 blocking agents available in clinics, and immunotherapy-based regimen alone or in combination with chemotherapy is now preferred option. Combination trials assessing combination of ICIs with chemotherapy, targeted therapy and other immunotherapy are ongoing. Controversies remain regarding the use of ICIs in targetable oncogene-addicted subpopulations, but their initial treatment recommendations remained unchanged, with specific tyrosine kinase inhibitors as the choice. For the majority of patients without targetable driver oncogenes, deciding between therapeutic options can be difficult due to lack of direct cross-comparison studies. There are continuous efforts to find predictive biomarkers to find those who respond better to ICIs. PD-L1 protein expressions by immunohistochemistry and tumor mutational burden have emerged as most well-validated biomarkers in multiple clinical trials. However, there still is a need to improve patient selection, and to establish the most effective concurrent or sequential combination therapies in different NSCLC clinical settings. In this review, we will introduce currently used ICIs in NSCLC and analyze most recent trials, and finally discuss how, when and for whom ICIs can be used to provide promising avenues for lung cancer treatment.

• Korean Journal of Agricultural Science
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• v.45 no.3
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• pp.385-400
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• 2018

Marker-assisted backcrossing (MABC) is useful for selecting offspring with a highly recovered genetic background for a recurrent parent at early generation unlike rice and other field crops. Molecular marker sets applicable to practical MABC are scarce in vegetable crops including tomatoes. In this study, we used the National Center for Biotechnology Information- short read archive (NCBI-SRA) database that provided the whole genome sequences of 234 tomato accessions and selected 27,680 tag-single nucleotide polymorphisms (tag-SNPs) that can identify haplotypes in the tomato genome. From this SNP dataset, a total of 143 tag-SNPs that have a high polymorphism information content (PIC) value (> 0.3) and are physically evenly distributed on each chromosome were selected as a MABC marker set. This marker set was tested for its polymorphism in each pairwise cross combination constructed with 124 of the 234 tomato accessions, and a relatively high number of SNP markers polymorphic for the cross combination was observed. The reliability of the MABC SNP set was assessed by converting 18 SNPs into Luna probe-based high-resolution melting (HRM) markers and genotyping nine tomato accessions. The results show that the SNP information and HRM marker genotype matched in 98.6% of the experiment data points, indicating that our sequence analysis pipeline for SNP mining worked successfully. The tag-SNP set for the MABC developed in this study can be useful for not only a practical backcrossing program but also for cultivar identification and F1 seed purity test in tomatoes.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.2
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• pp.122-128
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• 2010

To meet the NOx limit without a penalty of fuel consumption, urea-SCR system is currently regarded as promising NOx reduction technology for diesel engines. SCR system has to achieve maximal NOx conversion in combination with minimal $NH_3$ slip. In this study, the performance characteristics of urea-SCR system with open loop control were assessed in the European Transient Cycle(ETC) for heavy duty diesel engine. The SCR inlet temperaure varied in the range of 200 to $340^{\circ}C$ in the ETC cycle. Open loop control calculated the urea flow rate based on the NOx and NSR map which gave for each combination of SCR inlet temperature and space velocity the normalized $NH_3$ to NOx stoichiometric ratio which resulted in a steady-state $NH_3$ slip of 20ppm. During the ETC cycle, the open loop control with the optimized NSR offset achieved NOx reduction of 80% while keeping the average $NH_3$ slip below 10ppm and maximum 20ppm. It was also found that NOx sensor was cross-sensitive to $NH_3$ and a control strategy for cross-sensitivity compensation was required in order to use a NOx sensor as feedback device.

• Journal of Digital Contents Society
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• v.17 no.1
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• pp.33-41
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• 2016

This study aims to suggest practical ways to interact effectively with consumers based on current situation of 'media creative' and media use patterns. Cases of digital signage are reviewed in the perspective of cross media, and the strategic meanings of cross media are explored according to interactivity. Results are collected through 'Naver' search engine service, and can be possibly assorted into five media combined types: SNS-combined, QR codes or Augmented Reality(AR)-combined, Brand App(application)-combined, Online to Offline-combined, and Behavioral factors-combined ones. Some strategic suggestions on media creative are given for effective interaction with consumers.

• Korean journal of applied entomology
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• v.40 no.4
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• pp.321-326
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• 2001

Contribution of Wolbachia infection to fitness of a species (developmental time, adult life span, fecundity and ovipositional period) was measured in the susceptible and dicofol-resistant strains of two spotted spider mite, Tetranychus urticae Koch, on miniature roses. Based on ftsZPCR assay, Wolbachia infection was confirmed only in the susceptible strain. The susceptible strain had significantly higher fecundity (eggs/female) and shorter developmental times than the resistant strain. Longer adult life span and ovipositional period were observed in the susceptible strain. Fitness differences were appeared to influence dicofol resistance development. Similar measurements were performed with progeny from two reciprocal $F_1$crosses. Similar to other examples of cytoplasmic incompatibility induced by Wolbachia, subsequent cross between uninfected female and infected male spider mites were different from the other combination: a high egg mortality and a male-biased sex ratio. When the intrinsic rate of natural increase was calculated, the cross between uninfected female and infected male spider mites had a significantly lower rate($0.09\pm$0.01) than did the other combination ($0.20\pm$0.01). These results suggest that the dynamic and evolution of the fitness are closely associated with dicofol resistance and Wolbachia infection in the two spotted spider mites.

