• Journal of Physiology & Pathology in Korean Medicine
• /
• v.21 no.5
• /
• pp.1154-1162
• /
• 2007

This study was to investigate the effects of Bee-venom Treatment on the monosodium iodoacetate(MIA)- induced osteoarthritis in rats. Arthritis was induced by injection of MIA(0.5 mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was injected with normal saline once a day for 20 days, while treated group was injected with Bee-venom extract once a day for same duration. Body weights were measured at 0, 5, 10, 15, 20 days after injection. At the end of experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan contents of articular cartilages were analysed by safranine O staining method. The contents of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 in synovial fluids were analysed by ELISA method. And also, COX-2 and iNOS immunohistochemical examination on the knee joints were performed. Body weights of the treated group were increased compared with control group at 20 days after injection. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control group. PG contents in articular cartilages of the treated group were significantly increased compared with control group. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control group. $TNF-{\alpha}$ contents in synovial fluids of the treated group were decreased compared with control group. Positive reactions of COX-2 in chondrocytes and synovial membranes of the treated group were decreased compared with the control group. On the basis of these results, we concluded that Bee-venom treatment has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it's effects were related with reduced secretion of $TNF-{\alpha}$ and COX-2 from osteoarthritic chondrocytes and synovial membranes.

• Journal of Animal Science and Technology
• /
• v.47 no.2
• /
• pp.293-304
• /
• 2005

This experiment was carried out to investigate effects of honeybee venom treatment on the body weight gain, feed conversion and growth rate' in pigs. One hundred twenty nine piglets(LY) from 12 sows were allocated into two groups; honeybee venom-treated group (66 piglets from 6 sows) and non-treated control group (63 piglets from 6 sows). Natural honeybee venom was administrated at 0, 3, 14, 30, and 74 days after birth. The acupoints were Hai-men(ST-25), Du-kou(CV-8) and liao-chao(GV-I) points at 0 day, the regions of castration and tail ampution at 3 days, liao-chao(GV-1) and Bai-hui(GV-20) points at 14(weaning), 30(move into piglet stall) and 74(move into grower stall) days after birth. Control group was injected 1 ml of saline to the same site. Average body weight at 150 days after birth was 98.44 kg in bee venom treated group and 86.24 kg in control group, respectively. Average body weight of treated group was significantly increased by 14.15%(P < 0.0001). Average daily gain of bee venom treated group and control group were 649 g and 569 g, respectively, increased by 14.06%(P< 0.0001). Feed conversion of the treated group was 2.21 and control group was 2.49, increased by 11.25% in control group(P < 0.001). Survival rate at weaning was 95.5 % in treated group and 92.0% in control group, at growing(74 days after birth) was 92.4% in treated group and 85.7% in control group and survival rate at finishing(l50 days after birth) was 89.5 % and 79.4 %, respectively. Collecting together, the results in this study showed that growth performance and feed conversion were increased by treatment of natural honeybee venom to pigs. These results suggested that the treatment of bee venom could be used effectively for the increase productivity of livestock industry.

• Journal of Korean Academy of Nursing
• /
• v.22 no.1
• /
• pp.29-41
• /
• 1992

The purpose of this research was to study the effects of antenatal breast care on decreases in breast discomfort and increases in the breast feeding rate during the postpartum period. A nonequivalent control group posttest research design was used. The experimental group consisted of fifty -one pregnant women(primigravida) who were receiving antenatal care in the OBGYN clinics of four hospitals between March 5 and May 30, 1991. The control group was made up of seventy - five postpartum women who delivered at two hospitals OBGYN clinic and one midwife clinic between May 4 and June 15, and between September 5 and October 15, 1991. Data were collected via telephone interviews on the seventh postpartum day and at the end of the second month. Data analysis methods used frequencies and the x$^2$- test. The results were as follows : 1. The rate of breast feeding practice at two months was higher in the experimental group(70.6%) than in the control group(25.3%) (p＜.01). 2. Nipple soreness in the early breast feeding period was lower in the experimental group(14.6%) than in the control group(25.3)(p＜.01). 3. Severe breast discomfort in the early breast feeding period was lower in the experimental group (12.5%) than in the control group(39.2%)(P＜.01). 4. There was a significant relationship between the breast feeding practice and the planned feeding method(p＜.05), and between breast feeding practice and nipple soreness(p＜.01) in the experimental group, and the presence of a job(p＜.01), the sex of the infant(p＜.05), and the first feeding time(p＜.05) in the control group. 5. The reasons for unsuccessful breast feeding were a deficiency of breast milk (66.7% in the experimental group, 30.4% in the control group), poor sucking on the part of the baby(13.3% in the experimental group, 21.4% in the control group).

