• Molecules and Cells
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• v.46 no.9
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• pp.538-544
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• 2023

The formation of uniform vitreous ice is a crucial step in the preparation of samples for cryogenic electron microscopy (cryo-EM). Despite the rapid technological progress in EM, controlling the thickness of vitreous ice on sample grids with reproducibility remains a major obstacle to obtaining high-quality data in cryo-EM imaging. The commonly employed classical blotting process faces the problem of excess water that cannot be absorbed by the filter paper, resulting in the formation of thick and heterogeneous ice. In this study, we propose a novel approach that combines the recently developed nanowire self-wicking technique with the classical blotting method to effectively control the thickness and homogeneity of vitrified ice. With simple procedures, we generated a copper oxide spike (COS) grid by inducing COSs on commercially available copper grids, which can effectively remove excess water during the blotting procedure without damaging the holey carbon membrane. The ice thickness could be controlled with good reproducibility compared to non-oxidized grids. Incorporated into other EM techniques, our new modification method is an effective option for obtaining high-quality data during cryo-EM imaging.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.33 no.6
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• pp.276-281
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• 2023

With the high design freedom of the additive manufacturing process, there is a growing interest in multi-dimensional lattice structures among researchers, who are studying intricate structural modeling that is challenging to produce using conventional manufacturing processes. In the case of titanium alloy implants for human insertion, a multi-dimensional lattice structure is employed to ensure compatibility with bones, adjusting strength and elastic modulus to levels similar to those of bones. Therefore, securing a database on the mechanical properties based on lattice structure design variables and the development of related simulation techniques are believed to efficiently facilitate the customization of implants. In this study, lattice structures were additively manufactured using Ti-6Al-4V alloy, and the elastic modulus was measured based on design parameters. The results were compared with simulations, and an approach to finite element analysis for accurate prediction of the elastic modulus was proposed.

• Steel and Composite Structures
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• v.50 no.3
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• pp.347-362
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• 2024

Controlling vibrations and noise in steel box girders is important for reducing noise pollution and avoiding discomfort to residents of dwellings along bridges. The fundamental approach to solving this problem involves first identifying the main path of transmission of the vibration energy and then cutting it off by using targeted measures. However, this requires an investigation of the characteristics of flow of vibration energy in the steel box girder, whereas most studies in the area have focused on analyzing its single-point frequency response and overall vibrations. To solve this problem, this study examines the transmission of vibrations through the segments of a steel box girder when it is subjected to harmonic loads through structural intensity analysis based on standard finite element software and a post-processing code created by the authors. We identified several frequencies that dominated the vibrations of the steel box girder as well as the factors that influenced their emergence. We also assessed the contributions of a variety of vibrational waves to power flow, and the results showed that bending waves were dominant in the top plate and in-plane waves in the vertical plate of the girder. Finally, we analyzed the effects of commonly used stiffened structures and steel-concrete composite structures on the flow of vibration energy in the girder, and verified their positive impacts on energy regionalization. In addition to providing an efficient tool for the relevant analyses, the work here informs research on optimizing steel box girders to reduce vibrations and noise in them.

• Ocean and Polar Research
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• v.28 no.4
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• pp.385-393
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• 2006

