• Korean Journal of Biological Psychiatry
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• v.29 no.2
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• pp.33-39
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• 2022

Objectives The early growth response 3 (EGR3) gene located in chromosome 8p21.3 is one of the susceptibility loci in many psychiatric disorders. EGR3 gene plays critical roles in signal transduction in the brain, which is involved in neuronal plasticity, neuronal development, learning, memory, and circadian rhythms. Recent studies have suggested EGR3 as a potential susceptibility gene for bipolar disorder (BPD). However, this requires further replication with an independent sample set. Methods To investigate the genetic role of EGR3 in Korean patients, we genotyped six single-nucleotide polymorphisms (SNPs) in the chromosome region of EGR3 in 1076 Korean BPD patients and 773 healthy control subjects. Results Among the six examined SNPs of EGR3 (rs17088531, rs1996147, rs3750192, rs35201266, rs7009708, rs1008949), SNP rs35201266, rs7009708, rs1008949 showed a significant association with BPD (p = 0.0041 for rs35201266 and BPD2, p = 0.0074 for rs1008949 and BPD, p = 0.0052 for rs1008949 and BPD1), which withstand multiple testing correction. In addition, the 'G-C-C-C' and 'G-C-G-C' haplotypes of EGR3 were overrepresented in the patients with BPD (p = 0.0055, < 0.0001, respectively) and the 'G-T-G-C' haplotype of EGR3 was underrepresented in patients with BPD (p = 0.0040). Conclusions In summary, our study supports the association of EGR3 with BPD in Korean population sample, and EGR3 could be suggested as a compelling susceptibility gene in BPD.

• Smart Structures and Systems
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• v.31 no.4
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• pp.325-334
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• 2023

Computer vision-based damage detection enables non-contact, efficient and low-cost bridge health monitoring, which reduces the need for labor-intensive manual inspection or that for a large number of on-site sensing instruments. By leveraging recent semantic segmentation approaches, we can detect regions of critical structural components and identify damages at pixel level on images. However, existing methods perform poorly when detecting small and thin damages (e.g., cracks); the problem is exacerbated by imbalanced samples. To this end, we incorporate domain knowledge to introduce a hierarchical semantic segmentation framework that imposes a hierarchical semantic relationship between component categories and damage types. For instance, certain types of concrete cracks are only present on bridge columns, and therefore the noncolumn region may be masked out when detecting such damages. In this way, the damage detection model focuses on extracting features from relevant structural components and avoid those from irrelevant regions. We also utilize multi-scale augmentation to preserve contextual information of each image, without losing the ability to handle small and/or thin damages. In addition, our framework employs an importance sampling, where images with rare components are sampled more often, to address sample imbalance. We evaluated our framework on a public synthetic dataset that consists of 2,000 railway bridges. Our framework achieves a 0.836 mean intersection over union (IoU) for structural component segmentation and a 0.483 mean IoU for damage segmentation. Our results have in total 5% and 18% improvements for the structural component segmentation and damage segmentation tasks, respectively, compared to the best-performing baseline model.

• Journal of Veterinary Clinics
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• v.40 no.1
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• pp.8-15
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• 2023

Atopic dermatitis (AD) is a common skin disease in animals and several therapeutic trials with various drugs have been conducted for more effective management of AD. However, these trials have not been able to properly address all the aspects of AD management because of the lack of good efficacy or due to significant side effects of the drugs being tested. Synbio-glucan functional spray is a functional skin spray using Synbio-glucan composed of β-glucan and probiotics. We designed a functional spray composed of Synbio-glucan (patent application number:10-1805863), distilled water, glycerin, solubilizer, and 40% alcohol. We tested the efficacy and safety of the functional spray on six dogs with AD. The trial was conducted with the consent of the caregivers. The spray was applied to the skin lesions, including the trunk, axillae, inguinal region, or periocular areas, thrice a day for 30 days. To evaluate the efficacy of this functional spray, we assessed the pruritus visual analog scale (PVAS) and the canine atopic dermatitis extent and severity index (CADESI)-4. At the end of one month, the results clinical scores after functional spray treatment showed a significant decrease in the PVAS (p = 0.03) and CADESI-4 (p = 0.03) in all the subject dogs with AD. This study thus confirmed that the Synbio-glucan functional spray is efficacious and safe for the treatment of AD in dogs.

