• Tuberculosis and Respiratory Diseases
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• v.68 no.1
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• pp.6-9
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• 2010

Background: The efficacious use of interventional bronchoscope for patients with central airway obstruction due to malignant or benign lesions has been proven. Among many therapeutic bronchoscopic procedures, endobronchial cryotherapy is an established recanalization method for the obstruction of the respiratory tract. Recently, the use of this procedure has been increasing in Korea. However, limited data are available in the literature regarding its efficacy in Korea. Methods: Thirty patients, who had been treated with a flexible cryoprobe for cryotherapy were enrolled; clinical characteristics and treatment outcomes were analyzed. The patients had been treated with the technique using nitrous oxide as a cryogen under local anesthesia. Objective outcomes were 3 different degrees of therapeutic success by use of follow-up bronchoscopic findings as follows: successful, partially successful, and unsuccessful response. Subjective outcomes were evaluated as an improvement in symptoms. Results: The mean age of enrolled patients was $59{\pm}11$ years and there was a male (22/30) dominance. Twenty-three patients had malignant tumor and 7 patients had benign lesions with central airway obstruction. Successful recanalization was achieved in 11 (37%) patients, and partially successful response was achieved in 15 (50%) patients. Dyspnea was improved in 84.2% (16/19) of patients. At least one respiratory symptom was resolved in 91.3% (21/23) patients. Seven patients (23.3%) needed additional bronchoscopic electrocautery because of the bleeding as a complication of cryotherapy. Conclusion: Endobronchial cryotherapy is an effective and less expensive procedure for the management of central airway obstruction. However, the procedure should be performed under the preparing for an emergency situation, such as massive bleeding.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.282-290
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• 2020

Background: Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regulation mechanisms. Methods: Ginseng berry polysaccharide extract (GBPE) and purified ginseng berry polysaccharide portion (GBPP) were used to evaluate their activities on human HCT-116 and HT-29 CRC cell proliferation. Interleukin-8 secretion analysis was performed on HT-29 cells. Naive CD4 cell isolation and T-helper cell differentiation were performed and determined using flow cytometry for Th1 and Treg in addition to cell cycle and apoptotic investigation. Results: GBPE and GBPP significantly inhibited interleukin-8 secretion and cancer cell proliferation, inhibited CD4⁺IFN-γ⁺ cell (Th1) differentiation, and decreased CD4⁺FoxP3⁺ cell (Treg) differentiation. Compared to the GBPE, GBPP showed more potent antiinflammatory activities on the malignant cells. This is consistent with the observation that GBPP can also inhibit Th1-cell differentiation better, suggesting that it has an important role in antiinflammation, whereas Treg cells hinder the body's immune response against malignancies. Supported by cell cycle and apoptosis data, GBPE and GBPP, at various degrees, remarkably enhanced the anticancer activities of 5-fluorouracil. Conclusion: Data from this project suggested that Asian ginseng berry potentially has clinical utility in managing enteric inflammation and suppressing CRC through immunomodulation mechanisms.

• Wind and Structures
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• v.10 no.1
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• pp.1-22
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• 2007

The suppression of aerodynamic response of long-span suspension bridges during erection and after completion by using single TMD and multi TMD is presented in this paper. An advanced finite-element-based aerodynamic model that can be used to analyze both flutter instability and buffeting response in the time domain is also proposed. The frequency-dependent flutter derivatives are transferred into a time-dependent rational function, through which the coupling effects of three-dimensional aerodynamic motions under gusty winds can be accurately considered. The modal damping of a structure-TMD system is analyzed by the state-space approach. The numerical examples are performed on the Akashi Kaikyo Bridge with a main span of 1990 m. The bridge is idealized by a three-dimensional finite-element model consisting of 681 nodes. The results show that when the wind velocity is low, about 20 m/s, the multi TMD type 1 (the vertical and horizontal TMD with 1% mass ratio in each direction together with the torsional TMD with ratio of 1% mass moment of inertia) can significantly reduce the buffeting response in vertical, horizontal and torsional directions by 8.6-13%. When the wind velocity increases to 40 m/s, the control efficiency of a multi TMD in reducing the torsional buffeting response increases greatly to 28%. However, its control efficiency in the vertical and horizontal directions reduces. The results also indicate that the critical wind velocity for flutter instability during erection is significantly lower than that of the completed bridge. By pylon-to-midspan configuration, the minimum critical wind velocity of 57.70 m/s occurs at stage of 85% deck completion.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2017.05a
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• pp.240-244
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• 2017

Experimental verification in the rig test stage for component development is a vital link between the aeromechanical design and structural integrity validation process. Based on this premise, Non-Intrusive Stress Measuring System was adopted on the axial compressor test rig to measure the static and dynamic tip deflection of all blades by using tip-timing sensors. Through analyzing vibration characteristics, we evaluated the vibratory stresses seen on the blades fatigue critical location; detected synchronous resonances which are the source of High Cycle Fatigue (HCF) in blades; presented non-synchronous vibration response by aerodynamic excitation and individual blade mis-tuning patterns.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.830-831
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• 2007

