• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.6
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• pp.672-680
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• 2023

Weight is a critical factor in the ship design process given that it has a substantial impact on the hydrodynamic performance of ships. Typically, ships are optimally designed for specific conditions with a fixed draft and displacement. However, in reality, weight and draft can vary within a certain range owing to operational activities, such as fuel consumption, ballast adjustments, and loading conditions . Therefore, we investigated how resistance changes under three different loading conditions, namely overload, design-load, and lightship, for small craft, using both model experiments and numerical simulations. Additionally, we examined the sensitivity of weight changes to resistance to enhance the performance of ships, ultimately reducing power requirements in support of the International Maritime Organization's (IMO) goal of reducing CO2 emissions by 50% by 2050. We found that weight changes have a more significant impact at low Froude Numbers. Operating under overload conditions, which correspond to a 5% increase in draft and an 11.1% increase in displacement, can lead to a relatively substantial increase in total resistance, up to 15.97% and 14.31% in towing tests and CFD simulations, respectively.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2004.11a
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• pp.17-23
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• 2004

Not all individuals respond identically, or at times in the same direction, to dietary interventions. These inconsistencies likely arise because of diet and genomic interactions (nutrigenomics effects). A host of factors may influence the response to bioactive food components including specific polymorphisms (nutrigenetic effect), DNA methylation patterns and other epigenomic factors (nutritional epigenomic effects), capacity to induce anuo. suppress specific mRNA expression and patterns (nutritional transcriptomics), the occurrence and activity of proteins (proteomic effects), and/or the dose and temporal changes in cellular small molecular weight compounds will not only provide clues about specificity in response to food components, but assist in the identification of surrogate tissues and biomarkers that can predict a response. While this 'discovery' phase is critical for defining mechanisms and targets, and thus those who will benefit most from intervention, its true usefulness depends on moving this understanding into 'development' (interventions for better prevention, detection, diagnosis, and treatment) and a 'delivery' phase where information is provided to those most in need. It is incumbent on those involved with food and nutrition to embrace the 'omics' that relate to nutrition when considering not only the nutritional value of foods and their food components, but also when addressing acceptability and safety. The future of 'Nutrigenomics and Health Promotion' depends on the ability of the scientific community to identity appropriate biomarkers and susceptibility variants, effective communications about the merits of such undertakings with the health care community and with consumers, and doing all of this within a responsible bioethical framework.

• 연구논문집
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• s.27
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• pp.57-73
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• 1997

The bogie between the track and the railway vehicle body, is one of the most important component in railroad vehicle. Its effects on the safety of both passengers and vehicle itself, and on the overall performance of the vehicle such as riding quality, noise and vibration are critical. The bogie is mainly consisted of the bogie frame, suspensions, wheels and axles, braking system, and transmission system. The complex shapes of the bogie frame and the complicate loading condition (both static and dynamic) induced in real operation make it difficult to design the bogie frame fulfilling all the requirements. The complicated loads applied to the bogie frame are i) static load due to the weight of the vehicle and passengers, ii) quasi-static load due to the rolling in curves iii) dynamic load due to the relative motion between the track, bogie, and vehicle body. In designing the real bogie frame, fatigue analysis based on the above complicated loading conditions is a must. In this study, stress analysis of the bogie frame has been performed for the various loading conditions according to the UIC Code 6 15-4. Magnitudes of the stress amplitude and mean stress were estimated based on the stress analysis results to simulate the operating loads encountered in service. Fatigue strength of the bogie frame was evaluated by using the constant life diagram of the material. 3-D surface modelling, finite element meshing, and finite element analysis were performed by Pro-Engineer, MSC/PATRAN, and MSC/NASTRAN, respectively.