Screening performance of the existing intake screens (drum and travelling screen) on mass impingement of marine animals, a euphausiid, Euphausia pacifica and a scyphozoan medusae, Aurelia aurita that have often clogged intake screens of the Uljin Nuclear Power Plant, was tested. The maximum tolerable densities of marine animals in the inflowing seawater upon the screen were estimated with two different approaches. First the maximum density of jellyfish was calculated from (1) passing amount of seawater per unit time through the screens and (2) the covered area of animals on the screens clogged. The maximum density of krill tolerable in the drum screen was cited from a simulated record of Uljin NPP, then those in the travelling screens were also calculated using the data of drum screen and ratio of seawater amount passing through the screens under the condition of 0.5m water column (W.C.) of the differential pressure (AP) produced by screens, an established permissible limit of ${\Delta}P$. Secondly, the screening performances were also tested by hydrodynamic measurements with various screen models in a circulating water channel equipped with a speed-controlling pump and a differential pressure gauge. From the first approach, the maximum tolerable densities of drum and travelling screen were calculated as 2.0 and $1.5ind/m^3$ for the Jellyfish and 900 and $680ind./m^3$ for the euphausiid, respectively. These densities estimated from the second approach were 2.1 and $0.8ind/m^3$ for the jellyfish and 1059 and $504ind/m^3$ for the euphausiid, respectively. These estimates were compared with the data from historic clogging events to evaluate the practical performance of these intake screens. The comparisons suggest a newly improved intake-screen of which performance should be at least seven times (approximately) better than the existing ones ior the krill and 3.2 times for the jellyfish, respectively, for preventing mass impingement, and for maintaining the condition of the differential pressure between the screens below 0.3 m W.C.

• Korea Journal of Hospital Management
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• v.5 no.1
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• pp.129-155
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• 2000

This empirical study, activity-based costing, a newly introduced approach that has proved to be an improvement over the conventional costing system in product or service costing, is applied at department of clinical pathology in K university hospital. The study subjects were 233 test procedures done in clinical laboratory of K university hospital. Activity analysis was done by interview, questionnaires, and time study, and the amount of resources consumed by each activity and their costs are then traced and applied to the laboratory tests. The main purpose of this study were to compare the test costs of activity-bases costing with those of conventional costing, and test fees of medical insurance, and to provide accurate cost informations for the decision makers of hospital. The major findings of this study were as belows. 1. The cost drivers for application of activity-based costing at clinical laboratory were cases of sample collection, case of specimen, cases of test, and volume-related allocation bases such as direct labor hours and total revenue of each test. 2. The profits of each clinical laboratory fields analyzed by conventional costing were different from the profits analyzed by activity-based costing, especially in the field of Urinalysis(approximately over estimated 750%). 3. The standard full costs by conventional costing were quite different from the costs computed by using activity-based costing, and the difference is most significant with the tests of long labor time. 4. From the comparison between costs computed by using activity-based costing and medical insurance fees, some test fees were significantly lower than the costs, especially in the non-automated fields. As described in this study, activity-based costing provides more accurate cost information than does conventional costing system. The former approach is especially important in the health care industry including hospitals in which planning and controlling the costs services provided are the key to maintaining a healthy financial status for the organization. Despite the contribution of activity-based costing the economic as well as technical feasibilities of implementing such a cost accounting system in an organization must be evaluated. In the development of activity-based costing systems, an activity analysis has to be conducted to identify activities that consume resources. This involves a detailed study of the organization's logistics and accounting information systems, and it is an expensive project in itself. Besides, it can be quite difficult and time consuming to identify and trace resource consumption to a specific activity. Thus the activity-based costing system should be implemented only when the decrease in cost of error far exceeds the increase in cost of measurement. By combining activity-based costing with standard costing, health care administrators can better plan and control the costs of health services provided while ensuring that the organization's bottom line is healthy.

• Composites Research
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• v.23 no.2
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• pp.1-9
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• 2010

This study analyzes the apparent fracture toughness of a thick-walled cylinder with a functionally graded material (FGM) coating at the inner surface of the cylinder. The cylinder is assumed to have a single radial edge crack emanating from its inner surface. The crack surfaces and the inner surface of the cylinder are subjected to an internal pressure. The incompatible eigenstrain developed in the cylinder due to nonuniform coefficient of thermal expansion as a result of cooling from sintering temperature is taken into account. Based on a method of evaluating stress intensity factor introduced in our previous study, an approach is developed to calculate apparent fracture toughness. The approach is demonstrated for a cylinder with a TiC/$Al_{2}O_{3}$ FGM coating and some numerical results of apparent fracture toughness are presented graphically. The effects of material distribution profile, cylinder wall thickness, application temperature, and coating thickness on the apparent fracture toughness are investigated in details. It is found that all of these factors play an important role in controlling the apparent fracture toughness of the cylinder.