부하의 가격에 대한 높은 반응성(price-responsiveness)과 이를 이끌어 낼 수 있는 적절한 수요관리(demand response) 정책은 구조 개편된 전력 시장에서 가격 변동성 및 설비에 대한 투자 부족 문제를 효과적으로 해결하는 데 필수적이라는 데에는 많은 연구자들이 동의하고 있다. 그럼에도 불구하고, 특히 전력 사용을 미리 계획하지 않는 소규모 소비자들의 경우, 전력 소비가 본질적으로 매우 탄력적이지 못하므로(inelastic) 가격에 민감한 부하를 이끌어 내기 위한 수요관리 정책은 신중하게 세워져야 한다. 본 논문은 최종 소비자에게 전력을 제공하면서 critical peak pricing(CPP)를 동적으로 관리하고 이러한 수요관리에 대한 인센티브를 가진 개체를 도입함으로써 가격에 민감한 부하를 이끌어 내는 수요 반응의 접근법을 제시할 것이다. 가격에 민감한 부하 및 수요 반응 정책의 문제는 정책적, 경제적, 기술적 측면에서 검토되어야 하는 바이나, 본 논문에서는 기술적 측면 및 경제적인 인센티브의 수식화에 초점을 맞추었다. 정책에 인센티브를 가진 개체의 이윤 방정식을 세움으로써 문제를 정식화하였으며, 문제의 최적 해를 구하기 위해 예측 가격을 바탕으로 backward dynamic programming을 통한 swing option 평가 기법을 사용하여 최적의 수요관리 시점을 구해야 함을 제안하는 바이다.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.11 no.6
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• pp.175-180
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• 2001

Dynamic response localization of simple mistuned periodic structures is presented in this paper Mistuning in periodic structures can cause forced responses that are much larger than those of perfectly tuned structures. So mistuning results in the critical impact on high cycle fatigue of structures. Thus, it is of great importance to predict the mistuned forced response in an efficient way. In this paper, forced responses of coupled pendulum systems are investigated to identify the localization effect of periodic structures. The effects of mistuning and damping on the maximum forced response are examined. It is found that certain conditions of mistuning and coupling can cause strong localization and the localization becomes significant under weak damping. It is also found that the maximum forced response increases as the number of Periodic structures increases.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.141-148
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• 2006

This study describes a generation of artificial earthquake wane compatible with seismic design spectrum. In seismic response analysis of building structures, the input ground accelerations have considerable effect on dynamic characteristics of structures. Therefore, it is important to properly select input ground motions for seismic response analysis. In this paper, the artificial earthquake wave are generated according to previously recorded earthquake waves in past earthquake events. The artificial wave have identical phase angles to the recorded earthquake wane, and their overall response spectra are compatible with seismic design spectrum with 5% of critical viscous damping. Each simulated earthquake wave has a identical phase angles to the original recorded ground acceleration, and match to design response spectra in the range of period from 0.02 to 10.0 seconds. It is concluded that the artificial earthquake waves simulated in this paper ate applicable as input ground motions for a seismic response analysis of building structures.

• Advances in aircraft and spacecraft science
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• v.4 no.2
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• pp.185-202
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• 2017

In a flexible airvehicle, an assessment of the structural coupling levels through analysis and experiments provides structural data for the design of notch filters which are generally utilized in the flight control system to attenuate the flexible response pickup. This is necessitated as during flight, closed loop control actuation driven with flexible response inputs could lead to stability and performance related problems. In the present work, critical parameters influencing servoelastic response have been identified. A sensitivity study has been carried out to assess the extent of influence of each parameter. A multi-parameter tuning approach has been implemented to achieve an enhanced analytical model for improved predictions of aircraft servoelastic response. To illustrate the model updation approach, initial and improved test analysis correlation of lateral servoelastic responses for a generic flexible airvehicle are presented.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.184-191
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• 2000

In this research, a numerical model is developed for analysis of buried pipelines considering longitudinal permanent ground deformation(PGD) due to liquefaction induced lateral spreading. Buried pipelines and surrounding soil are medeled as continuous pipelines using the beam elements and a series of elasto-plastic springs uniformly distributed along the pipelines, respectively. Idealized various PGD patte군 based on the observation of PGD are used as a loading configuration and the length of the lateral spread zone is considered as a loading parameter. Numerical results are verified with other research results and efficient applicability of developed procedure is shown. Analyses are performed by varying different parameters such as PGD pattern, pipe diameter and pipe thickness. Results show that response of buried pipelines are more affected by pipe thickness than pipe diameter. Finally, the critical length of the lateral spread zone and the critical magnitude of PGD which cause yielding, local buckling or tension failure are proposed for the steel pipe which are normally used in Korea.

• Molecules and Cells
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• v.38 no.9
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• pp.750-758
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• 2015

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.