• Nutrition Research and Practice
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• v.17 no.2
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• pp.241-256
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• 2023

BACKGROUND/OBJECTIVES: Diabetes-specific oral nutritional supplements (ONS) have anti-hyperglycemic effects, while D-allulose exerts anti-diabetic and anti-obesity effects. In this study, we investigated the efficacy and safety of diabetes-specific ONS, including allulose, on glycemic and weight changes in overweight or obese patients with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A single-arm, historical-control pilot clinical trial was conducted on 26 overweight or obese patients with T2DM (age range: 30-70 yrs). The participants were administered 2 packs of diabetes-specific ONS, including allulose (200 kcal/200 mL), every morning for 8 weeks. The glycemic profiles, obesity-related parameters, and lipid profiles were assessed to evaluate the efficacy of ONS. RESULTS: After 8 weeks, fasting blood glucose (FBG) level significantly decreased from 139.00 ± 29.66 mg/dL to 126.08 ± 32.00 mg/dL (P = 0.007) and glycosylated hemoglobin (HbA1c) improved (7.23 ± 0.82% vs. 7.03 ± 0.69%, P = 0.041). Moreover, the fasting insulin (δ: -1.81 ± 3.61 μU/mL, P = 0.017) and homeostasis model assessment for insulin resistance (HOMA-IR) (δ: -0.87 ± 1.57, P = 0.009) levels decreased at 8 weeks, and body weight significantly decreased from 67.20 ± 8.29 kg to 66.43 ± 8.12 kg (P = 0.008). Body mass index (BMI) also decreased in accordance with this (from 25.59 ± 1.82 kg/m² to 25.30 ± 1.86 kg/m², P = 0.009), as did waist circumference (δ: -1.31 ± 2.04 cm, P = 0.003). CONCLUSIONS: The consumption of diabetes-specific ONS with allulose in overweight or obese patients with T2DM improved glycemic profiles, such as FBG, HbA1c, and HOMA-IR, and reduced body weight and BMI.

• Animal Bioscience
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• v.36 no.5
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• pp.761-767
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• 2023

Objective: The objective of this study was to determine whether dietary supplementation with a functional fatty acid blend (FA) that contains 31.4% butyric acid and 4.99% medium-chain FA improve growth performance, antioxidant capacity, immunity status, and anti-inflammatory ability in weaned piglets. Methods: One hundred and forty-four healthy piglets (Duroc×Landrace×Yorkshire) with an average body weight (BW) of 7.98±3.43 kg were randomly divided into three groups with six replicate pens and eight piglets per pen: Normal control (NC): a corn-soybean basal diet; FA1: a basal diet supplemented with 1,000 mg/kg of a functional FA; FA2: a basal diet supplemented with 2,000 mg/kg of a functional FA. The experiment lasted for 28 d. On d 14 and 28, one piglet in each pen from NC and FA2 groups was randomly selected for antioxidative index and immunoglobulins. On d 28, one piglet in each pen from NC and FA2 groups was randomly selected for intestinal morphology and inflammatory factor. Results: We observed that FA supplementation linearly increased (p<0.05) average daily gain and the final BW. There was higher (p<0.05) catalase on d 14, and immunoglobulin (Ig) A and IgM on d 28 in piglets supplemented with FA2 than in the NC group. Moreover, dietary FA2 reduced (p<0.05) crypt depth of ileum in piglets. The concentrations of tumor necrosis factor-α, interleukin (IL)-1β, IL-8, and IL-10 in jejunum were lower (p<0.05) in the FA2 group compared with the NC group. Conclusion: Therefore, the overall results suggests that the FA may help to improve gut health, antioxidant status, and immune parameters resulting in the improvement of growth performance.

• Journal of the Korean Geotechnical Society
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• v.26 no.12
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• pp.5-17
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• 2010

Coarse granular material is used as important fill material in most of large embankments such as railway, road, dam and so on. Therefore, the accurate design parameters of the coarse granular material are necessarily required in design and construction. The behavior of the coarse granular material was not well understood because of the lack of large testing equipment capable of coarse granular material. A large triaxial testing system was developed in this research, capable of large specimens of 500 mm, 300 mm and 150 mm in diameter. In the new large triaxial testing system, the load cell is installed inside the triaxial cell and axial displacement is measured locally on a specimen in order to improve control and measurement in small strain level. Urethane specimens of 300 mm and 50 mm in diameter were prepared. The large triaxial tests were performed on the 300 mm diameter urethane specimens while RC/TS and impact echo tests on the 50 mm diameter urethane specimens to verify this testing system. In this verification test results, we could ascertain the reasonable test results of the KRRI large triaxial testing system.