• Journal of Information Technology Services
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• v.22 no.2
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• pp.1-21
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• 2023

Due to the convergence and complexity of the 4th Industrial Revolution, the boundaries between industries have become unclear and ambiguous. Consequently, there is a lack of research on how firms engaged in this industry are changing their location behavior. Recently, some attempts to classify the industrial groups of the 4th Industrial Revolution and their detail occupations have been made, and this study adopts the classification of Lee and Jung (2020) of the Korea Institute for Industrial Economics & Trade. In this study, the 18 detailed industries commonly included in multiple industrial groups are defined as 'core industries' and are classified into manufacturing and service industries to explore the spatial patterns of firms' location. Specifically, this study aims to examine how the location behavior of firms in core industries of the 4th Industrial Revolution has changed from 2010 to 2019 in the Seoul metropolitan area, using the 「National Business Survey」 data. We employed two methods based on spatial auto-correlation: (i) spatial kernel density estimation analysis and (ii) local Moran's I_i analysis. The results indicate that the core industry firms form more distinct and larger clusters in 2019 based on the clusters formed in 2010. Specifically, manufacturing industry firms tended to concentrate in the southern region of Gyeonggi and parts of Seoul, while serivce industry firms were more concentrated in Seoul. These core industries play a critical role in industries and are closely related to the ICT industries, which generate high-added value and increase productivity in the front and rear industries. This study reveals that the agglomeration of these industries in specific regions is intensifying and may exacerbate regional inequality.

• Journal of the Korea Society of Computer and Information
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• v.14 no.4
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• pp.31-38
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• 2009

Lens distortion is inevitable phenomenon in machine vision system. More and more distortion phenomenon is occurring in order to choice of lens for minimizing cost and system size. As shown above, correction of lens distortion is critical issue. However previous lens correction methods using camera model have problem such as nonlinear property and complicated operation. And recent lens correction methods using neural network also have accuracy and efficiency problem. In this study, I propose new algorithms for correction of lens distortion. Distorted image is divided based on the distortion quantity using k-means. And each divided image region is corrected by using neural network. As a result, the proposed algorithms have better accuracy than previous methods without image division.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.6 no.10
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• pp.145-153
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• 2016

The purpose of the study is to draw competencies of faculty members at graduate school faculty to implements the NCS-based curriculum. A set of competency was deductively derived from a total of three professors and consultants with more than ten-year experiences and has been involved in developing the college curriculum. The political endeavors of the Korean government toward the competency-based education have been implemented as a movement to the NCS-based curriculum. The requirements for the reorganization of curriculum and education system as well as cooperation among faculty, industry, region and development part of NCS were suggested for the activation of NCS based education and the operation of NCS. However, one of the most critical factors in introducing and implementing the NCS-based curriculum is the role of faculty members. Therefore, it is an urgent issue to equip the faculties with required competencies. Result showed that the competencies required professors at graduate school for the NCS-based curriculum implementation were classified into four areas: marco-level curriculum development; micro-level course design; knowledge across areas; and attitude across areas.

• Structural Engineering and Mechanics
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• v.87 no.1
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• pp.47-56
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• 2023

Any pre-existed delamination defect present during manufacturing or induce during service loading conditions in the wingskin adherend invariably shows a greater loss of structural integrity of the spar wingskin joint (SWJ). In the present study, inter-laminar delamination propagation at the critical location of the SWJ has been carried out using contact and multi-point constraint finite elements available with commercial FE software (ANSYS APDL). Strain energy release rates (SERR) based on virtual crack closure technique have been computed for evaluation of the opening (Mode-I), sliding (Mode-II) and cross sliding (Mode-III) modes of delamination by sequential release of multi point constraint elements. The variations of different modes of SERR are observed to be significant by considering varied delamination lengths, material properties of adherends and radius of curvature of the SWJ panel. The SERR rates are seen to be much different at the two pre-embedded delamination ends. This shows dissimilar delamination propagation rates. The maximum is seen to occur in the delamination front in the unstiffened region of the wingskin. The curvature geometry and material anisotropy of SWJ adherends significantly influences the SERR values. Increase in the SERR values are observed with decrease in the radius of curvature of wingskin panel, keeping its width unchanged. SWJs made with flat FRP composite adherends have superior resistance to delamination damage propagation than curved composite laminated SWJ panels. SWJ made with Boron/Epoxy (B/E) material shows greater resistance to the delamination propagation.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2621-2627
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• 2023