• The Korean Society of Law and Medicine
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• v.12 no.2
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• pp.219-263
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• 2011

"Wrongful conception" is a medical malpractice claim in which the plaintiff is the parent of a normal, healthy infant whose conception was unplanned and unwanted. Medical malpractice in wrongful conception can be the result of a failure to provide informed consent to a patient, failure to properly perform a surgery, or a physician's negligent handling of a patient's problems. In the concrete, wrongful conception cases fall into two categories; those involving pre-conception negligence, such as a failed contraceptive, sterilization or failing of the controlling of embryo-number on the IVF, and those involving post-conception negligence, such as a failure to diagnose a pregnancy or to perform an abortion procedure. In addition, Medical malpractice can be the result of a failure to provide informed consent to a patient. When bad results occur by medical malpractice or failure to provide informed consent to a patient, the range of recovery of damages is decided by a traditional civil liability law. However the calculation of damages for wrongful conception is not easy because the high value of life is included in that case. So many courts opinions in foreign country and Seoul High Court decision in 1996 allow damages for the pregnancy, birthing process and sterilization costs, but refuses to allow damages for child rearing expenses. As to the range of recovery of damages for wrongful conception, one approach says that to allow damages in a suit such as this would mean that the physician would have to pay for the fun, joy and affection which plaintiff will have in the rearing and educating of the plaintiff's baby. To allow such damages would be against the dignity of the baby based on article 10 of the Constitution. However another approach says that damages are recoverable for all expenses related to child birth as well as for child rearing costs. Because the damages that the parents should bear a burden to the tort damage done is not a baby itself but child rearing costs. In other words, although the baby is healthy or not, economic burden of the parents can not be disregard. And denial of compensation for costs of child rearing may invalidate the role of liability law, grant the physician with a exemption certificate of liability. As a result, the medical field of procreation can be easily isolated from a liability of reparation. Therefore, on the liability law like the other medical malpractice action, parents who became pregnant or gave a birth by physician, wrongfully performed sterilization operation, etc. should be compensated for all damages relevant to unplanned and unwanted conception or birth as well as costs of child rearing.

• Korean Journal of Plant Tissue Culture
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• v.24 no.4
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• pp.239-256
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• 1997

Plants belonging to the category of 2n apomixis or agamospermy form embryos and seeds without the processes of normal meiosis and syngamy. Seeds produced in this way have identical genotype of their maternal parent. Three different types of agamospermy are recognized: diplospory, apospory, and adventitious (adventive) embryony. $F_1$ hybrid cultivars cannot be used as seed sources in the next ($F_2$) generation because this generation would be extremely variable as a result of genetic segregation. Hybrid vigor is also reduced in the $F_2$ generation. Therefore, parental stocks for hybrid seed production need to be maintained and cross must be continuously repeated. Agamospermic 2n apomixis would make it possible to fix the genotype of a superior variety so that clonal seeds faithfully representing that genotype could be continuously and cheaply produced independent of pollination. That is, $F_1$ hybrid seeds could be produced for many generations without loss of vigor or genotype alteration. Production of apomictic $F_1$ hybrid seed would be simplified because line isolation would not be necessary to produce seed or to maintain parental lines, and the use of male-sterile lines could be avoided. Overall, apomixis would enable a significant reduction in hybrid seed production costs. Additionally, the production of clonal seed is not only important for seed propagated crops, but also for the propagation of heterozygous fruit trees and timbers. Clonal seed would help avoid costly and time-consuming vegetative propagating methods that are currently used to ensure the large-scale production of these plants. Apomixis is scattered throughout the plant kingdom, but few important agricultural crops possess this trait Therefore, most research to date has centered on introgressing the trait of apomixis into agricultural crops such as wheat, maize, and some forage grasses from wild distant relatives by traditional cross breeding. The classical breeding approach, however is slow and often impeded by many breeding barriers. These problems could be surmounted by taking mutagenesis or molecular approach. Arabidopsis thaliana is a tiny sexually reproducing plant and is convenient in constructing and screening in molecular researches. Male-sterile mutants of Arabidopsis are particularly suitable genetic background for mutagenesis and screening for apomictic mutants. Molecular approaches towards isolating the genes controlling the apomictic process are feasible. Direct isolation of genes conferring apomixis development would greatly facilitate the transfer of this trait to wide variety of crops. Such studies are now in progress.

