• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1135-1140
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• 2012

An electrochromatographic microchip with carboxyl-group-derivatized mono-disperse silica packing was prepared from the corresponding colloidal silica solution by utilizing capillary action and self-assembly behavior. The silica beads in water were primed by the capillary action toward the ends of cross-patterned microchannel on a cyclic olefinic copolymer (COC) substrate. Slow evaporation of water at the front of packing promoted the self-assembled packing of the beads. After thermally binding a cover plate on the chip substrate, reservoirs for sample solutions were fabricated at the ends of the microchannel. The packing at the entrances of the microchannel was silver coated to fix utilizing an electroless silver-plating technique to prevent the erosion of the packed structure caused by the sudden switching of a high voltage DC power source. The electrochromatographic behavior of the microchip was explored and compared to that of the microchip with bare silica packing in basic borate buffer. Electrophoretic migration of Rhodamine B was dominant in the microchip with the carboxyl-derivatized silica packing that resulted in a migration approximated twice as fast, while the reversible adsorption was dominant in the bare silica-packed microchip. Not only the faster migration rates of the negatively charged FITC-derivatives of amino acids but also the different migration due to the charge interaction at the packing surface were observed. The electrochromatographic characteristics were studied in detail and compared with those of the bare silica packed microchip in terms of the packing material, the separation potential, pH of the running buffer, and also the separation channel length.

• Journal of Ginseng Research
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• 제19권1호
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• pp.56-61
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• 1995

Molecular cloning and restriction mapping on ATPase $\alpha$-subunit gene (atpA) were carried out to obtain genomic information concerned with the gene structure and organization in Korean ginseng mitochondria. Two different clones containing the homologous sequence of atpA gene were selected from SalI and PstI libraries of mitochondrial DNA (mtDNA) of Korean ginseng. The sizes of mtDNA fragments inserted in SalI and PstI clones were 3.4 kb and 13 kb, respectively. Southern blot analysis with [$^{32}P$] labelled Oenothera atPA gene probe showed that atpA gene sequence was located in 2.0 kb XkaI fragment in PstI clone and in 1.7 kb XbaI fragment in SalI clone. A partial sequening ascertained that the SalI clone included about 1.2 kb fragment from SalI restriction site to C-terminal sequence of this gene but about 0.3 kb N-terminal sequence of open reading frame was abscent. The PstI fragment was enough large to cover the full sequence of atpA gene. The same restriction pattern of the overlapped region suggests that both clones include the same fragment of atiA locus. Data of Southern blot analysis and partial nucleotide sequencing suggested that mtDNA of Korean ginseng has a single copy of atpA gene. Key words ATPase a-subunit, mitochondrial DNA, Panax ginseng.

• 한국세라믹학회지
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• 제44권7호
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• pp.362-367
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• 2007

Stent is a tiny structure made with either ceramic coating and/or bare metal. Being approximately $1{\sim}2 mm$ in diameter, it consists of holes, slots, or void space and is designed to cover entire medical lesions. Stent implantation into patients' arteries has been practiced for a little more than a decade in order to widen the blocked artery. The adoption of the stent has significantly improved the efficacy when compared with the previous medical practice by balloon angioplasty alone. Yet better biomedical performance of the stent is being demanded in order to eliminate the still existing problem of artery restenosis, which means the artery becomes narrowed again. Recent literature survey shows researches on ceramic coatings onto the stent surface, or material design to improve the mechanical response of the stent. This study focuses more on the material design and mechanical analysis. The results showed that the void configuration within the stent affects the mechanical response significantly. The rectangular shape was found to yield expansion at a relatively lower pressure than the elliptical slot for a slotted tube stent. The present results, when combined with research on coating at the stent surface, may provide stents with improved bio-medical performance.

