• The Korean Journal of Nuclear Medicine
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• v.35 no.6
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• pp.393-397
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• 2001

Surgery, radioiodine therapy, and thyroxine treatment represent established therapeutic measures of proven efficacy for the treatment of well-differentiated thyroid cancer. However, in some cases, dedifferentiation is noted and it makes tumors refractory to conventional treatment. Recently, retinoic acid redifferentiation therapy was evaluated in several in vitro and in vivo studios. We report a patient with papillary carcinoma in whom metastatic lesions became radioiodine negative on high-dose therapy. Redifferentiation therapy with retinoic acid induced radioiodine uptake in some of metastatic tissues. Side effects such as xerostomia and cheilosis were mild. We recommend retinoic acid redifferentiation therapy as an option for the treatment of thyroid cancer with negative radioiodine uptake after high-dose radioiodine therapy.

• Biomedical Science Letters
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• v.24 no.3
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• pp.157-167
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• 2018

The concept of gene therapy is to treat a disease by transferring therapeutic nucleic acids to a patient's cells. It took several decades from the basic theoretical proposal of gene therapy to the current promising treatment option for some important human diseases. The encountered adverse effects in the early clinical studies boosted the development of sophisticated vectors and elaborate clinical designs. The gene therapy is now considered to have the potential to cure many diseases that are incurable with conventional medications. By the end of 2017, about 2,600 clinical trials of gene therapy have been performed or are ongoing for a variety of diseases such as cancers, monogenic diseases, cardiovascular diseases and neurological diseases etc. Here, we present a brief introduction of technical achievement in relation to gene therapy development, and a review of the current status of global gene therapy clinical development.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.12 no.1
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• pp.13-27
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• 2017

Objectives: To evaluate and summarize the efficacy and safety of manual therapy in temporomandibular disorder(TMD). Methods: Ten databases (Pubmed, Cochrane, EMBASE, AMED, CINAHL, CNKI, and four Korean databases) were searched up to March 2017. Pain and range of motion(ROM) of temporomandibular joint were used as the primary outcome measure, and effective rates, dysfunction scale and adverse events were used as secondary outcome measures. The Cochrane risk of bias tool was used to evaluate the methodological quality. Results: 10 randomized controlled trials(RCTs) involving 603 participants were included. There were no significant differences between the two groups in comparison with placebo manual therapy group. In comparison with Wait-list and conventional treatment groups, manual therapy significantly alleviated pain and ROM. Five RCTs(50.0%) reported adverse events and there were no adverse cases by manual therapy. Conclusions: We found evidence that manual therapy may alleviate symptoms of patients with TMD. A positive effect was observed in comparison with conventional treatment and Wait-list, but no conclusion for the comparisons with placebo manual therapy. There is no evidence of worsening symptoms or causing adverse events.

• Journal of Korean Physical Therapy Science
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• v.28 no.2
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• pp.65-74
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• 2021

Background: The purpose of this study was investigated of effect of neuromuscular electrical stimulation combined with mirror therapy on static balance, weight support and ankle movement incline with chronic stroke patients. Design: Two-group pretest-posttest design. Methods: Thirty chronic stroke patients participated in this study. The study design is a two-group pretest-posttest design. A total of 30 people participated in the study, and 15 people were each assigned to the experimental group and control group. Experimental group received neuromuscular electrical stimulation combined with mirror therapy 30 minutes, and conventional physical therapy 30 minutes. Control group received conventional physical therapy 30 minutes. Both groups were conducted 5 times a week for 4 weeks. static balance and weight support was measured by force plate and ankle movement incline was measured by goniometer. Results: As a result of comparing the static balance, weight support and ankle movement incline change between experimental group and control group, statistically significant differences were found in all variables (p<.05). In the evaluation before and after the intervention, there was a statistically significant difference in all variables in the experimental group (p<.05), but there was no statistically significant difference in the control group (p>.05). Conclusion: Neuromuscular electrical stimulation combined with mirror therapy intervention improves static balance, increase paretic side weight support and ankle movement incline in chronic stroke patients. It could be an effective intervention for improve static balance, weight support and ankle movement for chronic stroke patients.

• The Korean Journal of Pain
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• v.35 no.2
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• pp.152-159
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• 2022

Background: Subjects with frozen shoulder (FS) might not be comfortable with vigorous physical therapy. Clinical trials assessing the effect of graded motor imagery (GMI) in FS are lacking. The aim of this study was to determine the effect of GMI as an adjunct to conventional physiotherapy in individuals with painful FS. Methods: Twenty subjects aged 40-65 years having stage I and II of FS were randomly divided into two study groups. The conventional physiotherapy group (n = 10) received electrotherapy and exercises while the GMI group (n = 10) received GMI along with the conventional physiotherapy thrice a week for 3 weeks. Pre- (Session 1) and post- (Session 9) intervention analysis for flexion, abduction, and external rotation range of motion (ROM) using a universal goniometer, fear of movement using the fear avoidance belief questionnaire (FABQ), pain with the visual analogue scale, and functional disability using the shoulder pain and disability index (SPADI) was done by a blinded assessor. Results: Statistically significant difference was seen within both the groups for all the outcomes. In terms of increasing abduction ROM as well as reducing fear of movement, pain, and functional disability, the GMI group was significantly better than control group. However, both groups were equally effective for improving flexion and external rotation ROM. Conclusions: Addition of GMI to the conventional physiotherapy proved to be superior to conventional physiotherapy alone in terms of reducing pain, kinesiophobia, and improving shoulder function for stage I and II of FS.