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.456-459
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• 2011

Among the various activated carbons available in the market, an optimum mixing method of two kind activated carbons with different adsorbability was investigated in this study. The representative adsorption behaviors of the activated carbon are the adsorption isotherm plots obtained by the BET-Analysis which suggests also basic information of adsorption filter design. So we have tested three cases with certifications, the one was the extreme case of coal cokes based activated carbon with highest BET-model and coconut-shell based activated carbon with the lowest Langmuir-model, the other middle and cross case were applied this method to two kinds of activated carbons with higher and lower specific surface areas which are not available but supplied as research samples by an authority of an Korean Research Institute.

• Journal of Integrative Natural Science
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• v.6 no.1
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• pp.34-38
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• 2013

Tributyltin hydride ($n-Bu_3SnH$), an endocrine disruptor, was slowly polymerized by the group 4 ${Cp^{\prime}}_2TiCl_2/N$-selectride (Cp' = $C_5H_5$, Cp; $Me-C_5H_4$, Me-Cp; $Me_5C_5$, $Cp^*$) catalyst combination to give two phases of products: one is an insoluble cross-linked solid, polystannane in 3-25% yield as minor product via disproportionation/dehydrocoupling combination process, and the other is an oil, hexabutyldistannane in 65-90% yield as major product via simple dehydrocoupling process. Disproportionation/dehydrocoupling process first produced a low-molecular-weight oligostannane possessing partial backbone Sn-H bonds which then underwent an extensive cross-linking reaction of backbone Sn-H bonds, resulting in the formation of an insoluble polystannane. The disproportionation/dehydrocoupling of a tertiary hydrostannane mediated by early transition metallocene/inorganic hydride is quite unusual and applicable.

• Cross-Cultural Studies
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• v.25
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• pp.237-265
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• 2011

This thesis is to argue what is the meaning of the expression of cherry blossoms appearing in "Genjimonogatari(源氏物語)" in relation with the structure of Monogatari after checking each example. First we reviewed some examples of the works before "Genjimonogatari", and clarified that cherry blossoms were used as metaphorical expressions of a beautiful woman in waka(和歌), and that at the same time cherry blossoms functioned as the symbol of futility, anxiety together with beauty. Especially in "Kokinshu(古今集)" we identified that there increased the examples where the combination of the expression as falling cherry blossoms, and fog and cherry blossoms was done. In "Genjimonogatari" we examined the examples of cherry blossoms of Chapter 1, Chapter 2, and clarified that Murasakinoue(紫の上) was a woman with an ideal character in looks and inner personality through the diverse viewpoints of characters. In Monogatari of Kashiwagi(柏木) of Chapter 2, the scene where he peeped Onnasannomiya(女三宮) was composed by the combination of cherry blossoms and fog, and we pointed out that we could feel the anxiety, ominousness of the love of the couple through this scene. And the composition of these scenes was also repeated in Monogatari of Chapter 3, and we discussed through these examples that the figurative expressions of cherry blossoms were used about the object of the love not to be realized. Next, we checked that Yugiri(夕霧) who had observed Kashiwagi's love toward Onnasannomiya gave a figurative expression of Kashiwagi's wife Ochibanomiya(落葉の宮) as cherry blossoms. Although Genji(源氏) realized Onnasannomiya's immaturity, Kashiwagi compared her to "cherry blossoms", and Yoogiri compared the woman whom Kashiwagi recognized as "Ochiba(落葉)" to "cherry blossoms", through which we have read the twisted human relation and ironical structure of Chaper 2. Finally, we checked the examples of cherry blossoms in Ooigimi(大君), Nakanokimi(中君), Ukihune(浮舟) who were Ujijujo's heroines. Ooigimi and Nakanokimi were expressed as cherry blossoms by Kaoru(?) and Nioumiya(?宮) and were disclosed as their ideal women. In contrast, Ukihune had something to do with two men with no such figurative expression, so it was pointed out that the absence of such metaphorical expression clarified that the meaning of her existence was nothing but the meaning as a mesiudo(召人).

• Journal of The Geomorphological Association of Korea
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• v.27 no.2
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• pp.1-17
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• 2020

This study evaluated a debris landform distribution potential area map in the southwest region of the Korean peninsula. A GIS spatial integration technique and logistic regression method were used to produce a distribution potential area map. Seven topographic and environmental factors were considered for analysis and 28 different data set were combined and used to get most effective results. Moreover, in an accuracy assessment, the extracted results of the Distribution Potential area were evaluated by conducting a cross-validation module. Block stream showed the highest accuracy in the combination No. 6, and that DEM (digital elevation model) and TWI (topographic wetness index) have relatively high influences on the production of the Block stream Distribution Potential area map. Talus showed the highest accuracy in the combination No. 13. We also found that slope, TWI and geology have relatively high influences on the production of the Talus Distribution Potential area map. In addition, fieldwork confirmed the accuracy of the input data that were used in this study, and the slope and geology were also similar. It was also determined that these input data were relatively accurate. In the case of angularity, the block stream was composed of sub-rounded and sub-angular systems and Talus showed differences according to the terrain formation. Although the results of the rebound strain measurement using a Schmidt's hammer did not shown any difference in topographic conditions, it is determined that the rebound strain results reflected the underlying geological setting.