In Experimental Advanced Superconducting Tokamak (EAST) experiments, to achieve long pulse and high-power ICRH system operation, a new kind of ICRH antenna has been designed. One of the most critical factors in limiting the operation of long pulse and high power is the intense heat load in the front face of the ICRH antenna, especially the Faraday Screen (FS). Therefore, the cooling channels of FS need to be designed. According to thermal-hydraulic analysis, the FS tubes are divided into several groups to achieve more excellent water cooling capability. The number of series and parallel tubes in one group is chosen as six. This antenna went into service in the spring of 2021, and it is delightful that the temperature distribution of the FS tube is below 400 ℃ in 14.5 s and 1.8 MW ICRH system operation. However, the active water-cooling design was not carried out on the upper and lower plates of FS, which led to severe ablations on that region under long pulse and high power operation, and the temperature is up to 800. Therefore, the upper and lower side plates of the FS were designed with water cooling based on thermal-hydraulic analysis. During the 2022 winter experiments, the temperature of ICRH antenna FS was lower than 400 in the pulse of 200s and the power of 1 MW operation.

• Structural Engineering and Mechanics
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• v.87 no.4
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• pp.317-332
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• 2023

Understanding and analysing the behaviour and response of historical structures in the face of climate changes and environmental conditions is of utmost significance for their preservation. There are several structural hazards associated with climate and hydrology changes in the region, including the settlement of piers, the rotation of piers, and temperature changes. The present study investigates the experimental and numerical structural behaviour of skewed and non-skewed Persian brick masonry barrel vaults under various conditions. The external loading conditions included pier rotation in five modes, settlement, and temperature variations in four states. Initially, the experiments extracted the mechanical properties of the scaled materials. Then, three semi-circular brick barrel vaults were tested with gravitational loads. The outcomes were used to develop and validate the finite element model. Following the development of the finite element model, numerical and parametric studies were conducted on the effect of the aforementioned structural hazards on the response of brick masonry barrel vaults with various Persian geometries (semi-circular, drop pointed, and four-centred), angles of skew (0, 15, 30, and 45 degrees), and dimensional ratios. According to the findings, the fragility of masonry materials makes historical structures susceptible to failure under different loading. A brick barrel vault fails in the presence of minor rotation and settlement of the piers. The four-centred geometric shape has the lowest performance among the seven Persian geometries; therefore, its health monitoring and retrofitting should be prioritised. In Isfahan, Iran, temperature variations, particularly during the warm seasons, cause critical conditions in such structures.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.339-343
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• 2015

To rapidly recover ceased functionality of a facility after a catastrophic seismic event, critical decisions on facility repair works are made within a limited period of time. However, prolonged damage assessment of facilities, due to massive damage in the surrounding region and the complicated damage judgment procedures, may impede restoration planning. To assist reliable structural damage estimation without a deep knowledge and rapid interactive analysis among facility damage and restoration operations during the approximate restoration project planning phase, we developed a prototype of distributed facility restoration simulations through the use of high-level architecture (HLA) (IEEE 1516). The simulation prototype, in which three different simulations (including a seismic data retrieval technique, a structural response simulator, and a restoration simulation module) interact with each other, enables immediate damage estimation by promptly detecting earthquake intensity and the restoration operation analysis according to estimated damage. By conducting case simulations and experiments, research outcomes provide key insights into post-disaster restoration planning, including the extent to which facility damage varies according to disaster severity, facility location, and structures. Additional insights arise regarding the extent to which different facility damage patterns impact a project's performance, especially when facility damage is hard to estimate by observation. In particular, an understanding of required type and amount of repair activities (e.g., demolition works, structural reinforcement, frame installation, or finishing works) is expected to support project managers in approximate work scheduling or resource procurement plans.