• Journal of Sasang Constitutional Medicine
• /
• v.24 no.4
• /
• pp.62-74
• /
• 2012

Objectives : The purpose of this study is to investigate the effect of oral administration of Yongyukjowi-tang(YJT) on the immune activity in aged Sprague-Dawley rat(SD rat). Methods : SD rats were divided into three groups: Yongyukjowi-tang groups(YJT groups), distilled water groups(control groups) and Vitamin C groups(positive control groups) which were administered an oral dose(1ml/1day) to 6, 48 and 68 weeks old SD rats for four weeks. After four weeks, the number of total leukocyte, CD3+, CD4+, CD8+, and the level of cytokine (IL-2, IL-4, IL-10, IFN-${\gamma}$) were measured in spleen tissue of each SD rats. Results and Conclusions : 1) The number of total leukocyte significantly increased in 52 weeks old YJT group and 72 weeks old YJT group in comparison with those of the control group. 2) The number of CD3+ cell significantly increased in 72 weeks old YJT group in comparison with those of the control group and the positive control group. 3) The number of CD8+ cell significantly increased in 52 weeks old YJT group in comparison with those of the control group. 4) The level of IL-2 significantly increased in 72 weeks old YJT group in comparison with those of the control group and the positive control group. 5) The level of IL-4 significantly increased in 52 weeks old YJT group in comparison with those of the positive control group. These results suggest that oral administration of YJT has an effect on increase of immune activity in aged rat.

• The Journal of Korean Medicine
• /
• v.22 no.3
• /
• pp.119-128
• /
• 2001

Objectives: Daechu (Dazhui: GV 14 (Governor Vessel))-point is located between the spinous process of the 7th cervical vertebra and that of the 1st thoracic vertebra. GV 14 has been used to treat high fever, neck pain, common cold, headache and so on. Fever may badly affect the improvement of stroke patients, so we investigated whether wet-cupping at GV 14 had effects on fever. Methods: In this study, 100 stroke patients were studied from Nov. 1999 to Oct. 2000. They were divided into the Sample group (n=49) and Control group (n=5l). The Sample group (n=49) was divided into Sample-Severe (n=2l), Sample-Mild (n=12), and Sample-Normal groups (n=16) and the Control group (n=5l) was divided into Control-Severe (n=8) and Control-Mild (n=43). We checked body temperature 6 times (just before treatment, after 30 ruin., 60, 90, 120 (2 hrs.), and 240 ruin. (4 hrs.)) in the Sample group and 3 times (just before treatment, after 120 min. (2 hrs.), and 240 ruin. (4 hrs.)) in the Control group. Results: In comparison with fever between before treatment and after 2 and 4 hours in each group, fever in the Sample subgroups decreased significantly in all cases, fever in the Control subgroups didn't decrease significantly in most cases except fever after 4 hours in the Control-Mild group. In comparison with fever differences between the Sample and Control group, fever of the Sample group more significantly decreased than that of the Control group in all comparisons. In comparison with fever among sample subgroups, fever of the Sample-Severe group decreased more than that of the Sample-Mild group but it was not significant. Conclusions: This study suggested that wet-cupping at GV 14 has significant effects on fever in stroke patients. We hope that this treatment will be used more widely as an emergent treatment.