• Industrial Engineering and Management Systems
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• 제11권3호
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• pp.233-240
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• 2012

The implementation of business process management (BPM) systems in large number of business organizations transforms BPM system into such a level of maturity and tends to collect large repositories of business process (BP) models. This issue encourages BP flexibility that leads to a large number of process variants derived from the same model, but differing in structure, to be stored in the large repositories of BP models. Therefore, the repositories may include thousands of activities and related business objects with variation of requirements and quality of service. It is a common practice to customize processes from reference processes or templates in order to reduce the time and effort required to design and deploy processes on all levels. In order to address redundancy and underutilization problems, a generic process model, called as reference BP, is absolutely necessary to cover the best of process variants. This study aims to develop multiple-objective business process genetic algorithm (MOBPGA) to find a set of non-dominated (Pareto) solutions of business reference model to enhance conventional approach which considered only a single objective on creating BP reference model by using proximity score measurement. A mixed-integer linear program is constructed to evaluate performance of the proposed MOBPGA on small-scale problems by using standard measures for multiple-objective techniques. The results will show the viability of applying MOBPGA in terms of simultaneously maximizing proximity score measurement, minimizing total duration, and total costs of the selected reference model.

• 한국항해항만학회지
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• 제33권3호
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• pp.235-240
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• 2009

해안철근콘크리트 구조물은 해수 또는 비래염분에 의하여 철근이 부식하게 되고 결과적으로 콘크리트에 균열로 발전하여 성능을 다하게 된다. 본 연구에서는 염해에 대한 해안 철근콘크리트 구조물의 내구성능 평가를 위하여 수치해석에 의한 결정론적 방법이 아니라 확률론에 입각한 성능평가를 위하여 확률론적 시뮬레이션 수법을 구축하였다. 시뮬레이션 수법으로는 몬테카를로법이 적용되었으며, 파괴확률에 대한 설계확률변수(표면염화물 농도, 초기 함유 염소이온농도, 철근의 피복두께, 염소이온 확산계수) 및 각각의 변동계수의 영향을 평가하였다. Fick의 확산방정식을 이용한 해석결과, 해안에서의 거리의 차 및 확산계수의 차에 의한 영향은 컸으며 상대적으로 변동계수의 영향은 그다지 높지 않다는 것을 알 수 있었다.

• 정보보호학회논문지
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• 제27권6호
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• pp.1295-1305
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• 2017

국내 블록암호표준(안)으로는 SEED암호가 있다. 이 암호는 한국정보보호진흥원(KISA)이 1998년 10월에 초안을 설계하고 같은 해 12월에 공개검증과정을 거쳐 안전성과 성능이 개선된 최종 수정안을 발표하였다. DES와는 달리 128비트 블록암호로서 여러 과정을 거쳐 2005년에 국제표준으로 확정되었다. DES와 같은 페이스텔 구조를 가진 블록암호로서 다만 입력비트블록이 DES의 두 배인 128비트로 늘어났다는 것이다. 본 논문에서는 첫째, SEED 암호의 일반적인 알고리즘을 소개하고 F-함수에서 적용되는 열쇠 값의 생성원리를 수학적으로 분석해 보았다. 둘째, S-함수의 8비트 입력 값에 대응되는 원시원소 ${\alpha}$ 의 멱승 값을 계산하는 표를 도출해 보았으며 마지막으로 G-함수 내에 설계되어져 있는 S-함수의 계산 원리를 수학적인 방법으로 새로운 정리와 예제를 통해 분석해 보는 것으로 한정하였다. 이러한 과정을 통하여 현재 알려져 있는 SEED암호의 취약점을 보완할 수 있는 새로운 암호체계를 개발하는데 필요한 아이디어와 이론적인 근거를 제공하는 데 어느 정도 도움이 되고자 한다.

• 한국가스학회지
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• 제21권3호
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• pp.39-45
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• 2017

LNG 산업의 핵심시설인 LNG 저장탱크는 주로 9% 니켈강형 내조와 프리스트레스 콘크리트의 외조로 구성되어 있다. 1896년 상업운전 이후 내조의 피로와 외조의 내구성 저하로 인한 구조물 성능 열화의 위험성 증대에 선제적으로 대응할 수 있도록 수명평가 프로그램이 필요하다. 이 연구는 LNG 저장탱크의 내조에 대해 피로평가와 외조의 내구성(탄산화, 염해)을 평가할 수 있는 수명평가 프로그램을 개발하였다. 내조 탱크는 3가지의 주요 시나리오를 정의하여 구조해석과 마이너 손상법칙이 적용된 피로수명 해석이 수행된다. 외조 탱크의 탄산화 평가는 이산화탄소 함량과 침투 깊이 데이터를 이용하여 콘크리트 피복두께에 따른 탄산화 진전을 예측한다. 외조 탱크의 염해 평가는 다양한 입력조건 고려와 신뢰도 있는 결과를 도출하기 위해 공개 프로그램인 Life-365프로그램에 연계하는 방안으로 구축하였다.

