• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제2권1호
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• pp.32-42
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• 1991

지금까지 시험불안을 진단하기 위해 여러 방법들이 동원되어 왔는데, 그 중 가장 널리 쓰이는 것은 자기보고에 의한 방법이다. Spielberger의 Test Anxiety Inventory(TAI)는 시험불안의 정서적, 인지적인 측면을 구분하여 측정할 수 있는 자기보고식 검사도구로서, 이를 우리나라 학생들에게 실시한 결과 그들의 시험불안 요인을 설명하기에 이 TAI 문항만으로는 적절하지 못하다고 판단되었다. 그리하여 우리나라 학생들을 개인별로 면담한 자료와 현재 사용되고 있는 기존의 검사문항을 추가시켜 문항분석을 통해서 25문항으로 이루어진 국민학생용과 35문항으로 된 중, 고등학생용을 완성하여 TAI-K라 정하였다. 이 TAI-K의 신뢰도 검증은 Cronbach's ${\alpha}와$ 2주 간격으로 검사-재검사 신뢰도를 통해서 이루어졌으며(국민학생용 : ${\alpha}=.90,$ 검사-재검사 신뢰도 : r=.78 ; 중, 고등학생용 : ${\alpha}=.94,$ r=.85), 타당도검증은 일반불안 척도들과 Self-esteem Scale, 성격요인 검사를 통해서 이루어졌다. 그 결과 시험불안은 일반불안과 정적상관이 높으며, Self-esteem과 부적상관을 갖고 있는 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.45-50
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• 2016

Background: The tobacco epidemic is a heralding health menace, particularly among college students. Tobacco usage among young can have an especially devastating effect as they can be exposed for longer periods. Data to estimate the prevalence of tobacco use in young adults will be a valuable addition to the existing resources. Materials and Methods: An analytical cross-sectional study was therefore carried out in Mangalore city using a pre-tested, self-administered questionnaire adapted from the Global Youth Tobacco Survey (GYTS) with a representative sample of 720 students aged 18-20 years selected from degree colleges by multi-stage random sampling. Results: Prevalence of 'ever users' and 'current users' of smoking were 20.4% and 11.4%, respectively. The mean age at initiation of cigarette smoking was 16 years and the majority (31 %) smoked in public places. Interestingly, 84% of them knew about the harmful effects of cigarette smoking. About one half of smokers had some or most of their friends smoking. Multivariate analysis revealed gender (OR=8.585: CI-3.26-22.5), pocket money (OR=4.165; CI=1.76-9.82) and peer's smoking habit (OR= 5.15; CI-2.21-11.9) have higher odds as correlates of tobacco usage among college students. Conclusions: It is of prime importance to highlight the role of prevention of smoking initiation rather than subsequently trying to stop the habit. Comprehensive interventions embracing family, friends and social milieu are needed to reduce tobacco use among students in India.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2707-2710
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• 2013

Background: This study used pre-hepatitis A vaccination era data in U.S. to study the relationship between serum hepatitis A antibody positivity with pancreas cancer mortality in adults. Patients and Methods: Public use National Health and Nutrition Examination Survey (NHANES III) data were employed. NHANES III uses complex probabilistic methods to sample nationally representative samples. Household adult laboratory and mortality data were merged. Sample persons who were available to be examined in the Mobile Examination Center (MEC) were included in this study. All results were obtained by using specialized survey software taking into account the primary sampling unit and stratification variables and the weights assigned to the sample persons examined in the MEC. Thus they are representative of the U.S. population. Results: The mean risk (95%CI) of death in the study population for pancreas cancer was 0.0014 (-0.000069 -.0029); their mean age (95%CI) at the mobile examination center (MXPAXTMR) was 473.43 (463.85-482.10); the follow up in months from their medical examination (permth_exm) was 170.12 (164.17-176.07). The odds ratios (S.E.) of the statistically significant univariables were: age, 1.007 (1.005-1.009); serum anti-hepatitis antibody status, 0.038 (0.004-0.376); and drinking hard liquor, 1.014 (1.004-1.023). The coefficients (S.E.) of the statistically significant variables after multivariate analysis were 0.006 (0.002-0.010) for age and -2.528 (-4.945--0.111) for serum anti-hepatitis A antibody negativity (using serum anti-hepatitis A antibody positivity as a reference). Conclusion: Serum hepatitis A antibody positivity correlates with higher pancreas cancer mortality in adults.

