• Translational and Clinical Pharmacology
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• v.25 no.2
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• Journal of the Korean Society for Library and Information Science
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• v.55 no.2
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• pp.51-90
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• 2021

Talent is a person who has the values and skills necessary to achieve effective goals and performance of the nation, society, organization, and individuals, or those who play a key role in generating the success or performance of the nation and companies. It can be said that it is a talented person who will achieve a well-equipped library world and a knowledge-based national society. In this study, in order to derive the talent image of the librarian, the talent image, competency, role of the librarian, librarian job development, PEST analysis, etc. suggested in various fields of society including the library world were performed. First, 11 human resources were derived, and 4 types of human resources were derived through the FGI process, and a verification process was conducted for users, librarians, and students. Finally, in this study, four librarian talents were proposed: creative convergence type talent, personality type talent, professional type talent, and communication type talent.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.1-10
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• 2023

The purpose of this study is to explore ways to nurture creative and fusion-type talents centered on ANT. In order to nurture creative and convergence-type talents centered on ANT, first, it is necessary to utilize Kao's Law in the network formation stage. Second, it is necessary to utilize the strong power of weak ties in the network formation stage. Third, in order to cause a stir in the stage of raising questions among the four stages of translation, the ability to ask questions must be developed. Fourth, education in various creative problem-solving techniques is needed to throw a stir. Fifth, in order to successfully intervene in the second stage of the four stages of translation, the stage of attracting attention, communication and critical thinking skills must be trained. Suggestions for follow-up research are: First, it is necessary to compare and analyze the four stages of translation and the stage of the creative problem-solving model presented by ANT. Second, it is expected that there will be follow-up studies that apply specific cases centering on ANT.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.3
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• pp.193-201
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• 2023

Hydrogen peroxide (H₂O₂) is a type of active oxygen species (ROS) that causes oxidative stress in cells and affects cell growth, proliferation, senescence, and death. The purpose of this study is to find active peptides that attenuate cytotoxicity of H₂O₂. A positional scanning synthetic tetrapeptide combinatorial library was screened to predict the sequence of potentially active peptides. As a result of comparing the effect of peptide pools on H₂O₂-induced death of human keratinocytes (HaCaT cells), various active peptide sequences were predicted. Especially, peptides containing cysteine (C) residue were predicted to be active. In follow-up experiments, the cytotoxicity and activity of cysteine-containing peptides of different lengths, such as C-NH₂, CC-NH₂, CCC-NH₂, and CCCC-NH₂ were examined. C-NH₂ and CC-NH₂ showed no significant cytotoxicity up to 1.0 mM, but CCC-NH₂, and CCCC-NH₂ showed relatively strong cytotoxicity. C-NH₂ and CC-NH₂ alleviated H₂O₂-induced cytotoxicity. CC-NH₂ was more cytoprotective compared to C-NH₂, C, N-acetyl cysteine (NAC), and glutathione (GSH). When intracellular ROS was measured by flow cytometry, H₂O₂ increased ROS production, and CC-NH₂ suppressed ROS production more effectively than C-NH₂, and it was as effective as C, NAC, and GSH. This study suggests that CC-NH₂ of the cysteine-containing peptides of different lengths has an antioxidant property that safely and effectively alleviates H₂O₂-induced cytotoxicity and ROS production.

• Journal of Korean Library and Information Science Society
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• v.53 no.2
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• pp.43-71
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• 2022

In this study, the vision and goal of librarian education and training were designed by reflecting the changes in the internal and external environment of the library and the human resource development (HRD) trend in order to prepare a mid- to long-term development plan for librarian education and training. To design the vision and goal of librarian education and training, redefining the necessity, goals, mission, and role of librarian education and training, and seeking strategies to realize the vision and goal of librarian education and training. Core competency and national competency standards (A detailed implementation plan was prepared for the development of NCS) - based educational operation guidelines. First, when analyzing domestic and foreign prior research and literature, the future librarian is a person with competencies that includes first, creative convergence, second, communication and cooperation, third, leading professional, and fourth, empathic and inclusive talent. It was identified that education and training should be established based on The curriculum according to the library's future talents and core competencies should be presented in the following process model, and the librarian competencies for each type of creative convergence type, communication cooperation type, leading professional type, and empathy and inclusive type should be derived, and It was identified that the education direction should be set in the direction of designing a curriculum for job competency improvement by setting the job competency according to the requirements.

• Science of Emotion and Sensibility
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• v.26 no.3
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• pp.69-82
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• 2023

High-tech sensibility textile and fashion, in which consumers' emotions and various textile and fashion technologies are converged, is an important industrial group. It is important to develop the ability to apply in practice by gathering the creative by understanding other fields and exchanging ideas through interdisciplinary collaboration in the field of emotional engineering. Through interdisciplinary research and collaboration, talent must be nurtured of individuals who would lead the era of the 4^th Industrial Revolution with the ability to empathize with others as well as the creative convergence-type intellectual ability necessary for the rapidly changing society. To determine content-creation methods, basic research is conducted. Additionally, this study investigates on the current status and educational process of the emotional textile-fashion industry worldwide. To nurture talents in the textile and fashion sensibility science, the basic contents are created to manage the knowledge that delivers sensibility science and the ICT related to this field, as well as in the intensive, PB-style conceptual design based on sensibility. The process from derivation of consumer emotion analysis and product development can be experienced through smart kit practice. Moreover, various methods are developed to set up intellectual property rights generated while developing ICT convergence products as start-ups. The study also covers new knowledge rights to develop emotional textile fashion.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.2
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• pp.246-251
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• 2021

This study is analyzed survey based on classes of computational thinking to identify problem solving ability, to reflect them in curriculum plan for software education. Through analyzing difficulties on computational thinking learners by pre/post test on problem solving ability, the education method of software curriculum was proposed. For this study, the subject, scope of content, and activity plan were organized into 15 weeks of software curriculum for 2 hours per week, and questionnaire was conducted for 63 students. As a result, the 'Humanities Departments' have shown higher problem solving ability improvement than 'Science and Engineering Departments'. Based on the results, in order to cultivate creative fusion-type talent, the theoretical systems that fundamentally define thinking and perception must be fused with each other. In addition, software education should be improved to be extended to non-majors in various fields.