• 대한예방한의학회지
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• 제22권2호
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• pp.25-32
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• 2018

Objectives : This study was conducted to investigate the frequent diseases among the people who had been treated by collaborative treatment of Korean medicine and Western medicine, and to compare their medical use behaviors before and after the collaborative first-stage pilot project between Korean medicine and Western medicine. Methods : 4,467 patients were identified as the patients who are participated in the collaborative first-stage pilot project between Korean medicine and Western medicine during the period between July 15, 2016 and March 31 2017. We used 28,480 records of Korean national health insurance claim data from January 1 2016 to March 31 2017 to analyzed present condition of cooperative medical usage. Also we conducted a paired t test to compare the percentage of collaborative treatment days before and after the pilot project period. Results : We found that the most frequent diseases treated in the pilot project were the diseases of musculoskeletal and nervous system and then 10 major diseases such as H, K, J, C (D), N, L, E, A, H and F disease codes in order. Also it was confirmed that 14 major and 53 medium diseases are included from more than 90% of total patients. As a result of high frequency of medical treatment in Western medicine or Korean medicine is "administration of Korean medicine", which is same as before and within the pilot project. The ratio of utilizing both Western and Korean medical care for the same disease on the same day by both general patients and patients in KCD-7 disease code group C, G, I, M and S had been increased significantly. Conclusions : The pilot project might change the behavior of utilizing the medical care service by increasing the ratio of collaborative treatment of Western medicine and Korean medicine for the same disease on the same day.

• 대한암한의학회지
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• 제27권1호
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• pp.1-12
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• 2022

Objectives: To report recurrent pancreatic cancer treated by Korean medicine based-integrated oncology treatment, who is improved quality of life without progression of cancer Method: A 63-year-old female patient diagnosed with recurrent pancreatic cancer in April, 2022 received Chemotherapy with Korean medicine based integrative oncology treatment. Radiologic outcome was assessed by Abdomen Computed Tomography (CT) based on Response Evaluation Criteria In Solid Tumors (RECIST). Clinical outcomes were assessed by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Eastern Cooperative Oncology Group (ECOG), Numeric Rating Scale (NRS) Result: During 2months of treatment, Cancer size was stable in Abdominal CT. Chief complaints, Abdominal pain and dyspepsia, were improved and ECOG score was improved from grade 2 to 1. There were no toxicity on laboratory test and no side effects of grade 3 or higher on NCI-CTCAE. Conclusion: This report shows that Korean medicine based integrative oncology treatment might contribute to synergetic effect to Chemotherapy and improvement of quality of life

• 대한장애인치과학회지
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• 제15권1호
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• pp.84-88
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• 2019

장애인의 교정 치료는 환자에 따라 치료 목표와 방법이 비장애인의 교정 치료와 달라질 수 있다. 교정 치료를 시작하기 전에 환자의 교정 치료의 한계에 대한 보호자와의 충분한 의사소통이 먼저 이루어져야 하고, 교정 치료는 환자가 견딜 수 있으면서 도움이 되는 방향으로 시행되어야 한다. 또한 교정치료 시 보호자들에게 구강위생관리의 중요성을 항상 강조하고 집에서의 구강 위생 관리를 위한 교육을 반드시 시행해야 한다.

• Journal of Animal Science and Technology
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• 제46권2호
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• pp.165-172
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• 2004