• Journal of Preventive Medicine and Public Health
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• 제53권5호
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• pp.323-331
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• 2020

Objectives: This study aimed to determine the prevalence and correlates of sexual intercourse among junior secondary and high school students in Indonesia from the 2015 Global School-based Health Survey (GSHS). Methods: The survey was conducted among 11 110 students from 75 schools in Indonesia using a self-administered questionnaire. Univariate and multivariate analyses were conducted to explore associations between sexual intercourse and socio-demographic variables, substance use, mental distress, and protective factors. Results: Overall, 5.3% of students reported having ever had sex (6.9% of boys and 3.8% of girls). Of students who engaged in sexual intercourse, 72.7% of boys and 90.3% of girls had an early sexual debut (before reaching the age of 15) and around 60% had multiple sex partners. Sexual intercourse was associated with gender, school grade, smoking, alcohol consumption, drug use, suicidal ideation, truancy, peer support, and parental supervision. Conclusions: These findings indicate a pressing need to develop more comprehensive sexual health education in the national curriculum. An effective strategy should also address other risky behaviours.

• 동의생리병리학회지
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• 제19권3호
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• pp.671-676
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• 2005

In this study, we investigated the antioxidant effect of extract from Monascus pillosus, on the human wild-type p53 and p21 expressing A549 lung epithelial cell line and MCF-7 mammary adenocarcinoma cell line stimulated by NO. $P21^{waf/cip1}$ was identified as a gene induced in senescent cells. It is a cyclin-dependent kinase inhibitor and has been shown to cause cell cycle arrest and apoptosis. While p53-regulated stimulation of p21 appears to be central for the permanent growth-arrest, the role of p21 in p53-triggered cell death is unclear. Low dose of sodium nitroprusside (SNP) induced the development of senescence associated with increased expression of p53 and p21 in A549 cells. Inhibition of p21 transactivating activity requires high level correlates with the amount of p53 necessary to cause cell death. Association of p21 and p53 results in inhibition of p21-stimulated transcription. This requires a higher p53 level than is necessary for transcriptional activation of endogenous p53-responsive gene but correlates well with the level of p53 necessary to cause cell death. Exposure to W-1 inhibited oxidative stresses-induced senescence-like arrest, resulting in a significant reduction in p53 and p21 steady state levels. These results suggest that p53 and p21 play a central role in the onset of senescence. Thus, it is important to emphasize control of oxidative balance in tumor prevention and aging.

• Journal of Pharmaceutical Investigation
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• 제28권4호
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• pp.275-282
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• 1998

In order to develop a desirable in vitro release which correlates well with in vivo bioavailability, hollow type suppository containing Propranolol HCl(PPH) powder in the cavity and conventional type suppository with dispersed PPH in the base were prepared. Polyvinyl alcohol (PVA) hydrogel as a base and PPH as a model drug were used for the preparation of suppository. The rates of drug release from the suppositories were studied by Paddle method, Muranish method, Dialysis tubing method and Rotating dialysis cell method. The release profiles from suppositories using the four different release tests were compared. After a rectal administration in rat, the mean $C_{max}$ of hollow type suppository was significantly lower than that of conventional type, but $T_{max}$, $AUC_{0{\to}12}$ and MRT of hollow type were significantly higher 1.6 times, 1.2 times and 1.9 times than those of conventional type, respectively. The computer program was used to simulate plasma concentration from in vitro released amounts of drug and in vivo pharmacokinetic parameters. Based on comparison of the simulated bioavailability from computer program with experimental bioavailability in rat we have found out in vitro release test which correlates well with in vivo bioavailability. Our results have shown the best correlation between in vitro release and in vivo bioavailability in PPH-PVA hydrogel hollow type suppository for the paddle method and conventional type suppository for the rotating dialysis cell method. In this work we propose that PPH-PVA hydrogel suppository shows in vitro-in vivo correlation. This data should help to optimize the formulation of the drug and provide a basis for quality control procedures.

• Clinical and Experimental Reproductive Medicine
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• 제42권1호
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• pp.14-21
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• 2015

Objective: It has previously been suggested that embryos developing from intracytoplasmic sperm-injected (ICSI) zygotes with three pronuclei (3PN) are endowed with a mechanism for self-correction of triploidy to diploidy. 3PN are also observed in zygotes after conventional in vitro fertilization (IVF). The parental origin, however, differs between the two fertilization methods. Whereas the vast majority of 3PN IVF zygotes are of dispermic origin and thus more likely to have two centrioles, the 3PN ICSI zygotes are digynic in origin and therefore, more likely to have one centriole. In the present study, we examine whether the parental origin of 3PN embryos correlates with the karyotype. Methods: The karyotype of each nucleus was estimated using four sequential fluorescence in situ hybridizations-each with two probes-resulting in quantitative information of 8 different chromosomes. The karyotypes were then compared and correlated to the parental origin. Results: 3PN ICSI embryos displayed a significantly larger and more coordinated reduction from the assumed initial 3 sets of chromosomes than 3PN IVF embryos. Conclusion: The differences in the parental origin-and hence the number of centrioles-between the 3PN IVF and the 3PN ICSI zygotes are likely to be the cause of the differences in karyotypes.

