• Journal of Yeungnam Medical Science
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• 제38권2호
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• pp.83-94
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• 2021

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2002년도 Proceedings of the International Welding/Joining Conference-Korea
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• pp.145-150
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• 2002

It has been well known that ductile fracture of steels is accelerated by triaxial stresses. The characteristics of ductile crack initiation in steels are evaluated quantitatively using two-parameters criterion based on equivalent plastic strain and stress triaxiality. It has been demonstrated by authors using round-bar specimens with circumferential notch in single tension that the critical strain to initiate ductile crack from specimen center depends considerably on stress triaxiality, but surface cracking of notch root is in accordance with constant strain condition. In order to evaluate the stress/strain state in the specimens, especially under dynamic loading, a thermal, elastic-plastic, dynamic finite element (FE) analysis considering the temperature rise due to plastic deformation has been carried out. This study provides the fundamental clarification of the effect of strength mismatching, which can elevate plastic constraint due to heterogeneous plastic straining, loading mode and loading rate on critical condition to initiate ductile crack from notch root using equivalent plastic strain and stress triaxiality based on the two-parameter criterion obtained on homogeneous specimens under static tension. The critical condition to initiate ductile crack from notch root for strength mismatched bend specimens under both static and dynamic loading would be almost the same as that for homogeneous tensile specimens with circumferential sharp notch under static loading.

• 한국정밀공학회지
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• 제15권6호
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• pp.159-166
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• 1998

The problem of interface crack in the bonded structures has received a great deal of attention in recent years. In this paper the aluminum bonded single lap-joint containing the interface edge crack is investigated. The tensile load and the average shear stress of the adhesive joints which have different crack length are obtained from the static tensile tests. The critical value of crack length to provoke the interface fracture is determined to a/L=0.4, where a is the interface crack length and L is the adhesive lap-length. The fracture mechanical parameters are introduced to confirm the existence of the critical crack length. The compliance and the stress intensity factors are calculated using the displacement and the stress near the interface crack tip by the boundary element method. These numerical results support the experimental results that the critical value of a/L is 0.4. It is known that the compliance and the stress intensity factors are the efficient parameters to estimate the bonded single lap-joint containing the interface edge crack.

• Structural Engineering and Mechanics
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• 제90권2호
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• pp.177-187
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• 2024

In this study, compared two distinct estimation methods (stress charts and regression equations) proposed by the Indian road congress design guideline (IRC:58-2015) to determine flexural stress in Jointed Plain Concrete Pavement (JPCP). The occurrence of critical flexural stresses in pavement slabs is due to the combined effects of wheel loads and temperature. These stresses depend on various factors such as material properties of concrete, soil-subgrade strength, loading, and geometric properties of the slab. In order to account for the practical variability of these factors, critical edge stresses are determined using both methods and compared considering tied concrete shoulder. IRC:58 (2015) suggests, the stresses calculated by both the procedures should provide the same results. However, when these stresses are compared for the same configurations and same loading conditions, large variations are observed. The effect of tied concrete shoulder on reduction in critical edge stress is observed. Based on the study, certain important conclusions and recommendations are presented.

• 한국도로학회논문집
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• 제8권3호
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• pp.143-153
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• 2006

본 연구는 콘크리트 도로 포장에 복륜 단축, 복륜 복축, 복륜 삼축 등 복륜 다축 하중이 포장의 중앙부와 모서리부에 작용할 때 포장의 응력 분포 및 최대 응력의 차이를 분석하고 이러한 응력의 차이가 콘크리트 탄성계수, 슬래브 두께, 그리고 지반 탄성계수에 따라 어떠한 특성을 갖는지를 분석하기 위하여 수행되었다. 변환영역에서의 해석법을 이용하여 중앙부 하중에 의한 응력을 구하였으며 유한요소법을 이용하여 모서리부 하중에 의한 응력을 구하였다. 여러 가지 변수에 대하여 중앙부 하중에 의한 최대 응력과 모서리부 하중에 의한 최대 응력을 비교하였으며 이러한 최대 응력 비율을 예측할 수 있는 공식을 개발하였다. 이러한 공식을 이용하여 중앙부 하중에 의한 최대 응력에서 모서리부 하중에 의한 최대 응력을 예측하여 최대 응력 비율 예측 공식의 정확성을 검증하였다. 연구결과 중앙부와 모서리부 하중에 의한 콘크리트 포장의 최대 응력 변화 경향은 매우 비슷하였으며 종방향 상의 최대 응력 발생 위치는 일치하였다. 모서리부 하중에 의한 최대 응력을 중앙부 하중에 의한 최대 응력으로 나눈 최대 응력 비율은 하중 축 수가 많아질수록 감소하며, 콘크리트 탄성계수가 증가, 슬래브 두께가 증가, 지반 탄성 계수가 감소, 그리고 하중 접지압이 증가할수록 커지게 된다.