본. 연.구.는. 한.우. 수.송.아.지.률. 연.령.별.(4, 9, 12, 및 16개월령 )로 거세하여 사육하는 동안 도체의 이화학적 특성을 비교 검토하기 위하여 실시되었다. 총 75두{형균 4개월령 )의 한우를 Control (비거세우) 및 Treatment I, II, III, 또는 IV(각각 4, 9, 12, 및 16개월령 에 거세)에 업의로 배치한 다음, 각각 7, 9, 12, 16, 및 28개월령 에 도축을 하였다. 한우 등심내 수훈 함량은 비거세우 및 거세우 공히 도축월령이 증가할수록 감소하였으며, 28개월령 도축시 거세우의 등심 내 명균 수분 함량은 68.63%로써, 비거세우의 72.18%에 비하여 유의척 (P <0.05)으로 낮았다. 한우 등심내 조지방 함량은 버거세우와 거세우 공히 도축월령이 증가할 수록 증가하였다. 특히, Treatment III(12 개월령 거세우)는 28 개월령에 도축시 모든 거세우들 중 가장 높은 10.24% 의 조지방 함량을 나타내었다. 한우 비거세우 의 동성 내 조단백질 함량운 도축월령에 상판 없이 23% 정도 이었다. 버거세우와 거세우 공히 등성내 보수력은 도촉월령이 증가함에 따라 증가하는 경향이었으며， 특히 거세우의 경우 16개월령 이후 급격한 보수력의 증가를 보여 28개월령 도축시에는 비거세우(70. 00%)에 비하여 거세우에서 현저하게( P <0.05) 높은( 78 .39%) 보수력을 나타내었다. 한우 버거세우는 도축월령이 증가할수록 등심내 palmitic acid(CI6: o)의 함량이 증가하였으며(20.92 \longrightarrow 24.22%), stearic acid (CI8 : 0)는 감소하였다(18.15\longrightarrow11.32%). 주요 불포화 지방산인 이eic acid(CI8: I)의 함량은 도축월령이 증가할수록 현저하게(P<0.05) 증가 (25.59 \longrightarrow 37.9%) 하였다. 거세우의 등심내 지방산 변화는 전체적으로 비거세우와 유사하였으나, 28 개월령 거세우의 경우 버거세우에 비하여 oleic acid의 함량이 높았으며，stearic acid 함량은 비거세우 보다 낮았다.

• Advances in Traditional Medicine
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• 제1권1호
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• pp.71-81
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• 2000

High molecular weight water-insoluble chitosan alone has been previously shown to exhibit in vitro stimulatory effect on macrophages nitric oxide (NO) production. However, high molecular weight water-soluble chitosan (WSC) had no effect on NO production by itself. When WSC was used in combination with recombinant $interferon-{\gamma}\;(Rifn-{\gamma})$, there was a marked cooperative induction of NO synthesis in a dose-dependent manner. The optimal effect of WSC on NO synthesis was shown at 24 h after treatment with $rIFN-{\gamma}$. The increased production of NO from $rIFN-{\gamma}$ plus WSC-stimulated RAW 264.7 macrophages was decreased by the treatment with $N^G$ $monomethyl-_L-arginine$. The increase in NO synthesis was reflected, as an increased amounts of inducible NO synthase (iNOS) protein. Synergy between $rIFN-{\gamma}$ and WSC was mainly dependent on WSC-induced nuclear $factor-_KB$ activation. The present results indicate that WSC may provide various activities such as anti-microbial, anti-tumoral, and anti-viral. In addition, since NO has emerged as an important intracellular and intercellular regulatory molecule having functions as diverse as vasodilation, neural communication, cell growth regulation and host defense, it is tempting to hypothesize that this WSC is involved in the local control of the various fundamental processes such as cardiagra, cardiac infarction, impotence etc.

• 한국태양에너지학회 논문집
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• 제37권6호
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• pp.39-49
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• 2017

Pool boiling, one of the key thermal-hydraulics phenomena, has been widely studied for improving heat transfer efficiencies and safety of nuclear power plants, refrigerating systems, solar-collector heat pipes, and other facilities and equipments. In the present study, the critical heat flux (CHF) and heat-transfer coefficients were tested under the pool-boiling state using graphene M-5 and M-15 nanofluids as well as oxidized graphene M-5 nanofluid. The results showed that the highest CHF increase for both graphene M-5 and M-15 was at the 0.01% volume fraction and, moreover, that the CHF-increase ratio for small-diameter graphene M-5 was higher than that for large-diameter graphene M-15. Also at the 0.01% volume fraction, the oxidized graphene M-5 nanofluid showed a 41.82%-higher CHF-increase ratio and a 26.7%-higher heat-transfer coefficient relative to the same nanofluid without oxidation treatment at the excess temperature where the CHF of distilled water occurs.

