• Advances in pediatric surgery
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• 제17권2호
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• pp.179-187
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• 2011

Experimental tracheal ligation (TL) has been shown to reverse the pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) and to normalize gas exchange. The purpose of this study was to determine whether the TL would correct the surfactant deficiency present in the fetal rabbit model of CDH by using lamellar body count. Lamellar bodies are synthesized and secreted by the type II pneumocytes of fetal lung. The phospholipids present in these bodies constitute the major component of pulmonary surfactant. Twenty-one pregnant New Zealand rabbits underwent hysterotomy and fetal surgery on gestational day 24. Two fetuses of each pregnant rabbit were operated. In the fetus of one end of bicornuate uterus, left DH was created by excision of fetal diaphragm through open thoracotomy (DH Group). In the fetus of the other end of bicornuate uterus, left DH and TL were created (TL Group). The fetuses were delivered by Cesarean section on gestational day 31. Fourteen in control group, 12 in the DH group and 13 in TL group were born alive. En bloc excision of lungs, bronchi and trachea was done in all newborn rabbits. A five Fr catheter was inserted through trachea and repeated irrigations with 10 cc normal saline were done. The irrigated fluid was centrifuged at $280{\times}g$ for 5 minutes and the lamellar bodies were counted with the upper level fluid in platelet channel of electronic cell counter. The average lamellar body counts were $37.1{\pm}14.2{\times}10^3/{\mu}L$ in control group, $11.5{\pm}4.4 {\times}10^3/{\mu}L$ in DH group, and $6.5{\pm}0.9{\times}10^3/{\mu}L$ in TL group. Lamellar body count in DH group was lower than in control group and did not increase after TL. This study shows TL has no therapeutic effect on decreased surfactant level of CDH and the pregnant rabbit is appropriate for the animal model of CDH.

• 응용통계연구
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• 제23권2호
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• pp.335-344
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• 2010

공간자료분석에서 공간적 상관성을 배제한 일반적인 회귀모형을 통한 모수 추정값들은 신뢰성의 문제가 지적 되어 오고 있다. 본 연구에서는 공간자료의 상관성을 고려한 모형을 구축하기 위하여 일변량 조건부자기회귀모형을 이용하였으며 베이지안 기법을 통하여 모수를 추정하고 공간상관성이 고려된 공간 가산자료모형과 고려되지 않은 일반 가산자료모형을 비교하였다. 연구 대상으로는 서울시의 25개 행정자치구별 총범죄 자료를 이용하였으며 자료분석을 통하여 도시계획과 같은 국가 정책의 수립에 참고자료로 활용될 수 있으리라 판단된다.

• 응용통계연구
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• 제30권4호
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• pp.529-538
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• 2017

Ghosh와 Kim에 의해 소개된 영 변환 모형은 0이 많거나 적을 때 계수형 자료(count data)를 분석하는 모형이다. 이 모형의 산포형태모수는 평균과 분산, 0 확률로 구성되며 ${\mu}$와 ${\sigma}^2$의 관계에 따라 2가지 형태를 가진다. 본 논문에서는 ${\sigma}^2{\geq}{\mu}$일 때, Ghosh와 Kim 영 변환확률 모형의 모수 ${\delta}$에 대한 영향함수를 도출하였다. 도출한 영향함수의 타당성을 검증하기 위해서 인구주택총조사 자료를 이용해 관측치가 제거된 경우에서 영향함수로 도출한 ${\delta}$ 추정치 변화값과 직접 계산한 ${\delta}$ 추정치 변화값을 비교하였다. 그 결과 영향함수는 ${\delta}$의 변화를 매우 정확히 추정하였다.

• 전자공학회논문지S
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• 제36S권7호
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• pp.104-115
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• 1999

본 논문은 세 개의 카메라로부터 얻어진 영상에서 표면 깊이 정보를 재구성하여 얼굴의 3차원 모델을 생성하는 효율적인 방법을 제안한다. 논문에서는 Trinocular 영상을 사용하여 binocular 영상 사용 시 발생하는 폐색 영역 문제와 깊이 해상도 한계를 개선하였다. 또한, MPC_MBS (Matching Pixel Count Multiple Baseline Stereo) 유사도 측정 방법을 제안하여 영상 정합 시 발생하는 Boundary overreach 현상을 줄이고 정합의 정확도와 정밀도를 개선하였다. 이 방법은 정합 때 발생하는 중복 계산을 제거함으로써 계산 시간도 줄일 수 있다. 모델 생성 시에는 추출된 변위 정보를 2차원 보간에 의해 소수점 단위까지 확장하여 연속적인 표면 깊이 정보를 추출하였고, 이로부터 일정 간격의 초기 삼각형 매쉬 모델을 생성하였다. 또한 삼각형 매쉬 모델의 데이터 크기를 줄이기 위하여 사용자가 지정하는 오차 이내에서 같은 평면으로 근사화 되는 꼭지점을 병합하는 알고리듬을 제안하여 효율적인 얼굴 모델 생성이 이루어지도록 하였다.