• Journal of agriculture & life science
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• v.50 no.5
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• pp.61-68
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• 2016

This study was focused to examine the effects of pre- or post-harvest Ca-chitosan treatment on the shelf-life of 'Daesung' hardy kiwifruit. In the preharvest treatment, Ca-chitosan at 200 mg/L was intensively sprayed to the fruit three times on August 20, 25, and 28 in an order whereas harvested fruits were dipped for 10 sec. at the same concentration of chitosan as the postharvest treatment. Fruits were stored at 17℃ for 9 days and 1℃ for 40 days, respectively. Soluble solid contents, titratable acidity, firmness, respiration rate, and weight loss were examined to configure the qualities of fruits during storage. The changes of fruit quality parameters occurred more rapidly in calcium-chitosan treatment compared to untreated control when fruit were stored at 17℃. Both pre- or post-harvest Ca-chitosan treatment, however, effectively decreases the weight and firmness of fruit stored at 1℃. Fruit respiration rate was also reduced, indicating the increase of shelf-life throughout ripening of the fruit.

• 한국체육학회지인문사회과학편
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• v.55 no.3
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• pp.613-626
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• 2016

The purpose of this study was to identify the effect of dance sport participation on body composition and cardiometabolic parameters in obese middle aged women, by analyzing the current literature(2005-2015). The data from 9 studies were included in this systematic review and meta-analysis, and Comprehensive Meta Analysis(CMA) Version 2.0 was used for statistical analysis. A total of 197 middle aged women(intervention group: n=98, control group: n=99) were included in this analysis. An average duration of the dance sports intervention was 12.2 weeks, 3.13 session per week and 75 minutes per session. Significant reduction in body weight, body fat percent, triglyceride, low density lipoprotein LDL-Cholesterol and leptin were observed while significant increase in high density lipoprotein HDL-cholesterol was observed after the intervention. There were large effect size in percent body fat, total cholesterol, HDL-cholesterol and LDL-cholesterol while medium and small effect size were observed for triglyceride and body weight, leptin, insulin and glucose, respectively. In conclusion, dance sport participation resulted in positive changes in body composition and cardiometabolic parameter in middle aged women.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5A
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• pp.433-442
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• 2010

A control of chloride diffusion coefficient is very essential for service life of reinforced concrete (RC) structures exposed to chloride attack so that much studies have been focused on this work. The purpose of this study is to derive the intended diffusion coefficient which satisfies intended service life and propose a technique for optimum concrete mixture through genetic algorithm(GA). For this study, 30 data with mixture proportions and related diffusion coefficients are analyzed. Utilizing 27 data, fitness function for diffusion coefficient is obtained with variables of water to binder ratio(W/B), weight of cement, mineral admixture(slag, flay ash, and silica fume), sand, and coarse aggregate. 3 data are used for verification of the results from GA. Average error from fitness function is observed to 18.7% for 27 data for diffusion coefficient with 16.0% of coefficient of variance. For the verification using 3 data, a range of error for mixture proportions through GA is evaluated to 0.3~9.3% in 3 given diffusion coefficients. Assuming the durability design parameters like intended service life, cover depth, surface chloride content, and replacement ratio of mineral admixture, target diffusion coefficient, where exterior conditions like relative humidity(R.H.) and temperature, is derived and optimum design mixtures for concrete are proposed. In this paper, applicability of GA is attempted for durability mixture design and the proposed technique would be improved with enhancement of comprehensive data set including wider range of diffusion coefficients.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1C
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• pp.43-52
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• 2006

Despite several constitutive models have been proposed and applied, it is still difficult to choose a suitable model and to estimate adequate analysis parameters. Furthermore, a cyclic shear behavior under the volume change caused by the seepage is more complex. None of the constitutive model is available at present in the expression of the cyclic behavior of soil under an additional volume change condition by seepage. Therefore, a new geotechnical hybrid simulation system which can control the pore water immigration was developed. The system enables a quantitative evaluation of the residual deformation such as lateral spreading and settlement caused by the liquefaction. The seismic responses in a one-dimensional slightly inclined multilayered soil system are taken into consideration, and the soils are governed by both equation of motion and the continuity equation. Furthermore, the estimation and the selection of the soil parameter for the representation of the strong nonlinearity of the material are not required, because soil behaviors under the earthquake motions are directly introduced instead of a numerical soil constitutive model. This paper presents the concept and specifications of the system. By applying the system to an example problem, the permeability effect on the seismic response during cyclic shear is studied. The importance of the volume change characteristics of sandy soil during and after cyclic shear is shown in conclusion.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3913-3923
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• 2023