• CDE review
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• v.4 no.3
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• pp.26-31
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• 1998

Recent trend of popularity of CAE(Computer Aided Engineering) tools and its availability, partly contributed by significant price reduction of H/W and SW, makes us believe CAE has already established terra firma as de jure tools, enablint the design improvement in the manufacturing am. However, if your jobs are required to be working closely with engineers located in the front line of manufacturing site, CAE is observed far from popularity, still being regarded as exclusive tools for engineers holding advanced degrees. Conventional methodologies depending on knowledge that was accumulated thorough trial and errors, depending primarily on engineering tables and formulas or proprietary know-how, are preferred as the de factor standard under the roof of contemporary development shops. Samsung camera, having stared its business since early 、80, has accumulated enough technological strength to compete in the world market. As today's consumers demand more sophisticated featured-lighter weight, built-in multi zoom and miniature size fitting in the palm-from camera manufacturer, so should Samsung camera respond to ever-delicate consumer's needs with great flexibility. Consequently conventional designers, without sophisticated analytical tools, with encounter solving the critical design factors that have never been treated as seriousness-marginal safety factors induced by reduced size of parts. In the study, CAE results of boss and gears were demonstrated as examples, which confirms the facts that the simple analysis done by front line designers, can bring distinguishable effects on the potential improvements of design and on the consequential influences on the future design process-simulation before actual tooling and productions.

• Journal of Power System Engineering
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• v.18 no.2
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• pp.57-61
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• 2014

Due to the changes of marine transportation industry, it requires ship in larger scale and high speed. In order to operate efficiently, the engine should be work in high power and high horse power. The increase of the number of the propeller blades and the pitch of the screw and the weight, vibration of shafting problems occurs. To evaluate the safety of the system through analyzing the dynamic characteristics propulsion shafting system, was used to prove or to verify the Lalanne & Ferraris model validation.. It indicates that the Program through Campbell diagram and Critical speed map, Root rocus map, to ensure the reliability of the experimental model.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.12
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• pp.3767-3781
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• 1996

Generally, dynamic loads are applied to real structures. Since the analysis with the dynamic load is extremely difficult, static loads are utilized by proper conversions of the dynamic loads. The dynamic loads are usually converted ot static loads by safety foactors of experiences. However, it may increase weight and decrease reliability. In this study, a method is proposed for the conversion process. An equivalent static load is calculated ot generate a same maximum displacement. The method is verified through numerical tests on a spring-mass systems of one and multi degrees-of freedom. It has been found that the duration time of the loads and the natural frequencies of the structures are critical in the conversion process. A road arem is a self-propelled howizer is selected for the application of the proposed method. The shape of the road arm is optimized under the converted static loads.

• The Research Journal of the Costume Culture
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• v.27 no.1
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• pp.1-10
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• 2019

Firefighters wear Personal Protective Equipment (PPE) for protection from environmental hazards. However, due to the layers of protective functions, the PPE inevitably adds excessive weight, bulkiness, and thermal stress to firefighters. This study investigated the adverse impact of wearing PPE as an occupational stressor on the firefighter's cognitive functioning. Twenty-three firefighters who had been involved in firefighting at least for 1 year were recruited. The overall changing trend in the firefighter's cognitive functioning (short-term memory, long-term memory, and inductive reasoning) was measured by the scores of three standardized cognitive tests at the baseline and the follow-up, after participating in a moderate-intensity physical activity, wearing a full ensemble of the PPE. The study findings evinced the negative impact of the PPE on the firefighter's cognitive functioning, especially in short-term memory and inductive reasoning. No significant influence was found on the firefighter's long-term memory. The results were consistent when the participant's age and BMI were controlled. The outcomes of the present study will not only fill the gap in the literature, but also provide critical justification to stakeholders, including governments, policymakers, academic communities, and industry, for such efforts to improve human factors of the firefighter's PPE by realizing the negative consequences of the added layers and protective functions on their occupational safety. Study limitations and future directions were also discussed.