• Journal of Korean Medicine for Obesity Research
• /
• v.14 no.1
• /
• pp.29-35
• /
• 2014

Objectives: This study was to investigate how body-shape perception could influence to weight control practice both in normal and obese group. Methods: We used 2012 Korea National Health and Nutrition Examination Survey to analysis 1) weight control practices of population; 2) consistency between body-shape perception and body mass index; 3) comparison weight control practices between normal group and body mass index (BMI) obese group in perceptional obese group; 4) odds ratio of BMI obese group using herbal drugs for weight control practice in perceptional obese group. Results: We found that study population tends to choose exercise, dietary restriction, meal skip, health functional food, one-food, drug, herbal drug, fasting and self-medication in order of frequency to control weight. The agreement between body-shape perception and BMI within obese group was approximately 64% with 0.40 of Cohen's Kappa coefficient, ranging from 0.384 to 0.423. Within perceptional obese group, choosing each weight control practice methods ratios between normal BMI group and obese BMI group were not significantly different. Within perceptional obese group, obese BMI group showed significant odds ratio (2.58, 95% confidence intervals, 1.38~4.85) than normal BMI group in choosing herbal medication for weight loss when adjusting other variables. Conclusions: We concluded that body-shape perception might be an important factor for choosing weight control program, and roles of Korean medical doctors thought to be enhanced for using herbal medication for weight loss.

• Journal of Korean Physical Therapy Science
• /
• v.30 no.1
• /
• pp.41-51
• /
• 2023

Background: The purpose of this study was to identify the effects of underwater and ground proprioceptive neuromuscular facilitation lower extremity pattern exercise on trunk control and lower extremity muscle activity of chronic stroke patients. Design: Pretest-posttest design: single blind. Methods: The subjects were 28 patients (experimental group, n=14 or control group, n=14) diagnosed with chronic stroke. The experimental group performed underwater proprioceptive neuromuscular facilitation lower extremity pattern exercise. The control group performed ground proprioceptive neuromuscular facilitation lower extremity pattern exercise. Training was conducted once a day for 30 minutes, five days per week for six. Trunk control was measured using the Trunk Impairment Scale. Lower extremity muscle activity was measured using surface electromyography. Results: As a result of comparison within groups, the experimental and control group showed significant difference for trunk control after the experiment (p<0.05). In comparison between two groups, the experimental group showed more significant difference in trunk control than the control group (p<0.05). In comparison within groups, the experimental group showed significant difference for lower extremity muscle activity after the experiment (p<0.05). In comparison between two groups, the experimental group showed more significant difference in lower extremity muscle activity than the control group (p<0.05). Conclusion: Based on these results, underwater proprioceptive neuromuscular facilitation lower extremity pattern exercise effectively improved the trunk control and lower extremity muscle activity of chronic stroke patients.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.2
• /
• pp.419-426
• /
• 2004

This experimental study was designed to investigate the effects of Yukgunja-tang(YGJT) on the inhibition of cerebral ischemia in rats. And We measured regional cerebral blood f1ow(rCBF) and pial arterial diameter(PAD) in cerebral ischemic rats, and cytokines production in serum Of cerebral ischemic rats. The results were as follows; Both rCBF and PAD were significantly and stably increased by YGJT(10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) 1 hr, IL-1β and TGF-β production of sample group were similar to that of control group, but sample group was decreased TNF-α production compared with control group, and was significantly increased IL-10 production in compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1 hr, sample group was significantly decreased IL-1β and TNF-α production compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was significantly increased IL-10 production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, and sample group was decreased TNF-α production in compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was increased IL-10 production compared with control group. This results were suggested that YGJT has inhibitive effect on the brain damage by inhibited IL-1β production and TNF-α production, but accelerated IL-10 production. We thought that YGJT should have an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.