Todays, medium energy resolution detectors are preferably used in radioisotope identification devices(RID) in nuclear and radioactive material categorization. However, there is still a need to develop or enhance « automated identifiers » for the useful RID algorithms. To decide whether any material is SNM or NORM, a key parameter is the better energy resolution of the detector. Although masking, shielding and gain shift/stabilization and other affecting parameters on site are also important for successful operations, the suitability of the RID algorithm is also a critical point to enhance the identification reliability while extracting the features from the spectral analysis. In this study, a RID algorithm based on Bayesian statistical method has been modified for medium energy resolution detectors and applied to the uranium gamma-ray spectra taken by a LaBr3:Ce detector. The present Bayesian RID algorithm covers up to 2000 keV energy range. It uses the peak centroids, the peak areas from the measured gamma-ray spectra. The extraction features are derived from the peak-based Bayesian classifiers to estimate a posterior probability for each isotope in the ANSI library. The program operations were tested under a MATLAB platform. The present peak based Bayesian RID algorithm was validated by using single isotopes(²⁴¹Am, ⁵⁷Co, ¹³⁷Cs, ⁵⁴Mn, ⁶⁰Co), and then applied to five standard nuclear materials(0.32-4.51% at.²³⁵U), as well as natural U- and Th-ores. The ID performance of the RID algorithm was quantified in terms of F-score for each isotope. The posterior probability is calculated to be 54.5-74.4% for ²³⁸U and 4.7-10.5% for ²³⁵U in EC-NRM171 uranium materials. For the case of the more complex gamma-ray spectra from CRMs, the total scoring (ST) method was preferred for its ID performance evaluation. It was shown that the present peak based Bayesian RID algorithm can be applied to identify ²³⁵U and ²³⁸U isotopes in LEU or natural U-Th samples if a medium energy resolution detector is was in the measurements.

• Journal of Animal Science and Technology
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• v.65 no.5
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• pp.951-970
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• 2023

This study utilized Italian ryegrass silage (IRGS) - based total mixed ration (TMR) as feedstuff and evaluated its effects on rumen fermentation, growth performance, blood parameters, and bacterial community in growing Hanwoo heifers. Twenty-seven Hanwoo heifers (body weight [BW], 225.11 ± 10.57 kg) were randomly allocated to three experimental diets. Heifers were fed 1 of 3 treatments as follows: TMR with oat, timothy, and alfalfa hay (CON), TMR with 19% of IRGS (L-IRGS), and TMR with 36% of IRGS (H-IRGS). Feeding high levels of IRGS (H-IRGS) and CON TMR to heifers resulted in a greater molar proportion of propionate in the rumen. The impact of different TMR diets on the BW, average daily gain, dry matter intake, and feed conversion ratio of Hanwoo heifers during the growing period did not differ (p > 0.05). Furthermore, the blood metabolites, total protein, albumin, aspartate aminotransferase, glucose, and total cholesterol of the heifers were not affected by the different TMR diets (p > 0.05). In terms of rumen bacterial community composition, 264 operational taxonomic units (OTUs) were observed across the three TMR diets with 240, 239, and 220 OTUs in CON, L-IRGS, and H-IRGS, respectively. IRGS-based diets increased the relative abundances of genera belonging to phylum Bacteroidetes but decreased the abundances of genus belonging to phylum Firmicutes compared with the control. Data showed that Bacteroidetes was the most dominant phylum, while Prevotella ruminicola was the dominant species across the three TMR groups. The relative abundance of Ruminococcus bromii in the rumen increased in heifers fed with high inclusion of IRGS in the TMR (H-IRGS TMR). The relative abundance of R. bromii in the rumen significantly increased when heifers were fed H-IRGS TMR while P. ruminicola increased in both L-IRGS and H-IRGS TMR groups. Results from the current study demonstrate that the inclusion of IRGS in the TMR is comparable with the TMR containing high-quality forage (CON). Thus, a high level of IRGS can be used as a replacement forage ingredient in TMR feeding and had a beneficial effect of possibly modulating the rumen bacterial community toward mainly propionate-producing microorganisms.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.99-106
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• 2013

We investigated the effects of gambigyeongsinhwan(GGH)(4) on body weight and non-alcoholic fatty liver disease(NAFLD) examined whether blood total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels and hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, GGH(4)-1, GGH(4)-2 and GGH(4)-3. After mice were treated with GGH(4) for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma ALT, leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Compared with controls, GGH(4)-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in GGH(4)-2. Compared with controls, GGH(4)-treated mice had lower feeding efficiency ratio and blood leptin level, the magnitudes of which was prominent in GGH(4)-2. Compared with controls, GGH(4)-treated mice had lower blood plasma total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels. Compared with controls, GGH(4)-2 treated mice had lower blood plasma ALT concentration. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by GGH(4), whereas the adipocyte number per unit area was significantly increased, suggesting that GGH(4) decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGH(4). In conclusion, these results suggest that GGH(4) exhibits anti-obesity effects through the modulation of feeding efficiency ratio and plasma obesity parameters. Moreover, it seems that GGH(4) also contributes to improve NAFLD through the regulation of plasma ALT and hepatic triglyceride accumulation.