• Mass Spectrometry Letters
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• v.12 no.3
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• pp.85-92
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• 2021

The therapeutic antibody drug market has experienced explosive growth as mAbs become the main therapeutic modality for a variety of diseases. Characterization of glycosylation that directly affects the efficacy and safety of therapeutic monoclonal antibodies (mAbs) is critical for therapeutics development, bioprocess system optimization, lot release, and comparability evaluation. The LC/MS approach has been widely used to structurally characterize mAbs, and recently attempts have been made to obtain comprehensive information on the primary structure and post-translational modifications (PTMs) of mAbs through intact protein analysis. In this study, we performed state-of-the-art LC/MS based intact protein analysis to readily identify and characterize glycoforms of various mAbs. Different glycoforms of mAbs produced in different expression cell lines including CHO, SP2/0 and HEK cells were monitored and compared. In addition, the comparability of protein molecular weight, glycoform pattern, and relative abundances of glycoforms between the commercialized trastuzumab biosimilar and the original product was determined in detail using the given platform. Intact mAb analysis allowed us to gain insight into the overall mAb structure, including the complexity and diversity of glycosylation. Furthermore, our analytical platform with high reproducibility is expected to be widely used for biopharmaceutical characterization required at all stages of drug development and manufacturing.

• Environmental Analysis Health and Toxicology
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• v.20 no.4 s.51
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• pp.279-286
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• 2005

Earthworm (Eisenia fetida) acute toxicity test was carried out and ecological risk assessment in soil was performed with national monitoring data. 14 day - $LC_{50}$ of nonylphenol and bisphenol A were 288.1 mg/kg and 90.1 mg/kg, respectively. And NOECs of nonylphenol and bisphenol A were 250 mg/kg and 50 mg/kg, respectively. Significant weight decrement was appeared at 70 mg/kg of bisphenol A, however, nonylphenol at concentrations tested did not severe adverse effect on the weight decrement. The environmental monitoring has been carrying out by NIER since 1999. Exposure levels of nonylphenol in soil were ND$\sim$10.55 $\mu$g/kg and those of bisphenol A were ND$\sim$15.50$\mu$g/kg in National Monitoring data which had been performed from 2000 to 2004. The measured soil exposure level was applied to evaluate the environmental risk assessment. The values of PNEC for bisphenol A and nonylphenol were determined as 0.5 mg/kg and 2.5 mg/kg, respectively using the safety factors which were suggested in EU and OECD. The values of HQ (PEC/PNEC) were determined to be below I for bisphenol A and nonylphenol when the maximum exposure levels for bispheol A (15.50$\mu$g/kg) and nonylphenol (10.55$\mu$g/kg) were applied. Conclusively, the environmental risk assessment of bisphenol A and nonylphenol was not critical in soil.

• Nuclear Engineering and Technology
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• v.50 no.4
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• pp.589-598
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• 2018

To maintain safety and reliability of reactors, redundant sensors are usually used to measure critical variables and estimate their averaged time-dependency. Nonhealthy sensors can badly influence the estimation result of the process variable. Since online condition monitoring was introduced, the online cross-calibration method has been widely used to detect any anomaly of sensor readings among the redundant group. The cross-calibration method has four main averaging techniques: simple averaging, band averaging, weighted averaging, and parity space averaging (PSA). PSA is used to weigh redundant signals based on their error bounds and their band consistency. Using the consistency weighting factor (C), PSA assigns more weight to consistent signals that have shared bands, based on how many bands they share, and gives inconsistent signals of very low weight. In this article, three approaches are introduced for improving the PSA technique: the first is to add another consistency factor, so called trend consistency (TC), to include a consideration of the preserving of any characteristic edge that reflects the behavior of equipment/component measured by the process parameter; the second approach proposes replacing the error bound/accuracy based weighting factor ($W^a$) with a weighting factor based on the Euclidean distance ($W^d$), and the third approach proposes applying $W^d$, TC, and C, all together. Cold neutron source data sets of four redundant hydrogen pressure transmitters from a research reactor were used to perform the validation and verification. Results showed that the second and third modified approaches lead to reasonable improvement of the PSA technique. All approaches implemented in this study were similar in that they have the capability to (1) identify and isolate a drifted sensor that should undergo calibration, (2) identify a faulty sensor/s due to long and continuous missing data range, and (3) identify a healthy sensor.