• 간호행정학회지
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• 제6권3호
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• pp.357-374
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• 2000

The purpose of this study was to validate knowledge outcomes included Nursing Outcomes Classification(NOC) developed by Johnson and Maas at the University of Iowa. A sample of 71 nurse experts working in university affiliated hospitals participated in this study. They were asked to rate indicators that examplified the outcomes on a scale of 1(indicator is not all characteristic) to 5(indicator is very characteristic). A questionnaire with an adaptation of Fehring's methodology was used to establish the content validity of outcomes. The results were as follow: 1. All indicators were considered to be 'supporting' and no indicators were considered to be 'nonsupporting'. 2. 'Knowledge: Treatment Regimen' attained and OCV score of 0.816 and was the highest OCV score among outcomes. 3. 'Knowledge: Energy Conservation' attained an OCV score of 0.748 and was the lowest OCV score among abuse outcomes. 4. 'Knowledge: Breastfeeding' attained an OCV score of 0.790 and was the highest indicator was 'description of benefits of breastfeeding'. 5. 'Knowledge: Child Safety' attained an OCV score of 0.778 and was the highest indicator was 'demonstration of first aids techniques'. 6. 'Knowledge: Diet' attained an OCV score of 0.779 and was the highest indicator was 'performance of self-monitoring activities'. 7. 'Knowledge: Disease Process' attained an OCV score of 0.815 and was the highest indicator was 'description of signs and symptoms'. 8. 'Knowledge: Health Behaviors' attained an OCV score of 0.800 and was the highest indicator was 'description of safe use of prescription drugs'. 9. 'Knowledge: Health Resources' attained an OCV score of 0.794 and was the highest indicator was 'description of need for follow-up care'. 10. 'Knowledge: Infection Control' attained an OCV score of 0.793 and was the highest indicator was 'description of signs and symptoms'. 11. 'Knowledge: Medication' attained an OCV score of 0.789 and was the highest indicator was 'description of correct administration of medication'. 12. 'Knowledge: Personal Safety' attained an OCV score of 0.804 and was the highest indicator was 'description of measures to reduce risk of accidental injury'. 13. 'Knowledge: Prescribed Activity' attained an OCV score of 0.810 and was the highest indicator was 'proper performance of exercise'. 14. 'Knowledge: Substance Use Control' attained an OCV score of 0.809 and was the highest indicator was 'description of signs of dependence during substance withdrawl'. 15. 'Knowledge: Treatment Procedure(s)' attained an OCV score of 0.795 and was the highest indicator was 'description of appropriate action for complications'. 16. 'Knowledge: Treatment Regimen' attained an OCV score of 0.816 and was the highest indicator was 'description of self-care responsibilities for emergency situations'. More outcomes need to be validated and outcomes sensitive to Korean culture need to be developed.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5531-5536
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• 2015

Background: Increased pricing of cigarettes might be one of the most effective approaches for reducing the prevalence of smoking. This study aimed to investigate the effects of increasing cigarette prices through taxation by a tobacco intervention policy on the changes in smoking prevalence in Korean university students. Materials and Methods: The participants in this study were 23,047 healthy university students aged 18-29 years from a health examination in 2011-2015. We investigated the adjusted prevalence of daily and occasional smoking before and after increasing cigarette prices through taxation. Results: The prevalence of occasional smoking was significantly decreased in 2015 from 2014 in both male (from 10.7% in 2014 to 5.4%) and female (from 3.6% to 1.1%) students, but the prevalence of daily smoking did not decrease significantly. The frequency of individuals who had attempted smoking cessation during the past year was significantly higher among occasional smokers in male students (90.2%) compared with daily smokers (64.9%). For female students, there were no differences in experience of smoking cessation, willingness for smoking cessation, or E-cigarette experience between daily and occasional smokers. Conclusions: We found that a policy of increasing cigarette prices through taxation is associated with decreases in the prevalence of occasional smokers, who have relatively lower nicotine dependence compared with individuals who smoke daily. The results of our study suggest that social support and direct intervention for smoking cessation at the community level are needed for university students alongside the pricing policy.

