• Korean Journal of Optics and Photonics
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• v.4 no.4
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• pp.452-456
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• 1993

The quantum efficiencies of photomultiplier tubes were measured by counting the coincidence photon pairs generated in the process of spontaneous parametric down-conversion. They were measured within 3% accuracy over the range of wavelength from 560 to 850 nm without any standard light source or detector. The values for 633 nm correspond to those obtained with a calibrated laser power meter within the measurement error.

• Nuclear Engineering and Technology
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• v.54 no.6
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• pp.2004-2010
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• 2022

Quantification of sensitive material is of vital importance when it comes to the movement of nuclear fuel throughout its life cycle. Within the electrorefiner vessel of electrochemical separation facilities, the task of quantifying plutonium by neutron analysis is especially challenging due to it being in a constant mixture with curium. It is for this reason that current neutron multiplicity methods would prove ineffective as a safeguards measure. An alternative means of plutonium verification is investigated that utilizes the (𝛼,n) signature that comes as a result of the eutectic salt within the electrorefiner. This is done by utilizing the multiplicity variable a and breaking it down into its constituent components: spontaneous fission neutrons and (𝛼,n) yield. From there, the (𝛼,n) signature is related to the plutonium content of the fuel.

• Korean Journal of Optics and Photonics
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• v.13 no.4
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• pp.308-313
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• 2002

One of the nonclassical effects in two-photon interference experiments, spatial quantum beating, is observed in fourth-order interference with pairs of photons produced by a spontaneous parametric down-conversion process. When photon pairs in different frequencies $\omega1$ and $\omega2$ are mixed together, and directed to two detectors, the coincidence counts exhibit a cosine modulation with difference frequency | $\omega1$- $\omega2$|. The measured coincidence counts turned out to have an interference pattern with periodicity of 10.45 ㎛ in position or 34.82fs in time delay, which corresponds to the period 2$\pi$/| $\omega1$- $\omega2$| for the beat frequency of 0.29${\times}10^{14}$Hz.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6417-6421
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• 2015

Viscum album var (VAV) also known as mistletoe, has long been categorized as a traditional herbal medicine in Asia. In addition to its immunomodulating activities, mistletoe has also been used in the treatment of chronic hepatic disorders in China and Korea. There are numerous reports showing that VAV possesses anti-cancer effects, however influence on human hepatocarcinoma has never been elucidated. In the present study, hot water extracts of VAV was evaluated for its potential anti-cancer effect in vitro. SK-Hep1 cells were treated with VAV (50-400ug/ml) for both 24 and 48 hours then cell viability was measured by cell counting kit-8 (CCK-8). Flow cytometry analysis was used to measure the proportion of SK-Hep1 in the different stages of cell cycle. RT-PCR and Western blot analysis were conducted to measure expression of cell cycle arrest related genes and proteins respectively. VAV dose dependently inhibited the proliferation of SK-Hep1 cells without any cytotoxicity with normal Chang liver cell (CCL-13). Flow cytometry analysis showed that VAV extract inhibited the cell cycle of SK-Hep1 cells via G1 phase arrest. RT-PCR and Western blot analysis both revealed that cyclin dependent kinase 2 (Cdk2) and cyclin D1 gene expression were significantly down regulated while p21 was upregulated dose dependently by VAV treatment. Combined down regulation of Cdk2, Cyclin D1 and up regulation of p21 can result in cell death. These results indicate that VAV showed evidence of anti-cancer activity through G1 phase cell cycle arrest in SK-Hep1 cells.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5667-5672
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• 2014

Folate receptor alpha ($FR{\alpha}$) mediates folate uptake by endocytosis, and while folate is essential to DNA methylation and synthesis and may have an important role in proliferating cells. $FR{\alpha}$ is known to be expressed in rapidly proliferating cells, including many cancer cell lines, but there has been no systematic assessment of expression in cervical cancer cell lines. The aim of the present study was to evaluate the effects of $FR{\alpha}$ on proliferation and apoptosis of cervical cells and correlation mechanism. In this study, we investigated the biological function of $FR{\alpha}$ in Hela cells using RNA interference. Cell proliferation was evaluated by Cell Counting Kit-8 (CCK8) assay, while cell cycling and apoptosis were assessed by flow cytometry, mRNA levels by real time-PCR and protein levels of $FR{\alpha}$, c-Fos and c-Jun by Western blotting. The results revealed that $FR{\alpha}$ was highly expressed in Hela cells and its silencing with a small interfering RNA (siRNA) inhibited cell proliferation and induced cell apoptosis, arresting the cell cycle in G0/G1 stages while decreasing the proportion in S and G2/M stages, and suppressed the expression levels of c-Fos and c-Jun. In conclusion, the results of this study indicated that $FR{\alpha}$ down-regulation might be capable of suppressing cervical cancer cell proliferation and promoting apoptosis. It suggested that $FR{\alpha}$ might be a novel therapeutic target for cervical cancer.