• 대한간호학회지
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• 제38권3호
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• pp.437-444
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• 2008

Purpose: This study aimed to identify the relationships among physical symptoms, activities of daily living, and health-related quality of life (HRQoL) in community-dwelling older adults. Methods: A stratified random sampling method was conducted to recruit participants from May 10 to August 17, 2007. Physical symptoms were measured using the Physical Health Questionnaire (PHQ), activities of daily living using the Late-Life Functional and Disability Instrument (LLFDI), and HRQoL using the Medical Outcomes Short-Form Health Survey (SF-36) in 242 community-dwelling elderly Korean people. Results: The HRQoL correlates with the physical symptoms (r=-.31) and the function component (r=.59). Of the two disability parts of the LLFDI, the limitation dimension correlates higher (r=.57) with HRQoL than the frequency dimension (r=.42). The HRQoL is significantly associated with the function component, and disability limitation in capability which explained 44.4% of variance in physical health. Conclusion: These results may contribute to a better understanding of physical symptoms, activities of daily living, and HRQoL in community-dwelling older adults. Therefore, health programs for prompting older adult's health should be planned based on results of the study.

• 대한가정학회지
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• 제26권3호
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• pp.209-224
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• 1988

The purpose of this study is to investigate the relations between spouse's self-disclosure and marital adjustment. A measurement tools used for this study are self-disclosure scale, which was adapted and reproducted from Jourard's Self-Disclosure! Questionnaire(JSDQ), and marital adjustment scale, which was modified and supplemented form Dyadic Adjustment Scale (D.A.S). developed by Spanier. The subjects were 154 married couples dwelling in Seoul and questionnaires are recorded separately by both spouses. Statistical methods such as frequency, percentage, mean, standard deviation, one way ANOVA and pearson correlation were used for data analysis. The results of this study are as follows; 1) For husband, self-disclosure degree was significant difference according to level of education. That is, the more husband was higher level of education, the more husband tended to disclose to wife. 2) Among the variables to have influence on the marital adjustment, level of education and marriage pattern had influence on wive's martial adjustment and family income and marriage pattern had influence on husbands' marital adjustment. 3) Wives were higher disclosed than husbands and wives were more disclosed than perceived husbands' disclosure. 4) There were positive correlation between the self-disclosure of husbands and the marital adjustment of wives. (r+.3872, p<.005) And there were positive correlation between the self-disclosure of wives and the marital adjustment of husbands. (r=.4997, p<.005) 5) For wives, the perception of husbands' disclosure correlates with wives' marital adjustment. (r=.4592, p<.005) For husbands, the perception of wives' disclosure correlates with husbands' marital adjustment.(r=.5610, p<.005) From this results, full and honest self-disclosure is needed for high marital adjustment of a married couple. In the future, a study on the relationship between self-disclosure and marital adjustment is need to various measure of many subject.

• 보건교육건강증진학회지
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• 제20권4호
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• pp.13-26
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• 2003

Objectives： The aim of the present study was to determine the prevalence depressive symptoms, and the correlates of depressive symptoms, and to propose countermeasures for individual depression risk factors among college students. Methods： One university and three colleges in Jeju-do were selected as the study population and a total of 1000 students were selected by multiphasic cluster sampling to represent each department and year within each college. Of the 945 total respondents, 421 were men and 524 were women. The Beck Depression Inventory was used to evaluate depression and the BDI STEN score was used to assess depressive symptoms. Multiple logistic regression analysis was performed for comparisons. Results： 1. The prevalence of depressive symptoms among men was 14.4%, while among women the level rose to 26.8%. 2. Those with poor life satisfaction scores were significantly more likely to have depressive symptoms than those with good life satisfaction (odds ratio (OR) ＝ 2.62； (95% confidence interval (95%CI), 1.483-4.629). 3. Students over 23 years old were significantly more likely to have low levels of depressive symptoms than those under 18 (OR ＝ 0.439； 95%CI, 0.247-0.779). 4. Groups with poor body image satisfaction had higher levels of depressive symptoms when compared to respondents who had good body image (OR = 2.847; 95%CI, 1.341-6.045). 5. Students with poor perceived health status were significantly more likely to have high levels of depressive symptoms than those with good perceived health status (OR ＝ 2.029； 95%CI, 1.157-3.557). Conclusion： Universities and colleges should provide education programs, such as health education that facilitates the development of a healthy body image. In addition, they should focus on various scholarships that could improve satisfaction with student life, especially for alienated students. Furthermore, colleges should help direct students towards engagement in more productive work, and lead social policies away from the dominance of appearance.