• 자동차안전학회지
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• 제9권3호
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• pp.7-12
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• 2017

The whiplash is the most important issue of low speed rear-impact. So auto makers are committed to developing a seat to improve whiplash injury. Most NCAP tests have been used by same pulse (Mid Velocity 16kph). Only Euro NCAP uses different pulse that consists of Low, Mid, High velocity. But Euro NCAP also uses same pulse in Mid velocity as other NCAP test. That Mid velocity NCAP pulse was made by rear impact that has 90's vehicle structure properties. That pulse was used until now days. However these days, auto maker use more high tensile steel than 90's as customer and society demand more fuel efficiency and light vehicle with good safety structure. So modern vehicles have different pulse patterns of rear impact than NCAP pulse and 90's vehicle crash properties. In this paper, the test was conducted by following condition. Target car was impacted by the rigid barrier with certain velocity. Finally target vehicle gained delta V 16kph which was same velocity as NCAP Mid Velocity pulse. It is critical velocity which occur long period neck injury. It is very different pulse that was gained by real car impact from NCAP pulse. And it has higher peak G with high fluctuation and short duration than NCAP pulse.

• BMB Reports
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• 제48권7호
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• pp.369-370
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• 2015

Actin dynamics is critical for the formation and sustainment of the immunological synapse (IS) during T cell interaction with antigen-presenting cells (APC). Thus, many actin regulating proteins are involved in spatial and temporal actin remodeling at the IS. However, little is known whether or how actin stabilizing protein controls IS and the consequent T cell functions. TAGLN2 − an actin-binding protein predominantly expressed in T cells − displays a novel function to stabilize cortical F-actin, thereby augmenting F-actin contents at the IS, and acquiring leukocyte function-associated antigen-1 activation following T cell activation. TAGLN2 also competes with cofilin to protect F-actin in vitro and in vivo. During cytotoxic T cell interaction with cancer cells, the expression level of TAGLN2 at the IS correlates with the T cell adhesion to target cancer cells and production of lytic granules such as granzyme B and perforin, thus expressing cytotoxic T cell function. These findings identify a novel function for TAGLN2 as an actin stabilizing protein that is essential for stable immunological synapse formation, thereby regulating T cell immunity. [BMB Reports 2015; 48(7): 369-370]

• 한국물환경학회지
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• 제29권1호
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• pp.36-44
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• 2013

HSPF model based on BASINS was applied to analyze effects of watershed management measures for water quality conservation in the Hwaseong Reservoir watershed. The model was calibrated against the field measurements of meteorological data, streamflow and water qualities ($BOD_5$, T-N, T-P) at each observatory for 4 years (2007-2010). The water quality characteristics of inflow streams were evaluated. The 4 scenarios for the water quality improvement were applied to inflow streams and critical area from water pollution based on previous researches. The reduction efficiency of point and non-point sources in inflow streams was evaluated with each scenario. The results demonstrate that the expansion of advanced treatment system within wastewater treatment plants (WWTPs) and construction of pond-wetlands would be great effective management measures. In order to satisfactory the target water quality of reservoir, the measures which can control both point source and non-point source pollutants should be implemented in the watershed.

• Journal of Communications and Networks
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• 제9권4호
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• pp.473-481
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• 2007

Energy efficiency is one of the most critical concerns for wireless sensor networks. By allowing sensor nodes in close proximity to cooperate in transmission to form a virtual multiple-input multiple-output(MIMO) system, recent progress in wireless MIMO communications can be exploited to boost the system throughput, or equivalently reduce the energy consumption for the same throughput and BER target. However, these cooperative transmission strategies may incur additional energy cost and system overhead. In this paper, assuming that data collectors are equipped with antenna arrays and superior processing capability, energy efficiency of relevant traditional and cooperative transmission strategies: Single-input-multiple-output(SIMO), space-time block coding(STBC), and spatial multiplexing(SM) are studied. Analysis in the wideband regime reveals that, while receive diversity introduces significant improvement in both energy efficiency and spectral efficiency, further improvement due to the transmit diversity of STBC is limited, as opposed to the superiority of the SM scheme especially for non-trivial spectral efficiency. These observations are further confirmed in our analysis of more realistic systems with limited bandwidth, finite constellation sizes, and a target error rate. Based on this analysis, general guidelines are presented for optimal transmission strategy selection in system level and link level, aiming at minimum energy consumption while meeting different requirements. The proposed selection rules, especially those based on system-level metrics, are easy to implement for sensor applications. The framework provided here may also be readily extended to other scenarios or applications.