• Journal of Korean Physical Therapy Science
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• v.9 no.2
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• pp.17-26
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• 2002

This study is aimed to compare the effect of visuo-perceptual biofeedback sitting balance training and conventional sitting balance training using Balance Master on stroke patients with that of program in order to analyze the effect it has on dynamic postural balance. The subjects are twenty-four stroke patients who are receiving physical therapy in Ilsan Paik Hospital and can maintain sitting posture by themselves. These patients were divided to control group and experimental group randomly. In order to compare to control and experimental group before and after the balance training, they were tested with Mann-Whitney U test and in order to compared the changes before and after the balance training, they were tested with Wilcoxon signed-ranks test. The results are as follows: we measured the ability of dynamic posture balance control with limit of stability(LOS) test and rhythmic weight shift test. There was an increasing improvement in the ability of dynamic posture balance control of the experimental group that had visuo-perceptual biofeedback sitting balance control training using the Balance Master(p<0.05, p<0.01). According to the results from above, compared to conventional sitting balance training programs, visuo-perceptual biofeedback sitting balance control training using the Balance Master is considered to be a more valuable therapy in balance control improvement and physical function improvement. It is considered that if the weak points are made up, the training with Balance Master will give help to stroke patients and to patients with balance control disabilities and will further more contribute to successful rehabilitation therapy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.10
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• pp.6187-6192
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• 2014

The use of WBRT(whole brain radiation therapy) has increased due to the increase in the incidence of metastatic brain tumors. The development of radiation therapy techniques is expected to improve the quality of life. The VMAT (Volumetric Modulated Arc Therapy) is an excellent treatment technique that can distinguish the dose in each volume. Therefore, this study compared conventional WBRT and VMAT for hair loss according to the scalp dose using a head phantom. The CI (Conformity Index), HI (Homogeneity Index) and QOC (Quality of Coverage) were measured brain tissue. A 20 percent and 50 percent dose was measured at the scalp, eyeball, lens, and c-spine. Conventional WBRT is excellent at 10 percent of brain tissue. VMAT is far superior at 1000 percent at the other organs. VMAT at the prescribed dose can be used as radiation therapy of metastatic brain tumors with less hair loss.

• The Journal of Korean Physical Therapy
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• v.15 no.1
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• pp.185-195
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• 2003

This study was performed to investigate the effects on the general features of low back pain. The study subjects were low back pain patients treated with physical therapy at general hospitals located in Gyeonggi-do from August 2, 2000 to September 10. Total number of distributed questionnaires were 300, and 281 questionnaires were collected and analysed finally. The results were follows: 1. 76.3$\%$ of male answers that participate in sports, 60.6$\%$ of female answers that participate in sports and there are significant differences of two group(p < 0.01). 2. In case of male, preferential sports were running, tennis, golf, the others, but in case of female, preferential sports were walking, ascent of a mountain, swimming(p < 0.01). 3. In case of male, the most frequency preferred to participate in sports by patients was 30minutes daily, but in case of female, 3 times a week(p < 0.05). 4. The onset time of low back pain was 28.3$\%$ in the morning, 23.7$\%$ in the afternoon, 23.2$\%$ in motion according. 5. The onset conditions of low back pain was 48.5% during exercise, 44.4$\%$ after exercise. 6. Regardless of gender, low back pain patients want to go to a hospital for treatment. Otherwise, male preferred conventional treatment than a hospital, but female preferred a hospital than conventional treatment(p < 0.05). 7. Regardless of gender, 97.5$\%$ of patients is answered that the most preferential treatment method was physical therapy, 8. 92.2$\%$ of patients is answered that physical therapy was effective.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.3
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• pp.255-262
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• 2014

PURPOSE: This study was to investigate the effectiveness of TENS on balance in stroke patients by analyzing some components such as foot pressure, limit of stability and velocity sway after providing somatosensroy input using TENS. METHODS: Twenty five subjects participated and were randomly divided into two groups, TENS group (n=13) and control group (n=12) by the computer program. Interventions were given to subjects 5 days a week for four weeks. TENS group were treated with TENS for 60 minutes in addition to the conventional therapy which included 30-minute exercise and rehabilitation ergometer training for 15 minutes. Control group performed only conventional therapy. TENS was applied on the skin of soleus, tibialis anterior, tensor fascia latae and vastus medialis in affected side. Foot pressure, limit of stability and velocity sway for balance test were measured using Biorescue. RESULTS: TENS group was significantly increased limit of stability and foot pressure in affected side more than control group. And in eye closed condition, TENS group was significantly decreased velocity sway more than control group. CONCLUSION: The application of TENS is effective to improve the somatosensory input of affected side and to increase the motor function and balance ability.

• Journal of the Korean Society of Physical Medicine
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• v.13 no.2
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• pp.53-60
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• 2018

PURPOSE: This study aimed to identify the effect of a backward walking exercise using a mirror on balance and gait in patients with stroke. METHODS: Twenty subjects with post-stroke hemiparesis volunteered to participate in this study. The experimental and control groups performed backward walking exercise plus conventional therapy or conventional physical therapy, respectively, for 6 weeks. Assessment instruments included the Berg Balance Scale (BBS), timed up and go test (TUG), and 10-m walking test (10MWT). Evaluation was performed before and after the 6-week training period. We conducted a paired t-test to compare the within-group changes before and after the intervention. An independent t-test was used to compare between-group differences. The statistical significance level was set at ${\alpha}=.05$ for all variables. RESULTS: The experimental group showed a significant within-group change in the BBS, TUG, and 10MWT (p<.05). The control group also showed a significant change (p<.05). A significant difference was observed between the experimental and control groups with regard to changes in the BBS, TUG, and 10MWT results after the interventions (p<.05). CONCLUSION: This study demonstrated that backward walking exercise using a mirror may be valuable for future research. Further studies with a wider range of pathology and longer experiment duration are required to validate the results of the present study.