• 대한기계학회논문집A
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• 제37권4호
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• pp.491-496
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• 2013

인장시험을 유한요소 시뮬레이션하여 등가응력-등가소성변형률 곡선, 임계 등가응력과 임계 등가소성변형률을 결정하였다. 그리고, 이 곡선을 입력하여 파괴시험을 유한요소 시뮬레이션하여 평면변형률 파괴인성치를 결정하여 보려고 하였다. 균열선단절점에서 등가소성변형률이 임계 등가소성변형률에 도달할 때 균열개구변위를 임계 균열개구변위로 취하여 균열성장조건으로 사용되었다. 임계 등가소성변형률이나 단면감소율과 파괴시험 임계 균열개구변위와 관련성을 찾아보고, 임계 등가응력과 임계 등가소성변형률을 동시에 적용하여 파괴시험 파괴인성치와의 관련성도 찾아보았다.

• 산업융합연구
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• 제18권4호
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• pp.77-86
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• 2020

본 연구는 간호대생의 비판적 사고성향, 임상실습 스트레스, 핵심기본간호술 자신감, 임상실습 적응 정도를 파악하는 서술적 조사연구이다. 2019년 6월부터 7월까지 간호대학생 4학년 207명에게 자가설문지를 통해 조사하였다. 수집된 자료는 SPSS/WIN v24.0을 이용하여 t-test, ANOVA와 다중회귀분석을 시행하여 분석하였다. 임상실습 스트레스와 비판적 사고성향은 음의 상관관계(r=-.18, p=.010)로 나타났다. 핵심기본간호술 수행자신감은 비판적 사고성향과 양의 상관관계(r=.25, p<.001), 임상실습 스트레스와 음의 상관관계(r=-.17, p=.017)를 나타냈다. 임상실습 스트레스는 임상실습 적응과 양의 상관관계(r=.44, p<.001)를 보였고, 임상실습 적응에 가장 큰 영향을 미치는 요인(β=.43)으로 나타났으며(F=18.34, p<.001), 설명력은 약 23.1%였다. 이상과 같이 임상실습 스트레스는 임상실습 적응에 영향을 미치는 요인으로, 간호대학생의 임상실습에서 받는 스트레스 요인들을 파악하고 교육과정 개발에 반영할 필요가 있다.

• Journal of Mechanical Science and Technology
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• 제18권11호
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• pp.1978-1988
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• 2004

Hybrid finite element analysis was used to analyze the influence of bearing stiffness on the static properties of a planetary gear system with manufacturing errors. The effects of changes in stiffness were similar for most of the manufacturing errors. State variables were most affected by the stiffness of the planet ,bearings. Floating either the sun or carrier helps to equal load sharing and minimizes the critical tooth stress. The effects of a floating sun and carrier are similar, but it is not recommended that both float, because this can induce greater critical tooth stress. Planet bearing stiffness should be optimized. Both load sharing and critical tooth stress should be considered to determine optimal bearing stiffness.

• 한국생산제조학회지
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• 제7권3호
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• pp.104-109
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• 1998

This document is a experimental study on fatigue life of brace mounting weld joint. A brace is used to put sub-frame together on the main frame with high strength bolts. It has low fatigue life so a patch is in need for improving a fatigue characteristics of welded joint in brace mounting This paper presents the most pertinent patch size for truck. For this, a critical stress is computed at the point of fatigue crack occurred on truck frame by finite Element Analysis. Using by this critical stress. Designers are able to determin whether fatigue crack is occurred and are able to select a pertinent patch type. And then, with a selected patch type, structural joint stiffness was estimated to compare to the conventional and other patch type or brace mounting Finally, fatigue test were performed to prove a suitability of selected prototype compare with the conventional and other patch type or brace mounting.

• 중환자간호학회지
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• 제12권1호
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• pp.22-35
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• 2019

Purpose : This study was to determine the levels of environmental stressor, posttraumatic stress disorder, and quality of life in intensive care units (ICU) survivors after intensive care, and to explore the factors affecting posttraumatic stress disorder and quality of life. Methods: With a longitudinal survey design, data were collected from 116 patients who were discharged from the ICU of a university hospital. The environmental stressor, posttraumatic stress disorder, and quality of life were measured immediately following and 1 month after the ICU discharge. Results: Of all the subjects, 16.4% experienced posttraumatic stress disorder after discharge. Multiple regression analysis revealed that ICU environmental stressors, experience of ICU readmission, using psychotropic drugs and narcotic analgesics, and ICU admission after surgery or cardiac intervention accounted for 22.2% of posttraumatic stress disorder. Posttraumatic stress disorder and sedation status when entering ICU accounted for 28.3% of the quality of life 1 month after ICU discharge. Conclusion: Nursing interventions focused on ICU environmental stressors would not only reduce environmental stress but also contribute to the reduction of posttraumatic stress disorder and later improvement of quality of life.