• Clinical and Experimental Reproductive Medicine
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• 제31권1호
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• pp.59-65
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• 2004

Objectives: The aim of this study was to assess toxicities of cryoprotectants. Methods: Toxicities of two cryoprotectants, dimethyl sulfoxide (DMSO) and 1, 2-propanediol (PROH), were investigated using a murine embryo model. Female F-1 mice were stimulated with gonadotropin, induced ovulation with hCG and mated. Two cell embryos were collected and cultured after exposure to either DMSO or PROH. Embryo development was evaluated up to the blastocyst stage. Blastocysts were stained with bis-benzimide to evaluate the cell count and with terminal deoxynucleotidyl transferase mediated dUTP nick labeling (TUNEL) to assess apoptosis. Results: The total cell count of blastocysts that were treated with DMSO at the 2-cell stage was significantly lower than that were treated with PROH ($75.9{\pm}27.0$) or the control ($99.0{\pm}18.3$) (p<0.001). On comparison of two cryoprotectant treated groups, the DMSO treated group showed a decreased cell count compared with the PROH treated group (p<0.05). Both DMSO ($14.2{\pm}1.5$) and PROH ($11.2{\pm}1.4$) treated groups showed higher apoptosis rates of cells in the blastocyst compared with the control ($6.2{\pm}0.9$, p<0.0001). In addition, the DMSO treated group showed more apoptotic cells than the PROH treated group (p<0.001). Conclusions: The potential toxicity of cryoprotectants was uncovered by prolonged exposure of murine embryos to either DMSO or PROH at room temperature. When comparing two cryoprotective agents, PROH appeared to be less toxic than DMSO at least in a murine embryo model.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.76-88
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• 2009

Back ground and Objective : There is a need for objectification and scientific verification of Pattern identification in Oriental medicine. The purpose of this study was to investigate the skin characteristics of Qi deficiency and Blood deficiency animal models. Material and Methods : Sprague-Dawley rats were divided into three groups: normal group, Qi deficiency group and Blood deficiency group. The Qi deficiency animal model was induced through restriction of food (75g/kg/day) for 20 days. Blood deficiency animal model was induced by bleeding from tail vein(0.3 ml/time) 8 times. The normal animal model was kept without any intervention. The general condition was observed by measuring body weight, body temperature, blood pressure, pulse rate, and hematological and biochemical parameters. The skin characteristics were observed by measuring the erythema index(EI), melanin index(Ml), transepidermal water loss(TEWL) and dermal microcirculation. Results : 1. In the Qi deficiency group, body weight was lower than the other groups. In the Qi deficiency group, blood pressure was lower than in the Normal group. There was no difference in body temperature and pulse rate between the three groups. 2. In the Qi deficiency group, blood sugar was lower than in the Blood deficiency group. There was no difference in triacylglycerol between the three groups. In the Qi deficiency group, the WBC count was lower than in the Blood deficiency group. RBC count was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively. In the Qi deficiency group, Hb and Hct were higher than the other groups. 3. EI and MI were decreased in the Qi deficiency group, and EI showed a significant decrease. 4. EI and MI were increased in the Blood deficiency group, and MI showed a significant increase. 5. TEWL was significantly increased in the Qi deficiency group, while it was decreased in the Blood deficiency group, TEWL was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively and all three groups showed significant difference. 6. In the Qi deficiency group, dermal microcirculation was lower than the other groups. Conclusion : The above results show that the erythema index decreases in the Qi deficiency model, and the melanin index increases in the Blood deficiency model. The Qi deficiency animal model shows an increase in transepidermal water loss, while the Blood deficiency animal model shows a decrease. Further studies should develop new models of Pattern Identification that are more specific.

• Asian-Australasian Journal of Animal Sciences
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• 제25권9호
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• pp.1216-1222
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• 2012

Somatic cells count (SCC), milk yield (MY) and pedigree information of 2,791 first lactation cows that calved between 1990 and 2010 on 259 Thai farms were used to estimate genetic parameters and trends for SCC and its genetic association with MY. The SCC were log-transformed (lnSCC) to make them normally distributed. An average information-restricted maximum likelihood procedure was used to estimate variance components. A bivariate animal model that considered herd-yr-season, calving age, and regression additive genetic group as fixed effects, and animal and residual as random effects was used for genetic evaluation. Heritability estimates were 0.12 (SE = 0.19) for lnSCC, and 0.31 (SE = 0.06) for MY. The genetic correlation estimate between lnSCC and MY was 0.26 (SE = 0.59). Mean yearly estimated breeding values during the last 20 years increased for SCC (49.02 cells/ml/yr, SE = 26.81 cells/ml/yr; p = 0.08), but not for MY (0.37 kg/yr, SE = 0.87 kg/yr; p = 0.68). Sire average breeding values for SCC and MY were higher than those of cows and dams (p<0.01). Heritability estimates for lnSCC and MY and their low but positive genetic correlation suggested that selection for low SCC may be feasible in this population as it is in other populations of dairy cows. Thus, selection for high MY and low SCC should be encouraged in Thai dairy improvement programs to increase profitability by improving both cow health and milk yield.