• 보건행정학회지
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• 제7권2호
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• pp.65-88
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• 1997

In Korea, telemedicine is still under the beginning stage, but we expect that the developing 'Information Highway' will make this technology more common place and more easily used in coming soon. Currently, three hospitals are providing telemedicine services with their subsidiary hospitals which are far away from their remote place. However, the fee schedule of telemedicine services are not well-settled down, of course not reimbursed through current health insurance system. This study aims to develop new payment system for medical services provided through telemedicaine system. To design appropriate fee schedule for telemedicine services, we, first, review the current insurance payment system and telemedicine system both in domestic and foreign countries focusing on its payment system. A framework of telemedicine payment system is proposed in following steps based on information we acquired from this stage. Second. We decide the span of cost items which should be covered by telemedicine payment scheme. In hear, we suggest payment method for telemedicine services should be designed as dual structure which are telemedicine fee that should be reimbursed through payment scheme and any costs related to capital investment that should not be covered by payment system. Which is, payment system for telemedicine services should cover only service-related costs and any costs related to capital investment should be generated through third party such as government, health insurance association, etc. Finally, we suggest new fee schedules for telemedicine services. The key issues on developing telemedicine fee schedules are related with the determination of appropriate additional rate($\alpha$). The reasonable additional rate($\alpha$) must determine through careful evaluation of any additional efforts(e. g. : additional work hours which are related to providing telemedicine services). This study shows the process of how to determine appropriate additional rate($\alpha$).

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 1997년도 International Symposium on Fire Science and Technology
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• pp.146-153
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• 1997

An experimental study was performed of natural-convection downward smolder spread across a sawdust bed peripherally enclosed with an insulating container, to examine the effect of the open- ing condition at the top end on downward smolder spread. Experiments were conducted by using relatively coarse sawdust and 25-cm-long cylindrical container The variations of temperature profiles along the bed axis with time were determined far different opening conditions and were com-pared with those in smolder spread from open top to open bottom. It was shown that the smolder zone initiated from open top toward closed bottom penetrates the bed with keeping high peak temperature like the case of open top to open bottom spread, although mean spread rate is smaller. This indicates that the downward smolder zone can be sustained stably if sufficient air or oxygen Is supplied from the back of it by natural convection even if upward draft entering from the bottom of the bed is absent. When the top end was partially closed by mounting a cover after stable smolder spread had begun from open top toward open bottom, the temperature at the peak decreased more than 200 K and the smolder zone became to spread with thickening residue. In this case, the shape of temperature profiles continuously changed or decayed until end-effect at the open bottom end enhanced the reaction. The temperature at the shrunk peak, free from the end-effect, was almost identical with the temperature at the exothermic oxidative-degradation zone in smolder spread from open top to open bottom. from these results, it can be inferred for natural-convection downward smolder spread that the oxidation reaction of the char is very sensitive to the oxygen supply by natural convection in the space above the smolder zone, and that the top end opening condition strongly alters the completeness of reactions, structure, and behavior of the smolder zone.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2012년도 추계학술발표대회
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• pp.450-451
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• 2012

The need of Clinical Decision Support System (CDSS) in healthcare setup is increasing day by day. EHR Meaningful Use advocates CDSS as an important component of EHR/EMR systems. CDSS can be ranged from a simple to a very sophisticated system. The more complex CDSS systems need more attention to develop because of many reasons including its Knowledge Base (KB) structure/maintenance/evolution, inference capabilities and usability. Above all the KB maintenance and evolution is very crucial and important from the perspective of useful decision capabilities. Also the richness of the KB is important to cover the decision gaps handling a particular situation in the course of patient care. It cannot be expected from the clinicians to remember everything in regard to patient diagnosis and treatment. Similarly, it is also crucial for clinicians to keep themselves updated with the new research in the area. That is the reason they frequently require accessing to the online knowledge resources. Literature proved that online knowledge resources are capable providing answers to questions that might not be answered rely only on clinician wisdom and experience. This paper provides the theme of meaningful utilization of online knowledge resources in the context of diagnosis and treatment process for cancer patients more specifically Head and Neck cancer.