• Korean Journal of Optics and Photonics
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• v.22 no.6
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• pp.276-282
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• 2011

We performed experiments on Hong-Ou-Mandel type two-photon interference with frequency entangled photon pairs at 1.5 ${\mu}m$ telecommunication band generated through femtosecond pulsed spontaneous parametric down-conversion. Two different angular frequencies ${\omega}_1$ and ${\omega}_2$ were selected using CWDM(coarse wavelength division multiplexing) filters at the output ports of the interferometer. The coincidence counting rates were measured with varying path-length difference between the two interferometer arms to observe the two-photon interference patterns of spatial beating. The obtained visibilities in the net coincidence were close to the theoretical limit of 100%.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1099-1104
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• 2014

Aims and Background: Ginsenoside Rh2, which exerts the potent anticancer action both in vitro and in vivo, is one of the most well characterized ginsenosides extracted from ginseng. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between ginsenoside Rh2 and phosphoglucose isomerase/autocrine motility factor (PGI/AMF). Methods: $KG1{\alpha}$, a leukemia cell line highly expressing PGI/AMF was assessed by western blot analysis and reverse transcription- PCR (RT-PCR) assay after transfection of a small interfering (si)-RNA to silence PGI/AMF. The effect of PGI/AMF on proliferation was measured by typan blue assay and antibody array. A cell counting kit (CCK)-8 and flow cytometry (FCM) were adopted to investigate the effects of Rh2 on PGI/AMF. The relationships between PGI/AMF and Rh2 associated with Akt, mTOR, Raptor, Rag were detected by western blot analysis. Results: KG1${\alpha}$ cells expressed PGI/AMF and its down-regulation significantly inhibited proliferation. The antibody array indicated that the probable mechanism was reduced expression of PARP, State1, SAPK/JNK and Erk1/2, while those of PRAS40 and p38 were up-regulated. Silencing of PGI/AMF enhanced the sensibility of $KG1{\alpha}$ to Rh2 by suppressing the expression of mTOR, Raptor and Akt. Conclusion: These results suggested that ginsenoside Rh2 suppressed the proliferation of $KG1{\alpha}$, the same as down-regulation of PGI/AMF. Down-regulation of PGI/AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1${\alpha}$ by reducing Akt/mTOR signaling.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.352-364
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• 2007

It is essential to reduce track maintenance costs and to extend the periodic replacements of continuous welded rails based on accumulated passing tonnage. As recently train load decrease and rail joints wear down less, the periodic replacements of continuous welded rails can be extended. There are many kinds of rail damage like squat, head-check and corrugation. These can be taken nondestructive or naked eye test. So the periodic replacements of continuous welded rails based on accumulated passing tonnage were examine with focusing on a crack of rail bottom of continuous welded rail. Therefore, this study measure dynamic response of track by metro train load, it compute impact coefficient and track spring coefficient for estimating a condition of actual track system. Also, it is converted the measured stress waveform into stress frequency histogram by the rain-flow counting methods, and then the equivalence of stress is calculated. As apply s-n curve of a new welded rail, accumulated fatigue damage ratio of laid rail and remaining service lives is estimated. This study suggest a plan of the periodic replacements of continuous welded rails based on accumulated passing tonnage classified by the types of track system.

• Speech Sciences
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• v.11 no.2
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• pp.105-117
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• 2004

Recently, many scholars have emphasized the importance of English listening ability for smoother communication. Most audio materials, however, were recorded in a quiet sound-proof booth. Therefore, students who have spent so much time listening to the ideal audio materials are expected to have difficulty communicating with native speakers in the real life. In this study, we examined how well thirty three Korean university students and five native speakers will repeat the recorded English sentences under noise and speed conditions. The subjects' production was scored by listening to each recorded sentence and counting the number of words correctly produced and determined the percent ratios of correctly produced words to the total words in each sentence. Results showed that the student group correctly repeated around 65% of all the words in each sentence while the native speakers demonstrated almost perfect match. It seemed that the students had difficulty perceiving and repeating function words in various conditions. Also, high-proficiency student group outperformed the low-proficiency student group particularly in their repetition of function words. In addition, the student subjects' accuracy of repetition remarkably dropped when the normal sentences were both sped up and mixed with noise. Finally, it was observed that the Korean students' percent correct ratio fell down as the stimulus sentence became longer.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.9
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• pp.172-178
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• 2002

One of the ever-increasing demands on the performances of heterodyne interferometers is to improve the measurement resolution, of which current state -of-the-art reaches the region of sub-nanometers. So far, the demand has been met by increasing the clock speed that drives the electronics involved fur the phase measurement of the Doppler shift, but its further advance is being hampered by the technological limit of modem electronics. To cope with the problem, in this investigation, we propose a new scheme of phase -measuring electronics that reduces the measurement resolution without further increase in clock speed. Our scheme adopts a super-heterodyne technique that lowers the original beat frequency to a level of 1 MHz by mixing it with a stable reference signal generated from a special phase- locked-loop. The technique enables us to measure the phase of Doppler shift with a resolution of 1.58 nanometer at a sampling rate of 1 MHz. To avoid the undesirable decrease in the maximum measurable speed caused by the lowered beat frequency, a special form of frequency up-down counting technique is combined with the super-heterodyning. This allows performing required phase unwrapping simply by using programmable digital gates without 2n ambiguities up to the maximum velocity guaranteed by the original beat frequency.