• 대한간호학회지
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• 제42권6호
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• pp.819-832
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• 2012

Purpose: This study was conducted to identify risk factors that influence the probability and severity of elder abuse in community-dwelling older adults. Methods: This study was a cross-sectional descriptive study. Self-report questionnaires were used to collect data from community-dwelling Koreans, 65 and older (N=416). Logistic regression, negative binomial regression and zero-inflated negative binomial regression model for abuse count data were utilized to determine risk factors for elder abuse. Results: The rate of older adults who experienced any one category of abuse was 32.5%. By zero-inflated negative binomial regression analysis, the experience of verbal-psychological abuse was associated with marital status and family support, while the experience of physical abuse was associated with self-esteem, perceived economic stress and family support. Family support was found to be a salient risk factor of probability of abuse in both verbal-psychological and physical abuse. Self-esteem was found to be a salient risk factor of probability and severity of abuse in physical abuse alone. Conclusion: The findings suggest that tailored prevention and intervention considering both types of elder abuse and target populations might be beneficial for preventative efficiency of elder abuse.

• 한국축산식품학회지
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• 제40권6호
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• pp.896-907
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• 2020

Imaging technique or computer vision (CV) technology has received huge attention as a rapid and non-destructive technique throughout the world for measuring quality attributes of agricultural products including meat and meat products. This study was conducted to test the ability of CV technology to predict the quality attributes of beef. Images were captured from longissimus dorsi muscle in beef at 24 h post-mortem. Traits evaluated were color value (L*, a*, b*), pH, drip loss, cooking loss, dry matter, moisture, crude protein, fat, ash, thiobarbituric acid reactive substance (TBARS), peroxide value (POV), free fatty acid (FFA), total coliform count (TCC), total viable count (TVC) and total yeast-mould count (TYMC). Images were analyzed using the Matlab software (R2015a). Different reference values were determined by physicochemical, proximate, biochemical and microbiological test. All determination were done in triplicate and the mean value was reported. Data analysis was carried out using the programme Statgraphics Centurion XVI. Calibration and validation model were fitted using the software Unscrambler X version 9.7. A higher correlation found in a* (r=0.65) and moisture (r=0.56) with 'a*' value obtained from image analysis and the highest calibration and prediction accuracy was found in lightness (r²_c=0.73, r²_p=0.69) in beef. Results of this work show that CV technology may be a useful tool for predicting meat quality traits in the laboratory and meat processing industries.

• 한국컴퓨터정보학회논문지
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• 제17권6호
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• pp.75-81
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• 2012

본 논문에서는 QoS 라우팅 알고리즘의 성능을 유지하면서 LSU(Link State Update) 메시지의 수를 제어할 수 있는 QoS 라우팅 링크 상태 갱신 알고리즘을 제안하였다. 기존에 제시된 대부분의 LSU 알고리즘은 QoS 라우팅의 성능을 향상시키는데 중점을 두고 있기 때문에 LSU 메시지의 수가 늘어나더라도 제어할 수 있는 메커니즘을 가지고 있지 않다. 특히 트래픽 통계에 근거한 적응형 알고리즘의 경우 더욱더 그러하며 트래픽이 과도하거나 변화가 심할 경우 이와 비례해서 LSU 메시지 수도 증가하여 과도한 LSU 메시지가 성능을 오히려 좋지 않게 한다. 제시하는 알고리즘은 QoS 라우팅 성능과 상충관계에 있는 과도한 LSU 메시지의 수를 제어하기 위해 요구 대역폭이 가용대역폭에 미치는 영향에 따라 LSU 메시지의 중요도를 구분하고 중요도와 단위시간 당 업데이트 비율 ${\gamma}$에 따라 LSU 메시지의 전송 여부를 결정하여 LSU 메시지 수를 제어한다. 성능 평가를 위해 기존에 제시된 다양한 LSU 알고리즘과 본 논문에서 제안하는 알고리즘을 MCI 네트워크상에서 라우팅 Blocking 확률과 링크 당 평균 LSU 메시지의 개수 등을 성능 평가 항목으로 하여 시뮬레이션을 수행하였고 제안하는 알고리즘의 우수성을 확인하였다.