• The Korean Journal of Physiology and Pharmacology
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• v.19 no.3
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• pp.229-234
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• 2015

Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation in patients undergoing continuous renal replacement therapy and extra corporeal membrane oxygenation. Oxidative stress is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial function. We investigated whether NM could inhibit endothelial dysfunction induced by tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$ ). Human umbilical vein endothelial cells (HUVECs) were treated with TNF-${\alpha}$ for 24 h. The effects of NM on monocyte adhesion, vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) protein expression, p38 mitogenactivated protein kinase (MAPK) activation, and intracellular superoxide production were then examined. NM ($0.01{\sim}100{\mu}g/mL$) did not affect HUVEC viability; however, it inhibited the increases in reactive oxygen species (ROS) production and p66shc expression elicited by TNF-${\alpha}$ (3 ng/mL), and it dose dependently prevented the TNF-${\alpha}$ -induced upregulation of endothelial VCAM-1 and ICAM-1. In addition, it mitigated TNF-${\alpha}$ -induced p38 MAPK phosphorylation and the adhesion of U937 monocytes. These data suggest that NM mitigates TNF-${\alpha}$ -induced monocyte adhesion and the expression of endothelial cell adhesion molecules, and that the anti-adhesive effect of NM is mediated through the inhibition of p66shc, ROS production, and p38 MAPK activation.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.13 no.5
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• pp.209-220
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• 2013

Handover is the technology to minimize data lose of mobile devices and make continuous communication possible even if the device could be moved from one digital cell site to another one. That is, it is a function that enables the mobile user to avoid the disconnection of phone conversations when moving from a specific mobile communication area to another. Today, there are a lot of ongoing researches for fast and efficient hand-over, in order to address phone call's delay and disconnection which are believed to be the mobile network's biggest problems, and these should essentially be resolved in all mobile networks. Thanks to recent technology development in mobile network, the LTE network has been commercialized today and it has finally opened a new era that makes it possible for mobile phones to process data at high speed. In LTE network environment, however, a new authentication key must be generated for the hand-over. In this case, there can be a problem that the authentication process conducted by the hand-over incurs its authentication cost and delay time. This essay suggests an efficient key caching hand-over method which simplifies the authentication process: when UE makes hand-over from oMME to nMME, the oMME keeps the authentication key for a period of time, and if it returns to the previous MME within the key's lifetime, the saved key can be re-used.

• Journal of the Korean Association of Geographic Information Studies
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• v.16 no.2
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• pp.75-87
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• 2013

This study developed a GIS-based suitability assessment model of coastal zoning system that is needed in the substantial classification of coastal zoning system according to the establishment of law about coastal zoning system. First, this study investigated several kinds of regulations, GIS database and application system related coastal area. Also, grid data model was selected as the GIS analytical model for calculating items of suitability assessment of coastal zoning system. And Grid-based analytical method was suggested for calculating items composing of sea and spatial location characteristics including physical one. Critical values of items were presented using standards that were suggested in coastal regulations and land suitability assessment. Especially, this study presented a calculation method of continuous pattern as fuzzy set function for reflecting the characteristics of GIS data. And this study classified the suitability grade using Z-score and developed model designating coastal zone as conservation management priority, utilization management priority, and planning management priority. This study is judged that very efficient business performance is possible if we consider the spatial coverage of study area and GIS database when the suitability assessment model of coastal zoning system that is suggested in this study, is applied to business works.

• International Commerce and Information Review
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• v.15 no.4
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• pp.267-286
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• 2013

The WCO Time Release Study (TRS) is a unique tool and method for measuring the actual performance of Customs activities. The ultimate aim of TRS is to improve the performance of the function being measured. To be more specific, TRS is used for identifying bottlenecks in the international supply chain and/or constraints affecting Customs release, assessing newly introduced and modified techniques, procedures, technologies and infrastructure, or administrative changes, establishing baseline trade facilitation performance measurement, identifying opportunities for trade facilitation improvements and estimating the country's approximate comparative position as a benchmark tool. The effective utilization methods of TRS for trade facilitation in Korea Customs Services are as follows ; Firstly, it is necessary to make every efforts to identify bottlenecks in border-related procedures and improve their procedures for continuous and more improved trade facilitation. Secondly, it is necessary to optimize and simplify export-related procedures using the TRS in exportation for efficiency of total international supply chain. Thirdly, it is necessary to make coordinated border management with main trading partners. Lastly, it is necessary to enhance Korea's international status to support underdeveloped countries in the field of trade procedures.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.1
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• pp.32-40
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• 2008

Fuzzy rules are very useful and efficient to describe classification rules especially when the attribute values are continuous and fuzzy in nature. However, it is generally difficult to determine membership functions for generating efficient fuzzy classification rules. In this paper, we propose a method of automatic generation of efficient fuzzy classification rules using evolutionary algorithm. In our method we generate a set of initial membership functions for evolutionary algorithm by supervised clustering the training data set and we evolve the set of initial membership functions in order to generate fuzzy classification rules taking into consideration both classification accuracy and rule comprehensibility. To reduce time to evaluate an individual we also propose an evolutionary algorithm with data partition evaluation in which the training data set is partitioned into a number of subsets and individuals are evaluated using a randomly selected subset of data at a time instead of the whole training data set. We experimented our algorithm with the UCI learning data sets, the experiment results showed that our method was more efficient at average compared with the existing algorithms. For the evolutionary algorithm with data partition evaluation, we experimented with our method over the intrusion detection data of KDD'99 Cup, and confirmed that evaluation time was reduced by about 70%. Compared with the KDD'99 Cup winner, the accuracy was increased by 1.54% while the cost was reduced by 20.8%.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.491-499
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• 2002

