• The Journal of Internal Korean Medicine
• /
• v.31 no.4
• /
• pp.829-836
• /
• 2010

Purpose : This study investigated the diurnal rhythm of cortisol in male and female adolescents. Methods : Salivary cortisol was examined in 52 normally developing subjects aged 13 to 14 years. Subjects provided saliva samples at 08:00h, 12:00h, 16:00h and 20:00h. Results : Males and females showed similar pattern of cortisol, which elevated cortisol in the morning and decreased in the evening. There were no differences of gender at 08:00h, 12;00h and 20:00h. There were also not difference between males and females using an area under the curve analysis. Conclusions : The same diurnal cortisol rhythm were found in male and female adolescents. Further research is needed to examine differences of gender in cortisol awakening response.

• The Journal of Internal Korean Medicine
• /
• v.35 no.1
• /
• pp.50-58
• /
• 2014

Objectives : The aim of this study was to analyze relationship between post-stroke depression (PSD) and cold, heat, deficiency and excess patterns. Methods : Twenty-eight PSD patients were recruited from STROKE center and measured with questionnaires for cold, heat, deficiency and excess patternvalues and saliva for cortisol awakening response (CAR). Saliva samples were collected immediately, 15, 30 and 45 min after awakening. In addition, Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS) were conducted for PSD severity. We conducted correlation analysis to find the relationship between cold, heat, deficiency and excess patterns and CAR or BDI and HDRS. Results : Deficiency and excess patterns werepositively correlated with area under the curve with respect to the increase (AUCi), but not with area under the curve with respect to the global (AUCg), in CAR. Furthermore, it was negatively correlated with BDI and HDRS, while cold and heat patterns were not correlated with CAR, BDI and HDRS. Conclusions : In terms of deficiency and excess patterns, the higher the PSD severity, the higher the deficiency and the lower the PSD severity, the higher the excess. However, there was not a significant relationship between PSD and cold and heat patterns.