• Korean Journal of Acupuncture
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• 제30권3호
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• pp.145-150
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• 2013

목적 : 본 연구는 코카인 연구에 사용된 경혈을 고찰하고 그 효능을 경락학설의 관점에서 해석하기 위해 수행되었다. 방법 : 논문 검색 사이트 PubMed에서 50 개의 논문, KISS에서 16 개의 논문, OASIS에서 9 개의 논문, NDSL에서 40 개의 논문, DBPIA에서 19 개의 논문을 '코카인' 또는 '침'을 검색어로 하여 조사하였다. 영문로 작성된 코카인(남용, 의존, 민감화, 섭취, 금단 증상, 재발, 탐닉)에 관한 논문을 조사하였고 수기침이나 전침만을 대상으로 하였으며 이침은 제외하였다. 결과 : 가장 많이 이용된 경혈은 신문(HT7)이었고 합곡(LI4), 태연(LU9), 족삼리(ST36), 삼음교(SP6) 등은 한 번씩 사용되었다. 신문은 수소음심경이 뇌의 기능과 깊이 관련되어 있다는 것 및 혈명이 가지는 뜻으로부터 충분히 이해될 수 있으며 태연은 신문의 효능을 증강시키는 것으로 생각된다. 합곡은 머리 꼭대기로 흐르는 궐음경을 조절하는 것으로 생각되고 족삼리는 궐음과 관련된 스트레스 반응을 조절하는 것으로 보이며 삼음교는 정신질환에 효능이 있으므로 뇌 기능을 조절하기 위해 사용된 것으로 생각된다. 결론 : 코카인 연구에 사용된 경혈은 다양한 경로를 통해 뇌 기능에 영향을 주는 것으로 사료되며 장부상통 이론이 일정 부분 관련되어 있는 것으로 생각된다.

• 대한한의학회지
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• 제19권1호
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• pp.145-164
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• 1998

The purpose of this study is to evaluate the effect of Injinchunggantang-derivative on proliferation of hepatocyte in rats. Cell viability is studied by MTI assay. The gene related to cell replication such as p53, waf1, bcl-2 and $bcl-_{X_L}$ is quantitized by quantitative RT-PCR and the proteins coded by these genes are studied by Western blotting. The results are as follows. 1. The hepatocytes cultured in medium with lnjinchunggantang-derivative showed better viability compared with control grroup in MTI assay, and the hepatocytes cultured in medium with the Injinchunggantang-derivative-and-ethanol-mixed group showed better viability than the hepatocytes cultrued in 10% ethanol culture medium(control group), noting that Injinchunggantang-derivative has protective effect on hepatocyte injury. There was no dose- and time-dependence. 2. In quantitative RT-PCR, i) Bel-2 gene increased significantly both in Injinchunggantang-derivative group and in Injinchunggantang-derivative-and-ethanol-mixed group, while it showed no significant increase or decrease in other group. ii) $Bcl-_{X_L}$ gene increased significantly in Injinchunggantang-derivative group as well as in Injinchunggantang-deri vative-and-ethanol -mixed group. iii) P53 gene showed no significant increase or decrease in hepatocytes cultured in medium with 10% ethanol and in hepatocytes cultured in medium with Injinchunggantang-derivative-and-ethanol-mixed group, suggesting that 10% ethanol induced cell toxicity, thus increased p53 gene expression. iv) Wafl gene showed no significant increase or decrease in hepatocytes cutured in medium with Injinchtrnggantang-derivative, while increased in hepatocytes cultured in medium with 10% ethanol and in hepatocytes cultured in medium with Injinchtrnggantang-derivative-andethanol-mixed group, suggesting that 10% ethanol induced cell toxicity increased wafl gene expression. 3. In the study on protein by western blotting, the band of bcl-2 and $bcl-_{X_L}$ were widened in Injinchtrnggantang-derivative group. Especially the amount of $bcl-_{X_L}$ increased significantly compared with other groups. But in the study on p53 and wafl, there was no significant difference among those groups. Above study shows that Injinchunggantang-derivative has good effect on cell viability and that the genes resistant to cell death such as bcl-2 and $bcl-_{X_L}$ are induced by Injinchunggantang-derivative to resist to cell death by toxic agent And this is reconfirmed in protein study using' western blotting: These results suggest that Injinchunggantang-derivative has inhibitory effect on cell death as well as protective effect on hepatocyte. Therefore this prescription is recommended in various liver diseases such as chronic liver disease and-induced hepatic injury.

• 한국콘텐츠학회논문지
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• 제19권12호
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• pp.604-614
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• 2019