• 정보관리연구
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• 제31권4호
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• pp.1-12
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• 2000

도서관 운영에 수반되는 잠재적 리스크들은 막대한 경제적 손실을 초래할 수 있는 바 체계적인 관리가 요구되고 있다. 리스크의 인지, 리스크의 측정, 리스크 처리기법의 선택, 실행, 평가를 통한 리스크 관리과정은 대물(對物)리스크, 배상책임(賠償責任)리스크, 인사(人事)리스크를 가장 보편적인 방법인 보험에 의하여 처리되도록 제시하고 있다. 도서관의 체계적 리스크 관리를 위해서는 리스크 관리자를 선임하여 프로그램 개발과 보험가입에 책임이 주어져야 한다. 또한 제한적인 공제회의 보장대상은 보험상품 개발을 통해 충분한 리스크의 담보가 이루어져야 한다. 보다 체계적이고 현실적인 도서관 리스크 관리의 개선과 보험의 적용을 위해 추가적인 연구가 요구된다.

• 대한암한의학회지
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• 제22권2호
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• pp.13-24
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• 2017

Objectives: The purpose of this study is to report the effect of Korean Herbal Medicine (KHM) on a Renal Cell Carcinoma with multiple liver metastases patient. Methods: One renal cell carcinoma with multiple liver metastases patient was treated by KHM in conjunction with targeted anticancer agent (Afinitor). The effect of KHM was measured by scanning with Computed Tomography (CT), Blood Test, Visual Analogue Scale (VAS) and Eastern Cooperative Oncology Group scale. Results: Multiple hepatic tumors were reduced after the treatment during 5 months (Partial Remission, PR). As treatment was performed, complications induced by targeted anticancer agent (Afinitor) were alleviated. Conclusions: This case provides us a possibility that Korean Herbal Medicine offers potential benefits for renal cell carcinoma with multiple liver metastases patient.

• Journal of Hospice and Palliative Care
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• 제26권2호
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• pp.80-94
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• 2023

Purpose: This study aimed to identify attitudes toward advance directives (ADs) among female cancer patients and factors related to ADs. Methods: The study was conducted at a university hospital in Seoul from September 19, 2020, to January 20, 2021. The participants were 153 patients diagnosed with gynecological cancer or breast cancer. Data were collected using questionnaires and included general characteristics, disease- and AD-related characteristics, knowledge and attitudes about ADs, and attitudes about dignified death. Data were analyzed using the t-test, analysis of variance, and multiple regression analysis. Results: Only 2% of the participants completed ADs. The mean score for attitudes toward ADs was 3.30, indicating a positive knowledge and attitude toward dignified death. The factors related to attitudes toward ADs were attitudes toward dignified death (𝛽=0.25, P=0.001), experience discussing life-sustaining treatment (𝛽=0.17, P=0.037), preferred time to have a consultation about ADs (𝛽=0.19, P=0.046), intention to write ADs (𝛽=0.15, P=0.038), and Eastern Cooperative Oncology Group Performance Status (𝛽=-0.37, P<0.001). The explanatory power of these variables for attitudes toward ADs was 38.5%. Conclusion: Overall, patients preferred to have a consultation about ADs when they were still active, mentally healthy, and able to make decisions. Education about ADs should be provided to patients on the first day of hospitalization for chemotherapy or while awaiting treatment in an outpatient setting so patients can write ADs and discuss them with family and friends.

• Journal of Digestive Cancer Research
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• 제6권2호
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• pp.64-68
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• 2018

Pancreatic ductal adenocarcinoma is a dismal prognosis and 5^th leading cause of cancer related death in Korea. A large proportion of patients are diagnosed at advanced or metastatic stage. Therefore systemic chemotherapy has become the mainstay of treatment for pancreatic cancer. For most patients advanced or metastatic pancreatic cancer that has a good Eastern Cooperative Oncology Group performance status (ECOG PS) 0 or 1, we can recommend for FOLFIRINOX (leucovorin, 5-fluorouracil [5-FU], irinotecan and oxaliplatin) and gemcitabine plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Currently, steps towards improved therapeutic efficacy of palliative chemotherapy have been made by introducing these regimens. For patients with an ECOG PS of 2, gemcitabine monotherapy or S1 alone is recommended. The second-line therapy for patients initially treated with gemcitabine-based chemotherapy includes provide FOLFOX (leucovorin, 5-FU, and oxaliplatin), capecitabine plus oxaliplatin, and 5-FU plus liposomal irinotecan. The gemcitabine-based chemotherapy is a reasonable choice for patients treated with FOLFIRINOX. Currently, studies on selecting patients for biomarkers related to molecular biologic features of tumors are underway for the realization of precise medicine, and the development and verification of preclinical models for the development of new therapeutic agents are being carried out continuously.