A p-version finite element model based on degenerate shell element is proposed tot the analysis of orthotropic laminated plates. In the nonlinear formulation of the model, the total Lagrangian formulation is adopted with large deflection and moderate rotation being accounted tot in the sense of yon Karman hypothesis. The material model is based on the Huber-Mises yield criterion and Prandtl-Reuss flow rule in accordance with the theory of strain hardening yield function, which is generalized lot anisotropic materials by introducing the parameters of anisotropy. The model is also based on extension of equivalent-single layer laminate theory(ESL theory) with shear deformation, leading to continuous shear strain at the interface of two layers. The integrals of Legendre polynomials are used for shape functions with p-level varying from 1 to 10. Gauss-Lobatto numerical quadrature is used to calculate the stresses at the nodal points instead of Gauss points. The validity of the proposed P-version finite element model is demonstrated through several comparative points of iew in terms of ultimate load, convergence characteristics, nonlinear effect, and shape of plastic tone.

• Wind and Structures
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• v.30 no.4
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• pp.433-450
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• 2020

The strong turbulence characteristic of typhoon not only will significantly change flow field characteristics surrounding the large-scale wind turbine and aerodynamic force distribution on surface, but also may cause morphological evolution of coast dune and thereby form sand storms. A 5MW horizontal-axis wind turbine in a wind power plant of southeastern coastal areas in China was chosen to investigate the distribution law of additional loads caused by wind-sand coupling movement of coast dune at landing of strong typhoons. Firstly, a mesoscale Weather Research and Forecasting (WRF) mode was introduced in for high spatial resolution simulation of typhoon "Megi". Wind speed profile on the boundary layer of typhoon was gained through fitting based on nonlinear least squares and then it was integrated into the user-defined function (UDF) as an entry condition of small-scaled CFD numerical simulation. On this basis, a synchronous iterative modeling of wind field and sand particle combination was carried out by using a continuous phase and discrete phase. Influencing laws of typhoon and normal wind on moving characteristics of sand particles, equivalent pressure distribution mode of structural surface and characteristics of lift resistance coefficient were compared. Results demonstrated that: Compared with normal wind, mesoscale typhoon intensifies the 3D aerodynamic distribution mode on structural surface of wind turbine significantly. Different from wind loads, sand loads mainly impact on 30° ranges at two sides of the lower windward region on the tower. The ratio between sand loads and wind load reaches 3.937% and the maximum sand pressure coefficient is 0.09. The coupling impact effect of strong typhoon and large sand particles is more significant, in which the resistance coefficient of tower is increased by 9.80% to the maximum extent. The maximum resistance coefficient in typhoon field is 13.79% higher than that in the normal wind field.

• Journal of the Korea Society of Computer and Information
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• v.16 no.11
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• pp.123-135
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• 2011

The domestic market of database in Korea is estimated to be over 3.663 trillion won. The data migration is getting to be more important along with the continuous growth of the database industry. g-CRM and private recommending function are examples of the service that can be given through coupling among customer database, product database, geographic information database, and others. The core infrastructure is also the database which is integrated, perfect, and reliable. There are not enough researches on efficient way of data migration and integrating process and investigation of migrated data though trends of database in IT environment as above. In connection with this issue, we have made a model for data migration on scientific and technological contents and suggest the result of data migration process adapting that model. In addition, we verified migration's exhaustiveness, migration's consistency, and migration's coherence for investigation of migrated data and database. From the result, we conclude data migration based on proper model has a significant influence on the database consistency and the data values correctness and is essential to maintain high qualified database.

• Journal of the Korea Society of Computer and Information
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• v.15 no.8
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• pp.13-21
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• 2010

One of the most distinguished features of the DHP association rules mining algorithm is that it counts the support of hash key combinations composed of k items at phase k-1, and uses the counted support for pruning candidate large itemsets to improve performance. At this time, it is desirable for each hash key combination to have a separate count variable, where it is impossible to allocate the variables owing to memory shortage. So, the algorithm uses a direct hashing mechanism in which several hash key combinations conflict and are counted in a same hash bucket. But the direct hashing mechanism is not efficient because the distribution of hash key combinations is unvalanced by the characteristics sourced from the mining process. This paper proposes a mapped perfect hashing function which maps the region of hash key combinations into a continuous integer space for phase 3 and maximizes the efficiency of direct hashing mechanism. The results of a performance test experimented on 42 test data sets shows that the average performance improvement of the proposed hashing mechanism is 7.3% compared to the existing method, and the highest performance improvement is 16.9%. Also, it shows that the proposed method is more efficient in case the length of transactions or large itemsets are long or the number of total items is large.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.187-192
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• 2014

Various researches are performed to extract significant features from continuous images. The FAST algorithm has the simple structure for arithmetic operation and it is easy to extraction the features in real time. For this reason, the FPGA based hardware accelerator is implemented and widely applied for the FAST algorithm. The hardware accelerator needs the threshold to extract the features from images. The threshold is influenced not only the number of extracted features but also the total execution time. Therefore, the way of threshold control is important to stabilize the total execution time and to extract features as much as possible. In order to control the threshold, this paper proposes the PI controller. The function and performance for the proposed PI controller are verified by using test images and the PI control logic is designed based on Xilinx Vertex IV FPGA. The proposed scheme can be implemented by adding 47 Flip Flops, 146 LUTs, and 91 Slices to the FAST hardware accelerator. This proposed approach only occupies 2.1% of Flip Flop, 4.4% of LUTs, and 4.5% of Slices and can be regarded as a small portion of hardware cost.