본 연구는 수용-전념치료(ACT) 집단프로그램을 알코올중독자들에게 적용하여 심리적 유연성과 자기-자비 및 알코올중독 회복에 미치는 효과들을 평가하기 위한 목적으로 진행하였다. 수용-전념치료(ACT) 프로그램은 수용과 기꺼이 경험하기, 인지적 탈융합, 맥락적 자기, 현재순간 접촉, 가치명료화, 전념행동을 향상시키는 기술들을 포함한다. 본 연구에서는 ACT 집단프로그램을 통하여 심리적 유연성 증진뿐만 아니라, 자기-자비와 알코올중독자 회복 향상을 기대하였다. 입원 치료중인 알코올의존 환자 중 수용-전념 치료(ACT) 실험집단에 15명, 약물치료만 하는 TAU 통제집단과 CBT 통제집단에 동일하게 15명씩 참여하였다. ACT 집단프로그램은 주 1회, 8회기, 매 회기 90분으로 진행되었다. 수용-전념치료(ACT) 실험 집단과 통제 집단들의 사전, 사후 및 추후 측정치 평균들을 대상으로 반복 측정 다변량 분산분석과 사후 분석을 실시하였다. 프로그램 효과성 검증 결과, 수용-전념치료(ACT) 프로그램은 수용 및 경험하기, 인지적 탈융합, 현재순간 자각, 마음 챙김, 전념행동과 같은 심리적 유연성이 효과적으로 증가하였다. 또한 자기-자비와 알코올중독자 회복 효과가 유의미하게 증가하였음을 확인하였다.

• 대한간호학회지
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• 제28권1호
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• pp.70-80
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• 1998

This study is designed to contribute to the nursing intervention of adolescent domestic violence victims by describing specifically what they go through and on this basis work out a grounded theory on the adolescent's experience in domestic violence. The data were analyzed in the framework of grounded theory as mapped out by Strauss & Corbin(1990). The major findings of this research are as follows : The core category was found to be the the adaptation of "Joyudeum" or “Straight jacketing”. The sub-categories identified in the process of grounded data analysis were 'menacing', 'being harassed', 'being pressed', 'being attacked', 'being strapped', 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard', 'endurance', 'regulation', 'seriousness'. 'repitition'. 'being helpful', 'dependence', 'thinking oriented', 'blowing off', 'going astray', 'self-deprecating', 'shaking off', 'covering up', 'governing', 'being devoted', 'performing', 'being transformed'. 'bolting', 'being shaken', 'withdrawing', 'disliking', 'bitterness'. These categories were again grouped into 13 categories including 'threatening'. 'straight jacketing', 'tolerance', 'violence', 'supporter', 'supporting type', 'thinking oriented'. 'impulsive response', 'self-controlled', 'response', 'self-reliance', 'wandering', 'withdrawal' and pain'. Of these the five sub-categories 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard' were grouped into a core category "straight jacketing". Those adolescents brought up in a violent family go through three stages of the adaptation of "straight Jacketing". that is, generation, response and adaptation. The following four theses were confirmed on the basis of repetitive relations : 1) If a subject's tolerance is strong, the episodes of the violence are frequent and serious, with the resulting straight jacketing being stronger but the subject's supporter is highly mature, the supporting type is concrete and the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is self-reliance with part of it resulted in withdrawal and pain. 2) If a subject's tolerance is weak, the episodes of the violence are frequent but not serious, with the resulting straight jacketing being weaker but the subject's supporter is immature, the supporting type is superficial and the thinking oriented is extemporary, the responses to the straight jacketing result in an impulsion whose consequence is wandering with part of it resulted in withdrawal and pain. 3) If a subject's tolerance is weak, the episodes of the violence are frequent and serious, the straight jacketing is strong, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in an impulsion whose consequence is withdrawal and pain with part of it resulted in wandering. 4) If a subject's tolerance is strong and the episodes of the violence are infrequent and not serious, the straight jacketing is weak, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is withdrawal and pain with part of it resulted in self-reliance.

• The Korean Journal of Physiology and Pharmacology
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• 제2권3호
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• pp.297-305
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• 1998

This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of $2.4{\pm}0.9$ Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of $3.28{\pm}5.7\;M{\Omega}$ and a membrane time constant of $7.4{\pm}1.8$ ms. These neurons exhibited $2.4{\pm}0.2$ ms spike durations, which were similar to the average spike duration recorded in the neurons of the control group. Slightly less than half of these neurons were firing spontaneously with an average discharge rate of $2.4{\pm}1.1$ Hz. The average peak amplitude of the AHP following the spikes in these groups was $7.4{\pm}0.6$ mV with respect to the resting membrane potential. Cells in MK-801 and lidocaine treated group (5 mg/kg, i.c.v.) had an average input resistance of $3.45{\pm}6.0\;M{\Omega}$ and an average time constant of $8.0{\pm}1.4$ ms. The cells were firing spontaneously at an average discharge rate of $0.6{\pm}0.4$ Hz. Upon depolarization of the membrane by 0.8 nA for 400 ms, all of the tested cells exhibited accommodation of spike discharge. The most common synaptic response contained an EPSP followed by early-IPSP and late-IPSP. Analysis of the voltage dependence revealed that the early-IPSP and late-IPSP were putative $Cl^--and\;K^+-dependent$, respectively. Systemic injection of the NMDA receptor blocker, MK-801, did not block synaptic responses to the stimulation of the commissural pathway. No significant modifications of EPSP, early-IPSP, or late-IPSP components were detected in the MK-801 and/or lidocaine treated group. These results suggest that MK-801 and lidocaine manifest their CNS effects through firing pattern of hippocampal pyramidal cells and neural network pattern by changing the synaptic efficacy and cellular membrane properties.