• Korean Business Review
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• v.3
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• pp.23-46
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• 1990

I. Introduction: In management control, business analysis has to do with a performance evaluation and is accounted much of manager's decision making, Business indicator accounting is the vehicle of decision making and also feedback can be accomplished by it. This study is to build up a logic about what capacity for use the business indicator accounting has in making decision. Therefore it is significant to make clear the adjustment of decision and to study the function of business indicator. II. Adjustment of Decision and Accounting Work: Adjustment of decision is connected with accounting now that business indicator accounting has a function of decision making. And it should be tied up with specialization as a structure of system, organization, communication and stage system. III. Adjustment of Decision and Managerial Accounting: Managerial account makes a great contributin to the management in which each adjustment of decision should be accomplished. Let me make mention of how the adjustment of decision is accomplished concretely, and what contribution che managerial accounting makes. In an adjustment of decision, centralization and decentrialization of enterprise are very import and I think the three problems, such as the extent of sphere (procurement, production and maketing), the face of affairs (planning, implementing and controlling), the final surge (decision making and action) can be accomplished by the business indicator accounting. IV. Structure of System and Disciplinary Approach for Decision: Decision can be classified into syncronized decision and continuous decision, and is closely connected with centralization and decentralization. In the course of systematizing, the sort of decision is classified into a man in charge of decision, and object of decision, conditions of decision, and an adjusting of decision. For it's object, it has an analogical thinking and an analytic subdivision about the target area. And it is premised on getting a scientific understanding. I think a disciplinary approach remains in solving these intricate problems. V. Conclusion: In this study I dealt with a specialization as a structure in management system and a theory that adjustment is a necessary process in decision making. For an adjustment of decision, exchanging informations and communication are necessary, and accounting is in charge of the process. And then the centralization and decentralization of decision should be connected in the way of adjustment of decision. In case of decentralization, the adjustment of decision is accomplished by the exchanging informations through feedback, and in case of centralization, by the all-round planning. And also I found that syncronized decision and decentralized decision are linked together. It is natural that the function of business indicator accounting is called for to render more services for it. Therefore, according to the extent of centralization and decentralization accounting to adjust the decision, can be various. Consequently, in relation to the structure of system. I think it is necessary to make a theoretical and empirical study of the business indicator accounting.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.2
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• pp.132-147
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• 2008

So far ubiquitous service (u-service) priority has seldom been empirically examined based on the customer's view. It is usual to prioritize the relative importance of u-service variables by the supplier's intuition and a few specialist's experienced knowledge. Such approaches have the disadvantage that they provide only limited empirical information on the field practices in relation to u-service since customer demand of u-service is poorly defined despite abundant interest in this problem. Therefore, the aim of this research was to develop u-service priority model in the context of multi-criteria framework integrating customer and supplier's view, using high technology acceptance theory as major controlling factors. An important question was how to measure or represent criteria that is important to u-service and should be included in a priority model. The selection criteria for the model variables were derived from high technology acceptance theory and AHP approach through the analysis of frequency count, elimination of overlapping factors and brainstorming with specialists. Daegu showed top-rankings in transportation-aid service, guidance service for the eyesight disabled and u-telematics service. In contrast, disaster prevention service and industrial specialized town service ranked highly in the typical supplier's approach were not a dominant determining factor in the u-service priority. The model identified the fact that typical high priority service in terms of supplier's view did not necessarily accompany the important predictor for the u-service priority.