• Journal of Korean Academy of Nursing
• /
• v.14 no.2
• /
• pp.38-46
• /
• 1984

The purpose of this study was to test the effect of the structured preoperative teaching on post-operative recovery and to observe the effects of an structured preoperative teaching on the adult surgical patient's ventilatory function ability, the length of hospital stay, the number of analgesics within a 72 hour postoperative period, the length of early ambulation. The research question investigated in this study was: What would be the effects of a structured preoperative teaching upon the adult surgical patients postoperative recovery? This study was based on a sample of 40 patients who were scheduled for abdominal surgery. They were asssigned alternately to experimental and control group. Among 40 subjects, 20 were placed in the experimental group and 20 in the control group. Preoperative ventilation function testing of control and experimental subjects was done the evening before surgery and before the patient received the structured preoperative teaching. A structured preoperative teaching was given to the subjects in the exporimental group only by writer. Postoperative testing was done the 5th postoperative day. The data were collected over a period of two months, from Aug. 8 to Oct. 31, 1983. For the analysis of the data and test for the hypotheses, the t-test with mean difference was used. The results of this study regarding the four-hypotheses were as follows: 1. Experimental group which received structured preoperative eaching will have more increase to-cough and deep breathe as measured byhis forced vital capacity(FVC), forced expiratory volume 1 (FEV1), maximal voluntary volume 15 (MVV 15) than control group without structured preoperative teaching. The ventilation function ability was more increase in experimental group than in control group, the mean difference was statistically significant at 0.01 level. Hypotheses 1 was supported. 2. Experimental group with structured preoperative teaching will have more reduced the length of hospital stay than control group without structured preoperative teaching. The length of hospital stay of the experimental group and control group were 11.90 days and 16.05 days respectively. However, the difference was. not statistically significant at .05 level. Therefore the hypothese 2 was not supported. 3. Experimental group with structured preoperative teaching will have more reduce the number of analgesics within a 72 hour postoperative period than control group. The number of analgesics within a 72 hour' postoperative period of experimental group and control group were 1.65 times and 2.4 times. The difference was not statically significant at .05 level. Therefore, the hypotheses 3 was not supported. 4. Experimental group with structured preoperative. teaching will have more reduce the length of early ambulation than control group without structured preoperative teaching. The length of early ambulation of experimental group and control group were 2.2 days and 3.5 days respectively The difference was statistically signficant at 0.05 level. Thus the hypothess 4 was supported.

• The Journal of Korean Medicine
• /
• v.17 no.2 s.32
• /
• pp.168-177
• /
• 1996

In order to study the effect of aqua-acupuncture with Cervi Cornu (C.C.) extract solution manufactured by water-alcohol method on the lipid metabolism and osteoporosis, C.C. aqua-acupuncture was carried out every two days for 60 days on the corresponding bilateral loci of Shinsu (BL23), Taejo (BL11), and Hyonjong (GB39) from the 10th day after the ovariectomy for induced osteoporosis and thereafter the level of serum triglyceride, LDL, Ca, phosphorus and osteocalcin, as well as urine hydroxyproline were measured in the ovariectomized rats. The rats being studied were divided into a normal group (sham operation group), a control group (ovariectomized group), and a C.C. aqua-acupuncture group (group with C.C. aqua-acupunctured to the points of Shinsu, Taejo, and Hyonjong every two days for 60 days from the 10th day after the ovariectomy). The following results were obtained: 1. The serum triglyceride indicated an inhibited increase with statistical significance in the C.C. aqua-acupuncture group compared with the control group. 2. The serum LDL indicated an inhibited increase without any statistical significance in the C.C. aqua-acupuncture group compared with the control group. 3. The serum Ca showed an inhibited decrease without any statistical significance in the C.C. aqua-acupuncture group compared with the control group. 4. The serum phosphorus showed an inhibited decrease with statistical significance in the C.C. aqua-acupuncture group compared with the control group. 5. The serum osteocalcin indicated an inhibited decrease without any statistical significance in the C.C. aqua-acupuncture group compared with the control group. 6. The urine hydroxyproline showed an inhibited increase with statistical significance in the C.C. aqua-acupuncture group compared with the control group.