• Structural Engineering and Mechanics
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• 제37권6호
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• pp.575-592
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• 2011

For seismic resistant design of critical structures, a dynamic analysis, either response spectrum or time history is frequently required. Owing to the lack of recorded data and the randomness of earthquake ground motion that may be experienced by structure in the future, usually it is difficult to obtain recorded data which fit the requirements (site type, epicenteral distance, etc.) well. Therefore, the artificial seismic records are widely used in seismic designs, verification of seismic capacity and seismic assessment of structures. The purpose of this paper is to develop a numerical method using Artificial Neural Network (ANN) and wavelet packet transform in best basis method which is presented for the decomposition of artificial earthquake records consistent with any arbitrarily specified target response spectra requirements. The ground motion has been modeled as a non-stationary process using wavelet packet. This study shows that the procedure using ANN-based models and wavelet packets in best-basis method are applicable to generate artificial earthquakes compatible with any response spectra. Several numerical examples are given to verify the developed model.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.63-63
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• 2003

$\alpha$$_1$-Antityrpsin is a member of the serine protease inhibitor (SERPIN) family that shares a common tertiary structure. The reactive site loop (RSL) of serpins is exposed at one end of the molecule for protease binding. Upon cleavage by a target protease, the RSL is inserted into the major $\beta$-sheet A, which is a necessary process for formation of a tight inhibitory complex. Various biochemical and structural studies suggest that the rate of the RSL insertion upon binding a target protease is critical for inhibitory activity, and it is thought that helix F region (thFs3A and helix F) located in front of $\beta$-sheet A, should be lifted for the loop insertion during complex formation.

• 산업경영시스템학회지
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• 제41권2호
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• pp.74-83
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• 2018

It is very crucial activities that Korean army have to detect and recognize enemy's locations and types of weapon of their artillery firstly for effective operation of friendly force's artillery weapons during wartime. For these activities, one of the most critical artillery weapon systems is the anti-artillery radar (hereafter; radars) for immediate counter-fire operations against the target. So, in early wartime these radar's roles are very important for minimizing friendly force's damage because arbiters have to recognize a several enemy's artillery positions quickly and then to take an action right away. Up to date, Republic of Korea Army for tactical artillery operations only depends on individual commander's intuition and capability. Therefore, we propose these radars allocation model based on integer programming that combines ArcGIS (Geographic Information System) analysis data and each radar's performances which include allowable specific ranges of altitude, azimuth (FOV; field of view) and distances for target detection, and weapons types i.e., rocket, mortars and cannon ammo etc. And we demonstrate the effectiveness of their allocation's solution of available various types of radar asset through several experimental scenarios. The proposed model can be ensured the optimal detection coverage, the enhancement of artillery radar's operations and assisting a quick decision for commander finally.

• BMB Reports
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• 제37권2호
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• BMB Reports
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• 제51권3호
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• pp.126-133
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• 2018

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate activities of YAP/TAZ. Because YAP and TAZ are transcriptional coactivators that lack DNA-binding activity, both proteins must interact with DNA-binding transcription factors to regulate target gene's expression. To activate target genes involved in cell proliferation, TEAD family members are major DNA-binding partners of YAP/TAZ. Accordingly, YAP/TAZ were originally classified as oncogenes. However, YAP might also play tumor-suppressing role. For example, YAP can bind to DNA-binding tumor suppressors including RUNXs and p73. Thus, YAP might act either as an oncogene or tumor suppressor depending on its binding partners. Here, we summarize roles of YAP depending on its DNA-binding partners and discuss context-dependent functions of YAP/TAZ.

• 한국군사과학기술학회지
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• 제15권4호
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• pp.374-380
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• 2012

In guided missile systems, reducing terminal-position error is the primary objective of the inertial navigation system. As a seeker is used to sense and track a target, the critical function of the inertial navigation system is to provide the seeker with accurate missile attitude information and help the seeker to keep tracking a target continuously. As inertial sensor body and missile body alignment errors are taken into account, it is desirable to minimize the alignment errors between the missile seeker and the attitude of inertial navigation system. Among the alignment errors, this paper addresses the methods of measuring and compensating misalignment between inertial sensor body and housing frame and shows test results of several experiments.