• 한국방사선학회논문지
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• 제16권3호
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• pp.257-263
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• 2022

방사선 근접치료에서 잘못된 선원의 위치는 정상조직에 불필요한 선량을 조사하게 되므로, 정도관리 항목에서 방사선원의 위치를 검증하는 것은 필수적이다. 이에 본 연구에서는 디지털 line 선량계의 기초 연구로써 polycrystalline mercury (II) iodide (HgI₂)기반의 unit cell 선량계를 제작하고 실리콘다이오드와 재현성, 선형성, 거리의존성에 대한 성능을 비교하였다. 그 결과 재현성은 relative standard deviation (RSD)이 1.21%로 RSD 평가 기준 1.5% 이내를 만족하였다. 선형성 평가는 선형계수 R²가 0.9997로 우수한 결과를 보였다. 거리 의존성은 inverse square value와 비교하였을 때, intensity 50%는 0.035 cm의 차이를 보이며 전체적으로 유사한 경향을 보였다. 본 연구는 HgI₂ 선량계의 성능 평가함으로써 근접치료 정도관리를 위한 디지털 선량계의 적용 가능성을 제시하고 있으며, 본 연구에 대한 결과는 광도전체 물질의 선량계로써의 특성분석에 대한 연구로, 방사선 및 검출기에 대한 모든 분야의 기초 자료로 활용될 수 있다.

• 한국결정성장학회지
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• 제32권5호
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• pp.175-182
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• 2022

MLCC(Multi-Layer Ceramic Capacitor)의 유전체 층에 사용되는 BaTiO₃는 유전 특성의 온도안정성을 향상시키기 위해 첨가제로서 희토류 및 Mg를 사용한다. 이러한 첨가제는 소결 중 입자성장 및 치밀화 거동, 결국 유전 특성에 지대한 영향을 주게 되므로 조성에 따른 미세구조 발현 양상을 살펴보는 것이 중요하다. 본 연구는 95BaTiO₃-1Dy₂O₃-2MgO-2SiO₂(mol%)의 조성에서 온도 변화에 따른 결정구조, 입자성장 및 밀도 변화를 관찰하고 이러한 변화가 유전 상수에 미치는 영향을 관찰하였다. 1200~1300℃의 온도범위에서 소결 온도가 증가함에 따라, 평균 입도는 눈에 띄게 커지는 반면 밀도의 변화는 미미하여 입자크기가 주요한 미세구조적 요소임을 밝혔다. 본 실험에서 관찰된 입자크기의 온도의존성은 기존 입자성장 이론에서 설명한 온도 변화에 따른 입자성장 거동의 변화양상과 잘 부합하였으며, 이러한 이해는 향후 희토류가 첨가된 BaTiO₃에서 유전 특성 향상을 위한 소결 미세구조 제어에 유용하게 활용될 수 있을 것이다.

• Journal of Gastric Cancer
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• 제22권2호
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• pp.120-134
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• 2022

Purpose: This study aimed to identify prognostic factors for patients with distant lymph node-involved gastric cancer (GC) using a machine learning algorithm, a method that offers considerable advantages and new prospects for high-dimensional biomedical data exploration. Materials and Methods: This study employed 79 features of clinical pathology, laboratory tests, and therapeutic details from 289 GC patients whose distant lymphadenopathy was presented as the first episode of recurrence or metastasis. Outcomes were measured as any-cause death events and survival months after distant lymph node metastasis. A prediction model was built based on possible outcome predictors using a random survival forest algorithm and confirmed by 5×5 nested cross-validation. The effects of single variables were interpreted using partial dependence plots. A contour plot was used to visually represent survival prediction based on 2 predictive features. Results: The median survival time of patients with GC with distant nodal metastasis was 9.2 months. The optimal model incorporated the prealbumin level and the prothrombin time (PT), and yielded a prediction error of 0.353. The inclusion of other variables resulted in poorer model performance. Patients with higher serum prealbumin levels or shorter PTs had a significantly better prognosis. The predicted one-year survival rate was stratified and illustrated as a contour plot based on the combined effect the prealbumin level and the PT. Conclusions: Machine learning is useful for identifying the important determinants of cancer survival using high-dimensional datasets. The prealbumin level and the PT on distant lymph node metastasis are the 2 most crucial factors in predicting the subsequent survival time of advanced GC.